Cited by 1,089Psoriasis: Treatment and PathogenesisT-cell and B-cell ImmunologyInflammatory Bowel Disease

The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.

ATP drives lamina propria TH17 cell differentiation

Atarashi, Koji, Nishimura, Junichi, Shima, Tatsuichiro, Umesaki, Yoshinori, Yamamoto, Masahiro, Onoue, Masaharu, Yagita, Hideo, Ishii, Naoto, Evans, Richard, Honda, Kenya, Takeda, Kiyoshi·2008·Nature

DOI 10.1038/nature07240

Open this paper in CoChat — free account

Abstract

Interleukin (IL)-17-producing CD4(+) T lymphocytes (T(H)17 cells) constitute a subset of T-helper cells involved in host defence and several immune disorders. An intriguing feature of T(H)17 cells is their selective and constitutive presence in the intestinal lamina propria. Here we show that adenosine 5'-triphosphate (ATP) that can be derived from commensal bacteria activates a unique subset of lamina propria cells, CD70(high)CD11c(low) cells, leading to the differentiation of T(H)17 cells. Germ-free mice exhibit much lower concentrations of luminal ATP, accompanied by fewer lamina propria T(H)17 cells, compared to specific-pathogen-free mice. Systemic or rectal administration of ATP into these germ-free mice results in a marked increase in the number of lamina propria T(H)17 cells. A CD70(high)CD11c(low) subset of the lamina propria cells expresses T(H)17-prone molecules, such as IL-6, IL-23p19 and transforming-growth-factor-beta-activating integrin-alphaV and -beta8, in response to ATP stimulation, and preferentially induces T(H)17 differentiation of co-cultured naive CD4(+) T cells. The critical role of ATP is further underscored by the observation that administration of ATP exacerbates a T-cell-mediated colitis model with enhanced T(H)17 differentiation. These observations highlight the importance of commensal bacteria and ATP for T(H)17 differentiation in health and disease, and offer an explanation of why T(H)17 cells specifically present in the intestinal lamina propria.

Integrity signals

Registry

Crossref · 10.1038/nature07240

Cites

33 of 33 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
Bettelli, E., Carrier, Y., Gao, W., Korn, T., Strom, T. B., Oukka, M., Weiner, H. L., & Kuchroo, V. K. (2006) · Nature · doi:10.1038/nature04753 · Cited by 6,992
The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells
Ivanov, I. I., McKenzie, B. S., Zhou, L., Tadokoro, C. E., Lepelley, A., Lafaille, J. J., Cua, D. J., & Littman, D. R. (2006) · Cell · doi:10.1016/j.cell.2006.07.035 · Cited by 5,145
TGFβ in the Context of an Inflammatory Cytokine Milieu Supports De Novo Differentiation of IL-17-Producing T Cells
Veldhoen, M., Hocking, R. J., Atkins, C. J., Locksley, R. M., & Stockinger, B. (2006) · Immunity · doi:10.1016/j.immuni.2006.01.001 · Cited by 3,605
Role of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathway
Yamamoto, M., Sato, S., Hemmi, H., Hoshino, K., Kaisho, T., Sanjo, H., Takeuchi, O., Sugiyama, M., Okabe, M., Takeda, K., et al. (2003) · Science · doi:10.1126/science.1087262 · Cited by 3,286
Transforming growth factor-β induces development of the TH17 lineage
Mangan, P. R., Harrington, L. E., O'Quinn, D. B., Helms, W. S., Bullard, D. C., Elson, C. O., Hatton, R. D., Wahl, S. M., Schoeb, T. R., & Weaver, C. T. (2006) · Nature · doi:10.1038/nature04754 · Cited by 3,087
Molecular Physiology of P2X Receptors
North, R. A. (2002) · Physiological Reviews · doi:10.1152/physrev.00015.2002 · Cited by 2,919
A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-β– and retinoic acid–dependent mechanism
Coombes, J. L., Siddiqui, K. R. R., Arancibia-Cárcamo, C. V., Hall, J. A., Sun, C., Belkaid, Y., & Powrie, F. M. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070590 · Cited by 2,708
Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria
Rescigno, M., Urbano, M., Valzasina, B., Francolini, M., Rotta, G., Bonasio, R., Granucci, F., Kraehenbuhl, J.-P., & Ricciardi‐Castagnoli, P. (2001) · Nature Immunology · doi:10.1038/86373 · Cited by 2,554
A microbial symbiosis factor prevents intestinal inflammatory disease
Mazmanian, S. K., Round, J. L., & Kasper, D. L. (2008) · Nature · doi:10.1038/nature07008 · Cited by 2,340
Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides
Liang, S. C., Tan, X.-Y., Luxenberg, D. P., Karim, R., Dunussi-Joannopoulos, K., Collins, M., & Fouser, L. A. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20061308 · Cited by 2,330

