The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
TAp63 suppresses metastasis through coordinate regulation of Dicer and miRNAs
Open accessAbstract
Aberrant expression of microRNAs (miRNAs) and the enzymes that control their processing have been reported in multiple biological processes including primary and metastatic tumours, but the mechanisms governing this are not clearly understood. Here we show that TAp63, a p53 family member, suppresses tumorigenesis and metastasis, and coordinately regulates Dicer and miR-130b to suppress metastasis. Metastatic mouse and human tumours deficient in TAp63 express Dicer at very low levels, and we found that modulation of expression of Dicer and miR-130b markedly affected the metastatic potential of cells lacking TAp63. TAp63 binds to and transactivates the Dicer promoter, demonstrating direct transcriptional regulation of Dicer by TAp63. These data provide a novel understanding of the roles of TAp63 in tumour and metastasis suppression through the coordinate transcriptional regulation of Dicer and miR-130b and may have implications for the many processes regulated by miRNAs.
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1 retracted
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Cited by
MicroRNA therapeutics: towards a new era for the management of cancer and other diseases
Rupaimoole, R., & Slack, F. J. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.246 · Cited by 4,741
MicroRNA biogenesis pathways in cancer
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Mutant p53 in Cancer: New Functions and Therapeutic Opportunities
Muller, P. A. J., & Vousden, K. H. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.01.021 · Cited by 1,545
Lujambio, A., & Lowe, S. W. (2012) · Nature · doi:10.1038/nature10888 · Cited by 1,084
Metadata
- Authors
- Su, X., Chakravarti, D., Cho, M. S., Liu, L., Gi, Y. J., Lin, Y.-L., Leung, M. L., El-Naggar, A., Creighton, C. J., Suraokar, M. B., Wistuba, I., & Flores, E. R.
- Venue
- Nature
- Published
- 2010-10-20
- Volume
- 467
- Issue
- 7318
- Pages
- 986-990
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2049088975
- Cited by
- 419
- References
- 28
- FWCI
- 12.92
- Type
- journal article
- Language
- en
- Open access
- green
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- Su, X., Chakravarti, D., Cho, M. S., Liu, L., Gi, Y. J., Lin, Y.-L., Leung, M. L., El-Naggar, A., Creighton, C. J., Suraokar, M. B., Wistuba, I., & Flores, E. R. (2010). TAp63 suppresses metastasis through coordinate regulation of Dicer and miRNAs. Nature. https://doi.org/10.1038/nature09459
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