Cited by 1,089Psoriasis: Treatment and PathogenesisT-cell and B-cell ImmunologyInflammatory Bowel Disease

The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.

ATP drives lamina propria TH17 cell differentiation

Atarashi, Koji, Nishimura, Junichi, Shima, Tatsuichiro, Umesaki, Yoshinori, Yamamoto, Masahiro, Onoue, Masaharu, Yagita, Hideo, Ishii, Naoto, Evans, Richard, Honda, Kenya, Takeda, Kiyoshi·2008·Nature

DOI 10.1038/nature07240

Open this paper in CoChat — free account

Abstract

Interleukin (IL)-17-producing CD4(+) T lymphocytes (T(H)17 cells) constitute a subset of T-helper cells involved in host defence and several immune disorders. An intriguing feature of T(H)17 cells is their selective and constitutive presence in the intestinal lamina propria. Here we show that adenosine 5'-triphosphate (ATP) that can be derived from commensal bacteria activates a unique subset of lamina propria cells, CD70(high)CD11c(low) cells, leading to the differentiation of T(H)17 cells. Germ-free mice exhibit much lower concentrations of luminal ATP, accompanied by fewer lamina propria T(H)17 cells, compared to specific-pathogen-free mice. Systemic or rectal administration of ATP into these germ-free mice results in a marked increase in the number of lamina propria T(H)17 cells. A CD70(high)CD11c(low) subset of the lamina propria cells expresses T(H)17-prone molecules, such as IL-6, IL-23p19 and transforming-growth-factor-beta-activating integrin-alphaV and -beta8, in response to ATP stimulation, and preferentially induces T(H)17 differentiation of co-cultured naive CD4(+) T cells. The critical role of ATP is further underscored by the observation that administration of ATP exacerbates a T-cell-mediated colitis model with enhanced T(H)17 differentiation. These observations highlight the importance of commensal bacteria and ATP for T(H)17 differentiation in health and disease, and offer an explanation of why T(H)17 cells specifically present in the intestinal lamina propria.

Integrity signals

Registry

Crossref · 10.1038/nature07240

Cites

33 of 33 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
Bettelli, E., Carrier, Y., Gao, W., Korn, T., Strom, T. B., Oukka, M., Weiner, H. L., & Kuchroo, V. K. (2006) · Nature · doi:10.1038/nature04753 · Cited by 6,992
The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells
Ivanov, I. I., McKenzie, B. S., Zhou, L., Tadokoro, C. E., Lepelley, A., Lafaille, J. J., Cua, D. J., & Littman, D. R. (2006) · Cell · doi:10.1016/j.cell.2006.07.035 · Cited by 5,145
TGFβ in the Context of an Inflammatory Cytokine Milieu Supports De Novo Differentiation of IL-17-Producing T Cells
Veldhoen, M., Hocking, R. J., Atkins, C. J., Locksley, R. M., & Stockinger, B. (2006) · Immunity · doi:10.1016/j.immuni.2006.01.001 · Cited by 3,605
Role of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathway
Yamamoto, M., Sato, S., Hemmi, H., Hoshino, K., Kaisho, T., Sanjo, H., Takeuchi, O., Sugiyama, M., Okabe, M., Takeda, K., et al. (2003) · Science · doi:10.1126/science.1087262 · Cited by 3,286
Transforming growth factor-β induces development of the TH17 lineage
Mangan, P. R., Harrington, L. E., O'Quinn, D. B., Helms, W. S., Bullard, D. C., Elson, C. O., Hatton, R. D., Wahl, S. M., Schoeb, T. R., & Weaver, C. T. (2006) · Nature · doi:10.1038/nature04754 · Cited by 3,087
Molecular Physiology of P2X Receptors
North, R. A. (2002) · Physiological Reviews · doi:10.1152/physrev.00015.2002 · Cited by 2,919
A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-β– and retinoic acid–dependent mechanism
Coombes, J. L., Siddiqui, K. R. R., Arancibia-Cárcamo, C. V., Hall, J. A., Sun, C., Belkaid, Y., & Powrie, F. M. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070590 · Cited by 2,708
Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria
Rescigno, M., Urbano, M., Valzasina, B., Francolini, M., Rotta, G., Bonasio, R., Granucci, F., Kraehenbuhl, J.-P., & Ricciardi‐Castagnoli, P. (2001) · Nature Immunology · doi:10.1038/86373 · Cited by 2,554
A microbial symbiosis factor prevents intestinal inflammatory disease
Mazmanian, S. K., Round, J. L., & Kasper, D. L. (2008) · Nature · doi:10.1038/nature07008 · Cited by 2,340
Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides
Liang, S. C., Tan, X.-Y., Luxenberg, D. P., Karim, R., Dunussi-Joannopoulos, K., Collins, M., & Fouser, L. A. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20061308 · Cited by 2,330