Flagged first, then by citations

Show all 33 references

Sorted by citations

Items 401–500 of 1,000

Intestinal microbiota sustains inflammation and autoimmunity induced by hypomorphic RAG defects
Rigoni, R., Fontana, E., Guglielmetti, S., Fosso, B., D’Erchia, A. M., Maina, V., Taverniti, V., Castiello, M. C., Mantero, S., Pacchiana, G., et al. (2016) · The Journal of Experimental Medicine · doi:10.1084/jem.20151116 · Cited by 70
CD 73 is a phenotypic marker of effector memory T h17 cells in inflammatory bowel disease
Doherty, G. A., Bai, A., Hanidziar, D., Longhi, M. S., Lawlor, G. O., Putheti, P., Csizmadia, E., Nowak, M., Cheifetz, A. S., Moss, A. C., et al. (2012) · European Journal of Immunology · doi:10.1002/eji.201242623 · Cited by 68
The interplay between the microbiome and the adaptive immune response in cancer development
Russo, E., Taddei, A., Ringressi, M. N., Ricci, F., & Amedei, A. (2016) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756283x16635082 · Cited by 68
Secretory IgA in complex with Lactobacillus rhamnosus potentiates mucosal dendritic cell-mediated Treg cell differentiation via TLR regulatory proteins, RALDH2 and secretion of IL-10 and TGF-β
Mikulic, J., Longet, S., Favre, L., Benyacoub, J., & Corthésy, B. (2016) · Cellular and Molecular Immunology · doi:10.1038/cmi.2015.110 · Cited by 67
Regulatory T cells in atherosclerosis and strategies to induce the endogenous atheroprotective immune response
Chistiakov, D. A., Sobenin, I. A., & Orekhov, A. N. (2013) · Immunology Letters · doi:10.1016/j.imlet.2013.01.014 · Cited by 67
Gastrointestinal Microbiota–Mediated Control of Enteric Pathogens
Yurist‐Doutsch, S., Arrieta, M., Vogt, S. L., & Finlay, B. B. (2014) · Annual Review of Genetics · doi:10.1146/annurev-genet-120213-092421 · Cited by 70
Epithelial Barrier Function in Gut-Bone Signaling
Rios‐Arce, N. D., Collins, F. L., Schepper, J. D., Steury, M. D., Raehtz, S., Mallin, H., Schoenherr, D. T., Parameswaran, N., & McCabe, L. R. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-66653-2_8 · Cited by 72
Cellular Plasticity of CD4+ T Cells in the Intestine
Brucklacher-Waldert, V., Carr, E. J., Linterman, M. A., & Veldhoen, M. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00488 · Cited by 70
Signatures in the gut microbiota of Japanese infants who developed food allergies in early childhood
Tanaka, M., Korenori, Y., Washio, M., Kobayashi, T., Momoda, R., Kiyohara, C., Kuroda, A., Saito, Y., Sonomoto, K., & Nakayama, J. (2017) · FEMS Microbiology Ecology · doi:10.1093/femsec/fix099 · Cited by 67
The roles of microRNAs in tumorigenesis and angiogenesis.
Yang, W., Lee, D. Y., & Ben‐David, Y. (2011) · PubMed Central · Cited by 66
Isolation and identification of ATP-secreting bacteria from mice and humans
Iwase, T., Shinji, H., Tajima, A., Sato, F., Tamura, T., Iwamoto, T., Yoneda, M., & Mizunoe, Y. (2010) · Journal of Clinical Microbiology · doi:10.1128/jcm.01941-09 · Cited by 61
Endogenous ethanol production in health and disease
Meijnikman, A. S., Nieuwdorp, M., & Schnabl, B. (2024) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-024-00937-w · Cited by 76
IL-10 engages macrophages to shift Th17 cytokine dependency and pathogenicity during T-cell-mediated colitis
Li, B., Gurung, P., Malireddi, R. K. S., Vogel, P., Kanneganti, T., & Geiger, T. L. (2015) · Nature Communications · doi:10.1038/ncomms7131 · Cited by 65
β8 Integrin Expression and Activation of TGF-β by Intestinal Dendritic Cells Are Determined by Both Tissue Microenvironment and Cell Lineage
Boucard-Jourdin, M., Kugler, D. G., Ahanda, M.-L. E., This, S., Calisto, J. D., Zhang, A., Mora, J. R., Stuart, L. M., Savill, J., Lacy‐Hulbert, A., et al. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1600244 · Cited by 68
The two faces of pannexins: new roles in inflammation and repair
Makarenkova, H. P., Shah, S. B., & Shestopalov, V. I. (2018) · Journal of Inflammation Research · doi:10.2147/jir.s128401 · Cited by 67
Gut microbiota contributes to the intestinal and extraintestinal immune homeostasis by balancing Th17/Treg cells
