Cited by 2,605MicroRNA in disease regulationMechanisms of cancer metastasisCancer Cells and Metastasis

The DOI matches its Crossref record; 48 of the 49 references it cites were found in a registry or an index.

Tumour invasion and metastasis initiated by microRNA-10b in breast cancer

Ma, Li, Teruya-Feldstein, Julie, Weinberg, Robert A.·2007·Nature

Open this paper in CoChat — free account

Abstract

MicroRNAs have been implicated in regulating diverse cellular pathways. Although there is emerging evidence that some microRNAs can function as oncogenes or tumour suppressors, the role of microRNAs in mediating cancer metastasis remains unexplored. Here we show, using a combination of mouse and human cells, that microRNA-10b (miR-10b) is highly expressed in metastatic breast cancer cells and positively regulates cell migration and invasion. Overexpression of miR-10b in otherwise non-metastatic breast tumours initiates robust invasion and metastasis. Expression of miR-10b is induced by the transcription factor Twist, which binds directly to the putative promoter of mir-10b (MIRN10B). The miR-10b induced by Twist proceeds to inhibit translation of the messenger RNA encoding homeobox D10, resulting in increased expression of a well-characterized pro-metastatic gene, RHOC. Significantly, the level of miR-10b expression in primary breast carcinomas correlates with clinical progression. These findings suggest the workings of an undescribed regulatory pathway, in which a pleiotropic transcription factor induces expression of a specific microRNA, which suppresses its direct target and in turn activates another pro-metastatic gene, leading to tumour cell invasion and metastasis.

Integrity signals

Registry

Crossref · 10.1038/nature06174

Cites

48 of 48 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Untitled work
Bartel (2004) · doi:10.1016/s0092-8674(04)00045-5 · Cited by 34,714
MicroRNA expression profiles classify human cancers
Lü, J., Getz, G. A., Miska, E. A., Alvarez-Saavedra, E., Lamb, J., Peck, D., Sweet-Cordero, A., Ebert, B. L., Mak, R. H., Ferrando, A. A., et al. (2005) · Nature · doi:10.1038/nature03702 · Cited by 9,637
MicroRNA signatures in human cancers
Calin, G. A., & Croce, C. M. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1997 · Cited by 7,668
Epithelial–mesenchymal transitions in tumour progression
Thiery, J. P. (2002) · Nature reviews. Cancer · doi:10.1038/nrc822 · Cited by 6,767
Oncomirs—MicroRNAs with a role in cancer
Esquela-Kerscher, A., & Slack, F. J. (2006) · Nature Reviews Cancer · doi:10.1038/nrc1840 · Cited by 5,884
Prediction of Mammalian MicroRNA Targets
Lewis, B. P., Shih, I.-H., Jones-Rhoades, M. W., Bartel, D. P., & Burge, C. B. (2003) · Cell · doi:10.1016/s0092-8674(03)01018-3 · Cited by 5,199
The pathogenesis of cancer metastasis: the ‘seed and soil’ hypothesis revisited
Fidler, I. J. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1098 · Cited by 4,686
Combinatorial microRNA target predictions
Krek, A., Grün, D., Poy, M. N., Wolf, R., Rosenberg, L., Epstein, E. J., MacMenamin, P., da Piedade, I., Gunsalus, K. C., Stoffel, M., et al. (2005) · Nature Genetics · doi:10.1038/ng1536 · Cited by 4,603
Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers
Calin, G. A., Sevignani, C., Dumitru, C. D., Hyslop, T., Noch, E., Yendamuri, S., Shimizu, M., Rattan, S., Bullrich, F., Negrini, M., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307323101 · Cited by 4,096
MicroRNA Gene Expression Deregulation in Human Breast Cancer
Iorio, M. V., Ferracin, M., Liu, C.-G., Veronese, A., Spizzo, R., Sabbioni, S., Magri, E., Pedriali, M., Fabbri, M., Campiglio, M., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1783 · Cited by 4,053

Flagged first, then by citations

Show all 49 references

1 of the 49 references couldn’t be matched to a known paper.

