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Defining mechanisms that regulate RNA polymerase II transcription in vivo

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Fuda, Nicholas J., Ardehali, M. Behfar, Lis, John T.·2009·Nature

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Abstract

In the eukaryotic genome, the thousands of genes that encode messenger RNA are transcribed by a molecular machine called RNA polymerase II. Analysing the distribution and status of RNA polymerase II across a genome has provided crucial insights into the long-standing mysteries of transcription and its regulation. These studies identify points in the transcription cycle where RNA polymerase II accumulates after encountering a rate-limiting step. When coupled with genome-wide mapping of transcription factors, these approaches identify key regulatory steps and factors and, importantly, provide an understanding of the mechanistic generalities, as well as the rich diversities, of gene regulation.

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Authors: Fuda, N. J., Ardehali, M. B., & Lis, J. T.
Affiliations: Cornell University (US)
ORCID: Fuda, Nicholas J.
Ardehali, M. Behfar
Lis, John T.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2009-09
Volume: 461
Issue: 7261
Pages: 186-192
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature08449
PMC: PMC2833331
OpenAlex: W2114040881
Cited by: 576
References: 75
Citations by year: 2026: 12 · 2025: 23 · 2024: 28 · 2023: 19 · 2022: 11 · 2021: 25 · 2020: 30 · 2019: 28 · 2018: 25 · 2017: 22 · 2016: 37 · 2015: 30 · 2014: 48 · 2013: 48 · 2012: 61
FWCI: 4.84
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Funders: National Institutes of Health
National Institute of General Medical Sciences (R01GM025232, R37GM025232, GM-25232)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
Keywords: RNA polymerase II, transcriptional regulation, transcription cycle, genome-wide mapping, transcription factors, gene expression regulation, mRNA, eukaryotic genomes
MeSH terms: Animals, Gene Expression Regulation, Humans, Kinetics, Promoter Regions, Genetic, RNA Polymerase II, Transcription Factors, Transcription, Genetic

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Defining mechanisms that regulate RNA polymerase II transcription in vivo

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