Wang, J., Hou, Y., Mu, L., Yang, M., & Ai, X. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.113570 · Cited by 75
Microbiota and Autoimmune Disease: The Hosted Self
Mathis, D. J., & Benoist, C. O. (2011) · Cell Host & Microbe · doi:10.1016/j.chom.2011.09.007 · Cited by 66
CD70 defines a subset of proinflammatory and CNS-pathogenic TH1/TH17 lymphocytes and is overexpressed in multiple sclerosis
Dhaeze, T., Tremblay, L., Lachance, C., Peelen, E., Zandee, S., Grasmuck, C., Bourbonnière, L., Larouche, S., Ayrignac, X., Rébillard, R., et al. (2019) · Cellular and Molecular Immunology · doi:10.1038/s41423-018-0198-5 · Cited by 63
A fresh look at the hygiene hypothesis: How intestinal microbial exposure drives immune effector responses in atopic disease
Brown, E., Arrieta, M., & Finlay, B. B. (2013) · Seminars in Immunology · doi:10.1016/j.smim.2013.09.003 · Cited by 68
Epithelial IFNγ signalling and compartmentalized antigen presentation orchestrate gut immunity
Malik, A., Sharma, D., Aguirre‐Gamboa, R., McGrath, S., Zabala, S., Weber, C. R., & Jabrì, B. (2023) · Nature · doi:10.1038/s41586-023-06721-1 · Cited by 63
The neuroimmune connectome in health and disease
Wheeler, M. A., & Quintana, F. J. (2025) · Nature · doi:10.1038/s41586-024-08474-x · Cited by 71
Interleukin-17: friend or foe in atherosclerosis?
Taleb, S., Tedgui, A., & Mallat, Z. (2010) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e32833dc7f9 · Cited by 65
Adenosine triphosphate acts as a paracrine signaling molecule to reduce the motility of T cells
Wang, C. M., Ploia, C., Anselmi, F., Sarukhan, A., & Viola, A. (2014) · The EMBO Journal · doi:10.15252/embj.201386666 · Cited by 63
Extracellular NAD+: a danger signal hindering regulatory T cells
Adriouch, S., Haag, F., Boyer, O., Séman, M., & Koch‐Nolte, F. (2012) · Microbes and Infection · doi:10.1016/j.micinf.2012.05.011 · Cited by 68
CD39 is upregulated during activation of mouse and human T cells and attenuates the immune response to Listeria monocytogenes
Raczkowski, F., Rissiek, A., Ricklefs, I., Heiß, K., Schumacher, V., Wundenberg, K., Haag, F., Koch‐Nolte, F., Tolosa, E., & Mittrücker, H. (2018) · PLoS ONE · doi:10.1371/journal.pone.0197151 · Cited by 65
Nutritional Modulation of Immune and Central Nervous System Homeostasis: The Role of Diet in Development of Neuroinflammation and Neurological Disease
Estrada, J. A., & Contreras, I. (2019) · Nutrients · doi:10.3390/nu11051076 · Cited by 65
TGF-β in transplantation tolerance
Regateiro, F. S., Howie, D., Cobbold, S. P., & Waldmann, H. (2011) · Current Opinion in Immunology · doi:10.1016/j.coi.2011.07.003 · Cited by 65
Development and regulation of RORγt+ innate lymphoid cells
Cording, S., Medvedovic, J., Cherrier, M., & Eberl, G. (2014) · FEBS Letters · doi:10.1016/j.febslet.2014.03.034 · Cited by 65
Immune recognition and response to the intestinal microbiome in type 1 diabetes
Paun, A., Yau, C., & Danska, J. S. (2016) · Journal of Autoimmunity · doi:10.1016/j.jaut.2016.02.004 · Cited by 67
3D Immunocompetent Organ‐on‐a‐Chip Models
Maharjan, S., Cecen, B., & Zhang, Y. S. (2020) · Small Methods · doi:10.1002/smtd.202000235 · Cited by 62
Influence of the Gut Microbiome on Autoimmunity in the Central Nervous System
Colpitts, S. L., & Kasper, L. H. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1601438 · Cited by 61
Immunological mechanisms underpinning faecal microbiota transplantation for the treatment of inflammatory bowel disease
Quraishi, M. N., Shaheen, W., Oo, Y. H., & Iqbal, T. H. (2019) · Clinical & Experimental Immunology · doi:10.1111/cei.13397 · Cited by 65
Purine metabolism controls innate lymphoid cell function and protects against intestinal injury
Crittenden, S., Cheyne, A., Adams, A. T., Forster, T., Robb, C. T., Felton, J. M., Ho, G., Rückerl, D., Rossi, A. G., Anderton, S. M., et al. (2018) · Immunology and Cell Biology · doi:10.1111/imcb.12167 · Cited by 60
Dendritic cell–epithelial cell crosstalk in the gut
Rescigno, M. (2014) · Immunological Reviews · doi:10.1111/imr.12181 · Cited by 61
Educating CD4 T cells with vaccine adjuvants: lessons from lipopolysaccharide
McAleer, J. P., & Vella, A. T. (2010) · Trends in Immunology · doi:10.1016/j.it.2010.08.005 · Cited by 62
The volatile anesthetic isoflurane induces ecto-5′-nucleotidase (CD73) to protect against renal ischemia and reperfusion injury
Kim, M., Ham, A., Kim, J. Y., Brown, K. M., D’Agati, V. D., & Lee, H. T. (2013) · Kidney International · doi:10.1038/ki.2013.43 · Cited by 58
Transitions in Oral and Intestinal Microflora Composition and Innate Immune Receptor-Dependent Stimulation during Mouse Development
Hasegawa, M., Osaka, T., Tawaratsumida, K., Yamazaki, T., Tada, H., Chen, G., Tsuneda, S., Núñez, G., & Inohara, N. (2009) · Infection and Immunity · doi:10.1128/iai.01043-09 · Cited by 58
T Lymphocyte Dynamics in Inflammatory Bowel Diseases: Role of the Microbiome
Larmonier, C. B., Shehab, K. W., Ghishan, F. K., & Kiela, P. R. (2015) · BioMed Research International · doi:10.1155/2015/504638 · Cited by 61
Altered Host-Microbe Interaction in HIV: A Target for Intervention with Pro- and Prebiotics
Hummelen, R., Vos, A. P., Land, B. V., van Norren, K., & Reid, G. (2010) · International Reviews of Immunology · doi:10.3109/08830185.2010.505310 · Cited by 57
T Cell–Derived CD70 Delivers an Immune Checkpoint Function in Inflammatory T Cell Responses
O’Neill, R., Du, W., Mohammadpour, H., Alqassim, E., Qiu, J., Chen, G. L., McCarthy, P. L., Lee, K. P., & Cao, X. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1700380 · Cited by 60
Colonic epithelial mTORC1 promotes ulcerative colitis through COX-2-mediated Th17 responses
Lin, X., Sun, Q., Zhou, L., He, M., Dong, X., Lai, M., Liu, M., Su, Y., Jia, C., Han, Z., et al. (2018) · Mucosal Immunology · doi:10.1038/s41385-018-0018-3 · Cited by 58
Differential Pathogenic Th17 Profile in Mesenteric Lymph Nodes of Crohn's Disease and Ulcerative Colitis Patients
Bsat, M., Chapuy, L., Rubio, M., Wassef, R., Richard, C. S., Schwenter, F., Loungnarath, R., Soucy, G., Mehta, H., & Sarfati, M. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01177 · Cited by 60
Immunostimulatory Effects Triggered by Enterococcus faecalis CECT7121 Probiotic Strain Involve Activation of Dendritic Cells and Interferon-Gamma Production
Molina, M. A., Díaz, A. M., Hesse, C., Ginter, W., Gentilini, M. V., Nuñez, G. G., Canellada, A. M., Sparwasser, T. D., Berod, L., Castro, M. S., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0127262 · Cited by 63
Development and Survival of Th17 Cells within the Intestines: The Influence of Microbiome- and Diet-Derived Signals
Chewning, J. H., & Weaver, C. T. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1401835 · Cited by 62
Systems biological approaches to measure and understand vaccine immunity in humans
Li, S., Nakaya, H. I., Kazmin, D. A., Oh, J. Z., & Pulendran, B. (2013) · Seminars in Immunology · doi:10.1016/j.smim.2013.05.003 · Cited by 61
Langerin+ DCs regulate innate IL-17 production in the oral mucosa during Candida albicans-mediated infection
Sparber, F., Dolowschiak, T., Mertens, S., Lauener, L., Clausen, B. E., Joller, N., Stoitzner, P., Tussiwand, R., & LeibundGut‐Landmann, S. (2018) · PLoS Pathogens · doi:10.1371/journal.ppat.1007069 · Cited by 58
Cross-Talk between Gut Microbiota and Heart via the Routes of Metabolite and Immunity
Bu, J., & Wang, Z. (2018) · Gastroenterology Research and Practice · doi:10.1155/2018/6458094 · Cited by 59
Microbiota-Propelled T Helper 17 Cells in Inflammatory Diseases and Cancer
Bellone, M., Brevi, A., & Huber, S. (2020) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00064-19 · Cited by 60
The Role of Bifidobacteria in Predictive and Preventive Medicine: A Focus on Eczema and Hypercholesterolemia
Marras, L., Caputo, M., Bisicchia, S., Soato, M., Bertolino, G., Vaccaro, S., & Inturri, R. (2021) · Microorganisms · doi:10.3390/microorganisms9040836 · Cited by 61
Peptidoglycan Recognition Protein 1 Enhances Experimental Asthma by Promoting Th2 and Th17 and Limiting Regulatory T Cell and Plasmacytoid Dendritic Cell Responses
Park, S. Y., Jing, X., Gupta, D., & Dziarski, R. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1202675 · Cited by 60
B cells as a critical node in the microbiota–host immune system network
Slack, E. M. C., Balmer, M. L., & Macpherson, A. J. (2014) · Immunological Reviews · doi:10.1111/imr.12179 · Cited by 66
Kombucha microbiome as a probiotic: a view from the perspective of post-genomics and synthetic ecology
Kozyrovska, N., Reva, O. N., Goginyan, V. B., & Vera, J.-P. P. D. (2012) · Biopolymers and Cell · doi:10.7124/bc.000034 · Cited by 64
Gut microbiota and hematopoietic stem cell transplantation: where do we stand?
Zama, D., Biagi, E., Masetti, R., Gasperini, P., Prete, A., Candela, M., Brigidi, P., & Pession, A. (2016) · Bone Marrow Transplantation · doi:10.1038/bmt.2016.173 · Cited by 60
Altered inactivation of commensal LPS due to acyloxyacyl hydrolase deficiency in colonic dendritic cells impairs mucosal Th17 immunity
Janelsins, B. M., Lu, M., & Datta, S. K. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1311987111 · Cited by 56
P2X7 Receptor at the Crossroads of T Cell Fate
Rivas-Yáñez, E., Barrera‐Avalos, C., Parra-Tello, B., Briceño, P., Rosemblatt, M. V., Saavedra-Almarza, J., Rosemblatt, M. S., Acuña‐Castillo, C., Bono, M. R., & Sauma, D. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21144937 · Cited by 62
Short-chain fatty acids bind to apoptosis-associated speck-like protein to activate inflammasome complex to prevent Salmonella infection
Tsugawa, H., Kabe, Y., Kanai, A., Sugiura, Y., Hida, S., Taniguchi, S., Takahashi, T., Matsui, H., Yasukawa, Z., Itou, H., et al. (2020) · PLoS Biology · doi:10.1371/journal.pbio.3000813 · Cited by 58
Polyphenols: Role in Modulating Immune Function and Obesity
Mamun, M. A. A., Rakib, A., Mandal, M., Kumar, S., Singla, B., & Singh, U. P. (2024) · Biomolecules · doi:10.3390/biom14020221 · Cited by 62
Immune Responses to Intestinal Microbes in Inflammatory Bowel Diseases
Hansen, J. J. (2015) · Current Allergy and Asthma Reports · doi:10.1007/s11882-015-0562-9 · Cited by 58
Therapeutic Effects of Novel Sphingosine-1-Phosphate Receptor Agonist W-061 in Murine DSS Colitis
Sanada, Y., Mizushima, T., Kai, Y., Nishimura, J., Hagiya, H., Kurata, H., Mizuno, H., Uejima, E., & Ito, T. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023933 · Cited by 56
Regulation of intestinal homeostasis by dendritic cells
Tezuka, H., & Ohteki, T. (2010) · Immunological Reviews · doi:10.1111/j.0105-2896.2009.00872.x · Cited by 58
Extracellular ATP and P2Y Receptor Activation Induce a Proinflammatory Host Response in the Human Urinary Tract
Säve, S., & Persson, K. (2010) · Infection and Immunity · doi:10.1128/iai.00074-10 · Cited by 56
Reducing CD73 Expression by IL1β-Programmed Th17 Cells Improves Immunotherapeutic Control of Tumors
Chatterjee, S., Thyagarajan, K., Kesarwani, P., Song, J. H., Soloshchenko, M., Fu, J., Bailey, S. R., Vasu, C., Kraft, A. S., Paulos, C. M., et al. (2014) · Cancer Research · doi:10.1158/0008-5472.can-14-1450 · Cited by 58
Functions of innate immune cells and commensal bacteria in gut homeostasis
Kayama, H., & Takeda, K. (2015) · The Journal of Biochemistry · doi:10.1093/jb/mvv119 · Cited by 57
Host-Gut Microbiota Crosstalk in Intestinal Adaptation
Marchix, J., Goddard, G. R., & Helmrath, M. A. (2018) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2018.01.024 · Cited by 56
Visions of Eye Commensals: The Known and the Unknown About How the Microbiome Affects Eye Disease
Leger, A. J. S., & Caspi, R. R. (2018) · BioEssays · doi:10.1002/bies.201800046 · Cited by 58
T helper 17 (Th17) cell responses to the gut microbiota in human diseases
Sun, C., Yang, N. Y., Zheng, Z., Liu, D., & Xu, Q. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114483 · Cited by 60
Intestinal Epithelial Barrier Dysfunction in Food Hypersensitivity
Yu, L. C. (2011) · Journal of Allergy · doi:10.1155/2012/596081 · Cited by 55
Microbiota regulation of inflammatory bowel disease and colorectal cancer
Liu, Z., Cao, A., & Cong, Y. (2013) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2013.09.002 · Cited by 55
