The DOI matches its Crossref record; 48 of the 49 references it cites were found in a registry or an index.
Tumour invasion and metastasis initiated by microRNA-10b in breast cancer
Abstract
MicroRNAs have been implicated in regulating diverse cellular pathways. Although there is emerging evidence that some microRNAs can function as oncogenes or tumour suppressors, the role of microRNAs in mediating cancer metastasis remains unexplored. Here we show, using a combination of mouse and human cells, that microRNA-10b (miR-10b) is highly expressed in metastatic breast cancer cells and positively regulates cell migration and invasion. Overexpression of miR-10b in otherwise non-metastatic breast tumours initiates robust invasion and metastasis. Expression of miR-10b is induced by the transcription factor Twist, which binds directly to the putative promoter of mir-10b (MIRN10B). The miR-10b induced by Twist proceeds to inhibit translation of the messenger RNA encoding homeobox D10, resulting in increased expression of a well-characterized pro-metastatic gene, RHOC. Significantly, the level of miR-10b expression in primary breast carcinomas correlates with clinical progression. These findings suggest the workings of an undescribed regulatory pathway, in which a pleiotropic transcription factor induces expression of a specific microRNA, which suppresses its direct target and in turn activates another pro-metastatic gene, leading to tumour cell invasion and metastasis.
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“This expression pattern is different from those of the other cancer-associated miRNAs, for example, miR-10b, which is often elevated in grade III and even grade II gliomas (Fig. 1) and dysregulated in some other cancers (41).”
From MicroRNA 21 Promotes Glioma Invasion by Targeting Matrix Metalloproteinase Regulators (2008) · cites this paper as [41]
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Gupta, R. A., Shah, N., Wang, K., Kim, J., Horlings, H. M., Wong, D. J., Tsai, M.-C., Hung, T., Argani, P., Rinn, J. L., et al. (2010) · Nature · doi:10.1038/nature08975 · Cited by 5,205
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Self-citationMetastasis: from dissemination to organ-specific colonization
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Metadata
- Authors
- Ma, L., Teruya-Feldstein, J., & Weinberg, R. A.
- Affiliations
- Whitehead Institute for Biomedical Research (US)
- Corresponding author
- Weinberg, Robert A.
- Venue
- Nature
- Published
- 2007-09-26
- Volume
- 449
- Issue
- 7163
- Pages
- 682-688
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2047529648
- Cited by
- 2,605
- References
- 49
- Citations by year
- 2026: 34 · 2025: 36 · 2024: 66 · 2023: 69 · 2022: 75 · 2021: 120 · 2020: 106 · 2019: 123 · 2018: 113 · 2017: 151 · 2016: 160 · 2015: 196 · 2014: 215 · 2013: 226 · 2012: 220
- FWCI
- 60.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mechanisms of cancer metastasis
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Keywords
- microRNA-10b, breast cancer, metastasis, tumor invasion, cell migration, Twist transcription factor, HOXD10, RhoC, Hox genes, microRNA target regulation, clinical progression
- MeSH terms
- rhoC GTP-Binding Protein, Animals, Base Sequence, Breast Neoplasms, Cell Movement, Humans, Lung Neoplasms, Neoplasm Invasiveness, Neoplasm Metastasis, Peritoneal Neoplasms, Transcription Factors, Gene Expression Regulation, Neoplastic, Homeodomain Proteins, rho GTP-Binding Proteins, MicroRNAs, Cell Line, Tumor, Mice, Twist-Related Protein 1
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