Cited by 3,592MicroRNA in disease regulationRNA Research and SplicingPlant Molecular Biology Research

The DOI matches its Crossref record; 49 of the 50 references it cites were found in a registry or an index.

The impact of microRNAs on protein output

Open access

Baek, Daehyun, Villén, Judit, Shin, Chanseok, Camargo, Fernando D., Gygi, Steven P., Bartel, David P.·2008·Nature

Open this paper in CoChat — free account

Abstract

MicroRNAs are endogenous approximately 23-nucleotide RNAs that can pair to sites in the messenger RNAs of protein-coding genes to downregulate the expression from these messages. MicroRNAs are known to influence the evolution and stability of many mRNAs, but their global impact on protein output had not been examined. Here we use quantitative mass spectrometry to measure the response of thousands of proteins after introducing microRNAs into cultured cells and after deleting mir-223 in mouse neutrophils. The identities of the responsive proteins indicate that targeting is primarily through seed-matched sites located within favourable predicted contexts in 3' untranslated regions. Hundreds of genes were directly repressed, albeit each to a modest degree, by individual microRNAs. Although some targets were repressed without detectable changes in mRNA levels, those translationally repressed by more than a third also displayed detectable mRNA destabilization, and, for the more highly repressed targets, mRNA destabilization usually comprised the major component of repression. The impact of microRNAs on the proteome indicated that for most interactions microRNAs act as rheostats to make fine-scale adjustments to protein output.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/nature07242

Cites

49 of 49 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Gene Ontology: tool for the unification of biology
Ashburner, M., Ball, C. A., Blake, J. A., Botstein, D., Butler, H., Cherry, J. M., Davis, A. P., Dolinski, K., Dwight, S. S., Eppig, J. T., et al. (2000) · Nature Genetics · doi:10.1038/75556 · Cited by 43,206
Conserved Seed Pairing, Often Flanked by Adenosines, Indicates that Thousands of Human Genes are MicroRNA Targets
Lewis, B. P., Burge, C. B., & Bartel, D. P. (2005) · Cell · doi:10.1016/j.cell.2004.12.035 · Cited by 11,855
Self-citation
<tt>BLAT</tt> —The <tt>BLAST</tt> -Like Alignment Tool
Kent, W. J. (2002) · Genome Research · doi:10.1101/gr.229202 · Cited by 8,480
A comparison of normalization methods for high density oligonucleotide array data based on variance and bias
Bolstad, B. M., Irizarry, R. A., Åstrand, M., & Speed, T. P. (2003) · Bioinformatics · doi:10.1093/bioinformatics/19.2.185 · Cited by 8,314
Stable isotope labeling by amino acids in cell culture, SILAC, as a simple and accurate approach to expression proteomics
Ong, S.-E., Blagoev, B., Kratchmarova, I., Kristensen, D. B., Steen, H., Pandey, A., & Mann, M. (2002) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m200025-mcp200 · Cited by 5,574
Prediction of Mammalian MicroRNA Targets
Lewis, B. P., Shih, I.-H., Jones-Rhoades, M. W., Bartel, D. P., & Burge, C. B. (2003) · Cell · doi:10.1016/s0092-8674(03)01018-3 · Cited by 5,199
Self-citation
Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs
Lim, L. P., Lau, N. C., Garrett-Engele, P., Grimson, A., Schelter, J. M., Castle, J., Bartel, D. P., Linsley, P. S., & Johnson, J. M. (2005) · Nature · doi:10.1038/nature03315 · Cited by 4,755
Self-citation
Combinatorial microRNA target predictions
Krek, A., Grün, D., Poy, M. N., Wolf, R., Rosenberg, L., Epstein, E. J., MacMenamin, P., da Piedade, I., Gunsalus, K. C., Stoffel, M., et al. (2005) · Nature Genetics · doi:10.1038/ng1536 · Cited by 4,603
miRBase: tools for microRNA genomics
Griffiths‐Jones, S., Saini, H. K., van Dongen, S., & Enright, A. J. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm952 · Cited by 4,349
Silencing of microRNAs in vivo with ‘antagomirs’
Krützfeldt, J., Rajewsky, N., Braich, R., Rajeev, K. G., Tuschl, T., Manoharan, M., & Stoffel, M. (2005) · Nature · doi:10.1038/nature04303 · Cited by 3,949

Flagged first, then by citations

Show all 50 references

1 of the 50 references couldn’t be matched to a known paper.

Sorted by citations

Items 801–900 of 1,013

The microRNA miR-124 controls gene expression in the sensory nervous system of Caenorhabditis elegans
Clark, A., Goldstein, L. D., Tevlin, M., Tavaré, S., Shaham, S., & Miska, E. A. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq083 · Cited by 95
miR-30 Family microRNAs Regulate Myogenic Differentiation and Provide Negative Feedback on the microRNA Pathway
Guess, M. G., Bjorkman, K. K., Harrison, B. C., & Leinwand, L. A. (2015) · PLoS ONE · doi:10.1371/journal.pone.0118229 · Cited by 94
Expression of miR-142-5p in Peripheral Blood Mononuclear Cells from Renal Transplant Patients with Chronic Antibody-Mediated Rejection
Danger, R., Paul, C., Giral, M., Lavault, A., Foucher, Y., Degauque, N., Pallier, A., Durand, M., Castagnet, S., Huyen, J. D. V., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060702 · Cited by 94
Engineered RNA viral synthesis of microRNAs
Varble, A., Chua, M. A., Perez, J. T., Manicassamy, B., García‐Sastre, A., & tenOever, B. R. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1003115107 · Cited by 97
MicroRNA Regulation of Molecular Networks Mapped by Global MicroRNA, mRNA, and Protein Expression in Activated T Lymphocytes
Grigoryev, Y. A., Kurian, S. M., Hart, T., Nakorchevsky, A., Chen, C., Campbell, D., Head, S. R., Yates, J. R., & Salomon, D. R. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1101233 · Cited by 95
Structure-mediated modulation of mRNA abundance by A-to-I editing
Brümmer, A., Yang, Y., Chan, T. W., & Xiao, X. G. (2017) · Nature Communications · doi:10.1038/s41467-017-01459-7 · Cited by 95
MicroRNA-221–222 Regulate the Cell Cycle in Mast Cells
Mayoral, R. J., Pipkin, M. E., Pachkov, M. V., van Nimwegen, E., Rao, A., & Monticelli, S. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.182.1.433 · Cited by 95
Regulation of fibrinogen production by microRNAs
Fort, A., Borel, C., Migliavacca, E., Antonarakis, S. E., Fish, R. J., & Neerman‐Arbez, M. (2010) · Blood · doi:10.1182/blood-2010-02-268011 · Cited by 94
Quantitative proteomics in biological research
Wilm, M. S. (2009) · PROTEOMICS · doi:10.1002/pmic.200900299 · Cited by 99
Understanding How miRNAs Post-Transcriptionally Regulate Gene Expression
Fabian, M. R., Sundermeier, T. R., & Sonenberg, N. (2009) · Progress in molecular and subcellular biology · doi:10.1007/978-3-642-03103-8_1 · Cited by 99
MiR-221 Influences Effector Functions and Actin Cytoskeleton in Mast Cells
Mayoral, R. J., Dehò, L., Rusca, N., Bartoniček, N., Saini, H. K., Enright, A. J., & Monticelli, S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026133 · Cited by 93
Argonaute CLIP-Seq reveals miRNA targetome diversity across tissue types
Clark, P., Loher, P., Quann, K., Brody, J. R., Londin, E. R., & Rigoutsos, I. (2014) · Scientific Reports · doi:10.1038/srep05947 · Cited by 93
miRNA expression in diffuse large B-cell lymphoma treated with chemoimmunotherapy
Montes‐Moreno, S., Martı́nez, N., Sánchez‐Espiridión, B., Díaz‐Uriarte, R., Rodríguez, M. E., Sáez, A., Montalbán, C., Goméz-López, G., Pisano, D. G., García, J. F., et al. (2011) · Blood · doi:10.1182/blood-2010-11-321554 · Cited by 93
MicroRNA Networks in Mouse Lung Organogenesis
Dong, J., Jiang, G., Asmann, Y. W., Tomaszek, S. C., Jen, J., Kislinger, T., & Wigle, D. A. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010854 · Cited by 93
Altered Circulating miRNA Expression Profile in Pregestational and Gestational Obesity
Carreras‐Badosa, G., Bonmatí, A., Ortega, F. J., Mercader, J. M., Guindo-Martínez, M., Torrents, D., Prats‐Puig, A., Martínez‐Calcerrada, J., Platero-Gutierrez, E., de Zegher, F., et al. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-2872 · Cited by 93
Proteome profiling in IL-1β and VEGF-activated human umbilical vein endothelial cells delineates the interlink between inflammation and angiogenesis
Mohr, T. T., Haudek‐Prinz, V. J., Slany, A., Grillari, J., Micksche, M., & Gerner, C. (2017) · PLoS ONE · doi:10.1371/journal.pone.0179065 · Cited by 93
Tumor Necrosis Factor α–Induced MicroRNA‐18a Activates Rheumatoid Arthritis Synovial Fibroblasts Through a Feedback Loop in NF‐κB Signaling
Trenkmann, M., Brock, M., Gay, R. E., Michel, B. A., Gay, S., & Huber, L. (2012) · Arthritis & Rheumatism · doi:10.1002/art.37834 · Cited by 93
MicroRNA networks surrounding APP and amyloid-β metabolism — Implications for Alzheimer's disease
Schönrock, N., Matamales, M., Ittner, L. M., & Götz, J. (2011) · Experimental Neurology · doi:10.1016/j.expneurol.2011.11.013 · Cited by 96
Inducible deletion of epidermal Dicer and Drosha reveals multiple functions for miRNAs in postnatal skin
Teta, M., Choi, Y. S., Okegbe, T., Wong, G. S., Tam, O. H., Chong, M. M. W., Seykora, J. T., Nagy, A., Littman, D. R., Andl, T., et al. (2012) · Development · doi:10.1242/dev.070920 · Cited by 94
Development of Therapeutic-Grade Small Interfering RNAs by Chemical Engineering
Bramsen, J. B., & Kjems, J. (2012) · Frontiers in Genetics · doi:10.3389/fgene.2012.00154 · Cited by 92
Epigenetics: The Language of the Cell?
Huang, B., Jiang, C., & Zhang, R. (2014) · Epigenomics · doi:10.2217/epi.13.72 · Cited by 94
Enforced expression of miR-125b affects myelopoiesis by targeting multiple signaling pathways
Surdziel, E., Cabanski, M., Dallmann, I., Łyszkiewicz, M., Krueger, A., Ganser, A., Scherr, M., & Eder, M. (2011) · Blood · doi:10.1182/blood-2010-06-289058 · Cited by 93
MicroRNAs in inflammatory bowel disease - pathogenesis, diagnostics and therapeutics
Coskun, M. (2012) · World Journal of Gastroenterology · doi:10.3748/wjg.v18.i34.4629 · Cited by 92
Nrf2 Pathway in Age-Related Neurological Disorders: Insights into MicroRNAs
Paladino, S., Conte, A., Caggiano, R., Pierantoni, G. M., & Faraonio, R. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000491465 · Cited by 92
miR-20b, miR-98, miR-125b-1*, and let-7e* as new potential diagnostic biomarkers in ulcerative colitis
Coskun, M. (2013) · World Journal of Gastroenterology · doi:10.3748/wjg.v19.i27.4289 · Cited by 93
Regulation of Lipid Homeostasis by the Bifunctional SREBF2-miR33a Locus
Bommer, G. T., & MacDougald, O. A. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.02.004 · Cited by 94
Regulating the regulators: mechanisms controlling the maturation of microRNAs
Ding, X. C., Weiler, J., & Großhans, H. (2008) · Trends in biotechnology · doi:10.1016/j.tibtech.2008.09.006 · Cited by 94
Germ Cell Origins of Posttraumatic Stress Disorder Risk: The Transgenerational Impact of Parental Stress Experience
Rodgers, A. B., & Bale, T. L. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.03.018 · Cited by 91
Dysregulated microRNAs in neurodegenerative disorders
Lau, P., & Strooper, B. D. (2010) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2010.01.009 · Cited by 93
A global view of porcine transcriptome in three tissues from a full-sib pair with extreme phenotypes in growth and fat deposition by paired-end RNA sequencing
Chen, C., Ai, H., Ren, J., Li, W., Li, P., Qiao, R., Ouyang, J., Yang, M. Y., Ma, J., & Huang, L. (2011) · BMC Genomics · doi:10.1186/1471-2164-12-448 · Cited by 96
Big Effects of Small RNAs: A Review of MicroRNAs in Anxiety
Malan‐Müller, S., Hemmings, S. M. J., & Seedat, S. (2012) · Molecular Neurobiology · doi:10.1007/s12035-012-8374-6 · Cited by 91
Mirtrons, an emerging class of atypical miRNA
Curtis, H. J., Sibley, C. R., & Wood, M. J. A. (2012) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1122 · Cited by 96
Using microRNA Networks to Understand Cancer
Dragomir, M. P., Mafra, A. C. P., Dias, S. M. G., Vasilescu, C., & Călin, G. A. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19071871 · Cited by 93
MiR-206 decreases brain-derived neurotrophic factor levels in a transgenic mouse model of Alzheimer’s disease
Tian, N., Cao, Z., & Zhang, Y. (2014) · Neuroscience Bulletin · doi:10.1007/s12264-013-1419-7 · Cited by 93
Epigenetic mechanisms in pubertal brain maturation
Morrison, K. E., Rodgers, A. B., Morgan, C. P., & Bale, T. L. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.11.014 · Cited by 97
The road toward microRNA therapeutics
Seto, A. G. (2010) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2010.03.003 · Cited by 91
Identification of Ovarian Cancer Metastatic miRNAs
Vang, S., Wu, H.-T., Fischer, A. K., Miller, D. H., MacLaughlan, S. D., Douglass, E. M., Steinhoff, M. M., Collins, C. C., Smith, P. J., Brard, L., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0058226 · Cited by 90
MicroRNA-181a modulates gene expression of zinc finger family members by directly targeting their coding regions
Huang, S., Wu, S., Ding, J., Lin, J., Lin, W., Gu, J., & He, X. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq564 · Cited by 90
miR-33a promotes glioma-initiating cell self-renewal via PKA and NOTCH pathways
Wang, H., Sun, T., Hu, J. Y., Zhang, R., Rao, Y., Wang, S., Chen, R., McLendon, R. E., Friedman, A. H., Keir, S. T., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci75284 · Cited by 90
Proteomics and metabolomics in ageing research: from biomarkers to systems biology
Hoffman, J. M., Lyu, Y., Pletcher, S. D., & Promislow, D. (2017) · Essays in Biochemistry · doi:10.1042/ebc20160083 · Cited by 90
Cell cycle-targeting microRNAs promote differentiation by enforcing cell-cycle exit
Otto, T., Candido, S. V., Pilarz, M. S., Sicińska, E., Bronson, R. T., Bowden, M., Stukan, I., Mulry, K. A., Fassl, A., Han, R. C., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1702914114 · Cited by 93
Regulation of B‐cell development and function by micro RNA s
de Yébenes, V. G., Bartolomé‐Izquierdo, N., & Ramiro, A. R. (2013) · Immunological Reviews · doi:10.1111/imr.12046 · Cited by 94
miRNA Profiling Discriminates Types of Rejection and Injury in Human Renal Allografts
Wilflingseder, J., Regele, H. M., Perco, P., Kainz, A., Soleiman, A., Mühlbacher, F., Mayer, B., & Oberbauer, R. W. (2013) · Transplantation · doi:10.1097/tp.0b013e318280b385 · Cited by 90
Integrative analysis of gene and miRNA expression profiles with transcription factor–miRNA feed-forward loops identifies regulators in human cancers
Yan, Z., Shah, P. K., Amin, S. B., Samur, M., Huang, N., Wang, X., Misra, V., Ji, H., Gabuzda, D. H., & Cheng, L. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks395 · Cited by 91
Discovery of new microRNAs by small RNAome deep sequencing in childhood acute lymphoblastic leukemia
Schotte, D., Moqadam, F. A., Lange-Turenhout, E. A. M., Chen, C., van IJcken, W. F. J., Pieters, R., & den Boer, M. L. (2011) · Leukemia · doi:10.1038/leu.2011.105 · Cited by 89
MicroRNA-558 regulates the expression of cyclooxygenase-2 and IL-1β-induced catabolic effects in human articular chondrocytes
Park, S. J., Cheon, E. J., & Kim, H. A. (2013) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2013.04.012 · Cited by 89
Global analysis of the ovarian microRNA transcriptome: implication for miR-2 and miR-133 regulation of oocyte meiosis in the Chinese mitten crab, Eriocheir sinensis (Crustacea:Decapoda)
Song, Y., Shi, L., Liu, Z., & Qiu, G. (2014) · BMC Genomics · doi:10.1186/1471-2164-15-547 · Cited by 89
Modulation of the Unfolded Protein Response Is the Core of MicroRNA-122-Involved Sensitivity to Chemotherapy in Hepatocellular Carcinoma
Yang, F., Zhang, L., Wang, F., Wang, Y., Huo, X., Yin, Y., Wang, Y., Zhang, L., & Sun, S. (2011) · Neoplasia · doi:10.1593/neo.11422 · Cited by 89
Emerging roles of miR-210 and other non-coding RNAs in the hypoxic response
Huang, X., & Zuo, J. (2014) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmt141 · Cited by 91
MicroRNAs as Post-Transcriptional Machines and their Interplay with Cellular Networks
Janga, S. C., & Vallabhaneni, S. (2011) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-0332-6_4 · Cited by 91
Effects of oral butyrate and inulin supplementation on inflammation-induced pyroptosis pathway in type 2 diabetes: A randomized, double-blind, placebo-controlled trial
Roshanravan, N., Alamdari, N. M., Jafarabadi, M. A., Mohammadi, A., Shabestari, B. R., Nasirzadeh, N., Asghari, S., Mansoori, B., Akbarzadeh, M., Ghavami, A., et al. (2020) · Cytokine · doi:10.1016/j.cyto.2020.155101 · Cited by 89
MicroRNAs miR-144/144* and miR-16 in peripheral blood are potential biomarkers for naturalistic stress in healthy Japanese medical students
Katsuura, S., Kuwano, Y., Yamagishi, N., Kurokawa, K., Kajita, K., Akaike, Y., Nishida, K., Masuda, K., Tanahashi, T., & Rokutan, K. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2012.03.062 · Cited by 89
microRNAs in skeletal muscle differentiation and disease
Goljanek‐Whysall, K., Sweetman, D., & Münsterberg, A. (2012) · Clinical Science · doi:10.1042/cs20110634 · Cited by 89
A genome-wide transgenic resource for conditional expression ofDrosophilamicroRNAs
Bejarano, F., Bortolamiol-Bécet, D., Dai, Q., Sun, K., Saj, A., Chou, Y., Raleigh, D. R., Kim, K., Ni, J., Duan, H., et al. (2012) · Development · doi:10.1242/dev.079939 · Cited by 89
Coordinated effects of microRNA-494 induce G₂/M arrest in human cholangiocarcinoma
Yamanaka, S., Campbell, N. R., An, F., Kuo, S. C., Potter, J. J., Mezey, E., Maitra, A., & Selaru, F. M. (2012) · Cell Cycle · doi:10.4161/cc.21105 · Cited by 88
Global identification of miR‐373‐regulated genes in breast cancer by quantitative proteomics
Yan, G., Xu, S., Tan, Z., Liu, L., & He, Q. (2011) · PROTEOMICS · doi:10.1002/pmic.201000539 · Cited by 89
Infection of Epstein–Barr virus in a gastric carcinoma cell line induces anchorage independence and global changes in gene expression
Marquitz, A. R., Mathur, A., Shair, K. H. Y., & Raab‐Traub, N. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1202910109 · Cited by 88
miRSel: Automated extraction of associations between microRNAs and genes from the biomedical literature
Naeem, H., Küffner, R., Csaba, G., & Zimmer, R. (2010) · BMC Bioinformatics · doi:10.1186/1471-2105-11-135 · Cited by 88
Epigenetic-induced repression of microRNA-205 is associated with MED1 activation and a poorer prognosis in localized prostate cancer
Hulf, T., Sibbritt, T., Wiklund, E. D., Patterson, K., Song, J. Z., Stirzaker, C., Qu, W., Nair, S. S., Horvath, L. G., Armstrong, N. J., et al. (2012) · Oncogene · doi:10.1038/onc.2012.300 · Cited by 88
The role of microRNAs in chronic respiratory disease: recent insights
Stolzenburg, L. R., & Harris, A. (2017) · Biological Chemistry · doi:10.1515/hsz-2017-0249 · Cited by 91
Dysregulated genes and miRNAs in the apoptosis pathway in colorectal cancer patients
Slattery, M. L., Mullany, L. E., Sakoda, L. C., Wolff, R. K., Samowitz, W. S., & Herrick, J. S. (2018) · APOPTOSIS · doi:10.1007/s10495-018-1451-1 · Cited by 88
MicroRNA-Deficient Schwann Cells Display Congenital Hypomyelination
Yun, B., Anderegg, A., Menichella, D. M., Wrabetz, L. G., Feltri, M. L., & Awatramani, R. B. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.0876-10.2010 · Cited by 89
miR-200c is aberrantly expressed in leiomyomas in an ethnic-dependent manner and targets ZEBs, VEGFA, TIMP2, and FBLN5
Chuang, T., Panda, H., Luo, X., & Chegini, N. (2012) · Endocrine Related Cancer · doi:10.1530/erc-12-0007 · Cited by 89
Regulated post-transcriptional RNA cleavage diversifies the eukaryotic transcriptomePreprint
Mercer, T. R., Dinger, M. E., Bracken, C. P., Kolle, G., Szubert, J. M., Korbie, D. J., Askarian-Amiri, M., Gardiner, B., Goodall, G. J., Grimmond, S. M., et al. (2010) · Genome Research · doi:10.1101/gr.112128.110 · Cited by 92
Towards computational prediction of microRNA function and activity
Ulitsky, I., Laurent, L. C., & Ron Shamir, A. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq570 · Cited by 87
Advances in the molecular mechanisms of NLRP3 inflammasome activators and inactivators
Liu, D., Zeng, X., Li, X., Cui, C., Hou, R., Guo, Z., Mehta, J. L., & Wang, X. (2020) · Biochemical Pharmacology · doi:10.1016/j.bcp.2020.113863 · Cited by 88
The regulatory impact of RNA-binding proteins on microRNA targeting
Kim, S., Kim, S., Chang, H. R., Kim, D., Park, J., Son, N., Park, J., Yoon, M., Chae, G., Kim, Y., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-25078-5 · Cited by 87
Self-citation
Hepatocyte-derived exosomes from early onset obese mice promote insulin sensitivity through miR-3075
Ji, Y., Luo, Z., Gao, H., Reis, F. C. G., Bandyopadhyay, G. K., Jin, Z., Manda, K. A., Isaac, R., Yang, M., Fu, W., et al. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00444-1 · Cited by 91
3’UTR Diversity: Expanding Repertoire of RNA Alterations in Human mRNAs
Hong, D., & Jeong-Yu, S. (2023) · Molecules and Cells · doi:10.14348/molcells.2023.0003 · Cited by 96
Circulating miRNA as novel markers for diastolic dysfunction
Nair, N., Kumar, S., Góngora, E., & Gupta, S. (2012) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-012-1546-x · Cited by 87
Use of target protector morpholinos to analyze the physiological roles of specific miRNA-mRNA pairs in vivo
Staton, A. A., & Giráldez, A. J. (2011) · Nature Protocols · doi:10.1038/nprot.2011.423 · Cited by 90
Systematic Proteome Analysis Identifies Transcription Factor YY1 as a Direct Target of miR-34a
Chen, Q., Yu, L., Tsang, P., Wei, J. S., Song, Y., Cheuk, A., Chung, J., Hewitt, S. M., Veenstra, T. D., & Khan, J. I. (2010) · Journal of Proteome Research · doi:10.1021/pr1006697 · Cited by 89
The Drosophila miR-310 Cluster Negatively Regulates Synaptic Strength at the Neuromuscular Junction
Tsurudome, K., Tsang, K., Liao, E. H., Ball, R., Penney, J., Yang, J.-S., Elazzouzi, F., He, T., Chishti, A., Lnenicka, G., et al. (2010) · Neuron · doi:10.1016/j.neuron.2010.11.016 · Cited by 75
MicroRNAs, Aging, Cellular Senescence, and Alzheimer's Disease
Reddy, P. H., Williams, J. M., Smith, F., Bhatti, J. S., Kumar, S., Vijayan, M., Kandimalla, R. J. L., Kuruva, C. S., Wang, R., Mańczak, M., et al. (2017) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2016.12.009 · Cited by 89
KSHV microRNAs: Tricks of the Devil
Qin, J., Li, W., Gao, S., & Lu, C. (2017) · Trends in Microbiology · doi:10.1016/j.tim.2017.02.002 · Cited by 87
miRNAs in pancreatic cancer: Therapeutic potential, delivery challenges and strategies
Chitkara, D., Mittal, A., & Mahato, R. I. (2014) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2014.09.006 · Cited by 86
MicroRNAs and autoimmunity
Ceribelli, A., Satoh, M., & Chan, E. K. L. (2012) · Current Opinion in Immunology · doi:10.1016/j.coi.2012.07.011 · Cited by 88
MicroRNAs and their roles in developmental canalization
Posadas, D. M., & Carthew, R. W. (2014) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2014.03.005 · Cited by 96
MicroRNA pathways in neural development and plasticity
Vo, N., Cambronne, X. A., & Goodman, R. H. (2010) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2010.04.002 · Cited by 92
The microRNA body map: dissecting microRNA function through integrative genomics
Mestdagh, P., Lefever, S., Pattyn, F., Ridzon, D., Fredlund, E., Fieuw, A., Ongenaert, M., Vermeulen, J., Paepe, A. D., Wong, L., et al. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr646 · Cited by 87
Splicing of platelet resident pre-mRNAs upon activation by physiological stimuli results in functionally relevant proteome modifications
Nassa, G., Giurato, G., Cimmino, G., Rizzo, F. M., Ravo, M., Salvati, A., Nyman, T. A., Zhu, Y., Vesterlund, M., Lehtiö, J., et al. (2018) · Scientific Reports · doi:10.1038/s41598-017-18985-5 · Cited by 86
Aging Biomarkers: From Functional Tests to Multi‐Omics Approaches
Kudryashova, K. S., Burka, K., Kulaga, A. Y., Vorobyeva, N. S., & Kennedy, B. K. (2020) · PROTEOMICS · doi:10.1002/pmic.201900408 · Cited by 95
Intercellular Communication by Extracellular Vesicles and Their MicroRNAs in Asthma
Fujita, Y., Yoshioka, Y., Ito, S., Araya, J., Kuwano, K., & Ochiya, T. (2014) · Clinical Therapeutics · doi:10.1016/j.clinthera.2014.05.006 · Cited by 86
p53 activates the PANK1/ miRNA-107 gene leading to downregulation of CDK6 and p130 cell cycle proteins
Böhlig, L., Friedrich, M., & Engeland, K. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkq796 · Cited by 85
The relationship between the evolution of microRNA targets and the length of their UTRs
Cheng, C., Bhardwaj, N., & Gerstein, M. (2009) · BMC Genomics · doi:10.1186/1471-2164-10-431 · Cited by 86
miR-193a-3p regulates the multi-drug resistance of bladder cancer by targeting the LOXL4 gene and the Oxidative Stress pathway
Deng, H., Lv, L., Li, Y., Zhang, C. L., Meng, F., Pu, Y., Xiao, J., Qian, L., Zhao, W., Liu, Q., et al. (2014) · Molecular Cancer · doi:10.1186/1476-4598-13-234 · Cited by 85
Species-specific microRNA roles elucidated following astrocyte activation
Mor, E., Cabilly, Y., Goldshmit, Y., Zalts, H., Modai, S., Edry, L., Elroy‐Stein, O., & Shomron, N. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkq1325 · Cited by 85
miR-339-3p Is a Tumor Suppressor in Melanoma
Weber, C. E. M., Luo, C., Hotz‐Wagenblatt, A., Gardyan, A., Kordaß, T., Holland‐Letz, T., Osen, W., & Eichmüller, S. B. (2016) · Cancer Research · doi:10.1158/0008-5472.can-15-2932 · Cited by 85
MiR-760 suppresses human colorectal cancer growth by targeting BATF3/AP-1/cyclinD1 signaling
Cao, L., Liu, Y., Wang, D., Huang, L. J., Li, F., Liu, J., Zhang, C., Shen, Z., Gao, Q., Yuan, W., et al. (2018) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-018-0757-8 · Cited by 85
Dynamic miRNA–mRNA paradigms: New faces of miRNAs
Ni, W.-J., & Leng, X.-M. (2015) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2015.10.011 · Cited by 85
MicroRNA-1285 inhibits the expression of p53 by directly targeting its 3′ untranslated region
Tian, S., Huang, S., Wu, S., Guo, W., Li, J., & He, X. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.04.112 · Cited by 86
Activity-Based Profiling Reveals Reactivity of the Murine Thymoproteasome-Specific Subunit β5t
Florea, B. I., Verdoes, M., Li, N., van der Linden, W. A., Geurink, P. P., van den Elst, H., Hofmann, T., de Ru, A., van Veelen, P. A., Tanaka, K., et al. (2010) · Chemistry & Biology · doi:10.1016/j.chembiol.2010.05.027 · Cited by 89
Exploring complex miRNA-mRNA interactions with Bayesian networks by splitting-averaging strategy
Liu, B., Li, J., Tsykin, A., Liu, L., Gaur, A. B., & Goodall, G. J. (2009) · BMC Bioinformatics · doi:10.1186/1471-2105-10-408 · Cited by 84
Germ Cell-Specific Targeting of DICER or DGCR8 Reveals a Novel Role for Endo-siRNAs in the Progression of Mammalian Spermatogenesis and Male Fertility
Zimmermann, C., Romero, Y., Warnefors, M., Bilican, A., Borel, C., Smith, L. B., Kotaja, N., Kaessmann, H., & Nef, S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0107023 · Cited by 88
Genetic regulation of human adipose microRNA expression and its consequences for metabolic traits
Civelek, M., Hagopian, R., Pan, C., Che, N., Yang, W.-P., Kayne, P. S., Saleem, N. K., Cederberg, H., Kuusisto, J., Gargalovic, P. S., et al. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt159 · Cited by 89
CircRNA Is a Rising Star in Researches of Ocular Diseases
Zhang, C., Hu, J., & Yu, Y. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00850 · Cited by 84
Molecular Biomarkers and Their Implications for the Early Diagnosis of Selected Neurodegenerative Diseases
Doroszkiewicz, J., Groblewska, M., & Mroczko, B. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094610 · Cited by 88
Quantitative Prediction of miRNA-mRNA Interaction Based on Equilibrium Concentrations
Ragan, C., Zuker, M., & Ragan, M. A. (2011) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1001090 · Cited by 84
Profiling and Identification of Small rDNA-Derived RNAs and Their Potential Biological Functions
Wei, H., Zhou, B. Z., Zhang, F., Tu, Y., Hu, Y., Zhang, B., & Zhai, Q. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056842 · Cited by 87
Expression of miRNAs in ovine fetal gonads: potential role in gonadal differentiation
Torley, K. J., da Silveira, J. C., Smith, P. R., Anthony, R. V., Veeramachaneni, D. N. R., Winger, Q. A., & Bouma, G. J. (2011) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-9-2 · Cited by 85

Authors: Baek, D., Villén, J., Shin, C., Camargo, F. D., Gygi, S. P., & Bartel, D. P.
Affiliations: Whitehead Institute for Biomedical Research (US)
Harvard University (US)
Howard Hughes Medical Institute (US)
Corresponding author: Gygi, Steven P.
Bartel, David P.
ORCID: Villén, Judit
Shin, Chanseok
Camargo, Fernando D.
Gygi, Steven P.
Bartel, David P.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2008-07-30
Volume: 455
Issue: 7209
Pages: 64-71
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature07242
PMC: PMC2745094
OpenAlex: W1988163167
Cited by: 3,592
References: 50
Citations by year: 2026: 39 · 2025: 65 · 2024: 82 · 2023: 98 · 2022: 137 · 2021: 138 · 2020: 140 · 2019: 150 · 2018: 164 · 2017: 198 · 2016: 208 · 2015: 257 · 2014: 287 · 2013: 328 · 2012: 342
FWCI: 108.87
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Funders: Howard Hughes Medical Institute
Damon Runyon Cancer Research Foundation
National Human Genome Research Institute (R01HG003456)
National Institute of General Medical Sciences (R01GM067031)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
Keywords: microRNA, protein production, protein synthesis inhibition, mRNA destabilization, 3' untranslated region, miR-223, neutrophils, gene expression regulation, SILAC
MeSH terms: Animals, Gene Expression Regulation, HeLa Cells, Humans, Isotope Labeling, Male, Neutrophils, Transfection, Protein Biosynthesis, Oligonucleotide Array Sequence Analysis, MicroRNAs, Proteomics, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The impact of microRNAs on protein output

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks