Cited by 2,627Inflammasome and immune disordersinterferon and immune responsesImmune Response and Inflammation

The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

Open access

Hornung, Veit, Ablasser, Andrea, Charrel-Dennis, Marie, Bauernfeind, Franz, Horvath, Gabor, Caffrey, Daniel. R., Latz, Eicke, Fitzgerald, Katherine A.·2009·Nature

DOI 10.1038/nature07725PMC PMC2726264

Open this paper in CoChat — free account

Abstract

The innate immune system senses nucleic acids by germline-encoded pattern recognition receptors. RNA is sensed by Toll-like receptor members TLR3, TLR7 and TLR8, or by the RNA helicases RIG-I (also known as DDX58) and MDA-5 (IFIH1). Little is known about sensors for cytoplasmic DNA that trigger antiviral and/or inflammatory responses. The best characterized of these responses involves activation of the TANK-binding kinase (TBK1)-interferon regulatory factor 3 (IRF3) signalling axis to trigger transcriptional induction of type I interferon genes. A second, less well-defined pathway leads to the activation of an 'inflammasome' that, via caspase-1, controls the catalytic cleavage of the pro-forms of the cytokines IL1beta and IL18 (refs 6, 7). Using mouse and human cells, here we identify the PYHIN (pyrin and HIN domain-containing protein) family member absent in melanoma 2 (AIM2) as a receptor for cytosolic DNA, which regulates caspase-1. The HIN200 domain of AIM2 binds to DNA, whereas the pyrin domain (but not that of the other PYHIN family members) associates with the adaptor molecule ASC (apoptosis-associated speck-like protein containing a caspase activation and recruitment domain) to activate both NF-kappaB and caspase-1. Knockdown of Aim2 abrogates caspase-1 activation in response to cytoplasmic double-stranded DNA and the double-stranded DNA vaccinia virus. Collectively, these observations identify AIM2 as a new receptor for cytoplasmic DNA, which forms an inflammasome with the ligand and ASC to activate caspase-1.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/nature07725

Cites

30 of 30 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

MUSCLE: multiple sequence alignment with high accuracy and high throughput
Edgar, R. C. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh340 · Cited by 44,662
Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization
Hornung, V., Bauernfeind, F., Halle, A., Samstad, E. O., Kono, H., Rock, K. L., Fitzgerald, K. A., & Latz, E. (2008) · Nature Immunology · doi:10.1038/ni.1631 · Cited by 3,065
Self-citation
DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response
Takaoka, A., Wang, Z., Choi, M. K., Yanai, H., Negishi, H., Ban, T., Lu, Y., Miyagishi, M., Kodama, T., Honda, K., et al. (2007) · Nature · doi:10.1038/nature06013 · Cited by 1,704
Intracellular pattern recognition receptors in the host response
Meylan, E., Tschopp, J., & Karin, M. (2006) · Nature · doi:10.1038/nature04946 · Cited by 1,196
Recognition of Cytosolic DNA Activates an IRF3-Dependent Innate Immune Response
Stetson, D. B., & Medzhitov, R. M. (2006) · Immunity · doi:10.1016/j.immuni.2005.12.003 · Cited by 1,003
The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response
Muruve, D. A., Pétrilli, V., Zaiss, A. K., White, L. R., Clark, S. A., Ross, P. J., Parks, R. J., & Tschopp, J. (2008) · Nature · doi:10.1038/nature06664 · Cited by 965
A Toll-like receptor–independent antiviral response induced by double-stranded B-form DNA
Ishii, K. J., Coban, C., Kato, H., Takahashi, K., Torii, Y., Takeshita, F., Ludwig, H., Sutter, G., Suzuki, K., Hemmi, H., et al. (2005) · Nature Immunology · doi:10.1038/ni1282 · Cited by 771
Enzymatic Synthesis of Deoxyribonucleic Acid
Richardson, C. C., Schildkraut, C. L., Aposhian, H. V., & Kornberg, A. (1964) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)51772-5 · Cited by 718
Critical Role for Cryopyrin/Nalp3 in Activation of Caspase-1 in Response to Viral Infection and Double-stranded RNA
Kanneganti, T., Body–Malapel, M., Amer, A. O., Park, J., Whitfield, J. R., Franchi, L., Taraporewala, Z. F., Miller, D. J., Patton, J. T., Inohara, N., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m607594200 · Cited by 706
TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines
Ishii, K. J., Kawagoe, T., Koyama, S., Matsui, K., Kumar, H., Kawai, T., Uematsu, S., Takeuchi, O., Takeshita, F., Coban, C., et al. (2008) · Nature · doi:10.1038/nature06537 · Cited by 633

Flagged first, then by citations

Show all 30 references

Sorted by citations

Items 301–400 of 1,004

Therapeutic modulation of inflammasome pathways
Chauhan, D., Walle, L. V., & Lamkanfi, M. (2020) · Immunological Reviews · doi:10.1111/imr.12908 · Cited by 219
Recognition of nucleic acids by pattern‐recognition receptors and its relevance in autoimmunity
Kawasaki, T., Kawai, T., & Akira, S. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2011.01048.x · Cited by 226
Innate immune recognition of DNA: A recent history
Dempsey, A., & Bowie, A. (2015) · Virology · doi:10.1016/j.virol.2015.03.013 · Cited by 229
Sensing disease and danger: A survey of vertebrate PRRs and their origins
Hansen, J. D., Vojtech, L. N., & Laing, K. J. (2011) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2011.01.008 · Cited by 220
Mechanistic insights from inflammasome structures
Fu, J., Schroder, K., & Wu, H. (2024) · Nature reviews. Immunology · doi:10.1038/s41577-024-00995-w · Cited by 223
TRIM56-mediated monoubiquitination of cGAS for cytosolic DNA sensing
Seo, G. J., Kim, C., Shin, W.-J., Sklan, E. H., Eoh, H., & Jung, J. U. (2018) · Nature Communications · doi:10.1038/s41467-018-02936-3 · Cited by 214
A Virological View of Innate Immune Recognition
Iwasaki, A. (2012) · Annual Review of Microbiology · doi:10.1146/annurev-micro-092611-150203 · Cited by 230
The NLR family of innate immune and cell death sensors
Sundaram, B., Tweedell, R. E., Kumar, S. P., & Kanneganti, T. (2024) · Immunity · doi:10.1016/j.immuni.2024.03.012 · Cited by 224
Overcoming innate immune barriers that impede AAV gene therapy vectors
Muhuri, M., Maeda, Y., Ma, H., Ram, S., Fitzgerald, K. A., Tai, P. W. L., & Gao, G. (2021) · Journal of Clinical Investigation · doi:10.1172/jci143780 · Cited by 212
Self-citation
Innate Immunity to Adenovirus
Hendrickx, R., Stichling, N., Koelen, J. A., Kuryk, Ł., Lipiec, A., & Greber, U. F. (2014) · Human Gene Therapy · doi:10.1089/hum.2014.001 · Cited by 221
DNA Sensing in the Innate Immune Response
Briard, B., Place, D. E., & Kanneganti, T. (2020) · Physiology · doi:10.1152/physiol.00022.2019 · Cited by 222
Akt Kinase-Mediated Checkpoint of cGAS DNA Sensing Pathway
Seo, G. J., Yang, A., Tan, B., Kim, S., Liang, Q., Choi, Y., Yuan, W., Feng, P., Park, H.-S., & Jung, J. U. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.09.007 · Cited by 210
Identification and functions of pattern-recognition receptors
Kumagai, Y., & Akira, S. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.01.058 · Cited by 218
NLRP3 inflammasome activation by mitochondrial ROS in bronchial epithelial cells is required for allergic inflammation
Kim, S. R., Kim, D. I., Kim, S. H., Lee, H. J., Lee, K. S., Cho, S., & Lee, Y. C. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.460 · Cited by 209
Cytosolic DNA sensors regulating type I interferon induction
Keating, S. E., Baran, M., & Bowie, A. (2011) · Trends in Immunology · doi:10.1016/j.it.2011.08.004 · Cited by 212
NLRP3 Inflammasome Activation Induced by Engineered Nanomaterials
Sun, B., Wang, X., Ji, Z., Li, R., & Xia, T. (2012) · Small · doi:10.1002/smll.201201962 · Cited by 213
New Insights into Mechanisms Controlling the NLRP3 Inflammasome and Its Role in Lung Disease
Nardo, D. D., Nardo, C. M. D., & Latz, E. (2013) · American Journal Of Pathology · doi:10.1016/j.ajpath.2013.09.007 · Cited by 206
Self-citation
Chitosan but Not Chitin Activates the Inflammasome by a Mechanism Dependent upon Phagocytosis
Bueter, C. L., Lee, C. K., Rathinam, V. A. K., Healy, G. J., Taron, C. H., Specht, C. A., & Levitz, S. M. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.274936 · Cited by 205
Advances in the understanding of familial Mediterranean fever and possibilities for targeted therapy
Chae, J. J., Aksentijevich, I. A., & Kastner, D. L. (2009) · British Journal of Haematology · doi:10.1111/j.1365-2141.2009.07733.x · Cited by 205
Molecular evolutionary and structural analysis of the cytosolic DNA sensor cGAS and STING
Wu, X., Wu, F.-H., Wang, X., Wang, L., Siedow, J. N., Zhang, W., & Pei, Z. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku569 · Cited by 214
The DHX33 RNA Helicase Senses Cytosolic RNA and Activates the NLRP3 Inflammasome
Mitoma, H., Hanabuchi, S., Kim, T. I., Bao, M., Zhang, Z., Sugimoto, N., & Liu, Y. (2013) · Immunity · doi:10.1016/j.immuni.2013.07.001 · Cited by 204
Constitutive Interferon-Inducible Protein 16-Inflammasome Activation during Epstein-Barr Virus Latency I, II, and III in B and Epithelial Cells
Ansari, M. A., Singh, V. V., Dutta, S., Veettil, M. V., Dutta, D., Leela, C., Lu, J. L., Everly, D. N., & Chandran, B. (2013) · Journal of Virology · doi:10.1128/jvi.00805-13 · Cited by 213
NOD-like receptors and the innate immune system: Coping with danger, damage and death
Kersse, K., Bertrand, M. J. M., Lamkanfi, M., & Vandenabeele, P. (2011) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2011.09.003 · Cited by 214
Critical role of AIM2 in Mycobacterium tuberculosis infection
Saiga, H., Kitada, S., Shimada, Y., Kamiyama, N., Okuyama, M., Makino, M., Yamamoto, M., & Takeda, K. (2012) · International Immunology · doi:10.1093/intimm/dxs062 · Cited by 202
Post-translational regulation of inflammasomes
Yang, J., Liu, Z., & Xiao, T. S. (2016) · Cellular and Molecular Immunology · doi:10.1038/cmi.2016.29 · Cited by 211
The mammalian PYHIN gene family: Phylogeny, evolution and expression
Cridland, J. A., Curley, E. Z., Wykes, M., Schroder, K., Sweet, M. J., Roberts, T. L., Ragan, M. A., Kassahn, K. S., & Stacey, K. J. (2012) · BMC Evolutionary Biology · doi:10.1186/1471-2148-12-140 · Cited by 200
Hepatitis B Virus Polymerase Disrupts K63-Linked Ubiquitination of STING To Block Innate Cytosolic DNA-Sensing Pathways
Liu, Y., Li, J., Chen, J., Li, Y., Wang, W., Du, X., Song, W., Zhang, W., Lin, L., & Yuan, Z. (2014) · Journal of Virology · doi:10.1128/jvi.02760-14 · Cited by 207
Titanium ions form particles that activate and execute interleukin‐1β release from lipopolysaccharide‐primed macrophages
Pettersson, M., Kelk, P., Belibasakis, G. N., Bylund, D., Thorén, M. M., & Johansson, A. S. (2016) · Journal of Periodontal Research · doi:10.1111/jre.12364 · Cited by 200
Dual Engagement of the NLRP3 and AIM2 Inflammasomes by Plasmodium-Derived Hemozoin and DNA during Malaria
Kalantari, P., DeOliveira, R. B., Chan, J., Corbett, Y., Rathinam, V. A. K., Stutz, A., Latz, E., Gazzinelli, R. T., Golenbock, D. T., & Fitzgerald, K. A. (2014) · Cell Reports · doi:10.1016/j.celrep.2013.12.014 · Cited by 198
Self-citation
TRIM30α Is a Negative-Feedback Regulator of the Intracellular DNA and DNA Virus-Triggered Response by Targeting STING
Wang, Y., Lian, Q., Yang, B., Yan, S., Zhou, H., He, L., Lin, G., Lian, Z., Jiang, Z., & Sun, B. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1005012 · Cited by 197
Cryo-EM Structure of Caspase-8 Tandem DED Filament Reveals Assembly and Regulation Mechanisms of the Death-Inducing Signaling Complex
Fu, T.-M., Li, Y., Lu, A., Li, Z., Vajjhala, P. R., Cruz, A. C., Srivastava, D. B., DiMaio, F., Penczek, P. A., Siegel, R. M., et al. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.09.009 · Cited by 196
Cyclic di-AMP Is Critical for Listeria monocytogenes Growth, Cell Wall Homeostasis, and Establishment of Infection
Witte, C. E., Whiteley, A. T., Burke, T., Sauer, J., Portnoy, D. A., & Woodward, J. J. (2013) · mBio · doi:10.1128/mbio.00282-13 · Cited by 201
Mitophagy: a balance regulator of NLRP3 inflammasome activation
Kim, M., Yoon, J., & Ryu, J.-H. (2016) · BMB Reports · doi:10.5483/bmbrep.2016.49.10.115 · Cited by 202
Inhibition of AIM2 inflammasome-mediated pyroptosis by Andrographolide contributes to amelioration of radiation-induced lung inflammation and fibrosis
Gao, J., Peng, S., Shan, X., Deng, G., Shen, L., Sun, J., Jiang, C., Yang, X., Chang, Z., Sun, X., et al. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-2195-8 · Cited by 195
The mononuclear phagocyte system of the pig as a model for understanding human innate immunity and disease
Fairbairn, L., Kapétanovic, R., Sester, D. P., & Hume, D. A. (2011) · Journal of Leukocyte Biology · doi:10.1189/jlb.1110607 · Cited by 204
Disruption of glycolytic flux is a signal for inflammasome signaling and pyroptotic cell death
Sanman, L. E., Yu, Q., Eisele, N. A., Ng, T. M., van der Linden, W. A., Monack, D. M., Weerapana, E., & Bogyo, M. S. (2016) · eLife · doi:10.7554/elife.13663 · Cited by 198
Inflammation links excess fat to insulin resistance: the role of the interleukin‐1 family
Tack, C. J., Stienstra, R., Joosten, L. A. B., & Netea, M. G. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2012.01145.x · Cited by 199
Inflammasome, Inflammation, and Tissue Homeostasis
Rathinam, V. A. K., & Chan, F. K.-M. (2018) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2018.01.004 · Cited by 199
The innate and adaptive immune system of fish
Secombes, C. J., & Wang, T. (2012) · Elsevier eBooks · doi:10.1533/9780857095732.1.3 · Cited by 199
Of inflammasomes and pathogens – sensing of microbes by the inflammasome
Bauernfeind, F. G., & Hornung, V. (2013) · EMBO Molecular Medicine · doi:10.1002/emmm.201201771 · Cited by 198
Self-citation
Cellular Innate Immunity: An Old Game with New Players
Gasteiger, G., D’Osualdo, A., Schubert, D. A., Weber, A. N. R., Bruscia, E. M., & Hartl, D. (2016) · Journal of Innate Immunity · doi:10.1159/000453397 · Cited by 210
Chemotherapy-induced intestinal inflammatory responses are mediated by exosome secretion of double-strand DNA via AIM2 inflammasome activation
Lian, Q., Xu, J., Yan, S., Huang, M., Ding, H., Sun, X., Bi, A., Ding, J., Sun, B., & Geng, M. (2017) · Cell Research · doi:10.1038/cr.2017.54 · Cited by 191
The Recombinant Bacille Calmette–Guérin Vaccine VPM1002: Ready for Clinical Efficacy Testing
Nieuwenhuizen, N. E., Kulkarni, P. S., Shaligram, U. S., Cotton, M. F., Rentsch, C. A., Eisele, B., Grode, L., & Kaufmann, S. H. E. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01147 · Cited by 199
Response of host inflammasomes to viral infection
Chen, I.-Y., & Ichinohe, T. (2014) · Trends in Microbiology · doi:10.1016/j.tim.2014.09.007 · Cited by 198
Molecular mechanisms of inflammasome signaling
Mathur, A., Hayward, J. A., & Man, S. M. (2017) · Journal of Leukocyte Biology · doi:10.1189/jlb.3mr0617-250r · Cited by 192
Macrophage migration inhibitory factor is required for NLRP3 inflammasome activation
Lang, T., Lee, J. P. W., Elgass, K., Pinar, A. A., Tate, M. D., Aitken, E. H., Fan, H., Creed, S. J., Deen, N. S., Traoré, D. A. K., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-04581-2 · Cited by 199
Integrated NLRP3, AIM2, NLRC4, Pyrin inflammasome activation and assembly drive PANoptosis
Oh, S., Lee, J., Oh, J.-E., Yu, G., Ryu, H., Kim, D., & Lee, S. (2023) · Cellular and Molecular Immunology · doi:10.1038/s41423-023-01107-9 · Cited by 192
Antiviral immune responses in the genital tract: clues for vaccines
Iwasaki, A. (2010) · Nature reviews. Immunology · doi:10.1038/nri2836 · Cited by 195
Shiga Toxin/Lipopolysaccharide Activates Caspase-4 and Gasdermin D to Trigger Mitochondrial Reactive Oxygen Species Upstream of the NLRP3 Inflammasome
Platnich, J. M., Chung, H., Lau, A. N., Sandall, C. F., Bondzi‐Simpson, A., Chen, H., Komada, T., Trotman-Grant, A. C., Brandelli, J. R., Chun, J., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.09.071 · Cited by 193
Listeria monocytogenes -Infected Human Peripheral Blood Mononuclear Cells Produce IL-1β, Depending on Listeriolysin O and NLRP3
Meixenberger, K., Pache, F. C., Eitel, J., Schmeck, B., Hippenstiel, S., Slevogt, H., N’Guessan, P. D., Witzenrath, M., Netea, M. G., Chakraborty, T., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901346 · Cited by 186
Intracellular Nucleic Acid Sensing Triggers Necroptosis through Synergistic Type I IFN and TNF Signaling
Brault, M., Olsen, T. M., Martinez, J., Stetson, D. B., & Oberst, A. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1701492 · Cited by 195
USP7 and USP47 deubiquitinases regulate NLRP3 inflammasome activation
Palazón‐Riquelme, P., Worboys, J. D., Green, J., Valera, A., Martín‐Sánchez, F., Pellegrini, C., Brough, D., & López‐Castejón, G. (2018) · EMBO Reports · doi:10.15252/embr.201744766 · Cited by 194
A Novel Role for the NLRC4 Inflammasome in Mucosal Defenses against the Fungal Pathogen Candida albicans
Tomalka, J. A., Ganesan, S., Azodi, E., Patel, K., Majmudar, P. R., Hall, B. A., Fitzgerald, K. A., & Hise, A. G. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1002379 · Cited by 188
Self-citation
DHX9 Pairs with IPS-1 To Sense Double-Stranded RNA in Myeloid Dendritic Cells
Zhang, Z., Yuan, B., Lu, N., Facchinetti, V., & Liu, Y. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1101307 · Cited by 184
cGAS and Ifi204 Cooperate To Produce Type I IFNs in Response to Francisella Infection
Storek, K. M., Talmor, N., Ohlson, M. B., & Monack, D. M. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1402764 · Cited by 188
Immune Sensing Mechanisms that Discriminate Self from Altered Self and Foreign Nucleic Acids
Bartok, E., & Hartmann, G. (2020) · Immunity · doi:10.1016/j.immuni.2020.06.014 · Cited by 190
Pharmacological modulation of nucleic acid sensors - therapeutic potential and persisting obstacles
Vanpouille-Box, C., Hoffmann, J. A., & Galluzzi, L. (2019) · Nature Reviews Drug Discovery · doi:10.1038/s41573-019-0043-2 · Cited by 183
Sensing and Signaling in Antiviral Innate Immunity
O'Neill, L. A. J., & Bowie, A. (2010) · Current Biology · doi:10.1016/j.cub.2010.01.044 · Cited by 183
Conventional DCs reduce liver ischemia/reperfusion injury in mice via IL-10 secretion
Bamboat, Z. M., Ocuin, L. M., Balachandran, V. P., Obaid, H., Plitas, G., & DeMatteo, R. P. (2010) · Journal of Clinical Investigation · doi:10.1172/jci40008 · Cited by 188
Macrophages sense and kill bacteria through carbon monoxide–dependent inflammasome activation
Wegiel, B., Larsen, R., Gallo, D. J., Chin, B. Y., Harris, C. E., Mannam, P., Kaczmarek, E., Lee, P. J., Zuckerbraun, B. S., Flavell, R. A., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci72853 · Cited by 184
The AIM2-like Receptors Are Dispensable for the Interferon Response to Intracellular DNA
Gray, E. E., Winship, D., Snyder, J. M., Child, S. J., Geballe, A. P., & Stetson, D. B. (2016) · Immunity · doi:10.1016/j.immuni.2016.06.015 · Cited by 197
DNA-stimulated cell death: implications for host defence, inflammatory diseases and cancer
Paludan, S. R., Reinert, L. S., & Hornung, V. (2019) · Nature reviews. Immunology · doi:10.1038/s41577-018-0117-0 · Cited by 187
Self-citation
Promising Targets for Cancer Immunotherapy: TLRs, RLRs, and STING-Mediated Innate Immune Pathways
Li, K., Qu, S., Chen, X., Wu, Q., & Shi, M. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18020404 · Cited by 186
Adenovirus Membrane Penetration Activates the NLRP3 Inflammasome
Barlan, A., Griffin, T., McGuire, K. A., & Wiethoff, C. M. (2010) · Journal of Virology · doi:10.1128/jvi.01265-10 · Cited by 181
Innate and adaptive immune responses to viral infection and vaccination
Aoshi, T., Koyama, S., Kobiyama, K., Akira, S., & Ishii, K. J. (2011) · Current Opinion in Virology · doi:10.1016/j.coviro.2011.07.002 · Cited by 179
Caspase-11 Activation in Response to Bacterial Secretion Systems that Access the Host Cytosol
Casson, C. N., Copenhaver, A. M., Zwack, E. E., Nguyen, H. T., Strowig, T., Javdan, B., Bradley, W. P., Fung, T. C., Flavell, R. A., Brodsky, I. E., et al. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003400 · Cited by 181
Herpes Simplex Virus 1 Tegument Protein US11 Downmodulates the RLR Signaling Pathway via Direct Interaction with RIG-I and MDA-5
Xing, J., Wang, S., Lin, R., Mossman, K. L., & Zheng, C. (2012) · Journal of Virology · doi:10.1128/jvi.06713-11 · Cited by 178
Activation of host pattern recognition receptors by viruses
Brennan, K., & Bowie, A. (2010) · Current Opinion in Microbiology · doi:10.1016/j.mib.2010.05.007 · Cited by 176
USP3 inhibits type I interferon signaling by deubiquitinating RIG-I-like receptors
Cui, J., Song, Y., Li, Y., Zhu, Q., Tan, P., Qin, Y., Wang, H. Y., & Wang, R. (2013) · Cell Research · doi:10.1038/cr.2013.170 · Cited by 179
How is inflammation initiated? Individual influences of IL-1, IL-18 and HMGB1
Keyel, P. A. (2014) · Cytokine · doi:10.1016/j.cyto.2014.03.007 · Cited by 182
Structure of the Absent in Melanoma 2 (AIM2) Pyrin Domain Provides Insights into the Mechanisms of AIM2 Autoinhibition and Inflammasome Assembly
Jin, T., Perry, A., Smith, P. T., Jiang, J., & Xiao, T. S. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.468033 · Cited by 174
Pattern recognition receptors in zebrafish provide functional and evolutionary insight into innate immune signaling pathways
Li, Y., Li, Y., Cao, X., Jin, X., & Jin, T. (2016) · Cellular and Molecular Immunology · doi:10.1038/cmi.2016.50 · Cited by 177
Analysis of Drosophila STING Reveals an Evolutionarily Conserved Antimicrobial Function
Martin, M., Hiroyasu, A., Guzman, R. M., Roberts, S. A., & Goodman, A. G. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.05.029 · Cited by 173
Inflammasomes and host defenses against bacterial infections
Vladimer, G. I., Marty-Roix, R., Ghosh, S., Weng, D., & Lien, E. (2013) · Current Opinion in Microbiology · doi:10.1016/j.mib.2012.11.008 · Cited by 173
A single domain antibody fragment that recognizes the adaptor ASC defines the role of ASC domains in inflammasome assembly
Schmidt, F. I., Lu, A. Z., Chen, J. W., Ruan, J., Tang, C., Wu, H., & Ploegh, H. L. (2016) · The Journal of Experimental Medicine · doi:10.1084/jem.20151790 · Cited by 176
Mechanism and Regulation of Gasdermin-Mediated Cell DeathPreprint
Xia, S., Hollingsworth, L. R., & Wu, H. (2019) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a036400 · Cited by 177
The Inflammasome Component Nlrp3 Impairs Antitumor Vaccine by Enhancing the Accumulation of Tumor-Associated Myeloid-Derived Suppressor Cells
van Deventer, H. W., Burgents, J. E., Wu, Q. P., Woodford, R.-M. T., Brickey, W. J., Allen, I. C., McElvania-Tekippe, E., Serody, J. S., & Ting, J. P.-Y. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-1921 · Cited by 172
Pathogen Recognition and Activation of the Innate Immune Response in Zebrafish
van der Vaart, M., Spaink, H. P., & Meijer, A. H. (2012) · Advances in Hematology · doi:10.1155/2012/159807 · Cited by 184
IL-1 family cytokines trigger sterile inflammatory disease
Lukens, J. R., Gross, J. M., & Kanneganti, T. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00315 · Cited by 178
Vaccinia Virus Protein C6 Is a Virulence Factor that Binds TBK-1 Adaptor Proteins and Inhibits Activation of IRF3 and IRF7
Unterholzner, L., Sumner, R. P., Baran, M., Ren, H., Mansur, D. S., Bourke, N. M., Randow, F., Smith, G. L., & Bowie, A. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1002247 · Cited by 176
TRIM11 Suppresses AIM2 Inflammasome by Degrading AIM2 via p62-Dependent Selective Autophagy
Liu, T., Tang, Q., Liu, K., Xie, W., Liu, X., Wang, H., Wang, R., & Cui, J. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.07.019 · Cited by 176
Cellular and molecular regulation of innate inflammatory responses
Liu, J., & Cao, X. (2016) · Cellular and Molecular Immunology · doi:10.1038/cmi.2016.58 · Cited by 171
ASC/caspase-1/IL-1β signaling triggers inflammatory responses by promoting HMGB1 induction in liver ischemia/reperfusion injury
Kamo, N., Ke, B., Ghaffari, A. A., Shen, X., Busuttil, R. W., Cheng, G., & Kupiec‐Weglinski, J. W. (2013) · Hepatology · doi:10.1002/hep.26320 · Cited by 170
Structure, Activation and Regulation of NLRP3 and AIM2 Inflammasomes
Sharma, M., & de Alba, E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020872 · Cited by 173
Targeting the Inflammasome in Cardiovascular Disease
Olsen, M. B., Gregersen, I., Sandanger, Ø., Yang, K., Sokolova, M., Halvorsen, B. L., Gullestad, L. L., Broch, K., Aukrust, P., & Louwe, M. C. (2021) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2021.08.006 · Cited by 178
Inflammasomes link vascular disease with neuroinflammation and brain disorders
Lénárt, N., Brough, D., & Dénes, Á. (2016) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x16662043 · Cited by 170
Protective Role of Shiitake Mushroom-Derived Exosome-Like Nanoparticles in D-Galactosamine and Lipopolysaccharide-Induced Acute Liver Injury in Mice
Liu, B., Lu, Y., Chen, X., Muthuraj, P. G., Li, X., Pattabiraman, M., Zempleni, J., Kachman, S. D., Natarajan, S. K., & Yu, J. (2020) · Nutrients · doi:10.3390/nu12020477 · Cited by 170
Inflammasome components as new therapeutic targets in inflammatory disease
Coll, R. C., & Schroder, K. (2024) · Nature reviews. Immunology · doi:10.1038/s41577-024-01075-9 · Cited by 175
Sulforaphane inhibits multiple inflammasomes through an Nrf2-independent mechanism
Greaney, A. J., Maier, N. K., Leppla, S. H., & Moayeri, M. (2015) · Journal of Leukocyte Biology · doi:10.1189/jlb.3a0415-155rr · Cited by 167
Inflammasomes as mediators of immunity against influenza virus
Pang, I. K., & Iwasaki, A. (2010) · Trends in Immunology · doi:10.1016/j.it.2010.11.004 · Cited by 176
Inflammasomes in the lung
Pinkerton, J., Kim, R., Robertson, A. A. B., Hirota, J. A., Wood, L. G., Knight, D. A., Cooper, M. A., O'Neill, L. A. J., Horvat, J. C., & Hansbro, P. M. (2017) · Molecular Immunology · doi:10.1016/j.molimm.2017.01.014 · Cited by 170
Curli-Containing Enteric Biofilms Inside and Out: Matrix Composition, Immune Recognition, and Disease Implications
Tursi, S. A., & Tükel, Ç. (2018) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00028-18 · Cited by 171
The role of inflammasomes in vascular cognitive impairment
Poh, L., Sim, W. L., Jo, D., Dinh, Q. N., Drummond, G. R., Sobey, C. G., Chen, C., Lai, M. K. P., Fann, D. Y., & Arumugam, T. V. (2022) · Molecular Neurodegeneration · doi:10.1186/s13024-021-00506-8 · Cited by 167
Innate immune activation in neurodegenerative diseases
Castro‐Gomez, S., & Heneka, M. T. (2024) · Immunity · doi:10.1016/j.immuni.2024.03.010 · Cited by 176
Deubiquitinases Regulate the Activity of Caspase-1 and Interleukin-1β Secretion via Assembly of the Inflammasome
López‐Castejón, G., Luheshi, N., Compan, V., High, S., Whitehead, R. C., Flitsch, S. L., Kirov, A., Prudovsky, I. A., Swanton, E., & Brough, D. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.422238 · Cited by 175
A brain in flame; do inflammasomes and pyroptosis influence stroke pathology?
Barrington, J., Lemarchand, E., & Allan, S. M. (2016) · Brain Pathology · doi:10.1111/bpa.12476 · Cited by 168
The CARD plays a critical role in ASC foci formation and inflammasome signalling
Proell, M., Gerlic, M., Mace, P. D., Reed, J. C., & Riedl, S. J. (2012) · Biochemical Journal · doi:10.1042/bj20121198 · Cited by 168
Nuclear Membrane Rupture and Its Consequences
Maciejowski, J., & Hatch, E. M. (2020) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-020520-120627 · Cited by 170
Intracellular Pathogen Detection by RIG-I-Like Receptors
Dixit, E., & Kagan, J. C. (2013) · Advances in immunology · doi:10.1016/b978-0-12-410524-9.00004-9 · Cited by 172
A Mechanistic Understanding of Pyroptosis: The Fiery Death Triggered by Invasive Infection
Liu, X., & Lieberman, J. (2017) · Advances in immunology · doi:10.1016/bs.ai.2017.02.002 · Cited by 167

Authors: Hornung, V., Ablasser, A., Charrel-Dennis, M., Bauernfeind, F., Horvath, G., Caffrey, D. R., Latz, E., & Fitzgerald, K. A.
Affiliations: University of Massachusetts Chan Medical School (US)
Pfizer (United States) (US)
Corresponding author: Hornung, Veit
Fitzgerald, Katherine A.
ORCID: Hornung, Veit
Ablasser, Andrea
Horvath, Gabor
Latz, Eicke
Fitzgerald, Katherine A.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2009-01-21
Volume: 458
Issue: 7237
Pages: 514-518
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature07725
PMC: PMC2726264
OpenAlex: W2042816890
Cited by: 2,627
References: 30
Citations by year: 2026: 108 · 2025: 164 · 2024: 187 · 2023: 152 · 2022: 168 · 2021: 162 · 2020: 158 · 2019: 146 · 2018: 142 · 2017: 137 · 2016: 142 · 2015: 144 · 2014: 147 · 2013: 168 · 2012: 140
FWCI: 66.64
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
The Journal of the American Medical Association (JAMA) Network (American Medical Association) (submittedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
MPG.PuRe (Max Planck Society) (submittedVersion)
Funders: National Institute of Allergy and Infectious Diseases (AI065483, R01AI067497, R37AI067497, AI-067497, R01AI065483, R56AI067497)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: AIM2, cytosolic DNA sensing, inflammasome, caspase-1 activation, ASC, pyrin domain, double-stranded DNA, vaccinia virus, NF-κB activation, innate immunity, autoinflammation, autoimmunity, IL-1β, IL-18
MeSH terms: Animals, Cell Line, Cytoskeletal Proteins, Cytosol, DNA, DNA-Binding Proteins, Enzyme Activation, Humans, Inflammation, Nuclear Proteins, Poly dA-dT, Protein Binding, Vaccinia virus, Cell Death, Caspase 1, Apoptosis Regulatory Proteins, Mice, CARD Signaling Adaptor Proteins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks