The DOI matches its Crossref record; 52 of the 53 references it cites were found in a registry or an index.
Conversion of adult pancreatic α-cells to β-cells after extreme β-cell loss
Open accessAbstract
Pancreatic insulin-producing beta-cells have a long lifespan, such that in healthy conditions they replicate little during a lifetime. Nevertheless, they show increased self-duplication after increased metabolic demand or after injury (that is, beta-cell loss). It is not known whether adult mammals can differentiate (regenerate) new beta-cells after extreme, total beta-cell loss, as in diabetes. This would indicate differentiation from precursors or another heterologous (non-beta-cell) source. Here we show beta-cell regeneration in a transgenic model of diphtheria-toxin-induced acute selective near-total beta-cell ablation. If given insulin, the mice survived and showed beta-cell mass augmentation with time. Lineage-tracing to label the glucagon-producing alpha-cells before beta-cell ablation tracked large fractions of regenerated beta-cells as deriving from alpha-cells, revealing a previously disregarded degree of pancreatic cell plasticity. Such inter-endocrine spontaneous adult cell conversion could be harnessed towards methods of producing beta-cells for diabetes therapies, either in differentiation settings in vitro or in induced regeneration.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Emerging evidence in mice also shows considerable plasticity within islets, allowing intraislet cell conversions, but only in the face of extreme β-cell destruction ( 38 ).”
From β-Cell Failure in Type 2 Diabetes: Postulated Mechanisms and Prospects for Prevention and Treatment (2014) · cites this paper as [38]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Manipulating the mouse embryo: A laboratory manual
Hogan, B. L. M., Costantini, F. D., & Lacy, E. (1986) · Cited by 4,460
Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus
Srinivas, S., Watanabe, T., Lin, C.-S., William, C. M., Tanabe, Y., Jessell, T. M., & Costantini, F. (2001) · BMC Developmental Biology · doi:10.1186/1471-213x-1-4 · Cited by 3,121
Manipulating the mouse embryo: A laboratory manual
Johnson, M. (1986) · Trends in Genetics · doi:10.1016/0168-9525(86)90275-1 · Cited by 2,259
Adult pancreatic β-cells are formed by self-duplication rather than stem-cell differentiation
Dor, Y., Brown, J., Martinez, O. I., & Melton, D. A. (2004) · Nature · doi:10.1038/nature02520 · Cited by 2,219
In vivo reprogramming of adult pancreatic exocrine cells to β-cells
Zhou, Q., Brown, J., Kanarek, A., Rajagopal, J., & Melton, D. A. (2008) · Nature · doi:10.1038/nature07314 · Cited by 2,010
Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus
Herold, K. C., Hagopian, W., Auger, J. A., Poumian-Ruiz, E., Taylor, L., Donaldson, D., Gitelman, S. E., Harlan, D. M., Xu, D., Zivin, R. A., et al. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa012864 · Cited by 1,222
Xu, G., Stoffers, D. A., Habener, J. F., & Bonner-Weir, S. (1999) · Diabetes · doi:10.2337/diabetes.48.12.2270 · Cited by 1,209
β Cells Can Be Generated from Endogenous Progenitors in Injured Adult Mouse Pancreas
Xu, X., D’Hoker, J., Stangé, G. M., Bonné, S., Leu, N. D., Xiao, X., de Casteele, M. V., Mellitzer, G., Ling, Z., Pipeleers, D., et al. (2008) · Cell · doi:10.1016/j.cell.2007.12.015 · Cited by 1,010
Somatic Sex Reprogramming of Adult Ovaries to Testes by FOXL2 Ablation
Uhlenhaut, N. H., Jakob, S., Anlag, K., Eisenberger, T., Sekido, R., Kress, J., Treier, A.-C., Klugmann, C., Klasen, C., Holter, N. I., et al. (2009) · Cell · doi:10.1016/j.cell.2009.11.021 · Cited by 961
Burgoyne, R. D., & Morgan, A. (2003) · Physiological Reviews · doi:10.1152/physrev.00031.2002 · Cited by 934
Flagged first, then by citations
1 of the 53 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Items 901–1,000 of 1,000
The roles of micro RNA in pancreas development and regeneration
Rabe, T., Shamsi, F., & Mansouri, A. (2013) · Biomedical Reviews · doi:10.14748/bmr.v24.22 · Cited by 2
Creating new β cells: cellular transmutation by genomic alchemy
Moss, L. G. (2013) · Journal of Clinical Investigation · doi:10.1172/jci68348 · Cited by 2
Novel Treatments and the Future of DKD: What Is on the Horizon?
Wu, H., & Batuman, V. (2022) · Springer eBooks · doi:10.1007/978-3-030-86020-2_28 · Cited by 2
Mesenchymal Stem Cells from Mouse Hair Follicles Inhibit the Development of Type 1 Diabetes
Mićanović, D., Stanisavljević, S., Li, H., Koprivica, I., Jonić, N., Stojanović, I., Savković, V., & Saksida, T. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25115974 · Cited by 3
Hatano, R., Zhang, X., Lee, E., Kaneda, A., Tanaka, T., & Miki, T. (2024) · iScience · doi:10.1016/j.isci.2024.110656 · Cited by 2
Characterization of Human Pancreatic Islet Cells Using a Single-Cell Western Blot Platform
Lenz, G., MIAO, L. N., Lenz, A., Mares, J., Quijano, J. C., Zook, H. N., Komatsu, H., Garcia, P., Ferreri, K., Ku, H. T., et al. (2024) · Pancreas · doi:10.1097/mpa.0000000000002385 · Cited by 2
β-Cell Regeneration Is Driven by Pancreatic Plasticity
Holguín-Horcajo, A., Sancho, R., & Rovira, M. (2024) · Advances in anatomy, embryology and cell biology · doi:10.1007/978-3-031-62232-8_4 · Cited by 4
β-Cell Heterogeneity and Plasticity
Yong, H. J., & Wang, Y. J. (2024) · Advances in anatomy, embryology and cell biology · doi:10.1007/978-3-031-62232-8_3 · Cited by 2
Pancreatic islet organoids and organoids on-chip for type 1 diabetes
Mehanović, M., Lopes, M., Coffy, S., Pitaval, A., Freida, D., Gidrol, X., & Tubbs, E. (2025) · La Presse Médicale · doi:10.1016/j.lpm.2025.104302 · Cited by 2
Kao, D.-I., & Chen, S. (2013) · Springer eBooks · doi:10.1007/978-1-4614-7696-2_30 · Cited by 2
Pancreatic islet regeneration: Therapeutic potential, unknowns and controversy
Cockburn, I. L., & Ferris, W. F. (2015) · South African Journal of Science · doi:10.17159/sajs.2015/20140369 · Cited by 2
KURIKULUM PENDIDIKAN AGAMA ISLAM TAMAN KANAK-KANAK ISLAM TERPADU (TKIT) AL-AZHAR LAMGUGOB BANDA ACEH
Muthmainnah, M. (2017) · Bunayya Jurnal Pendidikan Anak · doi:10.22373/bunayya.v1i2.1321 · Cited by 2
Regulation of Pancreatic Islet Formation
Martı́n, F., Rojas, A., Carrasco, M., Delgado‐Sainz, I., Cobo‐Vuilleumier, N., Tejedo, J. R., Bedoya, F. J., Gauthier, B. R., & Soria, B. (2014) · Springer eBooks · doi:10.1007/978-94-007-6884-0_36-2 · Cited by 2
New role for alpha cells as a source for new beta cells
Watada, H. (2010) · Journal of Diabetes Investigation · doi:10.1111/j.2040-1124.2010.00069.x · Cited by 2
Nouvelles voies thérapeutiques du diabète de type 2 ciblées sur le glucagon et son récepteur
Moller, D. E., KAZDA, C. M., & Cueille, C. (2011) · Médecine des Maladies Métaboliques · doi:10.1016/s1957-2557(11)70208-5 · Cited by 2
Cell makeover for diabetes therapy
Bakhti, M., & Lickert, H. (2019) · Nature Metabolism · doi:10.1038/s42255-019-0048-5 · Cited by 2
Epigenetic Mechanisms in Liver and Pancreas Generation and Regeneration
Nicetto, D., McCarthy, R. L., & Zaret, K. S. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-814879-2.00010-8 · Cited by 2
Schwann Cells in Nerve Repair and Regeneration
Jessen, K. R., & Mirsky, R. (2020) · Springer eBooks · doi:10.1007/978-3-030-06217-0_6-1 · Cited by 2
Meier, J. J. (2015) · Elsevier eBooks · doi:10.1016/b978-0-323-18907-1.00032-9 · Cited by 3
Mapping regulators of cell fate determination: Approaches and challenges
Kumar, A., & Mali, P. (2020) · APL Bioengineering · doi:10.1063/5.0004611 · Cited by 2
C-Peptide-Positive, Autoantibody-Negative Type 1 Diabetes Mellitus
Fenner, R. M., Bookbinder, S., Kant, R., & Eberly, J. B. (2022) · Cureus · doi:10.7759/cureus.28360 · Cited by 2
Takahashi, H., Ito, R., Matsumura, Y., & Sakai, J. (2023) · BioEssays · doi:10.1002/bies.202300084 · Cited by 2
Tyurenkov, I. N., Faibisovich, T. I., Дубровина, М. А., Bakulin, D. A., & Куркин, Д. В. (2023) · Успехи физиологических наук · doi:10.31857/s030117982302008x · Cited by 4
Induction of mouse pancreatic ductal differentiation, an in vitro assay
Rhodes, J., Criscimanna, A., & Esni, F. (2012) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1007/s11626-012-9555-3 · Cited by 2
Lineage conversion of mouse fibroblasts to pancreatic α-cells
Liu, T., Sun, L., Jiang, B., Li, L., Cen, J., Chen, X., Zhang, Z., Wang, Q., Cheng, X., Shi, Y., et al. (2017) · Experimental & Molecular Medicine · doi:10.1038/emm.2017.84 · Cited by 2
Embryologic development of the liver, biliary tract, and pancreas
El‐Gohary, Y., Zhao, K., & Gittes, G. K. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-34062-5.00001-7 · Cited by 2
Expression of Wnt5a defines the major progenitors of fetal and adult Leydig cellsPreprint
Ademi, H., Stévant, I., Rands, C. M., Conne, B., & Nef, S. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.07.25.221069 · Cited by 2
Karaköse, E., Wang, X., Wang, P., Carcamo, S., Demircioğlu, D., Lambertini, L., Wood, O., Kang, R. B., Lu, G., Scott, D. K., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.09.07.556578 · Cited by 2
Kang, R. B., Lee, J., Varela, M., Li, Y., Rosselot, C., Zhang, T., Karaköse, E., Stewart, A. F., Scott, D. K., García-Ocaña, A., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.11.19.567715 · Cited by 3
Single-cell multiome analysis supports α-to-β transdifferentiation in human pancreasPreprint
Lee, M. Y. Y., Guessoum, O., El‐Mekkoussi, H., Conery, M., Manduchi, E., Schug, J., Descamps, H. C., Lahori, D., Da, T., Liu, C., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.02.14.638309 · Cited by 2
Singh, S., Pavan, M. K., Barella, L. F., Telang, J., Shree, A., Agarwal, S., Goel, A., Thaleshwari, S., Wess, J., Zafar, H., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.29.656754 · Cited by 2
Searching for stem cells in the adult pancreas: A futile effort?
Minami, K. (2013) · Journal of Diabetes Investigation · doi:10.1111/jdi.12061 · Cited by 1
Nucleofection as an Efficient Method for Alpha TC1-6 Cell Line Transfection
Đorđević, M., Paunović, V., Jovanović-Tucović, M., Tolić, A., Rajić, J., Dinić, S., Uskoković, A. S., Grdović, N., Mihailović, M., Marković, I., et al. (2022) · Applied Sciences · doi:10.3390/app12157938 · Cited by 1
Disruption of perinatal myeloid niches impacts the aging clock of pancreatic β cells
O'Sell, J., Cirulli, V., Pardike, S., Bentsen, M. A., Sdek, P., Anderson, J., Hailey, D. W., Regier, M. C., Gharib, S. A., & Crisá, L. (2024) · iScience · doi:10.1016/j.isci.2024.110644 · Cited by 1
Vangala, V., Chen, Y., Dinavahi, S. S., Gowda, K., Lone, N., Herlyn, M., Drabick, J. J., Helm, K. F., Zhu, J., Neves, R. I., et al. (2024) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.4c00453 · Cited by 1
Wong, A., & Alejandro, E. U. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1562646 · Cited by 3
Juksar, J., Mijdam, R., Bosman, S., van Oudenaarden, A., Carlotti, F., & de Koning, E. J. P. (2025) · Transplant International · doi:10.3389/ti.2025.13422 · Cited by 2
Hormone-switching islet cells: parallels to transmitter-switching neurons
Dor, Y., & Spitzer, N. C. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1587893 · Cited by 1
Tomosyn-2 Regulates Postnatal β-Cell Expansion and Insulin Secretion to Maintain Glucose Homeostasis
Perez, K. C., Alexander, J., Rahman, M. M., Alsharif, H. A., Liu, Y., Kim, J., Hunter, C. S., Nguyen, T. M., & Bhatnagar, S. (2026) · Diabetes · doi:10.2337/db25-0644 · Cited by 1
Streptozotocin induced hyperglycemia in the axolotl
Sørensen, P. L., Dittrich, A., & Lauridsen, H. (2025) · Developmental Dynamics · doi:10.1002/dvdy.70063 · Cited by 1
Lucibello, G., Ursino, G., Teixeira, P. D. S., Zahorán, S., Fanuele, F., Kallikourdis, M., Visentin, F., Veyrat‐Durebex, C., Widmer, A., Wu, Y., et al. (2025) · Endocrinology · doi:10.1210/endocr/bqaf131 · Cited by 1
Yanai, S., Sasaki, J., Lee, H., Takahashi, F., Kikuchi, Y., Morioka, S., Yamamoto, T., Yuguchi, K., Oikawa, M., Kajiho, H., et al. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2510306122 · Cited by 1
Modeling the spectrum of type 2 diabetes in mice
Grieco-St-Pierre, L., Hoyeck, M. P., Estall, J. L., & Bruin, J. E. (2026) · Endocrinology · doi:10.1210/endocr/bqag005 · Cited by 1
Plasticity and stringency: rethinking stem cell division modes
Bener, M. B., & Inaba, M. (2026) · Biochemical Society Transactions · doi:10.1042/bst20250202 · Cited by 1
Tian, L., Lu, Y., Wu, J., Zhao, G., & Xu, Y. (2026) · Life Sciences · doi:10.1016/j.lfs.2026.124475 · Cited by 1
Singh, S., Pavan, M. K., BARELLA, L. F., Telang, J., Shree, A., Agarwal, S., Goel, A., Thaleshwari, S., Wess, J., Zafar, H., et al. (2026) · Molecular Metabolism · doi:10.1016/j.molmet.2026.102387 · Cited by 4
Lallouet, M., Jaffredo, M., Pirog, A., Leal-Fischer, K., Gaitan, J., Meier, D. T., Renaud, S., Raoux, M., & Lang, J. (2026) · Science Advances · doi:10.1126/sciadv.aea9045 · Cited by 1
Cellular Mechanisms Of Mammalian Liver Regeneration
Yanger, K. (2013) · ScholarlyCommons (University of Pennsylvania) · Cited by 1
Pancreatic Regeneration in the Face of Diabetes
Ahmad, Z. (2012) · Humana Press eBooks · doi:10.1007/978-1-62703-098-4_9 · Cited by 1
Vicente-Salar, N., Santana, A., Juan-Picó, P., Reig, J., & Roche, E. (2013) · Cytotherapy · doi:10.1016/j.jcyt.2012.08.002 · Cited by 1
Stem cell aging and plasticity in the Drosophila nervous system
Flici, H., & Giangrande, A. (2012) · Fly · doi:10.4161/fly.19797 · Cited by 1
The Special Diabetes Program: Past Success, Future Promise
McCage, S., Albanese-O’Neill, A., & Everette, T. D. (2013) · Clinical Diabetes · doi:10.2337/diaclin.31.3.142 · Cited by 1
Criscimanna, A., Speicher, J. A., Houshmand, G., Shiota, C., Prasadan, K. L., Ji, B., Logsdon, C. D., Gittes, G. K., & Esni, F. (2011) · Cited by 1
Models of Regeneration of Beta Cells in Vivo
Ilie, I. R. P., & Ilie, R. (2013) · Cited by 1
Kawamoto, K. (2014) · Journal of Stem Cell Research & Therapy · doi:10.4172/2157-7633.1000221 · Cited by 1
Eliasson, L., & Wendt, A. (2016) · eLife · doi:10.7554/elife.16798 · Cited by 1
PANCREATIC ALPHA CELL DYSFUNCTION IN DIABETES MELLITUS AND ITS MANAGEMENT STRATEGIES
Pradhan, B., & Majhi, C. (2017) · Journal of Evidence Based Medicine and Healthcare · doi:10.18410/jebmh/2017/551 · Cited by 1
In Vivo Reprogramming for Regenerating Insulin-Secreting Cells
Lu, J., & Zhou, Q. (2017) · Stem cell biology and regenerative medicine · doi:10.1007/978-3-319-65720-2_2 · Cited by 1
Davis, M. L., Gassner, K., Barrueco, R. R., & Llobet‐Navàs, D. (2018) · Springer eBooks · doi:10.1007/978-3-319-90695-9_12 · Cited by 1
Anatomy, Physiology, and Embryology of the Pancreas
El‐Gohary, Y., & Gittes, G. K. (2013) · Elsevier eBooks · doi:10.1016/b978-1-4377-2206-2.00087-7 · Cited by 1
Beta Cell Transplantation and Regeneration
Weir, G. C., & Gaglia, J. L. (2015) · Elsevier eBooks · doi:10.1016/b978-0-323-18907-1.00050-0 · Cited by 1
Chawla, P., Delgadillo-Silva, L. F., & Ninov, N. (2019) · Current Opinion in Physiology · doi:10.1016/j.cophys.2019.11.009 · Cited by 1
Toit, D. F. D., Longo‐Mbenza, B., Page, B. J., & Tchokonte-Nana, V. (2011) · International Journal of Diabetes Mellitus · doi:10.1016/j.ijdm.2011.01.007 · Cited by 1
Bulgakova, S. V., Dolgikh, Y. A., Treneva, E. V., Sharonova, L. A., Kosareva, O. V., & Kurmaev, D. P. (2023) · Meditsinskiy sovet = Medical Council · doi:10.21518/ms2023-155 · Cited by 1
Fluorescein-based sensors to purify human α-cells for functional and transcriptomic analyses
Kahraman, S., Shibue, K., Jesus, D. F. D., Kim, H., Hu, J., Manna, D., Wagner, B. K., Choudhary, A., & Kulkarni, R. (2023) · eLife · doi:10.7554/elife.85056 · Cited by 1
Epigenetic modulation of cell fate during pancreas development.
Bele, S. D., Wokasch, A. S., & GANNON, M. A. (2023) · PubMed · Cited by 1
Ex-CyT-ing Applications of Single-cell CyTOF to Human Pancreatic Islets in Diabetes Research
Glorioso, K. E., & Stancill, J. S. (2024) · Endocrinology · doi:10.1210/endocr/bqae122 · Cited by 1
Sweet Spot Regulation of Maternal Metabolic Health and Nutrition on β-Cell Mass in the Offspring
Chung, G., Wong, A., Her, T. K., & Alejandro, E. U. (2024) · Advances in anatomy, embryology and cell biology · doi:10.1007/978-3-031-62232-8_7 · Cited by 1
Massoz, L., Bergemann, D., Lavergne, A., Reynders, C., Désiront, C., Goossens, C., Flasse, L. C., Peers, B., Voz, M. L., & Manfroid, I. (2024) · eLife · doi:10.7554/elife.88813.4 · Cited by 1
Britt, M., Abdilmasih, N., & Rezanejad, H. (2025) · Stem Cell Reviews and Reports · doi:10.1007/s12015-025-10859-y · Cited by 1
Pancreatic Plasticity and Reprogramming: Novel Directions Towards Disease Therapy
Willet, S. G., & Wright, C. V. E. (2011) · Humana Press eBooks · doi:10.1007/978-1-61779-225-0_15 · Cited by 1
Houbracken, I., Mfopou, J. K., & Bouwens, L. (2013) · Springer eBooks · doi:10.1007/978-1-4614-7696-2_20 · Cited by 1
Zulewski, H. (2015) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2015.11.001 · Cited by 1
Piro, S., Urbano, F., Folli, F. B., Finzi, G., Marselli, L., & Marchetti, P. (2016) · Endocrinology · doi:10.1007/978-3-319-27318-1_31-1 · Cited by 1
Pancreatic Islet Beta-Cell Replacement Strategies
Collier, J. J., & Burke, S. J. (2018) · Springer eBooks · doi:10.1007/978-3-319-37076-7_3-1 · Cited by 1
CONCISE REVIEW: β CELL REPLACEMENT THERAPIES IN TREATMENT OF DIABETES MELLITUS
Somuncu, O., ÇELİK, U., ERGUN, B., & Arpalı, E. (2019) · Trakya University Journal of Natural Sciences · doi:10.23902/trkjnat.469530 · Cited by 1
Islet Identity in Transplantation Procedures: The Intersection of Cellular Maturity and Function
Beamish, C. A., & Sabek, O. M. (2019) · OBM Transplantation · doi:10.21926/obm.transplant.1901055 · Cited by 1
Beta Living through Alpha Cells
Patzek, S. M., & Sneddon, J. B. (2019) · Cell stem cell · doi:10.1016/j.stem.2019.03.016 · Cited by 1
Diet as a therapeutic approach to diabetes management and pancreas regeneration
Villani, V., & Perin, L. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-814831-0.00015-4 · Cited by 1
Pancreatic plasticity: epigenetic mechanisms and connections to neoplasia
David, C. J. (2019) · Journal of Pancreatology · doi:10.1097/jp9.0000000000000036 · Cited by 1
The entero-insular axis: a journey in the physiopathology of diabetes
Malaguarnera, R., Scamporrino, A., Filippello, A., Mauro, S. D., Minardo, A., Purrello, F., & Piro, S. (2020) · Exploration of Medicine · doi:10.37349/emed.2020.00025 · Cited by 2
Reviewing Major Mechanisms of β-Cell Regeneration: A Prospective Treatment for Diabetes Mellitus
Jin, E. T., Djabali, E., Dadrass, F., & Hannon, E. (2020) · Georgetown Medical Review · doi:10.52504/001c.12643 · Cited by 2
Effects of a prolonged diet regimen on autophagic function in rat islets with aging
Gu, Z., Miao, X., Cui, J., Yang, F., Ma, L.-C., Li, C., Sun, B., & Yan, S. (2021) · Experimental Gerontology · doi:10.1016/j.exger.2021.111659 · Cited by 2
Piro, S., Urbano, F., Folli, F. B., Finzi, G., Marselli, L., & Marchetti, P. (2018) · Endocrinology · doi:10.1007/978-3-319-44675-2_31 · Cited by 1
Balamurugan, A. N., Loganathan, G., Tweed, B., Tucker, W. W., Venugopal, S., Mokshagundam, S. P., Hughes, M. G., & Williams, S. K. (2016) · Springer eBooks · doi:10.1007/978-3-319-20789-6_9-2 · Cited by 1
Pancreatic Islet Beta-Cell Replacement Strategies
Collier, J. J., & Burke, S. J. (2020) · Springer eBooks · doi:10.1007/978-3-319-08831-0_3 · Cited by 1
Carpino, G., Cardinale, V., Gauido, E., & Alvaro, D. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-814831-0.00026-9 · Cited by 1
Development and maintenance of the islet β cell
Mastracci, T. L., Mirmira, R. G., & Anderson, R. M. (2015) · Wiley eBooks · doi:10.1002/9781118387658.ch4 · Cited by 1
A window in time for β-cell regenerationPreprint
Weidemann, B. J., & Bass, J. T. (2020) · Genes & Development · doi:10.1101/gad.345769.120 · Cited by 1
Hansson, M. D., & Madsen, O. D. (2010) · Stem cell biology and regenerative medicine · doi:10.1007/978-1-60761-959-8_3 · Cited by 1
(2010) · Nature Medicine · doi:10.1038/nm0510-502 · Cited by 1
CRACD suppresses neuroendocrinal plasticity of lung adenocarcinomaPreprint
Kim, B.-J., Zhang, S., Huang, Y., Ko, K.-P., Zou, G., Zhang, J., Jun, S., Kim, K., Jung, Y., Park, K.-S., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.04.19.537576 · Cited by 1
Massoz, L., Bergemann, D., Lavergne, A., Reynders, C., Désiront, C., Goossens, C., Flasse, L. C., Peers, B., Voz, M. L., & Manfroid, I. (2023) · eLife · doi:10.7554/elife.88813 · Cited by 1
Wang, X. (2014) · KTH Publication Database DiVA (KTH Royal Institute of Technology) · Cited by 1
Pre-existing chromatin accessibility primes δ-cells for injury-induced endocrine plasticityPreprint
Graesslin, J., Chawla, P., Subramanian, P., Rajendran, A., Walda, E. I. C., Froschauer, A., Ninov, N., & Junker, J. P. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.05.24.727280 · Cited by 1
“Islet equivalent” stem cells and diabetes
Charif, R. (2013) · doi:10.25560/23899
El ratolí com a sistema model en biologia
Merlos‐Suárez, A. (2011) · RACO (Revistes Catalanes amb Accés Obert) (Consorci de Serveis Universitaris de Catalunya)
Stem Cell Therapies for Type I Diabetes
Ciriza, J., & Manilay, J. O. (2012) · InTech eBooks · doi:10.5772/47803
The Enigma of β-Cell Regeneration in the Adult Pancreas: Self-Renewal Versus Neogenesis
Criscimanna, A., Bertera, S., Esni, F., Trucco, M., & Bottino, R. (2011) · InTech eBooks · doi:10.5772/24421
Perspectives of Cell Therapy in Type 1 Diabetes
Maria, M., Cantaluppi, V., Favaro, E., Camussi, E., Deregibus, M. C., & Camussi, G. (2011) · InTech eBooks · doi:10.5772/22261
Metadata
- Authors
- Thorel, F., Népote, V., Avril, I., Kohno, K., Desgraz, R., Chera, S., & Herrera, P. L.
- Affiliations
- University of Geneva (CH)
- Nara Institute of Science and Technology (JP)
- Corresponding author
- Herrera, Pedro L.
- Venue
- Nature
- Published
- 2010-04-04
- Volume
- 464
- Issue
- 7292
- Pages
- 1149-1154
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC2877635
- OpenAlex
- W2323566388
- Cited by
- 1,136
- References
- 53
- Citations by year
- 2026: 27 · 2025: 40 · 2024: 53 · 2023: 45 · 2022: 53 · 2021: 72 · 2020: 82 · 2019: 81 · 2018: 78 · 2017: 74 · 2016: 78 · 2015: 76 · 2014: 78 · 2013: 107 · 2012: 73
- FWCI
- 100.01
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (U01DK072522)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- pancreatic beta-cell regeneration, beta-cell ablation, diphtheria toxin, insulin therapy, lineage tracing, diabetes treatment, transgenic mouse model, endocrine differentiation
- MeSH terms
- Insulin Secretion, Animals, Cell Count, Cell Differentiation, Diphtheria Toxin, Female, Glucagon, Humans, Insulin, Male, Mice, Transgenic, Regeneration, Biomarkers, Cell Death, Cell Lineage, Cell Proliferation, Glucagon-Secreting Cells, Insulin-Secreting Cells, Mice, Rats, Cell Transdifferentiation, Cellular Reprogramming
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review