The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Adult hippocampal neurogenesis buffers stress responses and depressive behaviour
Open accessAbstract
Glucocorticoids are released in response to stressful experiences and serve many beneficial homeostatic functions. However, dysregulation of glucocorticoids is associated with cognitive impairments and depressive illness. In the hippocampus, a brain region densely populated with receptors for stress hormones, stress and glucocorticoids strongly inhibit adult neurogenesis. Decreased neurogenesis has been implicated in the pathogenesis of anxiety and depression, but direct evidence for this role is lacking. Here we show that adult-born hippocampal neurons are required for normal expression of the endocrine and behavioural components of the stress response. Using either transgenic or radiation methods to inhibit adult neurogenesis specifically, we find that glucocorticoid levels are slower to recover after moderate stress and are less suppressed by dexamethasone in neurogenesis-deficient mice than intact mice, consistent with a role for the hippocampus in regulation of the hypothalamic-pituitary-adrenal (HPA) axis. Relative to controls, neurogenesis-deficient mice also showed increased food avoidance in a novel environment after acute stress, increased behavioural despair in the forced swim test, and decreased sucrose preference, a measure of anhedonia. These findings identify a small subset of neurons within the dentate gyrus that are critical for hippocampal negative control of the HPA axis and support a direct role for adult neurogenesis in depressive illness.
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“The relatively small number of new neurons in adult brains of humans and rodents is strongly linked to the pathogenesis and remission of neuropsychiatric disorders (38).”
From IL4-driven microglia modulate stress resilience through BDNF-dependent neurogenesis (2021) · cites this paper as [38]
In the citing paper
“Adult neurogenesis in the hippocampus seems to provide resilience to stress-induced anxiety (Anacker et al., 2018; Hill et al., 2015; Snyder et al., 2011).”
From Adult neurogenesis, glia, and the extracellular matrix (2019) · cites this paper as Snyder et al., 2011
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Cites
Physiology and neurobiology of stress and adaptation: central role of the brain
McEwen, B. S. (2007) · Physiological Reviews · doi:10.1152/physrev.00041.2006 · Cited by 5,429
Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants
Santarelli, L., Saxe, M., Gross, C., Surget, A., Battaglia, F., Dulawa, S., Weisstaub, N., Lee, J., Duman, R., Arancio, O., et al. (2003) · Science · doi:10.1126/science.1083328 · Cited by 4,321
Subventricular zone astrocytes are neural stem cells in the adult mammalian brain
Doetsch, F., Caillé, I., Lim, D. A., García-Verdugo, J. M., & Alvarez-Buylla, A. (1999) · Cell · doi:10.1016/s0092-8674(00)80783-7 · Cited by 3,898
Reconsidering anhedonia in depression: Lessons from translational neuroscience
Treadway, M. T., & Zald, D. H. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.06.006 · Cited by 1,579
Astrocytes give rise to new neurons in the adult mammalian hippocampus
Seri, B., Garcı́a-Verdugo, J. M., McEwen, B. S., & Alvarez-Buylla, A. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-18-07153.2001 · Cited by 1,495
David, D. J., Samuels, B. A., Rainer, Q., Wang, J.-W., Marsteller, D., Mendez, I., Drew, M., Craig, D. A., Guiard, B. P., Guilloux, J.-P., et al. (2009) · Neuron · doi:10.1016/j.neuron.2009.04.017 · Cited by 1,267
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Stress and Memory: Behavioral Effects and Neurobiological Mechanisms
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Martins-Macedo, J., Araújo, B., Anjo, S. I., Silveira-Rosa, T., Patrício, P., Alves, N. D., Silva, J. M., Teixeira, F. G., Manadas, B., Rodrigues, A. J., et al. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02490-z · Cited by 6
Metadata
- Authors
- Snyder, J. S., Soumier, A., Brewer, M., Pickel, J., & Cameron, H. A.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Cameron, Heather A.
- Venue
- Nature
- Published
- 2011-08
- Volume
- 476
- Issue
- 7361
- Pages
- 458-461
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC3162077
- OpenAlex
- W2023343492
- Cited by
- 1,473
- References
- 34
- Citations by year
- 2026: 59 · 2025: 61 · 2024: 87 · 2023: 79 · 2022: 96 · 2021: 109 · 2020: 107 · 2019: 93 · 2018: 87 · 2017: 109 · 2016: 132 · 2015: 123 · 2014: 118 · 2013: 97 · 2012: 95
- FWCI
- 34.57
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- National Science Foundation
- GlaxoSmithKline
- National Institutes of Health (Z01‐MH002784)
- National Institute of Mental Health (ZIAMH002784)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- adult hippocampal neurogenesis, stress response, depression, glucocorticoids, hypothalamic-pituitary-adrenal axis, dentate gyrus, anhedonia, food avoidance, behavioural despair, dexamethasone
- MeSH terms
- Animals, Behavior, Animal, Corticosterone, Depression, Dexamethasone, Glucocorticoids, Hippocampus, Hypothalamo-Hypophyseal System, Male, Mice, Inbred C57BL, Mice, Transgenic, Pituitary-Adrenal System, Receptors, Glucocorticoid, Restraint, Physical, Stress, Physiological, Swimming, Dentate Gyrus, Mice, Neurogenesis
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