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Defining mechanisms that regulate RNA polymerase II transcription in vivo
Open accessAbstract
In the eukaryotic genome, the thousands of genes that encode messenger RNA are transcribed by a molecular machine called RNA polymerase II. Analysing the distribution and status of RNA polymerase II across a genome has provided crucial insights into the long-standing mysteries of transcription and its regulation. These studies identify points in the transcription cycle where RNA polymerase II accumulates after encountering a rate-limiting step. When coupled with genome-wide mapping of transcription factors, these approaches identify key regulatory steps and factors and, importantly, provide an understanding of the mechanistic generalities, as well as the rich diversities, of gene regulation.
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“Pol II activity is tightly regulated by phosphorylation of its carboxy-terminal domain (CTD)140.”
From Molecular regulation of stem cell quiescence (2013) · cites this paper as [140]
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Metadata
- Authors
- Fuda, N. J., Ardehali, M. B., & Lis, J. T.
- Affiliations
- Cornell University (US)
- Venue
- Nature
- Published
- 2009-09
- Volume
- 461
- Issue
- 7261
- Pages
- 186-192
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC2833331
- OpenAlex
- W2114040881
- Cited by
- 576
- References
- 75
- Citations by year
- 2026: 12 · 2025: 23 · 2024: 28 · 2023: 19 · 2022: 11 · 2021: 25 · 2020: 30 · 2019: 28 · 2018: 25 · 2017: 22 · 2016: 37 · 2015: 30 · 2014: 48 · 2013: 48 · 2012: 61
- FWCI
- 4.84
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- National Institutes of Health
- National Institute of General Medical Sciences (R01GM025232, R37GM025232, GM-25232)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Keywords
- RNA polymerase II, transcriptional regulation, transcription cycle, genome-wide mapping, transcription factors, gene expression regulation, mRNA, eukaryotic genomes
- MeSH terms
- Animals, Gene Expression Regulation, Humans, Kinetics, Promoter Regions, Genetic, RNA Polymerase II, Transcription Factors, Transcription, Genetic
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