Flagged first, then by citations

Show all 33 references

Sorted by citations

Items 901–1,000 of 1,000

Role of Th17 cells and innate immunnity for the induction of autoimmune arthritis
Hashimoto, M., & Mimori, T. (2012) · Japanese Journal of Clinical Immunology · doi:10.2177/jsci.35.463 · Cited by 3
Physiological and Pathological Inflammation at the Mucosal Frontline
Kurashima, Y., & Kiyono, H. (2016) · Springer eBooks · doi:10.1007/978-4-431-56068-5_43 · Cited by 3
Interleukin-17 A-E
Monteleone, G., Marafini, I., & Troncone, E. (2017) · Wiley-VCH eBooks · doi:10.1002/9783527692156.ch22 · Cited by 3
Myeloid Cell-Specific Deletion of PDGFR-α Promotes Dysbiotic Intestinal Microbiota and thus Increased Colitis Susceptibility
Dörk, R., Pelczar, P., Shiri, A. M., Volmari, A., Zierz, E., Giannou, A. D., Böttcher, M., Bosurgi, L., Huber, S., & Manthey, C. (2023) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjad103 · Cited by 3
Crohn’s disease treatment and memory T-cell subset changes: insights from a case series
Chen, Z., Tang, Y.-Y., Sheng, S.-Y., Lu, C.-G., Xu, K.-W., Chen, G.-J., Wang, Y., Gu, Y., Song, X.-M., & Hong, H. (2024) · Translational Gastroenterology and Hepatology · doi:10.21037/tgh-23-21 · Cited by 3
Development of probiotic-based immunoparticles for pulmonary immunization against Hepatitis B
Sharma, K., Malik, B., Goyal, A. K., & Rath, G. (2014) · Journal of Pharmacy and Pharmacology · doi:10.1111/jphp.12247 · Cited by 3
Innate immunity and vaccine
Seya, T. (2010) · Vaccine · doi:10.1016/j.vaccine.2010.09.023 · Cited by 3
Mechanism of Th17 cell differentiation in the intestinal lamina propria
Atarashi, K., Takeda, K., & Honda, K. (2009) · Inflammation and Regeneration · doi:10.2492/inflammregen.29.263 · Cited by 3
Interleukin-23: Linking Mesenteric Lymph Node Dendritic Cells With Th1 Immunity in Crohn's Disease
Rescigno, M., & Iliev, I. D. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.09.029 · Cited by 3
Role of the Barrier Dysfunction of the Intestines in the Development of Alimentary Allergy in Children
Borovik, T. E., Makarova, S. G., Yatsyk, G. V., Степанова, Т. Н., & Грибакин, С. Г. (2013) · Вопросы современной педиатрии · doi:10.15690/vsp.v12i2.615 · Cited by 3
Effects of exercise training with Lactobacillus plantarum intake on ionized calcium‐binding adaptor molecule 1, glial fibrillary acidic protein, interleukin‐6 and interleukin‐1β in cuprizone‐induced demyelination mouse model of multiple sclerosis
Sajedi, D., Shabani, R., & Elmieh, A. (2021) · Clinical and Experimental Neuroimmunology · doi:10.1111/cen3.12673 · Cited by 3
Effector CD4 + T Cells in the Intestines
Maynard, C. L., & Weaver, C. T. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-415847-4.00034-3 · Cited by 3
Gastrointestinal Mucosal Immunology and Mechanisms of Inflammation
MURCH, S. H. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-67293-1.00005-0 · Cited by 3
Inflammatory bowel disease pathogenesis mediated by Th17 cells: cytokines, microbiota, and therapies
Park, J.-H., Lee, M. H., & Park, C. (2024) · Journal of Biomedical Translational Research · doi:10.12729/jbtr.2024.25.2.15 · Cited by 3
VNUT-mediated ATP release suppresses T helper 1 (T H 1) cell differentiation via the P2X7R-JNK-FOXO3a-Eomes signaling cascade
Wu, B., Sheng, L., Feng, Z., Wang, X., & Chen, L. (2025) · Science Advances · doi:10.1126/sciadv.adz7600 · Cited by 2
Diverse Roles of Heat Shock Proteins in Immune Activation and Tolerance: A Comprehensive Review of Mechanisms and Therapeutic Relevance
Ramaswamy, A., Wei, P. Y., & Pan, F. (2019) · Heat shock proteins · doi:10.1007/978-3-030-03952-3_10 · Cited by 2
The Human Microbiome
Andreou, N.-P., & Gazouli, M. (2021) · The microbiomes of humans, animals, plants, and the environment · doi:10.1007/978-3-030-59642-2_1 · Cited by 2
Phage Probiotics
Wong, S. L. (2016) · SpringerBriefs in biochemistry and molecular biology · doi:10.1007/978-3-319-45791-8_5 · Cited by 2
Mucosal vaccination in a murine gnotobiotic model of Giardia lamblia infection
Ihara, S., Nguyen, B., Miyamoto, Y., & Eckmann, L. (2024) · Infection and Immunity · doi:10.1128/iai.00065-24 · Cited by 2
Spatial heterogeneity and functional zonation of living tissues and organs in situ
Miyamoto, Y., & Ishii, M. (2024) · The Journal of Biochemistry · doi:10.1093/jb/mvae049 · Cited by 2
Intestinal Regulatory CD4 + T Cells
Gagliani, N., Huber, S., & Flavell, R. A. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-415847-4.00038-0 · Cited by 2
Microbial Sensing and Regulation of Mucosal Immune Responses by Intestinal Epithelial Cells
Rescigno, M. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-415847-4.00028-8 · Cited by 2
Interaction between gut microbiota and host immune cells
Nakagawa, R., & Yoshimura, A. (2015) · Inflammation and Regeneration · doi:10.2492/inflammregen.35.140 · Cited by 2
The role of gut microbiota and diet in experimental autoimmune encephalitis and multiple sclerosis
Okuno, T., Nakatsuji, Y., Kinoshita, M., Takata, K., Koda, T., Yamashita, K., Nanba, A., & Mochizuki, H. (2015) · Clinical and Experimental Neuroimmunology · doi:10.1111/cen3.12270 · Cited by 2
Pattern Recognition by Dendritic Cells and Its Application to Vaccine Adjuvant for Antitumor Immunotherapy
Seya, T., Azuma, M., & Matsumoto, M. (2016) · Springer eBooks · doi:10.1007/978-4-431-55031-0_16 · Cited by 2
Regulation of the human gut homeostasis by anti-inflammatory CD14+ CD163high CD160high myeloid cells
Kayama, H., & Takeda, K. (2016) · Japanese Journal of Clinical Immunology · doi:10.2177/jsci.39.441 · Cited by 2
Prebiotics and Probiotics in Aging Population
Magrone, T., & Jirillo, E. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-801816-3.00049-2 · Cited by 3
Recent Advancements in Microbiome–Immune Homeostasis and their Involvement in Cancer Immunotherapy
Konatala, A., Parackel, F., & Pola, S. (2021) · Springer eBooks · doi:10.1007/978-981-16-3156-6_12 · Cited by 2
Extracellular ATP released from Candida albicans activates non-peptidergic neurons to augment host defensePreprint
Edwards, T. N., Zhang, S., Liu, A. W., Cohen, J. A., Zhou, P. Y., Mogavero, S., Hube, B., Berman, J. G., Bougnoux, M., Mathers, A. R., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.01.27.921049 · Cited by 2
EGCG ameliorates DSS-induced colitis potentially via suppressing GPR43-mediated Th1 polarizationPreprint
Wu, M., Che, S., Wu, K., Zhu, M., Peng, C., Yin, Y., & Yang, G. (2023) · Research Square · doi:10.21203/rs.3.rs-2566908/v1 · Cited by 2
Released Bacterial ATP Shapes Local and Systemic Inflammation during Abdominal SepsisPreprint
Spari, D., Schmid, A., Sánchez‐Taltavull, D., Murugan, S., Keller, K., Ennaciri, N., Salm, L., Stroka, D., & Beldi, G. (2024) · eLife · doi:10.7554/elife.96678.1 · Cited by 2
