The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Neisseria meningitidis recruits factor H using protein mimicry of host carbohydrates
Open accessAbstract
The complement system is an essential component of the innate and acquired immune system, and consists of a series of proteolytic cascades that are initiated by the presence of microorganisms. In health, activation of complement is precisely controlled through membrane-bound and soluble plasma-regulatory proteins including complement factor H (fH; ref. 2), a 155 kDa protein composed of 20 domains (termed complement control protein repeats). Many pathogens have evolved the ability to avoid immune-killing by recruiting host complement regulators and several pathogens have adapted to avoid complement-mediated killing by sequestering fH to their surface. Here we present the structure of a complement regulator in complex with its pathogen surface-protein ligand. This reveals how the important human pathogen Neisseria meningitidis subverts immune responses by mimicking the host, using protein instead of charged-carbohydrate chemistry to recruit the host complement regulator, fH. The structure also indicates the molecular basis of the host-specificity of the interaction between fH and the meningococcus, and informs attempts to develop novel therapeutics and vaccines.
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Complement factor H polymorphism and age-related macular degeneration
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Complement factor H variant increases the risk of age-related macular degeneration
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Structural basis for complement factor H linked age-related macular degeneration
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Self-citation
Cited by
Complement and its role in innate and adaptive immune responses
Dunkelberger, J. R., & Song, W.-C. (2010) · Cell Research · doi:10.1038/cr.2009.139 · Cited by 1,932
Complement System Part II: Role in Immunity
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Bacterial Adhesins in Host-Microbe Interactions
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Reverse Vaccinology: Developing Vaccines in the Era of Genomics
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Complement component C3 – The “Swiss Army Knife” of innate immunity and host defense
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Metadata
- Authors
- Schneider, M. C., Prosser, B. E., Caesar, J. J. E., Kugelberg, E., Li, S., Zhang, Q., Quoraishi, S., Lovett, J. E., Deane, J. E., Sim, R. B., Roversi, P., Johnson, S., Tang, C. M., & Lea, S. M.
- Venue
- Nature
- Published
- 2009-02-18
- Volume
- 458
- Issue
- 7240
- Pages
- 890-893
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2127157242
- Cited by
- 314
- References
- 7
- FWCI
- 12.47
- Type
- journal article
- Language
- en
- Open access
- green
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- Schneider, M. C., Prosser, B. E., Caesar, J. J. E., Kugelberg, E., Li, S., Zhang, Q., Quoraishi, S., Lovett, J. E., Deane, J. E., Sim, R. B., Roversi, P., Johnson, S., Tang, C. M., & Lea, S. M. (2009). Neisseria meningitidis recruits factor H using protein mimicry of host carbohydrates. Nature. https://doi.org/10.1038/nature07769
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