Sorted by citations

Items 101–200 of 1,004

TAp63 suppresses metastasis through coordinate regulation of Dicer and miRNAs
Su, X., Chakravarti, D., Cho, M. S., Liu, L.-Z., Gi, Y. J., Lin, Y.-L., Leung, M. L., El‐Naggar, A. K., Creighton, C. J., Suraokar, M. B., et al. (2010) · Nature · doi:10.1038/nature09459 · Cited by 429
MicroRNA: trends in clinical trials of cancer diagnosis and therapy strategies
Kim, T., & Croce, C. M. (2023) · Experimental & Molecular Medicine · doi:10.1038/s12276-023-01050-9 · Cited by 432
Convergent multi-miRNA targeting of ApoE drives LRP1/LRP8-dependent melanoma metastasis and angiogenesis
Pencheva, N., Tran, H., Buss, C., Huh, D., Drobnjak, M., Busam, K., & Tavazoie, S. F. (2012) · Cell · doi:10.1016/j.cell.2012.10.028 · Cited by 415
LIFR is a breast cancer metastasis suppressor upstream of the Hippo-YAP pathway and a prognostic marker
Chen, D., Sun, Y., Wei, Y., Zhang, P., Rezaeian, A. H., Teruya‐Feldstein, J., Gupta, S., Liang, H., Lin, H., Hung, M., et al. (2012) · Nature Medicine · doi:10.1038/nm.2940 · Cited by 421
Self-citation
miR-200 Expression Regulates Epithelial-to-Mesenchymal Transition in Bladder Cancer Cells and Reverses Resistance to Epidermal Growth Factor Receptor Therapy
Adam, L., Zhong, M., Choi, W., Wei, Q., Nicoloso, M. S., Arora, A., Calin, G. A., Wang, H., Siefker-Radtke, A. O., McConkey, D. J., et al. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-2245 · Cited by 410
Exosome-mediated transfer of miR-10b promotes cell invasion in breast cancer
Singh, R., Pochampally, R. R., Watabe, K., Lü, Z., & Mo, Y. (2014) · Molecular Cancer · doi:10.1186/1476-4598-13-256 · Cited by 408
Unravelling the complexity of metastasis — molecular understanding and targeted therapies
Sethi, N. S., & Kang, Y. (2011) · Nature reviews. Cancer · doi:10.1038/nrc3125 · Cited by 405
A Pilot Study of Circulating miRNAs as Potential Biomarkers of Early Stage Breast Cancer
Zhao, H., Shen, J., Medico, L., Wang, D., Ambrosone, C. B., & Liu, S. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013735 · Cited by 398
MicroRNA 29c is down-regulated in nasopharyngeal carcinomas, up-regulating mRNAs encoding extracellular matrix proteins
Sengupta, S., den Boon, J. A., Chen, I., Newton, M. A., Stanhope, S. A., Cheng, Y.-J., Chen, C., Hildesheim, A., Sugden, B., & Ahlquist, P. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801130105 · Cited by 402
Extracellular Metabolic Energetics Can Promote Cancer Progression
Loo, J. M., Scherl, A., Nguyen, A., Man, F. Y., Weinberg, E., Zeng, Z., Saltz, L., Paty, P. B., & Tavazoie, S. F. (2015) · Cell · doi:10.1016/j.cell.2014.12.018 · Cited by 393
miR‐29a suppresses tristetraprolin, which is a regulator of epithelial polarity and metastasis
Gebeshuber, C. A., Zatloukal, K., & Martı̂nez, J. (2009) · EMBO Reports · doi:10.1038/embor.2009.9 · Cited by 387
Prioritization of disease microRNAs through a human phenome-microRNAome network
Jiang, Q., Hao, Y., Wang, G., Juan, L., Zhang, T., Teng, M., Liu, Y., & Wang, Y. (2010) · BMC Systems Biology · doi:10.1186/1752-0509-4-s1-s2 · Cited by 392
Organotropism: new insights into molecular mechanisms of breast cancer metastasis
Chen, W., Hoffmann, A. D., Liu, H., & Liu, X. (2018) · npj Precision Oncology · doi:10.1038/s41698-018-0047-0 · Cited by 418
Emerging Role of miR-106b-25/miR-17-92 Clusters in the Control of Transforming Growth Factor β Signaling
Petrocca, F., Vecchione, A. M., & Croce, C. M. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-1768 · Cited by 388
Antagomir-17-5p Abolishes the Growth of Therapy-Resistant Neuroblastoma through p21 and BIM
Fontana, L., Fiori, M. E., Albini, S., Cifaldi, L., Giovinazzi, S., Forloni, M., Boldrini, R., Donfrancesco, A., Federici, V., Giacomini, P., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002236 · Cited by 394
PBMDA: A novel and effective path-based computational model for miRNA-disease association prediction
You, Z., Huang, Z.-A., Zhu, Z., Yan, G., Li, Z., Wen, Z., & Chen, X. (2017) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1005455 · Cited by 386
Common genetic variants in pre-microRNAs were associated with increased risk of breast cancer in Chinese women
Hu, Z., Liang, J., Wang, Z., Tian, T., Zhou, X., Chen, J., Miao, R., Wang, Y., Wang, X., & Shen, H. (2008) · Human Mutation · doi:10.1002/humu.20837 · Cited by 374
Identification of forensically relevant body fluids using a panel of differentially expressed microRNAs
Hanson, E., Lubenow, H., & Ballantyne, J. (2009) · Analytical Biochemistry · doi:10.1016/j.ab.2009.01.037 · Cited by 379
The emerging role of miR-200 family of MicroRNAs in epithelial-mesenchymal transition and cancer metastasis
Korpal, M., & Kang, Y. (2008) · RNA Biology · doi:10.4161/rna.5.3.6558 · Cited by 383
GATA3 suppresses metastasis and modulates the tumour microenvironment by regulating microRNA-29b expression
Chou, J., Lin, J., Brenot, A., Kim, J., Provot, S., & Werb, Z. (2013) · Nature Cell Biology · doi:10.1038/ncb2672 · Cited by 380
Circulating microRNAs in breast cancer: novel diagnostic and prognostic biomarkers
Hamam, R., Hamam, D., Alsaleh, K. A., Kassem, M., Zaher, W., Alfayez, M., Aldahmash, A., & Alajez, N. M. (2017) · Cell Death & Disease · doi:10.1038/cddis.2017.440 · Cited by 322
Four miRNAs associated with aggressiveness of lymph node-negative, estrogen receptor-positive human breast cancer
Foekens, J. A., Sieuwerts, A. M., Smid, M., Look, M. P., de Weerd, V., Boersma, A. W. M., Klijn, J. G. M., Wiemer, E. A. C., & Martens, J. W. M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803304105 · Cited by 372
microRNA-205 Regulates HER3 in Human Breast Cancer
Iorio, M. V., Casalini, P., Piovan, C., Leva, G. D., Merlo, A. C., Triulzi, T., Ménard, S., Croce, C. M., & Tagliabue, E. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-2920 · Cited by 368
Phosphorylation of the Human MicroRNA-Generating Complex Mediates MAPK/Erk Signaling
Paroo, Z., Ye, X., Chen, S., & Liu, Q. (2009) · Cell · doi:10.1016/j.cell.2009.06.044 · Cited by 380
Raf kinase inhibitory protein suppresses a metastasis signalling cascade involving LIN28 and let‐7
Dangi-Garimella, S. Y., Yun, J., Eves, E. M., Newman, M. A., Erkeland, S. J., Hammond, S. M., Minn, A. J., & Rosner, M. R. (2009) · The EMBO Journal · doi:10.1038/emboj.2008.294 · Cited by 371
miR-205 Exerts Tumor-Suppressive Functions in Human Prostate through Down-regulation of Protein Kinase Cε
Gandellini, P., Folini, M., Longoni, N., Pennati, M., Binda, M., Colecchia, M., Salvioni, R., Supino, R., Moretti, R. M., Limonta, P., et al. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-2894 · Cited by 364
Up‐regulated microRNA‐143 transcribed by nuclear factor kappa B enhances hepatocarcinoma metastasis by repressing fibronectin expression†
Zhang, X., Liu, S., Hu, T., Liu, S., He, Y., & Sun, S. (2009) · Hepatology · doi:10.1002/hep.23008 · Cited by 357
miR-126 and miR-126* repress recruitment of mesenchymal stem cells and inflammatory monocytes to inhibit breast cancer metastasis
Zhang, Y., Yang, P., Sun, T., Li, D., Xu, X., Rui, Y., Li, C., Chong, M., Ibrahim, T., Mercatali, L., et al. (2013) · Nature Cell Biology · doi:10.1038/ncb2690 · Cited by 356
EMT Factors and Metabolic Pathways in Cancer
Georgakopoulos‐Soares, I., Chartoumpekis, D. V., Kyriazopoulou, V. E., & Zaravinos, A. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00499 · Cited by 364
Reprogramming of miRNA networks in cancer and leukemiaPreprint
Volinia, S., Galasso, M., Costinean, S., Tagliavini, L., Gamberoni, G., Drusco, A., Marchesini, J., Mascellani, N., Sana, M., Jarour, R. A., et al. (2010) · Genome Research · doi:10.1101/gr.098046.109 · Cited by 346
MicroRNA Sequence and Expression Analysis in Breast Tumors by Deep Sequencing
Farazi, T. A., Horlings, H. M., ten Hoeve, J. J., Mihailović, A., Halfwerk, H., Morozov, P. S., Brown, M., Hafner, M., Reyal, F., van Kouwenhove, M., et al. (2011) · Cancer Research · doi:10.1158/0008-5472.can-11-0608 · Cited by 347
Hypoxia potentiates Notch signaling in breast cancer leading to decreased E-cadherin expression and increased cell migration and invasion
Chen, J., Imanaka, N., Chen, J., & Griffin, J. D. (2010) · British Journal of Cancer · doi:10.1038/sj.bjc.6605486 · Cited by 346
Multilayer control of the EMT master regulators
Zheng, H., & Kang, Y. (2013) · Oncogene · doi:10.1038/onc.2013.128 · Cited by 348
MicroRNA-221/222 confers breast cancer fulvestrant resistance by regulating multiple signaling pathways
Rao, X., Leva, G. D., Li, M., Fang, F., Devlin, C. M., Hartman-Frey, C., Burow, M. E., Ivan, M., Croce, C. M., & Nephew, K. P. (2010) · Oncogene · doi:10.1038/onc.2010.487 · Cited by 348
Targeting miRNAs involved in cancer stem cell and EMT regulation: An emerging concept in overcoming drug resistance
Wang, Z. P., Li, Y., Ahmad, A., Azmi, A. S., Kong, D., Banerjee, S., & Sarkar, F. H. (2010) · Drug Resistance Updates · doi:10.1016/j.drup.2010.07.001 · Cited by 348
miR-30b/30d Regulation of GalNAc Transferases Enhances Invasion and Immunosuppression during Metastasis
Gaziel‐Sovran, A., Segura, M. F., Micco, R. D., Collins, M. K., Hanniford, D., de Miera, E. V., Rakus, J. F., Dankert, J. F., Shang, S., Kerbel, R. S., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.05.027 · Cited by 348
Comprehensive profiling of circulating microRNA via small RNA sequencing of cDNA libraries reveals biomarker potential and limitations
Williams, Z., Ben‐Dov, I. Z., Elias, R. T., Mihailovic, A., Brown, M., Rosenwaks, Z., & Tuschl, T. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1214046110 · Cited by 343
The epithelial to mesenchymal transition (EMT) and cancer stem cells: implication for treatment resistance in pancreatic cancer
Zhou, P., Li, B., Liu, F.-R., Zhang, M., Wang, Q., Liu, Y., Yao Zong, Y. U. A. N., & Li, D. (2017) · Molecular Cancer · doi:10.1186/s12943-017-0624-9 · Cited by 338
Causes and Consequences of MicroRNA Dysregulation
Iorio, M. V., & Croce, C. M. (2012) · The Cancer Journal · doi:10.1097/ppo.0b013e318250c001 · Cited by 337
Developing therapeutic microRNAs for cancer
Bader, A. G., Brown, D., Stoudemire, J., & Lammers, P. (2011) · Gene Therapy · doi:10.1038/gt.2011.79 · Cited by 346
Alterations of microRNAs and their targets are associated with acquired resistance of MCF‐7 breast cancer cells to cisplatin
Pogribny, I. P., Filkowski, J. N., Tryndyak, V., Golubov, A., Shpyleva, S., & Kovalchuk, O. (2010) · International Journal of Cancer · doi:10.1002/ijc.25191 · Cited by 332
Visualizing extravasation dynamics of metastatic tumor cells
Stoletov, K. V., Kato, H., Zardouzian, E., Kelber, J. A., Yang, J., Shattil, S. J., & Klemke, R. L. (2010) · Journal of Cell Science · doi:10.1242/jcs.069443 · Cited by 334
Involvement of miR-326 in chemotherapy resistance of breast cancer through modulating expression of multidrug resistance-associated protein 1
Liang, Z., Wu, H. C., Xia, J., Li, Y., Zhang, Y., Huang, K., Wagar, N., Yoon, Y., Cho, H. T., Scala, S., et al. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2009.10.017 · Cited by 331
Survival prediction of gastric cancer by a seven-microRNA signature
Li, X., Zhang, Y., Zhang, Y., Ding, J., Wu, K., & Fan, D. (2009) · Gut · doi:10.1136/gut.2008.175497 · Cited by 332
Metastatic breast cancer: the potential of miRNA for diagnosis and treatment monitoring
McGuire, A., Brown, J. A. L., & Kerin, M. J. (2015) · Cancer and Metastasis Reviews · doi:10.1007/s10555-015-9551-7 · Cited by 334
Epigenetic drivers of tumourigenesis and cancer metastasis
Chatterjee, A., Rodger, E. J., & Eccles, M. R. (2017) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2017.08.004 · Cited by 340
miR-200 Enhances Mouse Breast Cancer Cell Colonization to Form Distant Metastases
Dykxhoorn, D. M., Wu, Y., Xie, H., Yu, F., Lal, A., Petrocca, F., Martinvalet, D., Song, E., Lim, B., & Lieberman, J. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007181 · Cited by 329
Fusion of tumour cells with bone marrow-derived cells: a unifying explanation for metastasis
Pawelek, J. M., & Chakraborty, A. K. (2008) · Nature reviews. Cancer · doi:10.1038/nrc2371 · Cited by 328
Molecular signature and therapeutic perspective of the epithelial-to-mesenchymal transitions in epithelial cancers
Sabbah, M., Emami, S., Redeuilh, G., Julien-Grille, S., Prevost, G. P., Zimber, A., Ouelaa-Benslama, R., Bracke, M., Wever, O. D., & Gespach, C. P. (2008) · Drug Resistance Updates · doi:10.1016/j.drup.2008.07.001 · Cited by 325
Lost in translation: an assessment and perspective for computational microRNA target identification
Alexiou, P., Maragkakis, M., Papadopoulos, G. L., Reczko, M., & Hatzigeorgiou, A. G. (2009) · Computer applications in the biosciences · doi:10.1093/bioinformatics/btp565 · Cited by 330
Epithelial to mesenchymal transition and breast cancer
Tomaskovic‐Crook, E., Thompson, E. W., & Thiery, J. P. (2009) · Breast Cancer Research · doi:10.1186/bcr2416 · Cited by 323
Mechanisms of the Epithelial–Mesenchymal Transition by TGF-β
Wendt, M. K., Allington, T. M., & Schiemann, W. P. (2009) · Future Oncology · doi:10.2217/fon.09.90 · Cited by 325
miRNA control of tumor cell invasion and metastasis
Baranwal, S., & Alahari, S. K. (2009) · International Journal of Cancer · doi:10.1002/ijc.25014 · Cited by 316
Gut Microbiota Metabolism of Anthocyanin Promotes Reverse Cholesterol Transport in Mice Via Repressing miRNA-10b
Wang, D., Xia, M., Xiao, Y., Li, D., Wang, L., Xu, Y., Jin, T., & Ling, W. (2012) · Circulation Research · doi:10.1161/circresaha.112.266502 · Cited by 319
Foxo3 activity promoted by non-coding effects of circular RNA and Foxo3 pseudogene in the inhibition of tumor growth and angiogenesis
Yang, W., Du, W. W., Li, X., Yee, A., & Yang, B. B. (2015) · Oncogene · doi:10.1038/onc.2015.460 · Cited by 316
Dysregulation of microRNAs in cancer: Playing with fire
Melo, S. A., & Esteller, M. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.08.009 · Cited by 324
Exosome-mediated delivery of miR-9 induces cancer-associated fibroblast-like properties in human breast fibroblasts
Baroni, S., Romero-Cordoba, S. L., Plantamura, I., Dugo, M., D’Ippolito, E., Cataldo, A., Cosentino, G., Angeloni, V., Rossini, A., Daidone, M. G., et al. (2016) · Cell Death and Disease · doi:10.1038/cddis.2016.224 · Cited by 310
GATA3 in development and cancer differentiation: Cells GATA have it!
Chou, J., Provot, S., & Werb, Z. (2009) · Journal of Cellular Physiology · doi:10.1002/jcp.21943 · Cited by 309
Novel classes of non-coding RNAs and cancer
Šáňa, J., Vychytilova‐Faltejskova, P., Svoboda, M., & Slabý, O. (2012) · Journal of Translational Medicine · doi:10.1186/1479-5876-10-103 · Cited by 314
TRPS1 Targeting by miR-221/222 Promotes the Epithelial-to-Mesenchymal Transition in Breast Cancer
Stinson, S. Y., Lackner, M. R., Adai, A. T., Yu, N., Kim, H., O'Brien, C. L., Spoerke, J. M., Jhunjhunwala, S., Boyd, Z. S., Januario, T., et al. (2011) · Science Signaling · doi:10.1126/scisignal.2001538 · Cited by 309
MicroRNA and drug resistance
Ma, J., Dong, C., & Ji, C. (2010) · Cancer Gene Therapy · doi:10.1038/cgt.2010.18 · Cited by 304
MicroRNAs in cerebrospinal fluid identify glioblastoma and metastatic brain cancers and reflect disease activity
Teplyuk, N. M., Mollenhauer, B., Gabriely, G., Giese, A., Kim, E. L., Smolsky, M., Kim, R. Y., Saria, M. G., Pastorino, S., Kesari, S. P., et al. (2012) · Neuro-Oncology · doi:10.1093/neuonc/nos074 · Cited by 304
Human Glioma Growth Is Controlled by MicroRNA-10b
Gabriely, G., Yi, M., Narayan, R. S., Niers, J. M., Wurdinger, T., Imitola, J., Ligon, K. L., Kesari, S., Esau, C., Stephens, R. M., et al. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-3568 · Cited by 266
miR-206 Expression Is Down-regulated in Estrogen Receptor α–Positive Human Breast Cancer
Kondo, N., Toyama, T., Sugiura, H., Fujii, Y., & Yamashita, H. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-0180 · Cited by 305
Metastamir: The Field of Metastasis-Regulatory microRNA Is Spreading
Hurst, D. R., Edmonds, M. D., & Welch, D. R. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-2111 · Cited by 305
Profiling of 95 MicroRNAs in Pancreatic Cancer Cell Lines and Surgical Specimens by Real‐Time PCR Analysis
Zhang, Y., Li, M., Wang, H., Fisher, W. E., Lin, P. H., Yao, Q. C., & Chen, C. (2008) · World Journal of Surgery · doi:10.1007/s00268-008-9833-0 · Cited by 303
Mechanisms of metastasis
Hunter, K. W., Crawford, N. P. S., & Alsarraj, J. (2008) · Breast Cancer Research · doi:10.1186/bcr1988 · Cited by 311
MicroRNA‐10b is overexpressed in malignant glioma and associated with tumor invasive factors, uPAR and RhoC
Sasayama, T., Nishihara, M., Kondoh, T., Hosoda, K., & Kohmura, E. (2009) · International Journal of Cancer · doi:10.1002/ijc.24522 · Cited by 297
The MicroRNA miR-139 Suppresses Metastasis and Progression of Hepatocellular Carcinoma by Down-regulating Rho-Kinase 2
Wong, C. C., Wong, C., Tung, E. K. K., Au, S. L., Lee, J. M., Poon, R. T. P., Man, K., & Ng, I. O. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.10.006 · Cited by 296
Dysregulation of microRNAs in breast cancer and their potential role as prognostic and predictive biomarkers in patient management
van Schooneveld, E., Wildiers, H. P. M. W., Vergote, I. B., Vermeulen, P. B., Dirix, L. Y., & Laere, S. V. (2015) · Breast Cancer Research · doi:10.1186/s13058-015-0526-y · Cited by 297
The role of exosomes and miRNAs in drug‐resistance of cancer cells
Bach, D., Hong, J., Park, H. J., & Lee, S. K. (2017) · International Journal of Cancer · doi:10.1002/ijc.30669 · Cited by 301
Control of metastatic progression by microRNA regulatory networks
Pencheva, N., & Tavazoie, S. F. (2013) · Nature Cell Biology · doi:10.1038/ncb2769 · Cited by 299
MicroRNA-10b Promotes Migration and Invasion through KLF4 in Human Esophageal Cancer Cell Lines
Tian, Y., Luo, A., Cai, Y., Su, Q., Ding, F., Chen, H., & Liu, Z. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.062877 · Cited by 298
The Regulatory Role of MicroRNAs in EMT and Cancer
Zaravinos, A. (2015) · Journal of Oncology · doi:10.1155/2015/865816 · Cited by 304
miR-126 functions as a tumour suppressor in human gastric cancer
Feng, R., Chen, X., Yu, Y., Su, L., Yu, B., Li, J., Cai, Q., Yan, M., Liu, B., & Zhu, Z. (2010) · Cancer Letters · doi:10.1016/j.canlet.2010.06.004 · Cited by 293
New methods in the diagnosis of cancer and gene therapy of cancer based on nanoparticles
Zaimy, M. A., Saffarzadeh, N., Mohammadi, A., Pourghadamyari, H., Izadi, P., Sarli, A., Moghaddam, L. K., Paschepari, S. R., Azizi, H., Torkamandi, S., et al. (2017) · Cancer Gene Therapy · doi:10.1038/cgt.2017.16 · Cited by 294
miR-218 Suppresses Nasopharyngeal Cancer Progression through Downregulation of Survivin and the SLIT2-ROBO1 Pathway
Alajez, N. M., Lenarduzzi, M., Ito, E., Hui, A. B., Shi, W., Bruce, J., Yue, S., Huang, S. H., Xu, W., Waldron, J. N., et al. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-2754 · Cited by 283
Epithelial–mesenchymal transition and breast cancer: Role, molecular mechanisms and clinical impact
Foroni, C., Broggini, M., Generali, D., & Damia, G. L. M. (2011) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2011.11.001 · Cited by 285
MicroRNA-7, a Homeobox D10 Target, Inhibits p21-Activated Kinase 1 and Regulates Its Functions
Reddy, S. D. N., Ohshiro, K., Rayala, S. K., & Kumar, R. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-2103 · Cited by 278
MicroRNA-184 antagonizes microRNA-205 to maintain SHIP2 levels in epithelia
Yu, J., Ryan, D. G., Getsios, S., Oliveira-Fernandes, M., Fatima, A., & Lavker, R. M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803992105 · Cited by 283
Intronic miR-211 Assumes the Tumor Suppressive Function of Its Host Gene in Melanoma
Levy, C., Khaled, M., Iliopoulos, D., Janas, M. M., Schubert, S., Pinner, S. E., Chen, P., Li, S., Fletcher, A. L., Yokoyama, S., et al. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.11.020 · Cited by 284
MicroRNA control of epithelial–mesenchymal transition and metastasis
Zhang, J., & Ma, L. (2012) · Cancer and Metastasis Reviews · doi:10.1007/s10555-012-9368-6 · Cited by 282
Self-citation
MicroRNA-143 Regulates Human Osteosarcoma Metastasis by Regulating Matrix Metalloprotease-13 Expression
Osaki, M., Takeshita, F., Sugimoto, Y., Kosaka, N., Yamamoto, Y., Yoshioka, Y., Kobayashi, E., Yamada, T., Kawai, A., Inoue, T., et al. (2011) · Molecular Therapy · doi:10.1038/mt.2011.53 · Cited by 274
MicroRNA-1/206 Targets c-Met and Inhibits Rhabdomyosarcoma Development
Yan, D., Dong, X. D., Chen, X., Wang, L., Lu, C., Wang, J., Qu, J., & Tu, L. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.020511 · Cited by 273
MicroRNA-301 Mediates Proliferation and Invasion in Human Breast Cancer
Shi, W., Gerster, K., Alajez, N. M., Tsang, J., Waldron, L., Pintilie, M., Hui, A. B., Sykes, J. R., P’ng, C., Miller, N. A., et al. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-3369 · Cited by 266
miR-21 and miR-31 Converge on TIAM1 to Regulate Migration and Invasion of Colon Carcinoma Cells
Cottonham, C., Kaneko, S., & Xu, L. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.160069 · Cited by 265
Antisense Transcript Long Noncoding RNA (lncRNA) HOTAIR is Transcriptionally Induced by Estradiol
Bhan, A., Hussain, I., Ansari, K. I., Kasiri, S., Bashyal, A., & Mandal, S. S. (2013) · Journal of Molecular Biology · doi:10.1016/j.jmb.2013.01.022 · Cited by 263
Targeting oncomiRNAs and mimicking tumor suppressor miRNAs: New trends in the development of miRNA therapeutic strategies in oncology (Review)
Gambari, R., Brognara, E., Spandidos, D. A., & Fabbri, E. (2016) · International Journal of Oncology · doi:10.3892/ijo.2016.3503 · Cited by 267
Polymer Nanoparticles Mediated Codelivery of AntimiR-10b and AntimiR-21 for Achieving Triple Negative Breast Cancer Therapy
Devulapally, R., Sekar, N. M., Sekar, T. V., Foygel, K., Massoud, T. F., Willmann, J. K., & Paulmurugan, R. (2015) · ACS Nano · doi:10.1021/nn507465d · Cited by 260
Retinoic Acid Receptor Antagonists Inhibit miR-10a Expression and Block Metastatic Behavior of Pancreatic Cancer
Weiß, F. U., Marques, I. J., Woltering, J. M., Vlecken, D. H. W., Aghdassi, A. A., Partecke, L. I., Heidecke, C.-D., Lerch, M. M., & Bagowski, C. P. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.08.065 · Cited by 258
Identification of suitable endogenous control genes for microRNA gene expression analysis in human breast cancer
Davoren, P. A., McNeill, R. E., Lowery, A., Kerin, M. J., & Miller, N. (2008) · BMC Molecular Biology · doi:10.1186/1471-2199-9-76 · Cited by 258
MicroRNA expression analysis in triple-negative (ER, PR and Her2/neu) breast cancer
Radojicic, J., Zaravinos, A., Vrekoussis, T., Kafousi, M., Spandidos, D. A., & Stathopoulos, E. N. (2011) · Cell Cycle · doi:10.4161/cc.10.3.14754 · Cited by 259
Downregulated MicroRNA-200a in Meningiomas Promotes Tumor Growth by Reducing E-Cadherin and Activating the Wnt/β-Catenin Signaling Pathway
Saydam, O., Shen, Y., Würdinger, T., Senol, O., Böke, E., James, M. F., Tannous, B. A., Stemmer-Rachamimov, A. O., Yi, M., Stephens, R. M., et al. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00332-09 · Cited by 257
MicroRNA-199b-5p Impairs Cancer Stem Cells through Negative Regulation of HES1 in Medulloblastoma
Garzia, L., Andolfo, I., Cusanelli, E., Marino, N., Petrosino, G., Martino, D. D., Esposito, V., Galeone, A., Navas, L., Esposito, S., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004998 · Cited by 254
Dual-SERS biosensor for one-step detection of microRNAs in exosome and residual plasma of blood samples for diagnosing pancreatic cancer
Pang, Y., Wang, C., Lu, L., Wang, C., Sun, Z., & Xiao, R. (2019) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2019.01.039 · Cited by 254
The role of EMT and MET in cancer dissemination
Banyard, J., & Bielenberg, D. R. (2015) · Connective Tissue Research · doi:10.3109/03008207.2015.1060970 · Cited by 248
Hypoxia-inducible factor 1 and breast cancer metastasis
Liu, Z.-J., Semenza, G. L., & Zhang, H.-F. (2015) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b1400221 · Cited by 265
Label-Free Nanoplasmonic-Based Short Noncoding RNA Sensing at Attomolar Concentrations Allows for Quantitative and Highly Specific Assay of MicroRNA-10b in Biological Fluids and Circulating Exosomes
Joshi, G. K., McElyea, S. D., Liyanage, T., Lawrence, K. N., Mali, S. S., Sardar, R., & Korc, M. (2015) · ACS Nano · doi:10.1021/acsnano.5b04527 · Cited by 255
Modulation of miRNA activity in human cancer: a new paradigm for cancer gene therapy?
Tong, A. W., & Nemunaitis, J. J. (2008) · Cancer Gene Therapy · doi:10.1038/cgt.2008.8 · Cited by 251
Ethanol exposure induces differential microRNA and target gene expression and teratogenic effects which can be suppressed by folic acid supplementation
Wang, L.-L., Zhang, Z., Li, Q., Yang, R., Pei, X., Xu, Y., Wang, J., Zhou, S. F., & Li, Y. (2008) · Human Reproduction · doi:10.1093/humrep/den439 · Cited by 255

Authors: Ma, L., Teruya-Feldstein, J., & Weinberg, R. A.
Affiliations: Whitehead Institute for Biomedical Research (US)
Corresponding author: Weinberg, Robert A.
ORCID: Ma, Li
Weinberg, Robert A.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2007-09-26
Volume: 449
Issue: 7163
Pages: 682-688
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature06174
OpenAlex: W2047529648
Cited by: 2,605
References: 49
Citations by year: 2026: 34 · 2025: 36 · 2024: 66 · 2023: 69 · 2022: 75 · 2021: 120 · 2020: 106 · 2019: 123 · 2018: 113 · 2017: 151 · 2016: 160 · 2015: 196 · 2014: 215 · 2013: 226 · 2012: 220
FWCI: 60.84
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mechanisms of cancer metastasis
Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Keywords: microRNA-10b, breast cancer, metastasis, tumor invasion, cell migration, Twist transcription factor, HOXD10, RhoC, Hox genes, microRNA target regulation, clinical progression
MeSH terms: rhoC GTP-Binding Protein, Animals, Base Sequence, Breast Neoplasms, Cell Movement, Humans, Lung Neoplasms, Neoplasm Invasiveness, Neoplasm Metastasis, Peritoneal Neoplasms, Transcription Factors, Gene Expression Regulation, Neoplastic, Homeodomain Proteins, rho GTP-Binding Proteins, MicroRNAs, Cell Line, Tumor, Mice, Twist-Related Protein 1

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Tumour invasion and metastasis initiated by microRNA-10b in breast cancer

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks