Cited by 1,136Pancreatic function and diabetesDiabetes and associated disordersDiabetes Treatment and Management

The DOI matches its Crossref record; 52 of the 53 references it cites were found in a registry or an index.

Conversion of adult pancreatic α-cells to β-cells after extreme β-cell loss

Open access

Thorel, Fabrizio, Népote, Virginie, Avril, Isabelle, Kohno, Kenji, Desgraz, Renaud, Chera, Simona, Herrera, Pedro L.·2010·Nature

DOI 10.1038/nature08894PMC PMC2877635

Open this paper in CoChat — free account

Abstract

Pancreatic insulin-producing beta-cells have a long lifespan, such that in healthy conditions they replicate little during a lifetime. Nevertheless, they show increased self-duplication after increased metabolic demand or after injury (that is, beta-cell loss). It is not known whether adult mammals can differentiate (regenerate) new beta-cells after extreme, total beta-cell loss, as in diabetes. This would indicate differentiation from precursors or another heterologous (non-beta-cell) source. Here we show beta-cell regeneration in a transgenic model of diphtheria-toxin-induced acute selective near-total beta-cell ablation. If given insulin, the mice survived and showed beta-cell mass augmentation with time. Lineage-tracing to label the glucagon-producing alpha-cells before beta-cell ablation tracked large fractions of regenerated beta-cells as deriving from alpha-cells, revealing a previously disregarded degree of pancreatic cell plasticity. Such inter-endocrine spontaneous adult cell conversion could be harnessed towards methods of producing beta-cells for diabetes therapies, either in differentiation settings in vitro or in induced regeneration.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/nature08894

Cites

52 of 52 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Manipulating the mouse embryo: A laboratory manual
Hogan, B. L. M., Costantini, F. D., & Lacy, E. (1986) · Cited by 4,460
Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus
Srinivas, S., Watanabe, T., Lin, C.-S., William, C. M., Tanabe, Y., Jessell, T. M., & Costantini, F. (2001) · BMC Developmental Biology · doi:10.1186/1471-213x-1-4 · Cited by 3,121
Manipulating the mouse embryo: A laboratory manual
Johnson, M. (1986) · Trends in Genetics · doi:10.1016/0168-9525(86)90275-1 · Cited by 2,259
Adult pancreatic β-cells are formed by self-duplication rather than stem-cell differentiation
Dor, Y., Brown, J., Martinez, O. I., & Melton, D. A. (2004) · Nature · doi:10.1038/nature02520 · Cited by 2,219
In vivo reprogramming of adult pancreatic exocrine cells to β-cells
Zhou, Q., Brown, J., Kanarek, A., Rajagopal, J., & Melton, D. A. (2008) · Nature · doi:10.1038/nature07314 · Cited by 2,010
Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus
Herold, K. C., Hagopian, W., Auger, J. A., Poumian-Ruiz, E., Taylor, L., Donaldson, D., Gitelman, S. E., Harlan, D. M., Xu, D., Zivin, R. A., et al. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa012864 · Cited by 1,222
Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats.
Xu, G., Stoffers, D. A., Habener, J. F., & Bonner-Weir, S. (1999) · Diabetes · doi:10.2337/diabetes.48.12.2270 · Cited by 1,209
β Cells Can Be Generated from Endogenous Progenitors in Injured Adult Mouse Pancreas
Xu, X., D’Hoker, J., Stangé, G. M., Bonné, S., Leu, N. D., Xiao, X., de Casteele, M. V., Mellitzer, G., Ling, Z., Pipeleers, D., et al. (2008) · Cell · doi:10.1016/j.cell.2007.12.015 · Cited by 1,010
Somatic Sex Reprogramming of Adult Ovaries to Testes by FOXL2 Ablation
Uhlenhaut, N. H., Jakob, S., Anlag, K., Eisenberger, T., Sekido, R., Kress, J., Treier, A.-C., Klugmann, C., Klasen, C., Holter, N. I., et al. (2009) · Cell · doi:10.1016/j.cell.2009.11.021 · Cited by 961
Secretory Granule Exocytosis
Burgoyne, R. D., & Morgan, A. (2003) · Physiological Reviews · doi:10.1152/physrev.00031.2002 · Cited by 934

Show all 53 references

Sorted by citations

Items 601–700 of 1,000

Phenotypic plasticity in the pancreas: new triggers, new players
Demcollari, T. I., Cujba, A.-M., & Sancho, R. (2017) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2017.11.014 · Cited by 16
Deciphering the Identity of Renin Cells in Health and Disease
Guessoum, O., Martini, A. G., Sequeira-Lόpez, M. L. S., & Gómez, R. A. (2020) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2020.10.003 · Cited by 16
Effects of first-line diabetes therapy with biguanides, sulphonylurea and thiazolidinediones on the differentiation, proliferation and apoptosis of islet cell populations
Sarnobat, D., Moffett, R. C., Flatt, P. R., & Tarasov, A. I. (2021) · Journal of Endocrinological Investigation · doi:10.1007/s40618-021-01620-6 · Cited by 16
Co‐orthology of P ax4and P ax6to the flyeyelessgene: molecular phylogenetic, comparative genomic, and embryological analyses
Manousaki, T., Feiner, N., Begemann, G., Meyer, A., & Kuraku, S. (2011) · Evolution & Development · doi:10.1111/j.1525-142x.2011.00502.x · Cited by 16
Regenerative medicine using adult neural stem cells: the potential for diabetes therapy and other pharmaceutical applications
Kuwabara, T., & Asashima, M. (2012) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjs016 · Cited by 16
Heterogeneous Expression of Proinsulin Processing Enzymes in Beta Cells of Non-diabetic and Type 2 Diabetic Humans
Teitelman, G. (2019) · Journal of Histochemistry & Cytochemistry · doi:10.1369/0022155419831641 · Cited by 15
Relationships between type 2 diabetes, cell dysfunction, and redox signaling: A meta‐analysis of single‐cell gene expression of human pancreatic α‐ and β‐cells
Marques, E., Formato, E., Liang, W., Leonard, E., & Timme‐Laragy, A. R. (2021) · Journal of Diabetes · doi:10.1111/1753-0407.13236 · Cited by 15
Glycemic control releases regenerative potential of pancreatic beta cells blocked by severe hyperglycemia
Furth‐Lavi, J., Hija, A., Tornovsky-Babeay, S., Mazouz, A., Dahan, T., Stolovich-Rain, M., Klochendler, A., Dor, Y., Avrahami, D., & Gläser, B. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111719 · Cited by 14
A Standardized Method for In Vivo Mouse Pancreas Imaging and Semiquantitative β Cell Mass Measurement by Dual Isotope SPECT
Mathijs, I., Xavier, C., Peleman, C., Caveliers, V., Brom, M., Gotthardt, M., Herrera, P. L., Lahoutte, T., & Bouwens, L. (2014) · Molecular Imaging and Biology · doi:10.1007/s11307-014-0771-y · Cited by 15
Self-citation
Increase of beta cell mass by beta cell replication, but not neogenesis, in the maternal pancreas in mice
Zhao, X. (2014) · Endocrine Journal · doi:10.1507/endocrj.ej14-0040 · Cited by 15
Retinoblastoma tumor suppressor protein in pancreatic progenitors controls α- and β-cell fate
Cai, E. P., Wu, X., Schroer, S. A., Elia, A., Nostro, M. C., Zacksenhaus, E., & Woo, M. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1303386110 · Cited by 16
Resveratrol induces insulin gene expression in mouse pancreatic α-cells
Xie, S. Y., Sinha, R. A., Singh, B. K., Li, G. D., Han, W., & Yen, P. M. (2013) · Cell & Bioscience · doi:10.1186/2045-3701-3-47 · Cited by 15
β-Cell Generation: Can Rodent Studies Be Translated to Humans?
Carlotti, F., Zaldumbide, A., Ellenbroek, J. H., Spijker, H. S., Hoeben, R. C., & de Koning, E. J. P. (2011) · Journal of Transplantation · doi:10.1155/2011/892453 · Cited by 15
Combined Administration of Streptozotocin and Sucrose Accelerates the Appearance of Type 2 Diabetes Symptoms in Rats
Barragán-Bonilla, M. I., Mendoza-Bello, J. M., Aguilera, P., Parra‐Rojas, I., Illades‐Aguiar, B., Ramı́rez, M., & Espinoza-Rojo, M. (2019) · Journal of Diabetes Research · doi:10.1155/2019/3791061 · Cited by 17
Enzymatically stable analogue of the gut‐derived peptide xenin on beta‐cell transdifferentiation in high fat fed and insulin‐deficient Ins1Cre/+;Rosa26‐eYFP mice
Tanday, N., Moffett, R. C., Gault, V. A., Flatt, P. R., & Irwin, N. (2020) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.3384 · Cited by 14
A novel GPR119 agonist DA-1241 preserves pancreatic function via the suppression of ER stress and increased PDX1 expression
Kim, M.-K., Cheong, Y. H., Lee, S. H., Kim, T. H., Jung, I. H., Chae, Y., Lee, J.-H., Yang, E. K., Park, H., Yang, J.-S., et al. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112324 · Cited by 16
IL-2 Immunotherapy Reveals Potential for Innate Beta Cell Regeneration in the Non-Obese Diabetic Mouse Model of Autoimmune Diabetes
Durana, Y. D. D., Lau, J., Knee, D. A., Filippi, C. M., Londei, M., McNamara, P., Nasoff, M. S., DiDonato, M., Glynne, R. J., & Herman, A. E. (2013) · PLoS ONE · doi:10.1371/journal.pone.0078483 · Cited by 15
Direct Reprogramming for Pancreatic Beta-Cells Using Key Developmental Genes
Cavelti‐Weder, C., Li, W., Zumsteg, A., Stemann, M., Yamada, T., Bonner‐Weir, S., Weir, G. C., & Zhou, Q. (2015) · Current Pathobiology Reports · doi:10.1007/s40139-015-0068-0 · Cited by 17
Efficient generation of pancreatic β-like cells from the mouse gallbladder
Wang, Y., Galivo, F., Pelz, C., Haft, A., Lee, J., Kim, S. K., & Grompe, M. (2016) · Stem Cell Research · doi:10.1016/j.scr.2016.10.009 · Cited by 14
Reprogramming of Pancreatic Acinar Cells to Functional Beta Cells by In Vivo Transduction of a Polycistronic Construct Containing Pdx1, Ngn3, MafA in Mice
Cavelti‐Weder, C., Zumsteg, A., Li, W., & Zhou, Q. (2017) · Current Protocols in Stem Cell Biology · doi:10.1002/cpsc.21 · Cited by 15
Taurine improves glucose tolerance in STZ-induced insulin-deficient diabetic mice
Nakatsuru, Y., Murase‐Mishiba, Y., Bessho, M., Terasaki, J., Hanafusa, T., & Imagawa, A. (2018) · Diabetology International · doi:10.1007/s13340-018-0353-3 · Cited by 15
Temporal analysis of distribution pattern of islet cells and antioxidant enzymes for diabetes onset in postnatal critical development window in rats
Gallego, F. Q., Miranda, C. A., Sinzato, Y. K., Iessi, I. L., Dallaqua, B., Hernández‐Pando, R., Rocha, N. S., Volpato, G. T., & Damasceno, D. C. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.03.061 · Cited by 16
Genetic Cell Ablation
Grégoire, D., & Kmita, M. (2013) · Methods in molecular biology · doi:10.1007/978-1-60327-292-6_25 · Cited by 16
Sequential introduction and dosage balance of defined transcription factors affect reprogramming efficiency from pancreatic duct cells into insulin-producing cells
Miyashita, K., Miyatsuka, T., Matsuoka, T., Sasaki, S., Takebe, S., Yasuda, T., Watada, H., Kaneto, H., & Shimomura, I. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.01.083 · Cited by 14
Ptf1a+,ela3l− cells are developmentally maintained progenitors for exocrine regeneration following extreme loss of acinar cells in zebrafish larvae
Schmitner, N., Kohno, K., & Meyer, D. (2017) · Disease Models & Mechanisms · doi:10.1242/dmm.026633 · Cited by 16
Self-citation
Pancreatic endocrine cell arrangement during human ontogeny
Proshchina, A. E., Krivova, Y. S., Barabanov, V. M., & Saveliev, S. V. (2019) · Acta Histochemica · doi:10.1016/j.acthis.2019.05.010 · Cited by 14
Development, regeneration, and physiological expansion of functional β-cells: Cellular sources and regulators
Chernysheva, M. B., Ruchko, E. S., Karimova, M. V., Vorotelyak, E. A., & Vasiliev, А. V. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1424278 · Cited by 16
Concise Reviews: In Vitro-Produced Pancreas Organogenesis Models in Three Dimensions: Self-Organization From Few Stem Cells or Progenitors
Greggio, C., Franceschi, F. D., & Grapin‐Botton, A. (2014) · Stem Cells · doi:10.1002/stem.1828 · Cited by 16
Direct Lineage Conversion of Pancreatic Exocrine to Endocrine Beta Cells In Vivo with Defined Factors
Cavelti‐Weder, C., Li, W., Weir, G. C., & Zhou, Q. (2014) · Methods in molecular biology · doi:10.1007/978-1-4939-0512-6_17 · Cited by 15
A new paradigm in cell therapy for diabetes: Turning pancreatic α‐cells into β‐cells
Sangan, C. B., & Tosh, D. (2010) · BioEssays · doi:10.1002/bies.201000074 · Cited by 14
IL-6-dependent proliferation of alpha cells in mice with partial pancreatic-duct ligation
Cai, Y., Yuchi, Y., Groef, S. D., Coppens, V., Leuckx, G., Baeyens, L., de Casteele, M. V., & Heimberg, H. (2014) · Diabetologia · doi:10.1007/s00125-014-3242-8 · Cited by 13
Combined treatment with a dipeptidyl peptidase‐IV inhibitor (sitagliptin) and an angiotensin II type 1 receptor blocker (losartan) promotes islet regeneration via enhanced differentiation of pancreatic progenitor cells
Liang, J. B., Leung, K. K., Lam, S. Y., & Leung, P. S. (2012) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2012.01612.x · Cited by 14
Activins A and B Regulate Fate-Determining Gene Expression in Islet Cell Lines and Islet Cells From Male Mice
Andrzejewski, D., Brown, M., Ungerleider, N., Burnside, A., & Schneyer, A. L. (2015) · Endocrinology · doi:10.1210/en.2015-1167 · Cited by 14
Development and Regeneration in the Endocrine Pancreas
Mansouri, A. (2012) · ISRN Endocrinology · doi:10.5402/2012/640956 · Cited by 16
Stem Cells in the Treatment of InsulinDependent Diabetes Mellitus
Borisov, M. A., Petrakova, O. S., Gvazava, I. G., Kalistratova, E. N., & Vasiliev, A. V. (2016) · Acta Naturae · doi:10.32607/20758251-2016-8-3-31-43 · Cited by 13
Time zones of pancreatic islet metabolism
Petrenko, V., Philippé, J., & Dibner, C. (2018) · Diabetes Obesity and Metabolism · doi:10.1111/dom.13383 · Cited by 14
miR-29a Negatively Affects Glucose-Stimulated Insulin Secretion and MIN6 Cell Proliferation via Cdc42/β-Catenin Signaling
Duan, J., Qian, X., Li, J., Xiao, X., Lu, X., Lv, L., Huang, Q.-Y., Ding, W., Zhang, H., & Xiong, L. (2019) · International Journal of Endocrinology · doi:10.1155/2019/5219782 · Cited by 14
Advances and complications of regenerative medicine in diabetes therapy
Brovkina, O., & Dashinimaev, E. B. (2020) · PeerJ · doi:10.7717/peerj.9746 · Cited by 14
RasGAP-Derived Fragment N Increases the Resistance of Beta Cells towards Apoptosis in NOD Mice and Delays the Progression from Mild to Overt Diabetes
Bulat, N., Jaccard, E., Peltzer, N., Khalil, H., Yang, J.-Y., Dubuis, G., & Widmann, C. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022609 · Cited by 14
Epigenetic Regulation of Pancreatic Islets
Haumaître, C. (2013) · Current Diabetes Reports · doi:10.1007/s11892-013-0403-y · Cited by 14
Beta-cell function and human islet transplantation: can we improve?
Chen, J. H., & Gunton, J. E. (2021) · Journal of Endocrinology · doi:10.1530/joe-20-0590 · Cited by 16
Improved Tol2-mediated enhancer trap identifies weakly expressed genes during liver and β cell development and regeneration in zebrafish
Zhong, Y., Huang, W., Du, J., Wang, Z., He, J., & Luo, L. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.005568 · Cited by 15
Pax4-Ghrelin mediates the conversion of pancreatic ε-cells to β-cells after extreme β-cell loss in zebrafish
Yu, J., Ma, J., Li, Y., Zhou, Y., Luo, L., & Yang, Y. (2023) · Development · doi:10.1242/dev.201306 · Cited by 13
Pregnancy-induced metabolic reprogramming and regenerative responses to pro-aging stresses
Yu, D., Luo, L., Wang, H., & Shyh‐Chang, N. (2024) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2024.07.011 · Cited by 13
Efficient β-cell regeneration by a combination of neogenesis and replication following β-cell ablation and reversal of pancreatic duct ligation
Hao, E., Lee, S., & Levine, F. (2013) · Stem Cells · doi:10.1002/stem.1492 · Cited by 13
Current status of regeneration of pancreatic β‐cells
Minami, K., & Seino, S. (2013) · Journal of Diabetes Investigation · doi:10.1111/jdi.12062 · Cited by 13
Génération de cellules β-pancréatiques par conversion spontanée de cellules α chez des souris diabétiques
Thorel, F., & Herrera, P. L. (2010) · médecine/sciences · doi:10.1051/medsci/20102611906 · Cited by 13
Self-citation
Cellular stress drives pancreatic plasticity
Valdez, I., Teo, A. K. K., & Kulkarni, R. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.3010577 · Cited by 14
β‐Cell replacement as a treatment for type 1 diabetes: an overview of possible cell sources and current axes of research
Vieira, A., Courtney, M. L., Druelle, N., Avolio, F., Napolitano, T., Hadzic, B., Sanz, S. N., Ben-Othman, N., & Collombat, P. (2016) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12721 · Cited by 12
The Potential of Pancreatic Organoids for Diabetes Research and Therapy
Bittenglová, K., Habart, D., Saudek, F., & Koblas, T. (2021) · Islets · doi:10.1080/19382014.2021.1941555 · Cited by 16
Determinants of Pancreatic Islet Development in Mice and Men: A Focus on the Role of Transcription Factors
Lin, C.-L. V., & Vuguin, P. M. (2012) · Hormone Research in Paediatrics · doi:10.1159/000337219 · Cited by 14
Immunogenicity of β-cells for autologous transplantation in type 1 diabetes
Schuetz, C., & Markmann, J. F. (2015) · Pharmacological Research · doi:10.1016/j.phrs.2015.03.003 · Cited by 13
Progenitor cells and TNF-alpha involvement during morphological changes in pancreatic islets of obese mice
Thole, A. A., Rodrigues-Cunha, A. C. D. S., de Carvalho, S. N., Garcia‐Souza, É. P., Cortez, E. A. C., Stumbo, A. C., de Carvalho, L., & Moura, A. S. (2012) · Tissue and Cell · doi:10.1016/j.tice.2012.04.001 · Cited by 13
Transcriptional and epigenetic regulation in human islets
Bramswig, N. C., & Kaestner, K. H. (2013) · Diabetologia · doi:10.1007/s00125-013-3150-3 · Cited by 12
A synopsis of factors regulating beta cell development and beta cell mass
Prasadan, K. L., Shiota, C., Xiao, X., Ricks, D. M., Fusco, J. C., & Gittes, G. K. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2231-0 · Cited by 13
Respiratory virus-induced heterologous immunity
Pusch, E., Renz, H. E., & Skevaki, C. L. (2018) · Allergo Journal · doi:10.1007/s15007-018-1580-4 · Cited by 13
Wound healing, cellular regeneration and plasticity: the elegans way
Vibert, L., Daulny, A., & Jarriault, S. (2018) · The International Journal of Developmental Biology · doi:10.1387/ijdb.180123sj · Cited by 16
Insulin regulates glucagon-like peptide-1 secretion by pancreatic alpha cells
Liu, P., Song, J., Liu, H., Yan, F., He, T.-Y., Wang, L.-S., Shen, H.-Y., Hou, X.-G., & Chen, L. (2018) · Endocrine · doi:10.1007/s12020-018-1684-3 · Cited by 13
Betacellulin-Induced α-Cell Proliferation Is Mediated by ErbB3 and ErbB4, and May Contribute to β-Cell Regeneration
Lee, Y.-S., Song, G. J., & Jun, H. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.605110 · Cited by 13
Extreme makeover of pancreatic α-cells
Zaret, K. S., & White, M. F. (2010) · Nature · doi:10.1038/4641132a · Cited by 13
β cell regeneration and novel strategies for treatment of diabetes (Review).
Ji, Z., Lu, M., Xie, H., Yuan, H.-G., & Chen, Q. (2022) · Biomedical Reports · doi:10.3892/br.2022.1555 · Cited by 14
CDK8/19 inhibition plays an important role in pancreatic β-cell induction from human iPSCs
Sakuma, K., Tsubooka-Yamazoe, N., Hashimoto, K., Sakai, N., Asano, S., Watanabe-Matsumoto, S., Watanabe, T., Saito, B., Matsumoto, H., Ueno, H., et al. (2023) · Stem cell research & therapeutics · doi:10.1186/s13287-022-03220-4 · Cited by 12
Exploring the Effects of Metabolism-Disrupting Chemicals on Pancreatic α-Cell Viability, Gene Expression and Function: A Screening Testing Approach
Al‐Abdulla, R., Ferrero, H., Boronat‐Belda, T., Soriano, S., Quesada, I., & Alonso‐Magdalena, P. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021044 · Cited by 12
Glucagon-producing α-cell transcriptional identity and reprogramming towards insulin production
Oropeza, D., & Herrera, P. L. (2023) · Trends in Cell Biology · doi:10.1016/j.tcb.2023.07.004 · Cited by 12
Self-citation
Self-inducible secretion of glucagon-like peptide-1 (GLP-1) that allows MIN6 cells to maintain insulin secretion and insure cell survival
Nakashima, K., Shimoda, M., Hamamoto, S., Tatsumi, F., Hirukawa, H., Tawaramoto, K., Kanda, Y., & Kaku, K. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.11.008 · Cited by 13
Ductal Cell Reprogramming to Insulin-Producing Beta-Like Cells as a Potential Beta Cell Replacement Source for Chronic Pancreatitis
Jawahar, A. P., Narayanan, S., Loganathan, G., Pradeep, J., Vitale, G. C., Jones, C. M., Hughes, M. G., Williams, S. K., & Balamurugan, A. N. (2018) · Current Stem Cell Research & Therapy · doi:10.2174/1574888x13666180918092729 · Cited by 13
SETD4-expressing cells contribute to pancreatic development and response to cerulein induced pancreatitis injury
Tian, J.-Z., Xing, S., Feng, J.-Y., Yang, S.-H., Ding, Y.-F., Huang, X.-T., Yang, J.-S., & Yang, W.-J. (2021) · Scientific Reports · doi:10.1038/s41598-021-92075-5 · Cited by 7
Generation of mouse models for type 1 diabetes by selective depletion of pancreatic beta cells using toxin receptor-mediated cell knockout
Matsuoka, K., Saito, M., Shibata, K., Sekine, M., Shitara, H., Taya, C., Zhang, X., Takahashi, T. A., Kohno, K., Kikkawa, Y., et al. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.05.114 · Cited by 12
Self-citation
Transition of Endothelium to Cartilage and Bone
Shoshani, O., & Zipori, D. (2011) · Cell stem cell · doi:10.1016/j.stem.2010.12.004 · Cited by 12
[Reprogramming pancreatic cells to β cells].
Vieira, A., Druelle, N., Courtney, M., Avolio, F., Ben-Othman, N., Pfeifer, A., Gjernes, E., Faurite, B., & Collombat, P. (2013) · Medecine sciences : M/S · doi:10.1051/medsci/2013298014 · Cited by 14
Deletion of the Men1 Gene Prevents Streptozotocin-Induced Hyperglycemia in Mice
Yang, Y., Wang, H., & Hua, X. (2010) · Experimental Diabetes Research · doi:10.1155/2010/876701 · Cited by 12
Beneficial effects of parenteral GLP-1 delivery by cell therapy in insulin-deficient streptozotocin diabetic mice
Vasu, S., Moffett, R. C., McCluskey, J. T., Hamid, M., Irwin, N., & Flatt, P. R. (2013) · Gene Therapy · doi:10.1038/gt.2013.33 · Cited by 12
The Power and the Promise of Cell Reprogramming: Personalized Autologous Body Organ and Cell Transplantation
Palomo, A. B. A., Lucas, M., Dilley, R. J., McLenachan, S., Chen, F. K., Osete, J. R., Farrera-Sal, M., Lucas, A., Álvarez, I., Jaraquemada, D., et al. (2014) · Journal of Clinical Medicine · doi:10.3390/jcm3020373 · Cited by 12
Beta Cell Regeneration in Adult Mice: Controversy Over the Involvement of Stem Cells
Yu, K., Fischbach, S., & Xiao, X. (2014) · Current Stem Cell Research & Therapy · doi:10.2174/1574888x10666141126113110 · Cited by 12
In vivo generation and regeneration of β cells in zebrafish
Yang, B., Covington, B. A., & Chen, W. (2020) · Cell Regeneration · doi:10.1186/s13619-020-00052-6 · Cited by 12
Dreams for Type 1 Diabetes: Shutting Off Autoimmunity and Stimulating β-Cell Regeneration
Weir, G. C., & Bonner‐Weir, S. (2010) · Endocrinology · doi:10.1210/en.2010-0538 · Cited by 12
Nutritional programming of pancreatic β-cell plasticity
Hill, D. J. (2011) · World Journal of Diabetes · doi:10.4239/wjd.v2.i8.119 · Cited by 13
Beta‐cell function in type 2 diabetes ( T2DM ): Can it be preserved or enhanced?
Kassem, L. S., Rajpal, A., Barreiro, M. V. E., & Ismail‐Beigi, F. (2023) · Journal of Diabetes · doi:10.1111/1753-0407.13446 · Cited by 14
The Peutz-Jeghers kinase LKB1 suppresses polyp growth from intestinal cells of a proglucagon-expressing lineage
Zac‐Varghese, S., Trapp, S., Richards, P., Sayers, S. R., Sun, G., Bloom, S. R., Reimann, F. M., Gribble, F. M., & Rutter, G. A. (2014) · Disease Models & Mechanisms · doi:10.1242/dmm.014720 · Cited by 11
Endogenous Mechanisms of Cardiac Regeneration
Xiang, M. S. W., & Kikuchi, K. (2016) · International review of cytology · doi:10.1016/bs.ircmb.2016.04.002 · Cited by 11
Glucose-Lowering by Leptin in the Absence of Insulin Does Not Fully Rely on the Central Melanocortin System in Male Mice
Singha, A. K., Yamaguchi, J., Gonzalez, N. S., Ahmed, N. I., Toney, G. M., & Fujikawa, T. (2019) · Endocrinology · doi:10.1210/en.2018-00907 · Cited by 11
Therapeutic Strategies Targeting Pancreatic Islet β-Cell Proliferation, Regeneration, and Replacement
Goode, R. A., Hum, J. M., & Kalwat, M. A. (2022) · Endocrinology · doi:10.1210/endocr/bqac193 · Cited by 12
β-Cell Neogenesis: Experimental Considerations in Adult Stem Cell Differentiation
Iskovich, S., Goldenberg‐Cohen, N., Stein, J., Yaniv, I., Farkas, D. L., & Askenasy, N. (2010) · Stem Cells and Development · doi:10.1089/scd.2010.0342 · Cited by 11
Incretin hormones and beta-cell mass expansion: what we know and what is missing?
Tortosa, F., & Dotta, F. (2013) · Archives of Physiology and Biochemistry · doi:10.3109/13813455.2013.795175 · Cited by 10
Adult tissue sources for new β cells
Nichols, R. J., New, C., & Annes, J. P. (2013) · Translational research · doi:10.1016/j.trsl.2013.11.012 · Cited by 11
A genetic mouse model for progressive ablation and regeneration of insulin producing beta-cells
Shamsi, F., Parlato, R., Collombat, P., & Mansouri, A. (2014) · Cell Cycle · doi:10.4161/15384101.2014.952176 · Cited by 11
Pancreatic islet cell phenotype and endocrine function throughout diabetes development in non-obese diabetic mice
Kornete, M., Beauchemin, H., Polychronakos, C., & Piccirillo, C. A. (2012) · Autoimmunity · doi:10.3109/08916934.2012.752462 · Cited by 11
Gene Switches for Deliberate Regulation of Transgene Expression: Recent Advances in System Development and Uses
Vilaboa, N. E., Boellmann, F., & Voellmy, R. W. (2011) · Journal of Genetic Syndromes & Gene Therapy · doi:10.4172/2157-7412.1000107 · Cited by 11
GABA signaling: A route to new pancreatic β cells
Rutter, G. A. (2017) · Cell Research · doi:10.1038/cr.2017.20 · Cited by 11
Alpha to Beta Cell Reprogramming: Stepping toward a New Treatment for Diabetes
Osipovich, A. B., & Magnuson, M. A. (2018) · Cell stem cell · doi:10.1016/j.stem.2017.12.012 · Cited by 11
FCoR-Foxo1 Axis Regulates α-Cell Mass through Repression of Arx Expression
Kodani, N., Nakae, J., Kobayashi, M., Kikuchi, O., Kitamura, T., & Itoh, H. (2019) · iScience · doi:10.1016/j.isci.2019.100798 · Cited by 9
Beneficial effects of physical exercise for β‐cell maintenance in a type 1 diabetes mellitus animal model
Villaca, C. B. P., de Paula, C. C., de Oliveira, C. C., Vilas‐Boas, E. A., Santos-Silva, J. C., de Oliveira, S. F., Abdulkader, F., Ferreira, S. M., & Ortis, F. (2021) · Experimental Physiology · doi:10.1113/ep088872 · Cited by 11
Increased NKX6.1 expression and decreased ARX expression in alpha cells accompany reduced beta-cell volume in human subjects
Fujita, Y., Kozawa, J., Fukui, K., Iwahashi, H., Eguchi, H., & Shimomura, I. (2021) · Scientific Reports · doi:10.1038/s41598-021-97235-1 · Cited by 11
Inhibition of SGLT2 Preserves Function and Promotes Proliferation of Human Islets Cells In Vivo in Diabetic Mice
Karlsson, D., Ahnmark, A., Sabirsh, A., Andréasson, A., Gennemark, P., Sandinge, A.-S., Chen, L., Tyrberg, B., Lindén, D., & Winzell, M. S. (2022) · Biomedicines · doi:10.3390/biomedicines10020203 · Cited by 11
Lack of Wdr13 Gene in Mice Leads to Enhanced Pancreatic Beta Cell Proliferation, Hyperinsulinemia and Mild Obesity
Singh, V. P., Lakshmi, B. J., Singh, S., Shah, V., Goel, S., Sarathi, D. P., & Kumar, S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038685 · Cited by 11
Nogo-A Downregulation Improves Insulin Secretion in Mice
Bonal, C., Baronnier, D., Pot, C., Benkhoucha, M., Schwab, M. E., Lalive, P. H., & Herrera, P. L. (2012) · Diabetes · doi:10.2337/db12-0949 · Cited by 11
Self-citation
General Applicability of Synthetic Gene-Overexpression for Cell-Type Ratio Control via Reprogramming
Ishimatsu, K., Hata, T., Mochizuki, A., Sekine, R., Yamamura, M., & Kiga, D. (2013) · ACS Synthetic Biology · doi:10.1021/sb400102w · Cited by 11
Targeting polyamine biosynthesis to stimulate beta cell regeneration in zebrafish
Robertson, M. A., Padgett, L. R., Fine, J. A., Chopra, G., & Mastracci, T. L. (2020) · Islets · doi:10.1080/19382014.2020.1791530 · Cited by 11
Epigenetic landscape of pancreatic neuroendocrine tumours reveals distinct cells of origin and means of tumour progressionPreprint
Domenico, A. D., Pipinikas, C., Maire, R., Bräutigam, K., Simillion, C., Dettmer, M. S., Vassella, E., Thirlwell, C., Perren, A. A., & Marinoni, I. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.04.08.029785 · Cited by 11
Genetic lineage tracing identifies adaptive mechanisms of pancreatic islet β cells in various mouse models of diabetes with distinct age of initiation
Fu, Q., Qian, Y., Jiang, H., He, Y., Dai, H., Chen, Y., Xia, Z., Liang, Y., Zhou, Y., Gao, R., et al. (2023) · Science China Life Sciences · doi:10.1007/s11427-022-2372-y · Cited by 10

Authors: Thorel, F., Népote, V., Avril, I., Kohno, K., Desgraz, R., Chera, S., & Herrera, P. L.
Affiliations: University of Geneva (CH)
Nara Institute of Science and Technology (JP)
Corresponding author: Herrera, Pedro L.
ORCID: Kohno, Kenji
Chera, Simona
Herrera, Pedro L.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2010-04-04
Volume: 464
Issue: 7292
Pages: 1149-1154
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature08894
PMC: PMC2877635
OpenAlex: W2323566388
Cited by: 1,136
References: 53
Citations by year: 2026: 27 · 2025: 40 · 2024: 53 · 2023: 45 · 2022: 53 · 2021: 72 · 2020: 82 · 2019: 81 · 2018: 78 · 2017: 74 · 2016: 78 · 2015: 76 · 2014: 78 · 2013: 107 · 2012: 73
FWCI: 100.01
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
Archive ouverte UNIGE (University of Geneva) (submittedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (U01DK072522)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords: pancreatic beta-cell regeneration, beta-cell ablation, diphtheria toxin, insulin therapy, lineage tracing, diabetes treatment, transgenic mouse model, endocrine differentiation
MeSH terms: Insulin Secretion, Animals, Cell Count, Cell Differentiation, Diphtheria Toxin, Female, Glucagon, Humans, Insulin, Male, Mice, Transgenic, Regeneration, Biomarkers, Cell Death, Cell Lineage, Cell Proliferation, Glucagon-Secreting Cells, Insulin-Secreting Cells, Mice, Rats, Cell Transdifferentiation, Cellular Reprogramming

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Conversion of adult pancreatic α-cells to β-cells after extreme β-cell loss

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks