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The development of allergic inflammation
Open accessAbstract
Allergic disorders, such as anaphylaxis, hay fever, eczema and asthma, now afflict roughly 25% of people in the developed world. In allergic subjects, persistent or repetitive exposure to allergens, which typically are intrinsically innocuous substances common in the environment, results in chronic allergic inflammation. This in turn produces long-term changes in the structure of the affected organs and substantial abnormalities in their function. It is therefore important to understand the characteristics and consequences of acute and chronic allergic inflammation, and in particular to explore how mast cells can contribute to several features of this maladaptive pattern of immunological reactivity.
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“Overall, we recognise that these kinds of inflammatory, oxidative stress-related reactions are accumulative and somewhat irreversible [161], that they are consequently age-related, and (see [162-165] and later), and that most diseases and causes of mortality that are prevalent in the developed world are in this sense largely manifestations of this kind of aging.”
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Metadata
- Authors
- Galli, S. J., Tsai, M., & Piliponsky, A. M.
- Affiliations
- Stanford Medicine (US)
- Venue
- Nature
- Published
- 2008-07-01
- Volume
- 454
- Issue
- 7203
- Pages
- 445-454
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC3573758
- OpenAlex
- W2007589345
- Cited by
- 1,839
- References
- 102
- Citations by year
- 2026: 75 · 2025: 80 · 2024: 100 · 2023: 127 · 2022: 117 · 2021: 113 · 2020: 133 · 2019: 125 · 2018: 97 · 2017: 101 · 2016: 102 · 2015: 94 · 2014: 124 · 2013: 106 · 2012: 95
- FWCI
- 6.11
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- National Institutes of Health
- National Cancer Institute (R01CA072074)
- National Institute of Allergy and Infectious Diseases (R01AI023990, R01AI070813)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
- Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
- Keywords
- allergic inflammation, mast cells, anaphylaxis, allergic rhinitis, atopic dermatitis, asthma, allergen exposure, chronic inflammation, hypersensitivity
- MeSH terms
- Allergens, Animals, Chronic Disease, Epithelium, Humans, Hypersensitivity, Immunoglobulin E, Inflammation
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