The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Intracellular dynamics of hippocampal place cells during virtual navigation
Open accessAbstract
Hippocampal place cells encode spatial information in rate and temporal codes. To examine the mechanisms underlying hippocampal coding, here we measured the intracellular dynamics of place cells by combining in vivo whole-cell recordings with a virtual-reality system. Head-restrained mice, running on a spherical treadmill, interacted with a computer-generated visual environment to perform spatial behaviours. Robust place-cell activity was present during movement along a virtual linear track. From whole-cell recordings, we identified three subthreshold signatures of place fields: an asymmetric ramp-like depolarization of the baseline membrane potential, an increase in the amplitude of intracellular theta oscillations, and a phase precession of the intracellular theta oscillation relative to the extracellularly recorded theta rhythm. These intracellular dynamics underlie the primary features of place-cell rate and temporal codes. The virtual-reality system developed here will enable new experimental approaches to study the neural circuits underlying navigation.
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Cites
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Cited by
Enhancing Our Lives with Immersive Virtual Reality
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Modulation of visual responses by behavioral state in mouse visual cortex
Niell, C. M., & Stryker, M. P. (2010) · Neuron · doi:10.1016/j.neuron.2010.01.033 · Cited by 1,483
“In order to provide controlled visual stimuli while performing extracellular recording in an awake, moving animal, we adapted a recent technique to fix the head of the mouse while it stood or ran atop a freely floating foam ball (Dombeck et al., 2007; Harvey et al., 2009), which acts as a spherical treadmill.”
Gamma frequency entrainment attenuates amyloid load and modifies microglia
Iaccarino, H. F., Singer, A. C., Martorell, A. J., Rudenko, A., Gao, F., Gillingham, T. Z., Mathys, H., Seo, J., Kritskiy, O., Abdurrob, F., et al. (2016) · Nature · doi:10.1038/nature20587 · Cited by 1,328
Virtual reality in neuroscience research and therapy
Bohil, C. J., Alicea, B., & Biocca, F. A. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3122 · Cited by 1,108
Metadata
- Authors
- Harvey, C. D., Collman, F., Dombeck, D. A., & Tank, D. W.
- Venue
- Nature
- Published
- 2009-10
- Volume
- 461
- Issue
- 7266
- Pages
- 941-946
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1981737644
- Cited by
- 873
- References
- 43
- FWCI
- 21.62
- Type
- journal article
- Language
- en
- Open access
- green
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