Cited by 263Retinal Diseases and TreatmentsAngiogenesis and VEGF in CancerOcular Diseases and Behçet’s Syndrome

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CCR3 is a target for age-related macular degeneration diagnosis and therapy

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Takeda, Atsunobu, Baffi, Judit Z., Kleinman, Mark E., Cho, Won Gil, Nozaki, Miho, Yamada, Kiyoshi, Kaneko, Hiroki, Albuquerque, Romulo J. C., Dridi, Sami, Saito, Kuniharu, Raisler, Brian J., Budd, Steven J., Geisen, Pete, Munitz, Ariel, Ambati, Balamurali K., Green, Martha G., Ishibashi, Tatsuro, Wright, John D., Humbles, Alison A., Gerard, Craig J., Ogura, Yuichiro, Pan, Yuzhen, Smith, Justine R., Grisanti, Salvatore, Hartnett, M. Elizabeth, Rothenberg, Marc E., Ambati, Jayakrishna·2009·Nature

DOI 10.1038/nature08151PMC PMC2712122

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Abstract

Age-related macular degeneration (AMD), a leading cause of blindness worldwide, is as prevalent as cancer in industrialized nations. Most blindness in AMD results from invasion of the retina by choroidal neovascularisation (CNV). Here we show that the eosinophil/mast cell chemokine receptor CCR3 is specifically expressed in choroidal neovascular endothelial cells in humans with AMD, and that despite the expression of its ligands eotaxin-1, -2 and -3, neither eosinophils nor mast cells are present in human CNV. Genetic or pharmacological targeting of CCR3 or eotaxins inhibited injury-induced CNV in mice. CNV suppression by CCR3 blockade was due to direct inhibition of endothelial cell proliferation, and was uncoupled from inflammation because it occurred in mice lacking eosinophils or mast cells, and was independent of macrophage and neutrophil recruitment. CCR3 blockade was more effective at reducing CNV than vascular endothelial growth factor A (VEGF-A) neutralization, which is in clinical use at present, and, unlike VEGF-A blockade, is not toxic to the mouse retina. In vivo imaging with CCR3-targeting quantum dots located spontaneous CNV invisible to standard fluorescein angiography in mice before retinal invasion. CCR3 targeting might reduce vision loss due to AMD through early detection and therapeutic angioinhibition.

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Rosenfeld, P. J., Brown, D. M., Heier, J. S., Boyer, D. S., Kaiser, P. K., Chung, C. Y., & Kim, R. Y. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa054481 · Cited by 5,886
Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele
Carmeliet, P., Ferreira, V., Breier, G., Pollefeyt, S., Kieckens, L., Gertsenstein, M., Fahrig, M., Vandenhoeck, A., Harpal, K., Eberhardt, C., et al. (1996) · Nature · doi:10.1038/380435a0 · Cited by 4,162
Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene
Ferrara, N., Carver-Moore, K., Chen, H., Dowd, M., Lu, L., O’Shea, K. S., Powell-Braxton, L., Hillan, K. J., & Moore, M. W. (1996) · Nature · doi:10.1038/380439a0 · Cited by 3,661
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Pegaptanib for neovascular age-related macular degeneration
Gragoudas, E. S., Adamis, A. P., Cunningham, E. T., Feinsod, M., & Guyer, D. R. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa042760 · Cited by 2,337
Genes Expressed in Human Tumor Endothelium
Croix, B. S., Rago, C., Velculescu, V. E., Traverso, G., Romans, K. E., Montgomery, E. A., Lal, A., Riggins, G. J., Lengauer, C., Vogelstein, B., et al. (2000) · Science · doi:10.1126/science.289.5482.1197 · Cited by 1,859
The eosinophil
Rothenberg, M. E., & Hogan, S. P. (2006) · Annual Review of Immunology · doi:10.1146/annurev.immunol.24.021605.090720 · Cited by 1,356
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Gene Expression Profiles in Normal and Cancer Cells
Zhang, L., Zhou, W., Velculescu, V. E., Kern, S. E., Hruban, R. H., Hamilton, S. R., Vogelstein, B., & Kinzler, K. W. (1997) · Science · doi:10.1126/science.276.5316.1268 · Cited by 1,186
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Ambati, J., Ambati, B. K., Yoo, S. H., Ianchulev, S., & Adamis, A. P. (2003) · Survey of Ophthalmology · doi:10.1016/s0039-6257(03)00030-4 · Cited by 959
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Sequence- and target-independent angiogenesis suppression by siRNA via TLR3
Kleinman, M. E., Yamada, K., Takeda, A., Chandrasekaran, V., Nozaki, M., Baffi, J., Albuquerque, R., Yamasaki, S., Itaya, M., Pan, Y., et al. (2008) · Nature · doi:10.1038/nature06765 · Cited by 939
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Flagged first, then by citations

Show all 49 references

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Mechanisms of Age-Related Macular Degeneration
Ambati, J., & Fowler, B. J. (2012) · Neuron · doi:10.1016/j.neuron.2012.06.018 · Cited by 1,062
Self-citation
International Union of Basic and Clinical Pharmacology. LXXXIX. Update on the Extended Family of Chemokine Receptors and Introducing a New Nomenclature for Atypical Chemokine Receptors
Bachelerie, F., Ben‐Baruch, A., Burkhardt, A. M., Combadière, C., Farber, J. M., Graham, G. J., Horuk, R., Sparre‐Ulrich, A. H., Locati, M., Luster, A. D., et al. (2013) · Pharmacological Reviews · doi:10.1124/pr.113.007724 · Cited by 888
The Mouse Retina as an Angiogenesis Model
Stahl, A., Connor, K. M., Sapieha, P. S., Chen, J., Dennison, R. J., Krah, N. M., Seaward, M. R., Willett, K. L., Aderman, C. M., Guerin, K. I., et al. (2010) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.10-5176 · Cited by 638
DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration
Kaneko, H., Dridi, S., Tarallo, V., Gelfand, B. D., Fowler, B. J., Cho, W. G., Kleinman, M. E., Ponicsan, S. L., Hauswirth, W. W., Chiodo, V. A., et al. (2011) · Nature · doi:10.1038/nature09830 · Cited by 601
Self-citation
DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88
Tarallo, V., Hirano, Y., Gelfand, B. D., Dridi, S., Kerur, N., Kim, Y., Cho, W. G., Kaneko, H., Fowler, B. J., Bogdanovich, S., et al. (2012) · Cell · doi:10.1016/j.cell.2012.03.036 · Cited by 592
Self-citation
Immunology of age-related macular degeneration
Ambati, J., Atkinson, J. P., & Gelfand, B. D. (2013) · Nature reviews. Immunology · doi:10.1038/nri3459 · Cited by 606
Self-citation
LRG1 promotes angiogenesis by modulating endothelial TGF-β signalling
Wang, X., Abraham, S., McKenzie, J. A. G., Jeffs, N. R., Swire, M., Tripathi, V. B., Luhmann, U. F. O., Lange, C., Zhai, Z., Arthur, H. M., et al. (2013) · Nature · doi:10.1038/nature12345 · Cited by 537
Fecal microbiota transfer between young and aged mice reverses hallmarks of the aging gut, eye, and brain
Parker, A., Romano, S., Ansorge, R., Aboelnour, A., Le Gall, G., Savva, G. M., Pontifex, M. G., Telatin, A., Baker, D., Jones, E., et al. (2022) · Microbiome · doi:10.1186/s40168-022-01243-w · Cited by 368
Animal models of choroidal and retinal neovascularization
Grossniklaus, H. E., Kang, S. J., & Berglin, L. (2010) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2010.05.003 · Cited by 350
Ophthalmic drug discovery: novel targets and mechanisms for retinal diseases and glaucoma
Zhang, K., Zhang, L., & Weinreb, R. N. (2012) · Nature Reviews Drug Discovery · doi:10.1038/nrd3745 · Cited by 320
Systemic and Ocular Safety of Intravitreal Anti-VEGF Therapies for Ocular Neovascular Disease
Tolentino, M. J. (2011) · Survey of Ophthalmology · doi:10.1016/j.survophthal.2010.08.006 · Cited by 303
Chemokine Mediated Monocyte Trafficking into the Retina: Role of Inflammation in Alteration of the Blood-Retinal Barrier in Diabetic Retinopathy
Rangasamy, S., McGuire, P. G., Nitta, C. F., Monickaraj, F., Oruganti, S. R., & Das, A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0108508 · Cited by 245
Nucleoside reverse transcriptase inhibitors possess intrinsic anti-inflammatory activity
Fowler, B. J., Gelfand, B. D., Kim, Y., Kerur, N., Tarallo, V., Hirano, Y., Amarnath, S., Fowler, D. H., Radwan, M., Young, M. T., et al. (2014) · Science · doi:10.1126/science.1261754 · Cited by 225
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Zandi, S., Nakao, S., Chun, K., Fiorina, P., Sun, D., Arita, R., Zhao, M., Kim, E., Schueller, O. J. A., Campbell, A. S., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.01.050 · Cited by 199
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Targeted Radiotherapy with Gold Nanoparticles: Current Status and Future Perspectives
Ngwa, W. F., Kumar, R., Sridhar, S., Korideck, H., Zygmanski, P., Cormack, R. A., Berbeco, R. I., & Makrigiorgos, G. M. (2014) · Nanomedicine · doi:10.2217/nnm.14.55 · Cited by 173
Cytokine concentration in aqueous humour of eyes with exudative age‐related macular degeneration
Jonas, J. B., Tao, Y. K., Neumaier, M., & Findeisen, P. (2012) · Acta Ophthalmologica · doi:10.1111/j.1755-3768.2012.02414.x · Cited by 159
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Hajrasouliha, A. R., Jiang, G., Lu, Q., Lü, H., Kaplan, H. J., Zhang, H., & Shao, H. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.470765 · Cited by 147
Systemic and ocular fluid compounds as potential biomarkers in age-related macular degeneration
Kersten, E., Paun, C. C., Schellevis, R. L., Hoyng, C. B., Delcourt, C., Lengyel, I., Pető, T., Ueffing, M., Klaver, C. C. W., Dammeier, S., et al. (2017) · Survey of Ophthalmology · doi:10.1016/j.survophthal.2017.05.003 · Cited by 146
CYTOKINE CONCENTRATION IN AQUEOUS HUMOR OF EYES WITH DIABETIC MACULAR EDEMA
Jonas, J. B., Jonas, R. A., Neumaier, M., & Findeisen, P. (2011) · Retina · doi:10.1097/iae.0b013e3182576d07 · Cited by 137
The Oral Iron Chelator Deferiprone Protects against Iron Overload–Induced Retinal Degeneration
Hadziahmetovic, M., Song, Y., Wolkow, N., Iacovelli, J., Grieco, S. F., Lee, J., Lyubarsky, A., Praticò, D., Connelly, J., Spino, M., et al. (2010) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.10-6207 · Cited by 119
Chemokine Receptor Antagonists
Pease, J. E., & Horuk, R. (2012) · Journal of Medicinal Chemistry · doi:10.1021/jm300682j · Cited by 105
Systemic administration of the iron chelator deferiprone protects against light-induced photoreceptor degeneration in the mouse retina
Song, D., Song, Y., Hadziahmetovic, M., Zhong, Y., & Dunaief, J. L. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.04.020 · Cited by 96
Inflammatory Mechanisms of Age-related Macular Degeneration
Knickelbein, J. E., Chan, C., Sen, H. N., Ferris, F. L., & Nussenblatt, R. B. (2015) · International Ophthalmology Clinics · doi:10.1097/iio.0000000000000073 · Cited by 98
Interferon γ–Inducible Protein-10 (IP-10) and Eotaxin as Biomarkers in Age-Related Macular Degeneration
Mo, F. M., Proia, A. D., Johnson, W. H., Cyr, D., & Lashkari, K. (2010) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.09-3910 · Cited by 97
Inflammatory Mediators and Angiogenic Factors in Choroidal Neovascularization: Pathogenetic Interactions and Therapeutic Implications
Campa, C., Costagliola, C., Incorvaia, C., Sheridan, C., Semeraro, F., Nadai, K. D., Sebastiani, A., & Parmeggiani, F. (2010) · Mediators of Inflammation · doi:10.1155/2010/546826 · Cited by 97
Targeted Intraceptor Nanoparticle Therapy Reduces Angiogenesis and Fibrosis in Primate and Murine Macular Degeneration
Luo, L., Zhang, X., Hirano, Y., Tyagi, P., Barabás, P., Uehara, H., Miya, T. R., Singh, N., Archer, B. J., Qazi, Y., et al. (2013) · ACS Nano · doi:10.1021/nn305958y · Cited by 95
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Sato, T., Takeuchi, M., Karasawa, Y., Enoki, T., & Ito, M. (2018) · Scientific Reports · doi:10.1038/s41598-018-19594-6 · Cited by 90
“Chemokine receptors as therapeutic targets: Why aren’t there more drugs?”
Solari, R. C. E., Pease, J. E., & Begg, M. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.06.060 · Cited by 91
IL-23–Independent Induction of IL-17 from γδT Cells and Innate Lymphoid Cells Promotes Experimental Intraocular Neovascularization
Hasegawa, E., Sonoda, K., Shichita, T., Morita, R., Sekiya, T., Kimura, A., Oshima, Y., Takeda, A., Yoshimura, T., Yoshida, S., et al. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1202495 · Cited by 87
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Blue light-induced inflammatory marker expression in the retinal pigment epithelium-choroid of mice and the protective effect of a yellow intraocular lens material in vivo
Narimatsu, T., Negishi, K., Miyake, S., Hirasawa, M., Osada, H., Kurihara, T., Tsubota, K., & Ozawa, Y. (2015) · Experimental Eye Research · doi:10.1016/j.exer.2015.01.003 · Cited by 84
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Zarbin, M. A., Montemagno, C. D., Leary, J. F., & Ritch, R. H. (2010) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2010.03.019 · Cited by 86
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Tuo, J., Grob, S., Zhang, K., & Chan, C. (2012) · Ocular Immunology and Inflammation · doi:10.3109/09273948.2011.628432 · Cited by 80
Novel peptide nanoparticle–biased antagonist of CCR3 blocks eosinophil recruitment and airway hyperresponsiveness
Grozdanović, M. M., Laffey, K. G., Abdelkarim, H., Hitchinson, B., Harijith, A. K., Moon, H.-G., Park, G. Y., Rousslang, L. K., Masterson, J. C., Furuta, G. T., et al. (2018) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2018.05.003 · Cited by 77
Penetratin-modified lutein nanoemulsion in-situ gel for the treatment of age-related macular degeneration
Ge, Y. C., Zhang, A., Sun, R., Xu, J., Yin, T., He, H., Gou, J., Kong, J., Zhang, Y. X., & Tang, X. (2020) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2020.1735348 · Cited by 76
CCL28 promotes breast cancer growth and metastasis through MAPK-mediated cellular anti-apoptosis and pro-metastasis
Yang, X. L., Liu, K. Y., Lin, F. J., Shi, H. M., & Ou, Z. L. (2017) · Oncology Reports · doi:10.3892/or.2017.5798 · Cited by 76
Neurovascular regulation in diabetic retinopathy and emerging therapies
Ji, L., Tian, H., Webster, K. A., & Li, W. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-03893-9 · Cited by 76
Disruption of Cell-Cell Junctions and Induction of Pathological Cytokines in the Retinal Pigment Epithelium of Light-Exposed Mice
Narimatsu, T., Ozawa, Y., Miyake, S., Kubota, S., Hirasawa, M., Nagai, N., Shimmura, S., & Tsubota, K. (2013) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.12-11572 · Cited by 73
Relative Contribution of VEGF and TNF-α in the Cynomolgus Laser-Induced CNV Model: Comparing the Efficacy of Bevacizumab, Adalimumab, and ESBA105
Lichtlen, P., Lam, T. T., Nork, T. M., Streit, T., & Urech, D. (2010) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.09-4890 · Cited by 75
Endoplasmic reticulum stress-regulated CXCR3 pathway mediates inflammation and neuronal injury in acute glaucoma
Ha, Y., Liu, H., Xu, Z., Yokota, H., Narayanan, S. P., Lemtalsi, T., Smith, S. B., Caldwell, R. W., Caldwell, R. B., & Zhang, W. (2015) · Cell Death and Disease · doi:10.1038/cddis.2015.281 · Cited by 73
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Cascella, R., Ragazzo, M., Strafella, C., Missiroli, F., Borgiani, P., Angelucci, F., Marsella, L., Cusumano, A., Novelli, G., Ricci, F., et al. (2014) · Journal of Ophthalmology · doi:10.1155/2014/582842 · Cited by 74
Regulation of signaling events involved in the pathophysiology of neovascular AMD.
Wang, H., & Hartnett, M. E. (2016) · Europe PMC (PubMed Central) · Cited by 72
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Gregory, K. J., Zhao, B., Bielenberg, D. R., Dridi, S., Wu, J., Jiang, W., Huang, B., Pirie-Shepherd, S. R., & Fannon, M. W. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013428 · Cited by 66
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Arginine metabolic control of airway inflammation
Asosingh, K., Lauruschkat, C. D., Alemagno, M., Frimel, M., Wanner, N., Weiss, K., Kessler, S. P., Meyers, D. A., Bennett, C. D., Xu, W., et al. (2020) · JCI Insight · doi:10.1172/jci.insight.127801 · Cited by 67
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Wang, X., Wang, T., Lam, E., Álvarez, D., & Sun, Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241512090 · Cited by 71
Current status of chemokine receptor inhibitors in development
Allegretti, M., Cesta, M. C., Garin, A., & Proudfoot, A. E. I. (2012) · Immunology Letters · doi:10.1016/j.imlet.2012.04.003 · Cited by 62
A Revised Hemodynamic Theory of Age-Related Macular Degeneration
Gelfand, B. D., & Ambati, J. (2016) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2016.06.009 · Cited by 65
Self-citation
Oxidative stress: The achilles' heel of neurodegenerative diseases of the retina
Cai, X. (2011) · Frontiers in bioscience · doi:10.2741/4033 · Cited by 63
Targeting chemokine receptors in allergic disease
Pease, J. E. (2011) · Biochemical Journal · doi:10.1042/bj20101132 · Cited by 66
Recent progress in the development of antagonists to the chemokine receptors CCR3 and CCR4
Pease, J. E., & Horuk, R. (2014) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2014.897324 · Cited by 59
Tyrosine Sulfation Influences the Chemokine Binding Selectivity of Peptides Derived from Chemokine Receptor CCR3
Zhu, J. Z., Millard, C. J., Ludeman, J. P., Simpson, L. S., Clayton, D., Payne, R. J., Widlanski, T. S., & Stone, M. J. (2011) · Biochemistry · doi:10.1021/bi101240v · Cited by 59
Circulating Autoantibodies in Age-Related Macular Degeneration Recognize Human Macular Tissue Antigens Implicated in Autophagy, Immunomodulation, and Protection from Oxidative Stress and Apoptosis
Iannaccone, A., Giorgianni, F., New, D. D., Hollingsworth, T., Umfress, A. C., Alhatem, A., Neeli, I., Lenchik, N. I., Jennings, B., Calzada, J. I., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0145323 · Cited by 62
Anti-angiogenic Therapy for Retinal Disease
Paulus, Y. M., & Sodhi, A. (2016) · Handbook of experimental pharmacology · doi:10.1007/164_2016_78 · Cited by 60
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Ye, F., Kaneko, H., Nagasaka, Y., Ijima, R., Nakamura, K., Nagaya, M., Takayama, K., Kajiyama, H., Senga, T., Tanaka, H., et al. (2015) · Scientific Reports · doi:10.1038/srep07705 · Cited by 55
Self-citation
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Li, H., Li, B., & Zheng, Y. (2024) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2024.5369 · Cited by 56
CCL24 contributes to HCC malignancy via RhoB- VEGFA-VEGFR2 angiogenesis pathway and indicates poor prognosis
Jin, L., Liu, W., Tian, M., Jiang, X., Wang, H., Zhou, P., Ding, Z., Peng, Y., Dai, Z., Qiu, S., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.14095 · Cited by 53
Comparison of chemokine and receptor gene expression between Wharton's jelly and bone marrow-derived mesenchymal stromal cells
Balasubramanian, S., Venugopal, P., SundarRaj, S., Zakaria, Z., Majumdar, A. S., & Ta, M. (2011) · Cytotherapy · doi:10.3109/14653249.2011.605119 · Cited by 52
A novel antiangiogenic and vascular normalization therapy targeted against human CD160 receptor
Chabot, S., Jabrane‐Ferrat, N., Bigot, K., Tabiasco, J., Provost, A. C., Golzio, M., Noman, M. Z., Giustiniani, J., Bellard, E., Brayer, S., et al. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20100810 · Cited by 51
Whole-exome sequencing implicates UBE3D in age-related macular degeneration in East Asian populations
Huang, L., Li, Y., Xie, X., Zhang, J., Cheng, C., Yamashiro, K., Chen, L., Ma, X., Cheung, C. M. G., Wang, Y.-S., et al. (2015) · Nature Communications · doi:10.1038/ncomms7687 · Cited by 51
Drusen with Accompanying Fluid underneath the Sensory Retina
Sikorski, B. L., Sampson, D. M., Kałuzny, J. J., Szkulmowski, M., Kowalczyk, A. A., & Wojtkowski, M. (2010) · Ophthalmology · doi:10.1016/j.ophtha.2010.04.017 · Cited by 52
Upregulation of CCR3 by Age-Related Stresses Promotes Choroidal Endothelial Cell Migration via VEGF-Dependent and -Independent Signaling
Wang, H., Wittchen, E. S., Jiang, Y., Ambati, B. K., Grossniklaus, H. E., & Hartnett, M. E. (2011) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.11-8230 · Cited by 51
Self-citation
The Antiangiogenic Effects of Integrin α5β1 Inhibitor (ATN-161) In Vitro and In Vivo
Wang, W., Wang, F., Lu, F., Xu, S., Hu, W., Huang, J., Gu, Q., & Sun, X. (2011) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.10-7097 · Cited by 51
Proteomic analysis of the aqueous humor in patients with wet age‐related macular degeneration
Yao, J., Liu, X., Yang, Q., Zhuang, M., Wang, F., Chen, X., Hang, H., Zhang, W., & Liu, Q. (2013) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.201200012 · Cited by 49
Prolonged blockade of VEGF receptors does not damage retinal photoreceptors or ganglion cells
Miki, A., Miki, K., Ueno, S., Wersinger, D. M. B., Berlinicke, C., Shaw, G. C., Usui, S., Wang, Y., Zack, D. J., & Campochiaro, P. A. (2010) · Journal of Cellular Physiology · doi:10.1002/jcp.22129 · Cited by 47
New Biomarker for Neovascular Age-Related Macular Degeneration: Eotaxin-2
Sharma, N. K., Prabhakar, S. K., Gupta, A., Singh, R., Gupta, P. K., Gupta, P., & Anand, A. (2012) · DNA and Cell Biology · doi:10.1089/dna.2012.1786 · Cited by 47
Age-related macular degeneration phenotypes are associated with increased tumor necrosis-alpha and subretinal immune cells in aged Cxcr5 knockout mice
Hu, H., Liu, Y., Wang, L., & Li, W. (2017) · PLoS ONE · doi:10.1371/journal.pone.0173716 · Cited by 47
Regulation of Ocular Angiogenesis by Notch Signaling: Implications in Neovascular Age-Related Macular Degeneration
Ahmad, I., Balasubramanian, S., Debbio, C. B. D., Parameswaran, S., Katz, A. R., Toris, C. B., & Fariss, R. N. (2011) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.10-6608 · Cited by 46
Aqueous humor cytokine profiling in patients with wet AMD.
Liu, F., Ding, X., Yu, Y., Li, J., Tang, M., Yuan, M., Hu, A., Zhan, Z., Li, Z., & Lü, L. (2016) · PubMed Central · Cited by 46
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Authors: Takeda, A., Baffi, J. Z., Kleinman, M. E., Cho, W. G., Nozaki, M., Yamada, K., Kaneko, H., Albuquerque, R. J. C., Dridi, S., Saito, K., Raisler, B. J., Budd, S. J., Geisen, P., Munitz, A., Ambati, B. K., Green, M. G., Ishibashi, T., Wright, J. D., Humbles, A. A., Gerard, C. J., Ogura, Y., Pan, Y., Smith, J. R., Grisanti, S., Hartnett, M. E., Rothenberg, M. E., & Ambati, J.
Affiliations: University of Kentucky (US)
University of North Carolina at Chapel Hill (US)
Cincinnati Children's Hospital Medical Center (US)
University of Utah (US)
Kyushu University (JP)
Harvard University (US)
Nagoya City University (JP)
Oregon Health & Science University (US)
University of Lübeck (DE)
Corresponding author: Ambati, Jayakrishna
ORCID: Takeda, Atsunobu
Kleinman, Mark E.
Cho, Won Gil
Nozaki, Miho
Kaneko, Hiroki
Dridi, Sami
Munitz, Ariel
Ambati, Balamurali K.
Humbles, Alison A.
Ogura, Yuichiro
Smith, Justine R.
Grisanti, Salvatore
Hartnett, M. Elizabeth
Rothenberg, Marc E.
Ambati, Jayakrishna
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2009-06-14
Volume: 460
Issue: 7252
Pages: 225-230
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature08151
PMC: PMC2712122
OpenAlex: W1978268544
Cited by: 263
References: 49
Citations by year: 2026: 5 · 2025: 7 · 2024: 10 · 2023: 8 · 2022: 18 · 2021: 11 · 2020: 12 · 2019: 11 · 2018: 10 · 2017: 20 · 2016: 22 · 2015: 14 · 2014: 20 · 2013: 22 · 2012: 22
FWCI: 23.93
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
RePEc: Research Papers in Economics (submittedVersion)
UNC Libraries
Funders: U.S. Department of Defense
American Health Assistance Foundation
International Retinal Research Foundation
Research to Prevent Blindness
Macula Vision Research Foundation
E. Matilda Ziegler Foundation for the Blind
National Institutes of Health
National Heart, Lung, and Blood Institute
National Eye Institute (R01EY017950, R01EY018836, R01EY015422, EY018836, R01EY018350, EY018350, EY 010572, EY017011, R01EY017182, EY017182, EY017950, EY015130, R01EY017011, P30EY010572, EY015422)
National Institute of Allergy and Infectious Diseases (R01AI039759, R37AI045898, AI 45898, AI039759)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK076893, DK076893)
Topics: Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
Keywords: age-related macular degeneration, CCR3, choroidal neovascularization, eotaxin, eosinophils, mast cells, endothelial cell proliferation, anti-VEGF therapy, early diagnosis, quantum dot imaging, retinal neovascularization, blindness prevention, anti-angiogenic therapy
MeSH terms: Chemokine CCL26, Animals, Cell Movement, Cells, Cultured, Choroid, Disease Models, Animal, Humans, Inflammation, Leukocytes, Ligands, Macular Degeneration, Mice, Inbred C57BL, Retina, Chemokines, CC, Choroidal Neovascularization, Vascular Endothelial Growth Factor A, Endothelial Cells, Quantum Dots, Cell Proliferation, Mice, Receptors, CCR3, Chemokine CCL11, Chemokine CCL24

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