Cited by 703Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsCancer-related cognitive impairment studies

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Multimodal techniques for diagnosis and prognosis of Alzheimer's disease

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Perrin, Richard J., Fagan, Anne M., Holtzman, David M.·2009·Nature

DOI 10.1038/nature08538PMC PMC2810658

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Abstract

Alzheimer's disease affects millions of people around the world. Currently, there are no treatments that prevent or slow the disease. Like other neurodegenerative diseases, Alzheimer's disease is characterized by protein misfolding in the brain. This process and the associated brain damage begin years before the substantial neurodegeneration that accompanies dementia. Studies using new neuroimaging techniques and fluid biomarkers suggest that Alzheimer's disease pathology can be detected preclinically. These advances should allow the design of new clinical trials and early mechanism-based therapeutic intervention.

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Authors: Perrin, R. J., Fagan, A. M., & Holtzman, D. M.
Affiliations: Washington University in St. Louis (US)
ORCID: Perrin, Richard J.
Fagan, Anne M.
Holtzman, David M.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2009-10
Volume: 461
Issue: 7266
Pages: 916-922
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature08538
PMC: PMC2810658
OpenAlex: W2085558649
Cited by: 702
References: 83
Citations by year: 2026: 20 · 2025: 29 · 2024: 30 · 2023: 28 · 2022: 43 · 2021: 56 · 2020: 38 · 2019: 38 · 2018: 36 · 2017: 48 · 2016: 33 · 2015: 49 · 2014: 53 · 2013: 58 · 2012: 60
FWCI: 5.97
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Funders: National Institutes of Health (5t32ns007205-32)
National Institute on Aging (P50AG005681, P01 AG0 3991, P01AG003991, P50AG00568125, P01AG026276)
National Institute of Neurological Disorders and Stroke (T32-NS007205)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Oncology › Cancer-related cognitive impairment studies
Keywords: Alzheimer's disease, multimodal diagnosis, prognosis, neuroimaging, fluid biomarkers, preclinical detection, protein misfolding, neurodegeneration, dementia, clinical trials
MeSH terms: Alzheimer Disease, Humans, Inflammation, Prognosis, Amyloid beta-Peptides, tau Proteins, Oxidative Stress, Proteomics

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Multimodal techniques for diagnosis and prognosis of Alzheimer's disease

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