Structural basis of RNA polymerase II backtracking, arrest and reactivation

Structural Basis of Transcription: An RNA Polymerase II Elongation Complex at 3.3 Å Resolution

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Architecture of RNA Polymerase II and Implications for the Transcription Mechanism

Cramer, P., Bushnell, D. A., Fu, J., Gnatt, A. L., Maier-Davis, B., Thompson, N. E., Burgess, R. R., Edwards, A. M., David, P. R., & Kornberg, R. D. (2000) · Science · doi:10.1126/science.288.5466.640 · Cited by 627

Structural Basis of Transcription: Role of the Trigger Loop in Substrate Specificity and Catalysis

Wang, D., Bushnell, D. A., Westover, K. D., Kaplan, C. D., & Kornberg, R. D. (2006) · Cell · doi:10.1016/j.cell.2006.11.023 · Cited by 459

The RNA–DNA Hybrid Maintains the Register of Transcription by Preventing Backtracking of RNA Polymerase

Nudler, E., MUSTAEV, A. A., Goldfarb, A., & LUKHTANOV, E. A. (1997) · Cell · doi:10.1016/s0092-8674(00)80180-4 · Cited by 441

Complete RNA Polymerase II Elongation Complex Structure and Its Interactions with NTP and TFIIS

Kettenberger, H., Armache, K., & Cramer, P. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.11.040 · Cited by 437

Global Analysis of Short RNAs Reveals Widespread Promoter-Proximal Stalling and Arrest of Pol II in Drosophila

Nechaev, S., Fargo, D. C., dos Santos, G., Liu, L., Gao, Y., & Adelman, K. (2010) · Science · doi:10.1126/science.1181421 · Cited by 424

Architecture of the RNA Polymerase II-TFIIS Complex and Implications for mRNA Cleavage

Kettenberger, H., Armache, K., & Cramer, P. (2003) · Cell · doi:10.1016/s0092-8674(03)00598-1 · Cited by 355

A ratchet mechanism of transcription elongation and its control.

Bar-Nahum, G., Epshtein, V., Ruckenstein, A., Rafikov, R., Mustaev, A., & Nudler, E. (2005) · Cell · doi:10.1016/j.cell.2004.11.045 · Cited by 348

Structural basis for substrate loading in bacterial RNA polymerase

Vassylyev, D., Vassylyeva, M. N., Zhang, J.-W., Palangat, M., Artsimovitch, I., & Landick, R. (2007) · Nature · doi:10.1038/nature05931 · Cited by 306

The Human PAF1 Complex Acts in Chromatin Transcription Elongation Both Independently and Cooperatively with SII/TFIIS

Kim, J., Guermah, M., & Roeder, R. G. (2010) · Cell · doi:10.1016/j.cell.2009.12.050 · Cited by 273

Organization and regulation of gene transcription

Cramer, P. (2019) · Nature · doi:10.1038/s41586-019-1517-4 · Cited by 793

Promoter-proximal pausing of RNA polymerase II: a nexus of gene regulationPreprint

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Structural Basis for Helicase-Polymerase Coupling in the SARS-CoV-2 Replication-Transcription Complex

Chen, J., Malone, B. F., Llewellyn, E., Grasso, M. J., Shelton, P. M. M., Olinares, P. D. B., Maruthi, K., Eng, E. T., Vatandaslar, H., Chait, B. T., et al. (2020) · Cell · doi:10.1016/j.cell.2020.07.033 · Cited by 461

Control of Transcriptional Elongation

Kwak, H., & Lis, J. T. (2013) · Annual Review of Genetics · doi:10.1146/annurev-genet-110711-155440 · Cited by 441

Structural Basis of Transcription Initiation

Zhang, Y., Feng, Y., Chatterjee, S., Tuske, S., Ho, M. X., Arnold, E., & Ebright, R. H. (2012) · Science · doi:10.1126/science.1227786 · Cited by 398

Structure of paused transcription complex Pol II–DSIF–NELF

Vos, S. M., Farnung, L., Urlaub, H., & Cramer, P. (2018) · Nature · doi:10.1038/s41586-018-0442-2 · Cited by 399

Gene Expression Is Circular: Factors for mRNA Degradation Also Foster mRNA Synthesis

Haimovich, G., Medina, D. A., Causse, S., Garber, M. G., Millán-Zambrano, G., Barkai, O., Chávez, S., Pérez-Ortín, J. E., Darzacq, X., & Choder, M. (2013) · Cell · doi:10.1016/j.cell.2013.05.012 · Cited by 356

Linking RNA Polymerase Backtracking to Genome Instability in E. coli

Dutta, D., Shatalin, K. Y., Epshtein, V., Gottesman, M. E., & Nudler, E. (2011) · Cell · doi:10.1016/j.cell.2011.07.034 · Cited by 322

Structural biology of SARS-CoV-2: open the door for novel therapies

Yan, W., Zheng, Y., Zeng, X., He, B., & Cheng, W. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-00884-5 · Cited by 314

Structural visualization of key steps in human transcription initiation

He, Y., Fang, J., Taatjes, D. J., & Nogales, E. (2013) · Nature · doi:10.1038/nature11991 · Cited by 304

The central role of RNA in human development and cognition

Mattick, J. S. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.05.001 · Cited by 283

Conflict Resolution in the Genome: How Transcription and Replication Make It Work

Hamperl, S., & Cimprich, K. A. (2016) · Cell · doi:10.1016/j.cell.2016.09.053 · Cited by 285

Systematic Identification of Signal-Activated Stochastic Gene Regulation

Neuert, G., Munsky, B. E., Tan, R. Z., Teytelman, L., Khammash, M., & van Oudenaarden, A. (2013) · Science · doi:10.1126/science.1231456 · Cited by 255

Coupling of RNA Polymerase II Transcription Elongation with Pre-mRNA Splicing

Saldi, T. K., Cortázar, M. A., Sheridan, R. M., & Bentley, D. L. (2016) · Journal of Molecular Biology · doi:10.1016/j.jmb.2016.04.017 · Cited by 266

RNA Polymerase Backtracking in Gene Regulation and Genome Instability

Nudler, E. (2012) · Cell · doi:10.1016/j.cell.2012.06.003 · Cited by 273

Causes and consequences of RNA polymerase II stalling during transcript elongation

González, M. N., Blears, D., & Svejstrup, J. Q. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-00308-8 · Cited by 262

Transcription-mediated replication hindrance: a major driver of genome instabilityPreprint

Gómez‐González, B., & Aguilera, A. (2019) · Genes & Development · doi:10.1101/gad.324517.119 · Cited by 235

Stochastic mechano-chemical kinetics of molecular motors: A multidisciplinary enterprise from a physicist’s perspective

Chowdhury, D. (2013) · Physics Reports · doi:10.1016/j.physrep.2013.03.005 · Cited by 221

RNA polymerase I structure and transcription regulation

Engel, C., Sainsbury, S., Cheung, A. C. M., Kostrewa, D., & Cramer, P. (2013) · Nature · doi:10.1038/nature12712 · Cited by 220

Structure of transcribing mammalian RNA polymerase II

Bernecky, C., Herzog, F., Baumeister, W. P., Plitzko, J. M., & Cramer, P. (2016) · Nature · doi:10.1038/nature16482 · Cited by 228

Structural basis of the nucleosome transition during RNA polymerase II passage

Kujirai, T., Ehara, H., Fujino, Y., Shirouzu, M., Sekine, S., & Kurumizaka, H. (2018) · Science · doi:10.1126/science.aau9904 · Cited by 210

RNA polymerase II speed: a key player in controlling and adapting transcriptome composition

Muniz, L., Nicolas, E., & Trouche, D. (2021) · The EMBO Journal · doi:10.15252/embj.2020105740 · Cited by 198

Stochastic resetting in backtrack recovery by RNA polymerases

Roldán, É., Lisica, A., Sánchez‐Taltavull, D., & Grill, S. W. (2016) · Physical review. E · doi:10.1103/physreve.93.062411 · Cited by 192

Mammalian Transcription-Coupled Excision Repair

Vermeulen, W., & Fousteri, M. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a012625 · Cited by 184

RNA Polymerase Accommodates a Pause RNA Hairpin by Global Conformational Rearrangements that Prolong Pausing

Kang, J. Y., Mishanina, T. V., Bellecourt, M. J., Mooney, R. A., Darst, S. A., & Landick, R. C. (2018) · Molecular Cell · doi:10.1016/j.molcel.2018.01.018 · Cited by 181

Structural Basis for NusA Stabilized Transcriptional Pausing

Guo, X., Myasnikov, A. G., Chen, J., Crucifix, C., Pápai, G., Takács, M., Schultz, P., & Weixlbaumer, A. (2018) · Molecular Cell · doi:10.1016/j.molcel.2018.02.008 · Cited by 170

Transcribing through the nucleosome

Teves, S. S., Weber, C. M., & Henikoff, S. (2014) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2014.10.004 · Cited by 176

RNA polymerase II transcription: Structure and mechanism

Liu, X., Bushnell, D. A., & Kornberg, R. D. (2012) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2012.09.003 · Cited by 167

Coupling of N7-methyltransferase and 3′-5′ exoribonuclease with SARS-CoV-2 polymerase reveals mechanisms for capping and proofreading

Yan, L., Yang, Y., Li, M., Zhang, Y., Zheng, L., Ge, J., Huang, Y., Liu, Z., Wang, T., Gao, S., et al. (2021) · Cell · doi:10.1016/j.cell.2021.05.033 · Cited by 147

Enhanced Chromatin Dynamics by FACT Promotes Transcriptional Restart after UV-Induced DNA Damage

Dinant, C., Ampatziadis-Michailidis, G., Lans, H., Tresini, M., Lagarou, A., Grosbart, M., Theil, A. F., van Cappellen, W. A., Kimurâ, H., Bártek, J., et al. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.08.007 · Cited by 145

The Spt4–Spt5 complex: A multi-faceted regulator of transcription elongation

Hartzog, G. A., & Fu, J. (2012) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2012.08.007 · Cited by 140

A Nexus for Gene Expression—Molecular Mechanisms of Spt5 and NusG in the Three Domains of Life

Werner, F. (2012) · Journal of Molecular Biology · doi:10.1016/j.jmb.2012.01.031 · Cited by 137

Structural Basis of Transcriptional Pausing in Bacteria

Weixlbaumer, A., Leon, K., Landick, R. C., & Darst, S. A. (2013) · Cell · doi:10.1016/j.cell.2012.12.020 · Cited by 140

Structural basis of nucleosome transcription mediated by Chd1 and FACT

Farnung, L., Ochmann, M., Engeholm, M., & Cramer, P. (2021) · Nature Structural & Molecular Biology · doi:10.1038/s41594-021-00578-6 · Cited by 129

Mechanisms of Bacterial Transcription Termination

Roberts, J. W. (2019) · Journal of Molecular Biology · doi:10.1016/j.jmb.2019.04.003 · Cited by 135

Functional Association of Gdown1 with RNA Polymerase II Poised on Human Genes

Cheng, B. W., Li, T., Rahl, P. B., Adamson, T. E., Loudas, N. B., Guo, J., Varzavand, K., Cooper, J. J., Hu, X., Gnatt, A. L., et al. (2012) · Molecular Cell · doi:10.1016/j.molcel.2011.10.022 · Cited by 129

Complete dissection of transcription elongation reveals slow translocation of RNA polymerase II in a linear ratchet mechanism

Dangkulwanich, M., Ishibashi, T., Liu, S.-X., Kireeva, M., Lubkowska, L., Kashlev, M., & Bustamante, C. (2013) · eLife · doi:10.7554/elife.00971 · Cited by 124

Structural basis for backtracking by the SARS-CoV-2 replication–transcription complex

Malone, B. F., Chen, J., Wang, Q., Llewellyn, E., Choi, Y. J., Olinares, P. D. B., Cao, X., Hernández, C., Eng, E. T., Chait, B. T., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2102516118 · Cited by 127

Structural Insights into the Eukaryotic Transcription Initiation Machinery

Nogales, E., Louder, R. K., & He, Y. (2017) · Annual Review of Biophysics · doi:10.1146/annurev-biophys-070816-033751 · Cited by 128

Mechanism of Translesion Transcription by RNA Polymerase II and Its Role in Cellular Resistance to DNA Damage

Walmacq, C., Cheung, A. C. M., Kireeva, M. L., Lubkowska, L., Ye, C., Gotte, D., Strathern, J. N., Carell, T., Cramer, P., & Kashlev, M. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.02.006 · Cited by 124

Dynamics of Pyrophosphate Ion Release and Its Coupled Trigger Loop Motion from Closed to Open State in RNA Polymerase II

Da, L.-T., Wang, D., & Huang, X.-H. (2012) · Journal of the American Chemical Society · doi:10.1021/ja210656k · Cited by 131

Pause & go: from the discovery of RNA polymerase pausing to its functional implications

Mayer, A., Landry, H. M., & Churchman, L. S. (2017) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2017.03.002 · Cited by 125

Structural insights into nuclear transcription by eukaryotic DNA-dependent RNA polymerases

Girbig, M., Misiaszek, A. D., & Müller, C. W. (2022) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00476-9 · Cited by 125

Elongation Factor TFIIS Prevents Transcription Stress and R-Loop Accumulation to Maintain Genome Stability

Zatreanu, D., Han, Z., Mitter, R., Tumini, E., Williams, H., Gregersen, L., Dirac-Svejstrup, A. B., Roma, S., Stewart, A., Aguilera, A., et al. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.07.037 · Cited by 124

Widespread Backtracking by RNA Pol II Is a Major Effector of Gene Activation, 5′ Pause Release, Termination, and Transcription Elongation Rate

Sheridan, R. M., Fong, N., D’Alessandro, A., & Bentley, D. L. (2019) · Molecular Cell · doi:10.1016/j.molcel.2018.10.031 · Cited by 123

Structural Biology of RNA Polymerase II Transcription: 20 Years On

Osman, S., & Cramer, P. (2020) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-042020-021954 · Cited by 120

Nascent RNA structure modulates the transcriptional dynamics of RNA polymerases

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RNA Polymerase II Transcription Elongation Control

Guo, J., & Price, D. H. (2013) · Chemical Reviews · doi:10.1021/cr400105n · Cited by 119

Mechanisms of backtrack recovery by RNA polymerases I and II

Lisica, A., Engel, C., Jahnel, M., Roldán, É., Galburt, E. A., Cramer, P., & Grill, S. W. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1517011113 · Cited by 117

A Movie of RNA Polymerase II Transcription

Cheung, A. C. M., & Cramer, P. (2012) · Cell · doi:10.1016/j.cell.2012.06.006 · Cited by 115

Structural Basis of Transcription: RNA Polymerase Backtracking and Its Reactivation

Abdelkareem, M., Saint-André, C., Takács, M., Pápai, G., Crucifix, C., Guo, X., Ortiz, J. O., & Weixlbaumer, A. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.04.029 · Cited by 111

Structural Basis of RNA Polymerase I Transcription Initiation

Engel, C., Gubbey, T., Neyer, S., Sainsbury, S., Oberthuer, C., Baejen, C., Bernecky, C., & Cramer, P. (2017) · Cell · doi:10.1016/j.cell.2017.03.003 · Cited by 105

Cryo-EM structures of human RNA polymerase III in its unbound and transcribing states

Girbig, M., Misiaszek, A. D., Vorländer, M. K., Lafita, A., Grötsch, H., Baudin, F., Bateman, A. G., & Müller, C. W. (2021) · Nature Structural & Molecular Biology · doi:10.1038/s41594-020-00555-5 · Cited by 105

Transcription-Coupled DNA Repair: From Mechanism to Human Disorder

van den Heuvel, D., van der Weegen, Y., Boer, D. E. C., Ogi, T., & Luijsterburg, M. S. (2021) · Trends in Cell Biology · doi:10.1016/j.tcb.2021.02.007 · Cited by 105

The fate of the messenger is pre-determined: A new model for regulation of gene expression

Haimovich, G., Choder, M., Singer, R. H., & Trcek, T. (2013) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2013.01.004 · Cited by 111

Intragenic Enhancers Attenuate Host Gene Expression

Cinghu, S., Yang, P., Kosak, J. P., Conway, A. E., Kumar, D., Oldfield, A. J., Adelman, K., & Jothi, R. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.09.010 · Cited by 100

Crystal Structure of a Transcribing RNA Polymerase II Complex Reveals a Complete Transcription Bubble

Barnes, C. O., Calero, M., Malik, I., Graham, B. W., Spåhr, H., Lin, G., Cohen, A. E., Brown, I. S., Zhang, Q., Pullara, F., et al. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.06.034 · Cited by 97

Structural basis of transcription elongation

Martínez-Rucobo, F. W., & Cramer, P. (2012) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2012.09.002 · Cited by 102

Histone exchange and histone modifications during transcription and aging

Das, C., & Tyler, J. K. (2011) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2011.08.001 · Cited by 103

Structural basis of initial RNA polymerase II transcription

Cheung, A. C. M., Sainsbury, S., & Cramer, P. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.396 · Cited by 96

Bridge helix bending promotes RNA polymerase II backtracking through a critical and conserved threonine residue

Da, L., Pardo‐Ávila, F., Xu, L., Silva, D., Zhang, L., Gao, X., Wang, D., & Huang, X. (2016) · Nature Communications · doi:10.1038/ncomms11244 · Cited by 91

Transcription factors TFIIF and TFIIS promote transcript elongation by RNA polymerase II by synergistic and independent mechanisms

Schweikhard, V., Meng, C., Murakami, K., Kaplan, C. D., Kornberg, R. D., & Block, S. M. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1405181111 · Cited by 92

Sequence Features and Transcriptional Stalling within Centromere DNA Promote Establishment of CENP-A Chromatin

Catania, S., Pidoux, A. L., & Allshire, R. C. (2015) · PLoS Genetics · doi:10.1371/journal.pgen.1004986 · Cited by 91

The RNA exosome promotes transcription termination of backtracked RNA polymerase II

Lemay, J., Larochelle, M., Marguerat, S., Atkinson, S. R., Bähler, J., & Bachand, F. (2014) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2893 · Cited by 95

The conflict between DNA replication and transcription

McGlynn, P., Savery, N. J., & Dillingham, M. S. (2012) · Molecular Microbiology · doi:10.1111/j.1365-2958.2012.08102.x · Cited by 92

The Ratcheted and Ratchetable Structural States of RNA Polymerase Underlie Multiple Transcriptional Functions

Sekine, S., Murayama, Y., Svetlov, V. V., Nudler, E., & Yokoyama, S. (2015) · Molecular Cell · doi:10.1016/j.molcel.2014.12.014 · Cited by 90

Molecular Structures of Transcribing RNA Polymerase I

Tafur, L., Sadian, Y., Hoffmann, N. A., Jakobi, A. J., Wetzel, R., Hagen, W. J. H., Sachse, C., & Müller, C. W. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.11.013 · Cited by 89

Mechanisms of Transcriptional Pausing in Bacteria

Kang, J. Y., Mishanina, T. V., Landick, R. C., & Darst, S. A. (2019) · Journal of Molecular Biology · doi:10.1016/j.jmb.2019.07.017 · Cited by 95

RNA polymerase I activity is regulated at multiple steps in the transcription cycle: Recent insights into factors that influence transcription elongation

Schneider, D. A. (2011) · Gene · doi:10.1016/j.gene.2011.08.006 · Cited by 87

Architecture of the RNA polymerase II-Paf1C-TFIIS transcription elongation complex

Xu, Y., Bernecky, C., Lee, C., Maier, K. C., Schwalb, B., Tegunov, D., Plitzko, J. M., Urlaub, H., & Cramer, P. (2017) · Nature Communications · doi:10.1038/ncomms15741 · Cited by 91

Mfd Dynamically Regulates Transcription via a Release and Catch-Up Mechanism

Le, T. T., Yang, Y., Tan, C., Suhanovsky, M. M., Fulbright, R. M., Inman, J. T., Li, M., Lee, J., Perelman, S. E., Roberts, J. W., et al. (2017) · Cell · doi:10.1016/j.cell.2017.11.017 · Cited by 85

Negative supercoil at gene boundaries modulates gene topology

Achar, Y. J., Adhil, M., Choudhary, R., Gilbert, N., & Foiani, M. (2020) · Nature · doi:10.1038/s41586-020-1934-4 · Cited by 85

Comparative overview of RNA polymerase II and III transcription cycles, with focus on RNA polymerase III termination and reinitiation

Arimbasseri, G. A., Rijal, K., & Maraia, R. J. (2013) · Transcription · doi:10.4161/trns.27369 · Cited by 82

Structural Basis for the Action of an All-Purpose Transcription Anti-termination Factor

Krupp, F., Said, N., Huang, Y., Loll, B., Bürger, J., Mielke, T., Spahn, C. M. T., & Wahl, M. C. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.01.016 · Cited by 83

Evolution of Two Modes of Intrinsic RNA Polymerase Transcript Cleavage

Ruan, W., Lehmann, E., Thomm, M., Kostrewa, D., & Cramer, P. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.222273 · Cited by 77

Elongation-Competent Pauses Govern the Fidelity of a Viral RNA-Dependent RNA Polymerase

Dulin, D., Vilfan, I. D., Berghuis, B. A., Hage, S., Bamford, D. H., Poranen, M. M., Depken, M., & Dekker, N. H. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.01.031 · Cited by 76

Distinct Mechanisms of Transcription Initiation by RNA Polymerases I and II

Engel, C., Neyer, S., & Cramer, P. (2018) · Annual Review of Biophysics · doi:10.1146/annurev-biophys-070317-033058 · Cited by 72

Stochastic pausing at latent HIV-1 promoters generates transcriptional bursting

Tantale, K., García-Oliver, E., Robert, M.-C., L’Hostis, A., Yang, Y., Tsanov, N., Topno, R., Gostan, T., Kozulic-Pirher, A., Shrivastava, M. B., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-24462-5 · Cited by 75

The Mechanisms of Substrate Selection, Catalysis, and Translocation by the Elongating RNA Polymerase

Belogurov, G. A., & Artsimovitch, I. (2019) · Journal of Molecular Biology · doi:10.1016/j.jmb.2019.05.042 · Cited by 71

Crosslinking-MS analysis reveals RNA polymerase I domain architecture and basis of rRNA cleavage

Jennebach, S., Herzog, F., Aebersold, R. H., & Cramer, P. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks220 · Cited by 72

Effect of a Monofunctional Phenanthriplatin-DNA Adduct on RNA Polymerase II Transcriptional Fidelity and Translesion Synthesis

Kellinger, M. W., Park, G. Y., Chong, J. P. C., Lippard, S. J., & Wang, D. (2013) · Journal of the American Chemical Society · doi:10.1021/ja405475y · Cited by 71

Structures of E. coli σS-transcription initiation complexes provide new insights into polymerase mechanism

Liu, B., Zuo, Y., & Steitz, T. (2016) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1520555113 · Cited by 76

Pol IV and RDR2: A two-RNA-polymerase machine that produces double-stranded RNA

Huang, K., Wu, X., Fang, C., Xu, Z.-G., Zhang, H.-W., Gao, J., Zhou, C., You, L., Gu, Z., Mu, W.-H., et al. (2021) · Science · doi:10.1126/science.abj9184 · Cited by 70

De Novo Heterozygous POLR2A Variants Cause a Neurodevelopmental Syndrome with Profound Infantile-Onset Hypotonia

Haijes, H. A., Koster, M. J. E., Rehmann, H., Li, D., Hakonarson, H. H., Cappuccio, G., Hančárová, M., Lehalle, D., Reardon, W., Schaefer, G. B., et al. (2019) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2019.06.016 · Cited by 70

Feedback to the central dogma: cytoplasmic mRNA decay and transcription are interdependent processes

Hartenian, E., & Glaunsinger, B. A. (2019) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409238.2019.1679083 · Cited by 68

Structural Basis of Poxvirus Transcription: Vaccinia RNA Polymerase Complexes

Grimm, C., Hillen, H. S., Bedenk, K., Bartuli, J., Neyer, S., Zhang, Q., Hüttenhofer, A., Erlacher, M. D., Dienemann, C., Schlösser, A., et al. (2019) · Cell · doi:10.1016/j.cell.2019.11.024 · Cited by 69

NTR1 is required for transcription elongation checkpoints at alternative exons in Arabidopsis

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Structure of the initiation-competent RNA polymerase I and its implication for transcription

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Structure of a backtracked hexasomal intermediate of nucleosome transcription

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