Gut Microbiome in Microbial Pathogenicity
Misra, P., & Singh, S. (2020) · Springer eBooks · doi:10.1007/978-981-15-8562-3_1 · Cited by 1
Endoplasmic reticulum stress in intestinal microecology: A controller of antineoplastic drug-related cardiovascular toxicity
Zhang, J., Li, X., Li, D.-X., Zhang, Z.-H., Hu, L., Sun, C.-X., Zhang, X., Wu, M., & Liu, L. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117720 · Cited by 1
Role of the intestinal microbiota in the pathogenesis of multiple sclerosis. Part 3. Gut microbiota as a potential trigger for multiple sclerosis
Abdurasulova, I. N. (2024) · Medical academic journal · doi:10.17816/maj633511 · Cited by 1
The Enigmatic Gut-Brain-Immune Trio in Brain and Behavior Disorders
Mythri, R. B. (2025) · Advances in medical diagnosis, treatment, and care (AMDTC) book series · doi:10.4018/979-8-3693-7432-0.ch019 · Cited by 1
Clostridioides difficile meets the adenosine system: the art of manipulating host homeostasis
Fettucciari, K., Cari, L., Spaterna, A., SORDO, R. D., Tavanti, F., Marconi, P., & Bassotti, G. (2025) · Journal of Biomedical Science · doi:10.1186/s12929-025-01160-8 · Cited by 1
Adeno‐associated viral vectors encoding anti‐P2X7 nanobodies reduce graft‐versus‐host disease in a humanised mouse model
Elhage, A., Hadaya, J. H., Sligar, C., Watson, D., Adriouch, S., & Sluyter, R. (2025) · Clinical & Translational Immunology · doi:10.1002/cti2.70061 · Cited by 1
Striking a balance: how the gut microbiome shapes the fate of intestinal CD4+ T cells
Till, J. M., Brock, O. D., & Ahern, P. P. (2025) · Discovery Immunology · doi:10.1093/discim/kyaf020 · Cited by 1
Protective role of the gut microbiota against Listeria monocytogenes: From colonization resistance to therapeutic approaches
Huang, J., Xia, X., Lu, J., Chen, X., Ye, K., Yu, J. X., Li, Z., Ma, Y., Qin, X., Liu, Y., et al. (2026) · Microbiological Research · doi:10.1016/j.micres.2026.128454 · Cited by 1
Microbiota-derived metabolites in intestinal immune disorders
Kayama, H., & Takeda, K. (2026) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2026.01.021 · Cited by 1
Compositional characterization and immunomodulatory efficacy of konjac-derived manno-oligosaccharides in cyclophosphamide-induced immunosuppressed mice
Guo, S.-J., Jiang, Y.-N., He, W.-Q., Li, C.-C., Ju, N., Gao, Z., & Guo, C. (2026) · Journal of Functional Foods · doi:10.1016/j.jff.2026.107195 · Cited by 1
Decoding the Gut Microbiome in Neuromuscular Diseases: a Review of Fundamental Mechanisms and Condition-Specific Evidence
Gupta, J., Chakraborty, A., Bhattacharya, D., Nag, M., Lahiri, D., Elayaperumal, S., Gill, H. S., Rajeev, M., Pandit, S., Sharma, S., et al. (2026) · SN Comprehensive Clinical Medicine · doi:10.1007/s42399-026-02402-y · Cited by 1
Lactobacillus paracasei from koumiss mediates intestinal stem cells to promote intestinal mucosal recovery through intestinal microbiota-metabolites
Ren, S., Li, J., Zhang, Q., Han, Y., & Cao, G. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1893728 · Cited by 1
The Role of Bacterial and Parasitic Infections in Chronic Inflammatory Disorders and Autoimmunity
Ehlers, S., & Rook, G. A. W. (2014) · ASM Press eBooks · doi:10.1128/9781555816872.ch41 · Cited by 1
Intestinal Immune System
Miura, S., Hokari, R., & Komoto, S. (2011) · Colloquium Series on Integrated Systems Physiology From Molecule to Function · doi:10.4199/c00037ed1v01y201107isp025 · Cited by 1
P2Y receptors in dendritic cells: from inflammation to tolerance
Communi, D., & Robaye, B. (2012) · Wiley Interdisciplinary Reviews Membrane Transport and Signalling · doi:10.1002/wmts.75 · Cited by 1
Intestinal microbiota mining: a Th17/Treg cell perspective
Song, X. (2015) · European Journal of BioMedical Research · doi:10.18088/ejbmr.1.4.2015.pp28-35 · Cited by 1
Value of Vitamin D Administration Versus Suppressing Gut Microbiota in Modifying Metabolic Associated Osteoarthritis in Rats
Gomaa, M., & Esmaeel, S. E. (2020) · The Medical Journal of Cairo University/The Medical Journal of Cairo University · doi:10.21608/mjcu.2020.104897 · Cited by 1
Enteric Glial Cells: Implications in Gut Pathology
Gulbransen, B. D., & Brown, I. A. M. (2014) · Springer eBooks · doi:10.1007/978-1-4939-0974-2_21 · Cited by 1
Transplantation Tolerance
Brinkman, C. C., Burrell, B. E., Scalea, J. R., & Bromberg, J. S. (2013) · Methods in molecular biology · doi:10.1007/978-1-62703-493-7_4 · Cited by 1
Enhancing Molecular‐Level Biological Monitoring with a Smart Self‐Assembling 19F‐Labeled Probe
Xu, Z., Wang, C., He, S., Wu, J., & Zhao, Y. (2024) · Angewandte Chemie · doi:10.1002/ange.202417112 · Cited by 1
Role of microbiota-gut-brain axis in autoimmunity and multiple sclerosis
Mishra, Y., Maity, D., & Kaundal, R. K. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-21680-0.00007-9 · Cited by 1
TH17 Cells in Organ Transplantation Rejection and Tolerance
Tsang, J. Y., Lu, L., & Jiang, S. (2011) · Springer eBooks · doi:10.1007/978-1-4419-9371-7_17 · Cited by 1
Role of the Gut Microbiota in Maintaining GI Health: Highlights on Inflammatory Bowel Disease
Gruber, L., & Haller, D. (2014) · Molecular and integrative toxicology · doi:10.1007/978-1-4471-6539-2_13 · Cited by 1
THE ETHIOPATOGENESIS AND THE ANALYSIS OF AN ANTIBIOTIC TREATMENT OF A SMALL INTESTINE BACTERIAL OVERGROWTH SYNDROME
Martynov, V. L., & Khairdinov, A. K. (2015) · Bulletin of Siberian Medicine · doi:10.20538/1682-0363-2015-3-49-62 · Cited by 1
Paradigm of T Cell Differentiation in IBD
Nagaishi, T., & Watanabe, M. (2017) · Springer eBooks · doi:10.1007/978-3-319-33703-6_14 · Cited by 1
Gut Barrier: Innate Immunity
den Hartog, G., Crowe, S. E., Das, S., & Ernst, P. B. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-809954-4.00027-x · Cited by 1
Innate Myeloid Cell Subset-Specific Gene Expression Patterns in the Human Colon are Altered in Crohn’s Disease Patients
Sekido, Y., Yasumizu, Y., Nishimura, J., Kayama, H., Matsuno, H., Ogino, T., Miyoshi, N., Takahashi, H., Haraguchi, N., Hata, T., et al. (2018) · Digestion · doi:10.1159/000490890 · Cited by 1
Role of “NAFLAN” Immune (Nasal/ Oral) Spray in Prevention of Respiratory Virus Infections (Including COVID 19) in Indian Volunteers: The Preliminary Report of a Phase 1 Clinical Trial
Davey, S. (2021) · doi:10.37179/rijcmph.000011 · Cited by 1
Spondyloarthropathies and Gut Microbiota
Soleimanifar, N., & Assadiasl, S. (2021) · Springer eBooks · doi:10.1007/978-981-16-4733-8_6 · Cited by 1
The Link Between Gut Microbiota and Autoimmune Diseases
Goyal, D., Dey, M., & Singh, R. K. (2022) · Springer eBooks · doi:10.1007/978-981-19-1946-6_3 · Cited by 1
Regulatory Roles of B Cells in Allergy and Inflammation
Takatsu, K., Ikutani, M., & Nagai, Y. (2011) · doi:10.1002/9781444346688.ch6 · Cited by 1
Efficacy of galactooliosaccharide (GOS) and/or rhamnosebased synbiotics in enhancing ecological performance of Lactobacillus reuteri in the human gut and characterization of its gos metabolic system
Rattanaprasert, M. (2015) · Lincoln (University of Nebraska) · Cited by 1
Immunity leashed - mechanisms of regulation in the human immune system
Torheim, E. A. (2010) · NORA - Norwegian Open Research Archives · Cited by 1
Nod1 and Nod2 in innate immune responses, adaptive immunity and bacterial infection.
Bourhis, L. L. (2010) · TSpace (University of Toronto) · Cited by 1
Use of lung microbiota strains to shape local immunity at steady state and during Mycobacterium tuberculosis infection in the mouse model
Bernard, L. (2020) · theses.fr (ABES) · doi:10.70675/589a776dz18d9z4813z9d6fzd73632aa4df7 · Cited by 1
Relationship Between Th17 and Regulatory T Cells in the Tumor Environment
Kryczek, I., Wu, K., Zhao, E., Wang, G., & Zou, W. (2011) · Springer eBooks · doi:10.1007/978-1-4419-9914-6_10
Eficácia terapêutica do Metotrexato na Artrite Reumatóide depende da expressão de células T reguladoras CD39+?
Peres, R. S. (2012) · doi:10.11606/d.17.2012.tde-23042012-100510
Microbial regulation of allergic inflammation
Hill, D. A. (2011) · Scholarly Commons (University of Pennsylvania)
Distribution and frequency of myeloid and t cell populations in the small intestine of newborn and weaned calves
Fries, P. N. (2011) · University Library - University of Saskatchewan (University of Saskatchewan)
Anatomy of the Gut Barrier and Establishment of Intestinal Homeostasis
Sellge, G., Schnupf, P., & Sansonetti, P. J. (2010) · Wiley eBooks · doi:10.1002/9783527629664.ch10
The roles of secreted protein acidic and rich in cystiene (Sparc) in intestinal inflammation, healing and fibrosis
Ng, Y. L. (2012) · Murdoch University Research Portal
The role of IL-2Rbeta-dependent signaling and CD103 in regulatory T cells for mucosal tolerance
Yuan, X. (2014)
The ontogeny and function of intestinal dendritic cells
Persson, E. K. (2014) · Lund University Publications (Lund University)
Phenotype and function of intestinal CD103+ dendritic cells
Gyllenbäck, E. J. (2011) · Lund University Publications (Lund University)
P2X7 Activation of Non-Primed Myeloid Cells Promotes the Shedding of Stimulatory Materials Within Microvesicles
Thomas, L. M. (2011) · D-Scholarship@Pitt (University of Pittsburgh)
The gut, immunoregulation and micro-organisms from man's evolutionary past
Rook, G. A. W. (2010) · Nutrition Bulletin · doi:10.1111/j.1467-3010.2010.01823.x
Probiotics, with special emphasis on their role in the management of irritable bowel syndrome
Stevenson, C., & Blaauw, R. (2012) · Pharmacy management
Editorial: Peer across the barrier—new live transmissions from the intestinal mucosa
Murdoch, J. R., & Junt, T. (2012) · Journal of Leukocyte Biology · doi:10.1189/jlb.0312159
Regulation of intestinal inflammation through interaction of intestinal environmental factors and innate immune cells
Kayama, H., & Takeda, K. (2015) · Inflammation and Regeneration · doi:10.2492/inflammregen.35.028
Shaping of mucosal dendritic cells by the intestinal environment
Massacand, J. C. (2009) · Repository for Publications and Research Data (ETH Zurich) · doi:10.3929/ethz-a-006023200
Une nouvelle vision de l’auto-immunité
Glaichenhaus, N. (2008) · médecine/sciences · doi:10.1051/medsci/20082411895
Interplay between Pathogenic and Immune Regulatory Mechanisms in G-alpha-i2 deficient colitis
Götlind, Y.-Y. C. (2011) · Gothenburg University Publications Electronic Archive (Gothenburg University)
THE INFLUENCE OF LACTOBACILLI AND STAPHYLOCOCCUS AUREUS ON IMMUNE RESPONSIVENESS IN VITRO
Haileselassie, Y. (2013) · KTH Publication Database DiVA (KTH Royal Institute of Technology)
The role of intestinal dendritic cells and the microbiota during oral Salmonella infection
Fernández, M. D. C. G. (2015) · Gothenburg University Publications Electronic Archive (Gothenburg University)
Regulation of immune responses by ATP-hydrolyzing ecto-enzymes
Takeda, K., Tsai, S. H., & Kayama, H. (2015) · Inflammation and Regeneration · doi:10.2492/inflammregen.35.172
Microbiota-Mediated Control of Enteric Pathogens
Yurist‐Doutsch, S., Arrieta, M., Vogt, S. L., & Finlay, B. B. (2014)
Review Article Role of toll-like receptors in multiple sclerosis
Miranda‐Hernandez, S., & Baxter, A. G. (2013)
Innate Immunity of Epidermis (1)
Sayama, K. (2014) · The Nishinihon Journal of Dermatology · doi:10.2336/nishinihonhifu.76.366
Lactobacilli- and Staphylococcus aureus mediated modulation of immune responses in vitro
Haileselassie, Y. (2016) · DiVA (Stockholm University)
MOLECULAR AND CELLULAR MECHANISMS IN ASTROCYTE-T CELL CROSS-TALK
Filipello, F. (2014) · Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) · doi:10.13130/filipello-fabia_phd2014-02-19
Studio delle caratteristiche fenotipiche e funzionali di sottopopolazioni linfocitarie immunomodulatorie in pazienti affetti da sclerosi multipla
Mitri, D. D. (2009) · Cineca Institutional Research Information System (Tor Vergata University) · doi:10.58015/di-mitri-diletta_phd2009-04-15
Role of the Microbiota in Immune Development
Zhao, Q. S., & Elson, C. O. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-374279-7.19019-8
SPECIALIZED FUNCTIONS OF LAMINA PROPRIA ANTIGEN-PRESENTING CELLS IN THE MAINTENANCE OF INTESTINAL IMMUNE-HOMEOSTASIS
Mazzini, E. (2013) · Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) · doi:10.13130/mazzini-elisa_phd2013-03-04
4. Recent Progress of Research and Clinics in Inflammatory Bowel Disease
Hibi∥, T., & Hisamatsu, T. (2013) · Nihon Naika Gakkai Zasshi · doi:10.2169/naika.102.2195
[The role of dendritic cells in the intestinal mucosa].
OTEKI, T. (2011) · Nippon Jibiinkoka Gakkai Kaiho · doi:10.3950/jibiinkoka.114.107
Regulatory T cells, Th17 effector cells and cytokine microenvironment in inflammatory bowel disease and coeliac disease.
Eastaff‐Leung, N. (2009) · Adelaide Research & Scholarship (AR&S) (University of Adelaide)
Characterizing immunomodulatory activity of lactic acid bacteria on cell types involved in innate immunity: Analysis of the effects of Lactobacillus rhamnosus R0011-derived milk ferments on macrophage polarization and of secretome effects on intestinal epithelial cell cytokine production
Jeffrey, M. P. (2015) · e-scholar@UOIT (University of Ontario Institute of Technology)
The role of intestinal mononuclear phagocytes in control of mucosal T cell homeostasis
Panea, C. (2016) · doi:10.7916/d8b56jwd
Effects of dietary fermentable material on innate and adaptive immune measures in male and female rats under resting and immunized conditions
Shastri, P. (2015) · e-scholar@UOIT (University of Ontario Institute of Technology)

Authors: Atarashi, K., Nishimura, J., Shima, T., Umesaki, Y., Yamamoto, M., Onoue, M., Yagita, H., Ishii, N., Evans, R., Honda, K., & Takeda, K.
Affiliations: The University of Osaka (JP)
Yakult Central Institute (JP)
Immunology Frontier Research Center, The University of Osaka (JP)
Tohoku University (JP)
University of Leicester (GB)
Corresponding author: Honda, Kenya
Takeda, Kiyoshi
ORCID: Atarashi, Koji
Nishimura, Junichi
Umesaki, Yoshinori
Yamamoto, Masahiro
Ishii, Naoto
Evans, Richard
Honda, Kenya
Takeda, Kiyoshi
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2008-08-20
Volume: 455
Issue: 7214
Pages: 808-812
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature07240
OpenAlex: W2051529467
Cited by: 1,089
References: 33
Citations by year: 2026: 19 · 2025: 37 · 2024: 51 · 2023: 34 · 2022: 39 · 2021: 49 · 2020: 52 · 2019: 56 · 2018: 54 · 2017: 54 · 2016: 64 · 2015: 72 · 2014: 81 · 2013: 78 · 2012: 71
FWCI: 38.38
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Leicester Research Archive (University of Leicester) (submittedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
Keywords: Th17 cell differentiation, ATP, intestinal lamina propria, commensal bacteria, intestinal dendritic cells, IL-17, interleukin-6, TGF-beta, germ-free mice, T cell-mediated colitis, inflammatory bowel disease, innate immunity
MeSH terms: Adenosine Triphosphate, Animals, Cell Differentiation, Cells, Cultured, Colitis, Disease Models, Animal, Feces, Female, Germ-Free Life, T-Lymphocytes, Helper-Inducer, Immunoglobulin A, Male, Mucous Membrane, Receptors, Purinergic P2, Interleukin-17, CD11c Antigen, Mice, CD27 Ligand

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

ATP drives lamina propria TH17 cell differentiation

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks