Cited by 1,136Pancreatic function and diabetesDiabetes and associated disordersDiabetes Treatment and Management

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Conversion of adult pancreatic α-cells to β-cells after extreme β-cell loss

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Thorel, Fabrizio, Népote, Virginie, Avril, Isabelle, Kohno, Kenji, Desgraz, Renaud, Chera, Simona, Herrera, Pedro L.·2010·Nature

DOI 10.1038/nature08894PMC PMC2877635

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Abstract

Pancreatic insulin-producing beta-cells have a long lifespan, such that in healthy conditions they replicate little during a lifetime. Nevertheless, they show increased self-duplication after increased metabolic demand or after injury (that is, beta-cell loss). It is not known whether adult mammals can differentiate (regenerate) new beta-cells after extreme, total beta-cell loss, as in diabetes. This would indicate differentiation from precursors or another heterologous (non-beta-cell) source. Here we show beta-cell regeneration in a transgenic model of diphtheria-toxin-induced acute selective near-total beta-cell ablation. If given insulin, the mice survived and showed beta-cell mass augmentation with time. Lineage-tracing to label the glucagon-producing alpha-cells before beta-cell ablation tracked large fractions of regenerated beta-cells as deriving from alpha-cells, revealing a previously disregarded degree of pancreatic cell plasticity. Such inter-endocrine spontaneous adult cell conversion could be harnessed towards methods of producing beta-cells for diabetes therapies, either in differentiation settings in vitro or in induced regeneration.

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Manipulating the mouse embryo: A laboratory manual
Johnson, M. (1986) · Trends in Genetics · doi:10.1016/0168-9525(86)90275-1 · Cited by 2,259
Adult pancreatic β-cells are formed by self-duplication rather than stem-cell differentiation
Dor, Y., Brown, J., Martinez, O. I., & Melton, D. A. (2004) · Nature · doi:10.1038/nature02520 · Cited by 2,219
In vivo reprogramming of adult pancreatic exocrine cells to β-cells
Zhou, Q., Brown, J., Kanarek, A., Rajagopal, J., & Melton, D. A. (2008) · Nature · doi:10.1038/nature07314 · Cited by 2,010
Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus
Herold, K. C., Hagopian, W., Auger, J. A., Poumian-Ruiz, E., Taylor, L., Donaldson, D., Gitelman, S. E., Harlan, D. M., Xu, D., Zivin, R. A., et al. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa012864 · Cited by 1,222
Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats.
Xu, G., Stoffers, D. A., Habener, J. F., & Bonner-Weir, S. (1999) · Diabetes · doi:10.2337/diabetes.48.12.2270 · Cited by 1,209
β Cells Can Be Generated from Endogenous Progenitors in Injured Adult Mouse Pancreas
Xu, X., D’Hoker, J., Stangé, G. M., Bonné, S., Leu, N. D., Xiao, X., de Casteele, M. V., Mellitzer, G., Ling, Z., Pipeleers, D., et al. (2008) · Cell · doi:10.1016/j.cell.2007.12.015 · Cited by 1,010
Somatic Sex Reprogramming of Adult Ovaries to Testes by FOXL2 Ablation
Uhlenhaut, N. H., Jakob, S., Anlag, K., Eisenberger, T., Sekido, R., Kress, J., Treier, A.-C., Klugmann, C., Klasen, C., Holter, N. I., et al. (2009) · Cell · doi:10.1016/j.cell.2009.11.021 · Cited by 961
Secretory Granule Exocytosis
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Merino, B., Alonso‐Magdalena, P., Lluesma, M., Ñeco, P., González, A., Marroquí, L., García‐Arévalo, M., Nadal, Á., & Quesada, I. (2015) · Scientific Reports · doi:10.1038/srep11622 · Cited by 36
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Liu, W., Mao, Y., Schoenborn, J., Wang, Z., Tang, G., & Tang, X. (2019) · Nutrition & Metabolism · doi:10.1186/s12986-019-0363-6 · Cited by 39
Reinforcing one-carbon metabolism via folic acid/Folr1 promotes β-cell differentiation
Karampelias, C., Rezanejad, H., Rosko, M., Duan, L., Lu, J., Pazzagli, L., Bertolino, P., Cesta, C. E., Liu, X., Korbutt, G. S., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-23673-0 · Cited by 36
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Krentz, N. A. J., Shea, L. D., Huising, M. O., & Shaw, J. (2021) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(21)00170-4 · Cited by 39
Pancreatic β-Cell Development and RegenerationPreprint
Kerper, N. R., Ashe, S., & Hebrok, M. (2021) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a040741 · Cited by 38
Metabolic adaptations to pregnancy in healthy and gestational diabetic pregnancies: the pancreas - placenta Axis
Szlapinski, S. K., & Hill, D. J. (2020) · Current Vascular Pharmacology · doi:10.2174/1570161118666200320111209 · Cited by 56
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Wei, R., Yang, J., Hou, W., Liu, G., Gao, M., Zhang, L., Wang, H., Mao, G., Gao, H., Chen, G., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0072513 · Cited by 34
In vivo conversion of adult α ‐cells into β ‐like cells: a new research avenue in the context of type 1 diabetes
Courtney, M. L., Pfeifer, A., Al‐Hasani, K., Gjernes, E., Vieira, A., Ben-Othman, N., & Collombat, P. (2011) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2011.01441.x · Cited by 35
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Pancreatic β-cell regeneration: Facultative or dedicated progenitors?
Afelik, S., & Rovira, M. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.11.008 · Cited by 42
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Clayton, H. W., Osipovich, A. B., Stancill, J. S., Schneider, J., Vianna, P. G., Shanks, C. M., Yuan, W., Gu, G., Manduchi, E., Stoeckert, C. J., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.10.068 · Cited by 35
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Chen, H., Zhou, W., Ruan, Y., Yang, L., Xu, N., Chen, R., Yang, R., Sun, J. M., & Zhang, Z. (2018) · Molecular Medicine · doi:10.1186/s10020-018-0044-3 · Cited by 35
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Taguchi, J., & Yamada, Y. (2017) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2017.07.008 · Cited by 34
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Karaköse, E., Ackeifi, C. A., Wang, P., & Stewart, A. F. (2018) · Diabetologia · doi:10.1007/s00125-018-4639-6 · Cited by 33
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Daems, C., Welsch, S., Boughaleb, H., Vanderroost, J., Robert, A. R., Sokal, E. M., & Lysy, P. A. (2019) · Journal of Diabetes Research · doi:10.1155/2019/2813489 · Cited by 34
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Jin, L., Gao, D., Feng, T., Tremblay, J. R., Ghazalli, N., Luo, A., Rawson, J., Quijano, J. C., Chai, J., Wedeken, L., et al. (2016) · Stem Cell Research · doi:10.1016/j.scr.2015.11.015 · Cited by 32
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Persistent hyperinsulinemic hypoglycemia of infancy: constitutive activation of the mTOR pathway with associated exocrine-islet transdifferentiation and therapeutic implications.
Alexandrescu, S., Tatevian, N., Olutoye, O. O., & Brown, R. E. (2010) · PubMed Central · Cited by 33
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Authors: Thorel, F., Népote, V., Avril, I., Kohno, K., Desgraz, R., Chera, S., & Herrera, P. L.
Affiliations: University of Geneva (CH)
Nara Institute of Science and Technology (JP)
Corresponding author: Herrera, Pedro L.
ORCID: Kohno, Kenji
Chera, Simona
Herrera, Pedro L.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2010-04-04
Volume: 464
Issue: 7292
Pages: 1149-1154
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature08894
PMC: PMC2877635
OpenAlex: W2323566388
Cited by: 1,136
References: 53
Citations by year: 2026: 27 · 2025: 40 · 2024: 53 · 2023: 45 · 2022: 53 · 2021: 72 · 2020: 82 · 2019: 81 · 2018: 78 · 2017: 74 · 2016: 78 · 2015: 76 · 2014: 78 · 2013: 107 · 2012: 73
FWCI: 100.01
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
Archive ouverte UNIGE (University of Geneva) (submittedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (U01DK072522)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords: pancreatic beta-cell regeneration, beta-cell ablation, diphtheria toxin, insulin therapy, lineage tracing, diabetes treatment, transgenic mouse model, endocrine differentiation
MeSH terms: Insulin Secretion, Animals, Cell Count, Cell Differentiation, Diphtheria Toxin, Female, Glucagon, Humans, Insulin, Male, Mice, Transgenic, Regeneration, Biomarkers, Cell Death, Cell Lineage, Cell Proliferation, Glucagon-Secreting Cells, Insulin-Secreting Cells, Mice, Rats, Cell Transdifferentiation, Cellular Reprogramming

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Conversion of adult pancreatic α-cells to β-cells after extreme β-cell loss

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