Adenosine-5'-Triphosphate (ATP) Protects Mice against Bacterial Infection by Activation of the NLRP3 Inflammasome
Xiang, Y., Wang, X., Yan, C., Gao, Q., Li, S., Liu, J., Zhou, K., Guo, X., Lee, W., & Zhang, Y. (2013) · PLoS ONE · doi:10.1371/journal.pone.0063759 · Cited by 55
Satb1 regulates the effector program of encephalitogenic tissue Th17 cells in chronic inflammation
Yasuda, K., Kitagawa, Y., Kawakami, R., Isaka, Y., Watanabe, H., Kondoh, G., Kohwi-shigematsu, T., Sakaguchi, S., & Hirota, K. (2019) · Nature Communications · doi:10.1038/s41467-019-08404-w · Cited by 55
Faecal cytokine profiling as a marker of intestinal inflammation in acutely decompensated cirrhosis
Riva, A., Gray, E. H., Azarian, S., Zamalloa, A., McPhail, M. J. W., Vincent, R. P., Williams, R. L., Chokshi, S., Patel, V., & Edwards, L. A. (2020) · JHEP Reports · doi:10.1016/j.jhepr.2020.100151 · Cited by 53
Interrelatedness between dysbiosis in the gut microbiota due to immunodeficiency and disease penetrance of colitis
Ray, A., & Dittel, B. N. (2015) · Immunology · doi:10.1111/imm.12511 · Cited by 52
How the interplay between antigen presenting cells and microbiota tunes host immune responses in the gut
Świątczak, B., & Rescigno, M. (2011) · Seminars in Immunology · doi:10.1016/j.smim.2011.11.004 · Cited by 54
Role of gut microbiota in graft-versus-host disease
Murphy, S. F., & Nguyen, V. H. (2011) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.3109/10428194.2011.580476 · Cited by 54
Intestinal Antigen-Presenting Cells
Flannigan, K. L., Geem, D., Harusato, A., & Denning, T. L. (2015) · American Journal Of Pathology · doi:10.1016/j.ajpath.2015.02.024 · Cited by 56
Biochemical Mechanisms of Pathogen Restriction by Intestinal Bacteria
Rangan, K. J., & Hang, H. C. (2017) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2017.08.005 · Cited by 55
Activation pathways that drive CD4 + T cells to break tolerance in autoimmune diseases*
Krovi, S. H., & Kuchroo, V. K. (2022) · Immunological Reviews · doi:10.1111/imr.13071 · Cited by 56
Getting the Bugs out of the Immune System: Do Bacterial Microbiota “Fix” Intestinal T Cell Responses?
Chow, J., & Mazmanian, S. K. (2009) · Cell Host & Microbe · doi:10.1016/j.chom.2008.12.006 · Cited by 54
Unveiling the gut-brain axis: structural and functional analogies between the gut and the choroid plexus vascular and immune barriers
Carloni, S., & Rescigno, M. (2022) · Seminars in Immunopathology · doi:10.1007/s00281-022-00955-3 · Cited by 57
Innate PI3K p110δ Regulates Th1/Th17 Development and Microbiota-Dependent Colitis
Steinbach, E. C., Kobayashi, T., Russo, S. M., Sheikh, S. Z., Gipson, G. R., Kennedy, S. T., Uno, J. K., Mishima, Y., Borst, L. B., Liu, B., et al. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1301533 · Cited by 54
Contraction of intestinal effector T cells by retinoic acid-induced purinergic receptor P2X7
Hashimoto‐Hill, S., Friesen, L., Kim, M., & Kim, C. H. (2016) · Mucosal Immunology · doi:10.1038/mi.2016.109 · Cited by 54
The impact of aging-induced gut microbiome dysbiosis on dendritic cells and lung diseases
Malik, J. A., Zafar, M. A., Lamba, T., Nanda, S., Khan, M. A., & Agrewala, J. N. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2290643 · Cited by 52
Diarylsulfonamides and their bioisosteres as dual inhibitors of alkaline phosphatase and carbonic anhydrase: Structure activity relationship and molecular modelling studies
al‐Rashida, M., Ejaz, S. A., Ali, S., Shaukat, A., Hamayoun, M., Ahmed, M., & Iqbal, J. (2015) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2015.03.054 · Cited by 51
Commensal A4 bacteria inhibit intestinal Th2‐cell responses through induction of dendritic cell TGF‐β production
Wu, W. H., Liu, H., Chen, F., Liu, H., Cao, A., Yao, S., Sun, M., Evans‐Marin, H., Zhao, Y., Zhao, Q. S., et al. (2016) · European Journal of Immunology · doi:10.1002/eji.201546160 · Cited by 53
Tissue-resident dendritic cells and diseases involving dendritic cell malfunction
Chen, K., Wang, J., Yuan, R., Xiang, Y., Li, L., Gong, W., Yang, T., Li, L., & Su, S. (2016) · International Immunopharmacology · doi:10.1016/j.intimp.2016.02.007 · Cited by 51
RORγt+ cells selectively express redundant cation channels linked to the Golgi apparatus
Drujont, L., Lemoine, A., Moreau, A., Bienvenu, G., Lancien, M., Cens, T., Guillot, F., Bériou, G., Bouchet‐Delbos, L., Fehling, H. J., et al. (2016) · Scientific Reports · doi:10.1038/srep23682 · Cited by 51
mTOR Inhibition Attenuates Dextran Sulfate Sodium-Induced Colitis by Suppressing T Cell Proliferation and Balancing TH1/TH17/Treg Profile
Hu, S., Chen, M., Wang, Y., Wang, Z., Pei, Y.-F., Fan, R., Liu, X., Wang, L., Zhou, J., Zheng, S., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0154564 · Cited by 56
CD30 Ligand Is a Target for a Novel Biological Therapy against Colitis Associated with Th17 Responses
Sun, X., Yamada, H., Shibata, K., Muta, H., Tani, K., Podack, E. R., Iwakura, Y., & Yoshikai, Y. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1002229 · Cited by 51
Host-Recognition of Pathogens and Commensals in the Mammalian Intestine
Rossi, O., van Baarlen, P., & Wells, J. M. (2011) · Current topics in microbiology and immunology · doi:10.1007/82_2011_191 · Cited by 50
Specific Microbiota-Induced Intestinal Th17 Differentiation Requires MHC Class II but Not GALT and Mesenteric Lymph Nodes
Geem, D., Contreras, O. M., McBride, M., Newberry, R. D., Koni, P. A., & Denning, T. L. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1303167 · Cited by 50
The diverse ontogeny and function of murine small intestinal dendritic cell/macrophage subsets
Persson, E. K., Gyllenbäck, E. J., & Agace, W. W. (2010) · Immunobiology · doi:10.1016/j.imbio.2010.05.013 · Cited by 54
Perilla frutescens extract ameliorates DSS-induced colitis by suppressing proinflammatory cytokines and inducing anti-inflammatory cytokines
Urushima, H., Nishimura, J., Mizushima, T., Hayashi, N., Maeda, K., & Ito, T. (2014) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00294.2014 · Cited by 50
The P2X7 Receptor Contributes to the Development of the Exacerbated Inflammatory Response Associated with Sepsis
Santana, P. T., Benjamim, C. F., Martinez, C. G., Kurtenbach, E., Takiya, C. M., & Coutinho‐Silva, R. (2015) · Journal of Innate Immunity · doi:10.1159/000371388 · Cited by 51
Human prophylactic vaccine adjuvants and their determinant role in new vaccine formulations
Pérez, O., Batista-Duharte, A., González, E., Zayas, C., Balboa, J. A., Cuello, M., Cabrera, O., Lastre, M., & Schijns, V. E. C. J. (2012) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2012007500067 · Cited by 50
Galacto-Oligosaccharides Modulate the Juvenile Gut Microbiome and Innate Immunity To Improve Broiler Chicken Performance
Richards, P. J., Lafontaine, G. M. F., Connerton, P. L., Liang, L., Asiani, K., Fish, N. M., & Connerton, I. F. (2020) · mSystems · doi:10.1128/msystems.00827-19 · Cited by 48
Extracellular ATP promotes breast cancer invasion and chemoresistance via SOX9 signaling
Yang, H., Geng, Y., Wang, P., Yang, H. K., Zhou, Y., Zhang, H., He, H., Fang, W., & Tian, X. (2020) · Oncogene · doi:10.1038/s41388-020-01402-z · Cited by 49
Butyrate Ameliorates Insufficient Sleep-Induced Intestinal Mucosal Damage in Humans and Mice
Gao, T., Wang, Z., Dong, Y., Cao, J., & Chen, Y. (2022) · Microbiology Spectrum · doi:10.1128/spectrum.02000-22 · Cited by 52
Density of CD163+CD11c+ Dendritic Cells Increases and CD103+ Dendritic Cells Decreases in the Coeliac Lesion
Beitnes, A.-C. R., Ráki, M., Lundin, K. E. A., Jahnsen, J., Sollid, L. M., & Jahnsen, F. L. (2011) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.2011.02549.x · Cited by 49
Th17 lineage commitment and HIV-1 pathogenesis
Ancuța, P., Monteiro, P., & Sékaly, R. (2010) · Current Opinion in HIV and AIDS · doi:10.1097/coh.0b013e3283364733 · Cited by 50
Harnessing Regulatory T Cells for the Treatment of Inflammatory Bowel Disease
Geem, D., Harusato, A., Flannigan, K. L., & Denning, T. L. (2015) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000343 · Cited by 51

Authors: Atarashi, K., Nishimura, J., Shima, T., Umesaki, Y., Yamamoto, M., Onoue, M., Yagita, H., Ishii, N., Evans, R., Honda, K., & Takeda, K.
Affiliations: The University of Osaka (JP)
Yakult Central Institute (JP)
Immunology Frontier Research Center, The University of Osaka (JP)
Tohoku University (JP)
University of Leicester (GB)
Corresponding author: Honda, Kenya
Takeda, Kiyoshi
ORCID: Atarashi, Koji
Nishimura, Junichi
Umesaki, Yoshinori
Yamamoto, Masahiro
Ishii, Naoto
Evans, Richard
Honda, Kenya
Takeda, Kiyoshi
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2008-08-20
Volume: 455
Issue: 7214
Pages: 808-812
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature07240
OpenAlex: W2051529467
Cited by: 1,089
References: 33
Citations by year: 2026: 19 · 2025: 37 · 2024: 51 · 2023: 34 · 2022: 39 · 2021: 49 · 2020: 52 · 2019: 56 · 2018: 54 · 2017: 54 · 2016: 64 · 2015: 72 · 2014: 81 · 2013: 78 · 2012: 71
FWCI: 38.38
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Leicester Research Archive (University of Leicester) (submittedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
Keywords: Th17 cell differentiation, ATP, intestinal lamina propria, commensal bacteria, intestinal dendritic cells, IL-17, interleukin-6, TGF-beta, germ-free mice, T cell-mediated colitis, inflammatory bowel disease, innate immunity
MeSH terms: Adenosine Triphosphate, Animals, Cell Differentiation, Cells, Cultured, Colitis, Disease Models, Animal, Feces, Female, Germ-Free Life, T-Lymphocytes, Helper-Inducer, Immunoglobulin A, Male, Mucous Membrane, Receptors, Purinergic P2, Interleukin-17, CD11c Antigen, Mice, CD27 Ligand

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

ATP drives lamina propria TH17 cell differentiation

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks