Hornung, Veit

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

Duewell, P., Kono, H., Rayner, K. J., Sirois, C. M., Vladimer, G., Bauernfeind, F. G., Abela, G. S., Franchi, L., Nuñez, G., Schnurr, M., et al. (2010) · Nature

Inflammasome and immune disordersAtherosclerosis and Cardiovascular Diseases

Cited by 4,026

A Mammalian microRNA Expression Atlas Based on Small RNA Library Sequencing

Landgraf, P., Rusu, M., Sheridan, R., Sewer, A., Iovino, N., Aravin, A., Pfeffer, S., Rice, A., Kamphorst, A. O., Landthaler, M., et al. (2007) · Cell

MicroRNA in disease regulationPlant Molecular Biology Research

Cited by 3,626

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

Hornung, V., Bauernfeind, F., Halle, A., Samstad, E. O., Kono, H., Rock, K. L., Fitzgerald, K. A., & Latz, E. (2008) · Nature Immunology

Inflammasome and immune disordersImmune Response and Inflammation

Cited by 3,065

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

Hornung, V., Ablasser, A., Charrel-Dennis, M., Bauernfeind, F., Horvath, G., Caffrey, D. R., Latz, E., & Fitzgerald, K. A. (2009) · Nature

Inflammasome and immune disordersinterferon and immune responses

Cited by 2,627

5'-Triphosphate RNA Is the Ligand for RIG-I

Hornung, V., Ellegast, J., Kim, S., Brzózka, K., Jung, A., Kato, H., Poeck, H., Akira, S., Conzelmann, K.-K., Schlee, M., et al. (2006) · Science

interferon and immune responsesImmune Response and Inflammation

Cited by 2,474

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

Halle, A., Hornung, V., Petzold, G. C., Stewart, C. R., Monks, B. G., Reinheckel, T., Fitzgerald, K. A., Latz, E., Moore, K. J., & Golenbock, D. T. (2008) · Nature Immunology

Inflammasome and immune disordersNeuroinflammation and Neurodegeneration Mechanisms

Cited by 2,441

Molecular mechanisms and cellular functions of cGAS–STING signalling

Hopfner, K.-P., & Hornung, V. (2020) · Nature Reviews Molecular Cell Biology

interferon and immune responsesImmune Response and Inflammation

Cited by 2,052

CGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING.

Ablasser, A., Goldeck, M., Cavlar, T., Deimling, T., Witte, G., Röhl, I., Hopfner, K.-P., Ludwig, J., & Hornung, V. (2013) · Nature

interferon and immune responsesDNA and Nucleic Acid Chemistry

Cited by 1,695

The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses

Rathinam, V. A. K., Jiang, Z., Waggoner, S. N., Sharma, S., Cole, L. E., Waggoner, L., Vanaja, S. K., Monks, B. G., Ganesan, S., Latz, E., et al. (2010) · Nature Immunology

Inflammasome and immune disordersImmune Response and Inflammation

Cited by 1,331

The DNA Inflammasome in Human Myeloid Cells Is Initiated by a STING-Cell Death Program Upstream of NLRP3

Gaidt, M. M., Ebert, T. S., Chauhan, D., Ramshorn, K., Pinci, F., Zuber, S., O’Duill, F., Schmid-Burgk, J. L., Hoss, F., Buhmann, R., et al. (2017) · Cell

Inflammasome and immune disordersinterferon and immune responses

Cited by 638

Cutting Edge: Reactive Oxygen Species Inhibitors Block Priming, but Not Activation, of the NLRP3 Inflammasome

Bauernfeind, F., Bartok, E., Rieger, A., Franchi, L., Núñez, G., & Hornung, V. (2011) · The Journal of Immunology

Inflammasome and immune disordersImmune Response and Inflammation

Cited by 617

NLRP3 inflammasome activity is negatively controlled by miR-223

Bauernfeind, F., Rieger, A., Schildberg, F. A., Knolle, P. A., Schmid-Burgk, J. L., & Hornung, V. (2012) · The Journal of Immunology

Inflammasome and immune disordersImmune Response and Inflammation

Cited by 544

Recognition of Endogenous Nucleic Acids by the Innate Immune System

Roers, A., Hiller, B., & Hornung, V. (2016) · Immunity

Immune Response and Inflammationinterferon and immune responses

Cited by 541

cGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein-DNA ladders

Andreeva, L., Hiller, B., Kostrewa, D., Lässig, C., de Oliveira Mann, C. C., Jan Drexler, D., Maiser, A., Gaidt, M., Leonhardt, H., Hornung, V., et al. (2017) · Nature

interferon and immune responsesDNA and Nucleic Acid Chemistry

Cited by 511

Mycobacterium tuberculosis Differentially Activates cGAS- and Inflammasome-Dependent Intracellular Immune Responses through ESX-1

Wassermann, R., Gulen, M. F., Sala, C., Perin, S. G., Lou, Y., Rybniker, J., Schmid-Burgk, J. L., Schmidt, T., Hornung, V., Cole, S. T., et al. (2015) · Cell Host & Microbe

Tuberculosis Research and Epidemiologyinterferon and immune responses

Cited by 401

5′-triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma

Poeck, H., Besch, R., Maihoefer, C., Renn, M., Tormo, D., Morskaya, S. S., Kirschnek, S., Gaffal, E., Landsberg, J., Hellmuth, J., et al. (2008) · Nature Medicine

RNA Interference and Gene Deliveryinterferon and immune responses

Cited by 387

Human NLRP1 is a sensor for double-stranded RNA

Bauernfried, S., Scherr, M. J., Pichlmair, A., Duderstadt, K. E., & Hornung, V. (2021) · Science

Inflammasome and immune disordersinterferon and immune responses

Cited by 304

Structural basis for sequestration and autoinhibition of cGAS by chromatin

Michalski, S., de Oliveira Mann, C. C., Stafford, C. A., Witte, G., Bartho, J., Lammens, K., Hornung, V., & Hopfner, K.-P. (2020) · Nature

interferon and immune responsesDNA and Nucleic Acid Chemistry

Cited by 256

Aging-Associated TNF Production Primes Inflammasome Activation and NLRP3-Related Metabolic Disturbances

Bauernfeind, F., Niepmann, S., Knolle, P. A., & Hornung, V. (2016) · The Journal of Immunology

Inflammasome and immune disordersAdipokines, Inflammation, and Metabolic Diseases

Cited by 137

The NLRP3 inflammasome renders cell death pro-inflammatory

Gaidt, M. M., & Hornung, V. (2018) · Journal of Molecular Biology

Inflammasome and immune disordersImmune Response and Inflammation

Cited by 124

Human TLR8 senses UR/URR motifs in bacterial and mitochondrial RNA

Krüger, A., Oldenburg, M., Chebrolu, C., Beisser, D., Kolter, J., Sigmund, A. M., Steinmann, J., Schäfer, S., Hochrein, H., Rahmann, S., et al. (2015) · The EMBO Reports

Immune Response and InflammationInflammasome and immune disorders

Cited by 99

Human plasmacytoid dendritic cells elicit a Type I Interferon response by sensing DNA via the cGAS‐STING signaling pathway

Bode, C., Fox, M., Tewary, P., Steinhagen, A., Ellerkmann, R. K., Klinman, D., Baumgarten, G., Hornung, V., & Steinhagen, F. (2016) · European Journal of Immunology

interferon and immune responsesImmune Response and Inflammation

Cited by 79