Cited by 1,473Neurogenesis and neuroplasticity mechanismsStress Responses and CortisolMemory and Neural Mechanisms

The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.

Adult hippocampal neurogenesis buffers stress responses and depressive behaviour

Open access

Snyder, Jason S., Soumier, Amélie, Brewer, Michelle, Pickel, James, Cameron, Heather A.·2011·Nature

DOI 10.1038/nature10287PMC PMC3162077

Open this paper in CoChat — free account

Abstract

Glucocorticoids are released in response to stressful experiences and serve many beneficial homeostatic functions. However, dysregulation of glucocorticoids is associated with cognitive impairments and depressive illness. In the hippocampus, a brain region densely populated with receptors for stress hormones, stress and glucocorticoids strongly inhibit adult neurogenesis. Decreased neurogenesis has been implicated in the pathogenesis of anxiety and depression, but direct evidence for this role is lacking. Here we show that adult-born hippocampal neurons are required for normal expression of the endocrine and behavioural components of the stress response. Using either transgenic or radiation methods to inhibit adult neurogenesis specifically, we find that glucocorticoid levels are slower to recover after moderate stress and are less suppressed by dexamethasone in neurogenesis-deficient mice than intact mice, consistent with a role for the hippocampus in regulation of the hypothalamic-pituitary-adrenal (HPA) axis. Relative to controls, neurogenesis-deficient mice also showed increased food avoidance in a novel environment after acute stress, increased behavioural despair in the forced swim test, and decreased sucrose preference, a measure of anhedonia. These findings identify a small subset of neurons within the dentate gyrus that are critical for hippocampal negative control of the HPA axis and support a direct role for adult neurogenesis in depressive illness.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/nature10287

Cites

34 of 34 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Physiology and neurobiology of stress and adaptation: central role of the brain
McEwen, B. S. (2007) · Physiological Reviews · doi:10.1152/physrev.00041.2006 · Cited by 5,429
Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants
Santarelli, L., Saxe, M., Gross, C., Surget, A., Battaglia, F., Dulawa, S., Weisstaub, N., Lee, J., Duman, R., Arancio, O., et al. (2003) · Science · doi:10.1126/science.1083328 · Cited by 4,321
Subventricular zone astrocytes are neural stem cells in the adult mammalian brain
Doetsch, F., Caillé, I., Lim, D. A., García-Verdugo, J. M., & Alvarez-Buylla, A. (1999) · Cell · doi:10.1016/s0092-8674(00)80783-7 · Cited by 3,898
Reconsidering anhedonia in depression: Lessons from translational neuroscience
Treadway, M. T., & Zald, D. H. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.06.006 · Cited by 1,579
Astrocytes give rise to new neurons in the adult mammalian hippocampus
Seri, B., Garcı́a-Verdugo, J. M., McEwen, B. S., & Alvarez-Buylla, A. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-18-07153.2001 · Cited by 1,495
Neurogenesis-dependent and -independent effects of fluoxetine in an animal model of anxiety/depression
David, D. J., Samuels, B. A., Rainer, Q., Wang, J.-W., Marsteller, D., Mendez, I., Drew, M., Craig, D. A., Guiard, B. P., Guilloux, J.-P., et al. (2009) · Neuron · doi:10.1016/j.neuron.2009.04.017 · Cited by 1,267
GFAP-expressing progenitors are the principal source of constitutive neurogenesis in adult mouse forebrain
Garcia, A. D. R., Doan, N., Imura, T., Bush, T. G., & Sofroniew, M. V. (2004) · Nature Neuroscience · doi:10.1038/nn1340 · Cited by 1,019
Methods of Behavior Analysis in Neuroscience
(2008) · CRC Press eBooks · doi:10.1201/9780367802622 · Cited by 777
Stress and adult neurogenesis
Mirescu, C., & Gould, E. (2006) · Hippocampus · doi:10.1002/hipo.20155 · Cited by 701
Stress and Memory: Behavioral Effects and Neurobiological Mechanisms
Sandi, C., & Pinelo-Nava, M. T. (2007) · Neural Plasticity · doi:10.1155/2007/78970 · Cited by 611

Flagged first, then by citations

Show all 34 references

Sorted by citations

Items 201–300 of 1,001

Untangling the Influences of Voluntary Running, Environmental Complexity, Social Housing and Stress on Adult Hippocampal Neurogenesis
Grégoire, C., Bonenfant, D., Nguyen, A. L., Aumont, A., & Fernandes, K. J. L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0086237 · Cited by 111
Behavioral and structural adaptations to stress
Cameron, H. A., & Schoenfeld, T. J. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2018.02.002 · Cited by 110
Self-citation
Gut microbiota, nutrition, and mental health
Merlo, G., Bachtel, G., & Sugden, S. G. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1337889 · Cited by 110
Region-dependent and stage-specific effects of stress, environmental enrichment, and antidepressant treatment on hippocampal neurogenesis
Tanti, A., Westphal, W.-P., Girault, V., Brizard, B., Devers, S., Leguisquet, A.-M., Surget, A., & Belzung, C. (2013) · Hippocampus · doi:10.1002/hipo.22134 · Cited by 109
Astrocytes’ Contribution to Adult Neurogenesis in Physiology and Alzheimer’s Disease
Cassé, F., Richetin, K., & Toni, N. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00432 · Cited by 109
ADULT NEUROGENESIS IN HUMANS: A Review of Basic Concepts, History, Current Research, and Clinical Implications.
Kumar, A., Pareek, V., Faiq, M. A., Ghosh, S. K., & Kumari, C. (2019) · PubMed · Cited by 110
The Nuclear Receptor REV-ERBα Regulates Fabp7 and Modulates Adult Hippocampal Neurogenesis
Schnell, A., Chappuis, S., Schmutz, I., Brai, E., Ripperger, J. A., Schaad, O., Welzl, H., Descombes, P., Alberi, L. A., & Albrecht, U. (2014) · PLoS ONE · doi:10.1371/journal.pone.0099883 · Cited by 108
Food‐derived hydrophilic antioxidant ergothioneine is distributed to the brain and exerts antidepressant effect in mice
Nakamichi, N., Nakayama, K., Ishimoto, T., Masuo, Y., Wakayama, T., Sekiguchi, H., Sutoh, K., Usumi, K., Iseki, S., & Kato, Y. (2016) · Brain and Behavior · doi:10.1002/brb3.477 · Cited by 107
Stimulation of entorhinal cortex–dentate gyrus circuitry is antidepressive
Yun, S., Reynolds, R. P., Petrof, I., White, A., Rivera, P. D., Segev, A., Gibson, A. D., Suarez, M., DeSalle, M. J., Ito, N., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0002-1 · Cited by 107
Characterization of the role of adult neurogenesis in touch‐screen discrimination learning
Swan, A. A., Clutton, J. E., Chary, P. K., Cook, S. G., Liu, G. G., & Drew, M. R. (2014) · Hippocampus · doi:10.1002/hipo.22337 · Cited by 106
Melatonin improves brain function in a model of chronic Gulf War Illness with modulation of oxidative stress, NLRP3 inflammasomes, and BDNF-ERK-CREB pathway in the hippocampus
Madhu, L. N., Kodali, M., Attaluri, S., Shuai, B., Melissari, L., Rao, X., & Shetty, A. K. (2021) · Redox Biology · doi:10.1016/j.redox.2021.101973 · Cited by 106
Current Understanding of the Neural Stem Cell Niches
Llorente, V., Velarde, P., Desco, M., & Gómez‐Gaviro, M. V. (2022) · Cells · doi:10.3390/cells11193002 · Cited by 106
Hippocampal injury-induced cognitive and mood dysfunction, altered neurogenesis, and epilepsy: Can early neural stem cell grafting intervention provide protection?
Shetty, A. K. (2014) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2013.12.001 · Cited by 106
Social defeat stress induces depression-like behavior and alters spine morphology in the hippocampus of adolescent male C57BL/6 mice
Iñiguez, S. D., Aubry, A., Riggs, L. M., Alipio, J. B., Zanca, R. M., Flores-Ramirez, F. J., Hernandez, M. A., Nieto, S. J., Musheyev, D., & Serrano, P. A. (2016) · Neurobiology of Stress · doi:10.1016/j.ynstr.2016.07.001 · Cited by 105
Brexanolone, a neurosteroid antidepressant, vindicates the GABAergic deficit hypothesis of depression and may foster resilience
Lüscher, B., & Möhler, H. (2019) · F1000Research · doi:10.12688/f1000research.18758.1 · Cited by 105
Hippocampus-dependent learning influences hippocampal neurogenesis
Epp, J. R., Chow, C., & Galea, L. A. M. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00057 · Cited by 105
Late Maturation of Adult-Born Neurons in the Temporal Dentate Gyrus
Snyder, J. S., Ferrante, S. C., & Cameron, H. A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048757 · Cited by 105
Self-citation
24-hour-restraint stress induces long-term depressive-like phenotypes in mice
Chu, X., Zhou, Y., Hu, Z., Lou, J., Song, W., Li, J., Liang, X., Chen, C., Wang, S., Yang, B., et al. (2016) · Scientific Reports · doi:10.1038/srep32935 · Cited by 105
Astrocytic Adenosine 5′-Triphosphate Release Regulates the Proliferation of Neural Stem Cells in the Adult Hippocampus
Cao, X., Li, L., Qin, X., Li, S.-J., Zhang, M., Wang, Q., Hu, H.-H., Fang, Y., Gao, Y., Li, X., et al. (2013) · Stem Cells · doi:10.1002/stem.1408 · Cited by 104
A place for the hippocampus in the cocaine addiction circuit: Potential roles for adult hippocampal neurogenesis
Castilla‐Ortega, E., Serrano, A., Blanco, E., Araos, P. F., Suárez, J., Pavón, F. J., de Fonseca, F. R., & Santín, L. J. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.03.030 · Cited by 104
Neuritin produces antidepressant actions and blocks the neuronal and behavioral deficits caused by chronic stress
Son, H., Banasr, M., Choi, M., Chae, S. Y., Licznerski, P., Lee, B., Voleti, B., Li, N., Lepack, A., Fournier, N. M., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1201191109 · Cited by 103
Neurogenesis in the Normal Ageing Hippocampus: A Mini-Review
Seib, D. R., & Martín-Villalba, A. (2014) · Gerontology · doi:10.1159/000368575 · Cited by 102
mTOR Inhibition Ameliorates Cognitive and Affective Deficits Caused by Disc1 Knockdown in Adult-Born Dentate Granule Neurons
Zhou, M., Li, W., Huang, S., Song, J., Kim, J. Y., Tian, X., Kang, E., Sano, Y., Liu, C. M., Balaji, J., et al. (2013) · Neuron · doi:10.1016/j.neuron.2012.12.033 · Cited by 102
A new look at an old drug: neuroprotective effects and therapeutic potentials of lithium salts
Carmassi, C., Grande, C. D., Gesi, C., Musetti, L., & Dell’Osso, L. (2016) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s106479 · Cited by 102
Adult neurogenesis, human after all (again): Classic, optimized, and future approaches
Lucassen, P. J., Fitzsimons, C. P., Salta, E., & Maletić‐Savatić, M. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.112458 · Cited by 102
Short-Chain Fatty Acids Ameliorate Depressive-like Behaviors of High Fructose-Fed Mice by Rescuing Hippocampal Neurogenesis Decline and Blood–Brain Barrier Damage
Tang, C., Wang, C., Wang, J., Wang, Q., Li, S., Wang, H., Zhou, F., & Li, J. (2022) · Nutrients · doi:10.3390/nu14091882 · Cited by 102
Synaptic Mechanisms Regulating Mood State Transitions in Depression
Parekh, P. K., Johnson, S. B., & Liston, C. (2022) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-110920-040422 · Cited by 101
Hippocampal Plasticity during the Peripartum Period: Influence of Sex Steroids, Stress and Ageing
Galea, L. A. M., Leuner, B., & Slattery, D. A. (2014) · Journal of Neuroendocrinology · doi:10.1111/jne.12177 · Cited by 102
Association between Mastication, the Hippocampus, and the HPA Axis: A Comprehensive Review
Azuma, K., Zhou, Q., Niwa, M., & Kubo, K. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18081687 · Cited by 101
Neuronal nitric oxide synthase and affective disorders
Zhou, Q., Zhu, X., Nemes, A. D., & Zhu, D. (2018) · IBRO Reports · doi:10.1016/j.ibror.2018.11.004 · Cited by 101
Lavender essential oil ameliorates depression-like behavior and increases neurogenesis and dendritic complexity in rats
Sánchez-Vidaña, D. I., Po, K. K. T., Fung, T. K. H., Chow, J. K.-W., Lau, W. K.-W., So, P., Lau, B. W.-M., & Tsang, H. W. H. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.02.042 · Cited by 101
Post-finasteride syndrome: An emerging clinical problem
Diviccaro, S., Melcangi, R. C., & Giatti, S. (2019) · Neurobiology of Stress · doi:10.1016/j.ynstr.2019.100209 · Cited by 101
Olfactory Functioning and Depression: A Systematic Review
Taalman, H., Wallace, C. J. K., & Milev, R. V. (2017) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2017.00190 · Cited by 100
In vivo imaging of adult human hippocampal neurogenesis: progress, pitfalls and promise
Ho, N. F., Hooker, J. M., Sahay, A., Holt, D. J., & Roffman, J. L. (2013) · Molecular Psychiatry · doi:10.1038/mp.2013.8 · Cited by 100
Epigenetics and depressive disorders: a review of current progress and future directions
Januar, V., Saffery, R., & Ryan, J. (2015) · International Journal of Epidemiology · doi:10.1093/ije/dyu273 · Cited by 99
Evidence for Stress-like Alterations in the HPA-Axis in Women Taking Oral Contraceptives
Hertel, J., König, J., Homuth, G., der Auwera, S. V., Wittfeld, K., Pietzner, M., Kacprowski, T., Pfeiffer, L., Kretschmer, A., Waldenberger, M., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-13927-7 · Cited by 99
Curcumin treatment leads to better cognitive and mood function in a model of Gulf War Illness with enhanced neurogenesis, and alleviation of inflammation and mitochondrial dysfunction in the hippocampus
Kodali, M., Hattiangady, B., Shetty, G. A., Bates, A. A., Shuai, B., & Shetty, A. K. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.01.009 · Cited by 99
Glucocorticoid-induced loss of DNA methylation in non-neuronal cells and potential involvement of DNMT1 in epigenetic regulation of Fkbp5
Yang, X., Ewald, E. R., Huo, Y., Tamashiro, K. L., Salvatori, R., Sawa, A., Wand, G. S., & Lee, R. S. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.03.035 · Cited by 99
Antidepressant-like Effects of Electroconvulsive Seizures Require Adult Neurogenesis in a Neuroendocrine Model of Depression
Schloesser, R. J., Orvoën, S., Jimenez, D. V., Hardy, N. F., Maynard, K. R., Sukumar, M., Manji, H. K., Gardier, A. M., David, D. J. P., & Martinowich, K. (2015) · Brain stimulation · doi:10.1016/j.brs.2015.05.011 · Cited by 99
Depletion of adult neurogenesis using the chemotherapy drug temozolomide in mice induces behavioural and biological changes relevant to depression
Egeland, M., Guinaudie, C., Du Preez, A., Musaelyan, K., Zunszain, P. A., Fernandes, C., Pariante, C. M., & Thuret, S. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.68 · Cited by 98
Adiponectin Exerts Neurotrophic Effects on Dendritic Arborization, Spinogenesis, and Neurogenesis of the Dentate Gyrus of Male Mice
Zhang, D., Wang, X., & Lu, X. (2016) · Endocrinology · doi:10.1210/en.2015-2078 · Cited by 98
Anatomical deficits in adult posttraumatic stress disorder: A meta-analysis of voxel-based morphometry studies
Meng, Y., Qiu, C., Zhu, H., Lama, S., Lui, S., Gong, Q., & Zhang, W. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.05.021 · Cited by 97
A central role for the acid sphingomyelinase/ceramide system in neurogenesis and major depression
Gulbins, E., Walter, S., Becker, K. A., Halmer, R., Liu, Y., Reichel, M., Edwards, M. J., Müller, C. P., Fassbender, K. C., & Kornhuber, J. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13145 · Cited by 97
Dorsal and ventral hippocampal adult-born neurons contribute to context fear memory
Huckleberry, K. A., Shue, F., Copeland, T., Chitwood, R. A., Yin, W., & Drew, M. R. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0109-6 · Cited by 97
Structural changes in amygdala nuclei, hippocampal subfields and cortical thickness following electroconvulsive therapy in treatment-resistant depression: longitudinal analysis
Gryglewski, G., Baldinger, P., Seiger, R., Godbersen, G. M., Michenthaler, P., Klöbl, M., Spurny‐Dworak, B., Kautzky, A., Vanicek, T., Kasper, S. F., et al. (2018) · The British Journal of Psychiatry · doi:10.1192/bjp.2018.224 · Cited by 96
GABA B(1) receptor subunit isoforms differentially regulate stress resilience
O’Leary, O. F., Felice, D., Galimberti, S., Savignac, H. M., Bravo, J. A., Crowley, T., Yacoubi, M. E., Vaugeois, J., Gassmann, M., Bettler, B., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1404090111 · Cited by 95
Ceramides and depression: A systematic review
Dinoff, A., Herrmann, N., & Lanctôt, K. L. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.02.008 · Cited by 95
Environmental and pharmacological modulations of cellular plasticity: Role in the pathophysiology and treatment of depression
Ota, K. T., & Duman, R. S. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.05.022 · Cited by 94
JNK1 controls adult hippocampal neurogenesis and imposes cell-autonomous control of anxiety behaviour from the neurogenic niche
Mohammad, H., Marchisella, F., Ortega‐Martínez, S., Hollós, P., Eerola, K., Komulainen, E., Kulesskaya, N., Freemantle, E., Fagerholm, V., Savontous, E., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.203 · Cited by 93
Ethosuximide Induces Hippocampal Neurogenesis and Reverses Cognitive Deficits in an Amyloid-β Toxin-induced Alzheimer Rat Model via the Phosphatidylinositol 3-Kinase (PI3K)/Akt/Wnt/β-Catenin Pathway
Tiwari, S. K., Seth, B., Agarwal, S., Yadav, A., Karmakar, M., Gupta, S. K., Choubey, V., Sharma, A., & Chaturvedi, R. K. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.652586 · Cited by 94
Aspirin binds to PPARα to stimulate hippocampal plasticity and protect memory
Patel, D. R., Roy, A., Kundu, M., Jana, M., Luan, C.-H., Gonzalez, F. J., & Pahan, K. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1802021115 · Cited by 95
Genetic epistasis between the brain-derived neurotrophic factor Val66Met polymorphism and the 5-HTT promoter polymorphism moderates the susceptibility to depressive disorders after childhood abuse
Grabe, H. J., Schwahn, C., Mahler, J., Appel, K., Schulz, A., Spitzer, C., Fenske, K., Barnow, S., Freyberger, H. J., Teumer, A., et al. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2011.09.010 · Cited by 93
Differential Effects of Stress and Glucocorticoids on Adult Neurogenesis
Schoenfeld, T. J., & Gould, E. (2013) · Current topics in behavioral neurosciences · doi:10.1007/7854_2012_233 · Cited by 93
Adult-born neurons facilitate olfactory bulb pattern separation during task engagement
Li, W. L., Chu, M. W., Wu, A., Suzuki, Y., Imayoshi, I., & Komiyama, T. (2018) · eLife · doi:10.7554/elife.33006 · Cited by 93
Effects of Electroconvulsive Therapy on Depression and Its Potential Mechanism
Li, M., Yao, X., Sun, L., Zhao, L., Xu, W., Zhao, H., Zhao, F., Zou, X., Cheng, Z., Li, B., et al. (2020) · Frontiers in Psychology · doi:10.3389/fpsyg.2020.00080 · Cited by 92
Diazepam Binding Inhibitor Promotes Stem Cell Expansion Controlling Environment-Dependent Neurogenesis
Dumitru, I., Neitz, A., Alfonso, J., & Monyer, H. (2017) · Neuron · doi:10.1016/j.neuron.2017.03.003 · Cited by 92
Early and late effects of maternal experience on hippocampal neurogenesis, microglia, and the circulating cytokine milieu
Eid, R. S., Chaiton, J. A., Lieblich, S. E., Bodnar, T. S., Weinberg, J., & Galea, L. A. M. (2019) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2019.01.021 · Cited by 92
The Ups and Downs of Modelling Mood Disorders in Rodents
Slattery, D. A., & Cryan, J. F. (2014) · ILAR Journal · doi:10.1093/ilar/ilu026 · Cited by 92
Astrocytes at the Hub of the Stress Response: Potential Modulation of Neurogenesis by miRNAs in Astrocyte-Derived Exosomes
Luarte, A., Cisternas, P., Caviedes, A., Bátiz, L. F., Lafourcade, C., Wyneken, Ú., & Henzi, R. (2017) · Stem Cells International · doi:10.1155/2017/1719050 · Cited by 91
Epigenetics and epilepsy
Roopra, A., Dingledine, R. J., & Hsieh, J. (2012) · Epilepsia · doi:10.1111/epi.12030 · Cited by 91
Acute psychosocial stress increases serum BDNF levels: an antagonistic relation to cortisol but no group differences after mental training
Linz, R., Puhlmann, L. M. C., Apostolakou, F., Mantzou, A., Papassotiriou, I., Chrousos, G. P., Engert, V., & Singer, T. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0391-y · Cited by 90
Mechanisms for Interferon-α-Induced Depression and Neural Stem Cell Dysfunction
Zheng, L.-S., Hitoshi, S., Kaneko, N., Takao, K., Miyakawa, T., Tanaka, Y., Xia, H., Kalinke, U., Kudo, K., Kanba, S., et al. (2014) · Stem Cell Reports · doi:10.1016/j.stemcr.2014.05.015 · Cited by 90
Saikosaponin D relieves unpredictable chronic mild stress induced depressive-like behavior in rats: involvement of HPA axis and hippocampal neurogenesis
Li, H., Zhao, Y.-H., Zeng, M.-J., Fang, F., Li, M., Qin, T.-T., Ye, L., Li, H.-W., Qu, R., & Ma, S.-P. (2017) · Psychopharmacology · doi:10.1007/s00213-017-4720-8 · Cited by 90
Neurogenesis in neurological and psychiatric diseases and brain injury: From bench to bedside
Ruan, L., Lau, B. W.-M., Wang, J., Huang, L., Zhuge, Q., Wang, B. Z., Jin, K., & So, K. (2014) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.12.006 · Cited by 89
Susceptibility and Resilience to Posttraumatic Stress Disorder–like Behaviors in Inbred Mice
Daws, S. E., Joseph, N. F., Jamieson, S., King, M. L., Chévere-Torres, I., Fuentes, I., Shumyatsky, G. P., Brantley, A. F., Rumbaugh, G., & Miller, C. A. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.06.030 · Cited by 89
Hippocampus and amygdala volume in relation to migraine frequency and prognosis
Liu, H., Chou, K., Lee, P., Fuh, J., Niddam, D. M., Lai, K., Hsiao, F., Lin, Y., Chen, W., Wang, S., et al. (2016) · Cephalalgia · doi:10.1177/0333102416678624 · Cited by 88
Sex Differences in Maturation and Attrition of Adult Neurogenesis in the Hippocampus
Yagi, S., Splinter, J. E. J., Tai, D., Wong, S. J., Wen, Y., & Galea, L. A. M. (2020) · eNeuro · doi:10.1523/eneuro.0468-19.2020 · Cited by 88
Activation of hypothalamic-enhanced adult-born neurons restores cognitive and affective function in Alzheimer’s disease
Li, Y., Luo, Y., Xie, L., Tart, D. S., Sheehy, R. N., Zhang, L., Coleman, L. G., Chen, X., & Song, J. (2023) · Cell stem cell · doi:10.1016/j.stem.2023.02.006 · Cited by 88
Wnt signaling in neuropsychiatric disorders: Ties with adult hippocampal neurogenesis and behavior
Hussaini, S. M. Q., Choi, C., Cho, C. H., Kim, H. J., Jun, H., & Jang, M. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.09.005 · Cited by 88
Rosiglitazone Exerts an Anti-depressive Effect in Unpredictable Chronic Mild-Stress-Induced Depressive Mice by Maintaining Essential Neuron Autophagy and Inhibiting Excessive Astrocytic Apoptosis
Zhao, Z., Zhang, L., Guo, X.-D., Cao, L., Xue, T.-F., Zhao, X., Yang, D., Yang, J., Ji, J., Huang, J.-Y., et al. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00293 · Cited by 88
Retracted
Adult Hippocampal Neurogenesis Modulates Fear Learning through Associative and Nonassociative Mechanisms
Seo, D.-O., Carillo, M. A., Lim, S. C., Tanaka, K. F., & Drew, M. R. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.0483-15.2015 · Cited by 87
Hippocampal dysfunctions caused by cranial irradiation: A review of the experimental evidence
Son, Y., Yang, M., Wang, H., & Moon, C. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.01.007 · Cited by 87
Negr1 controls adult hippocampal neurogenesis and affective behaviors
Noh, K., Lee, H., Choi, T.-Y., Joo, Y., Kim, S.-J., Kim, H., Kim, J. Y., Jahng, J. W., Lee, S., Choi, S.-Y., et al. (2019) · Molecular Psychiatry · doi:10.1038/s41380-018-0347-3 · Cited by 86
Effects of acute treadmill running at different intensities on activities of serotonin and corticotropin-releasing factor neurons, and anxiety- and depressive-like behaviors in rats
Otsuka, T., Nishii, A., Amemiya, S., Kubota, N., Nishijima, T., & Kita, I. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.10.055 · Cited by 86
Protective Autoimmunity: A Unifying Model for the Immune Network Involved in CNS Repair
Schwartz, M., & Raposo, C. (2014) · The Neuroscientist · doi:10.1177/1073858413516799 · Cited by 86
A Runner’s High for New Neurons? Potential Role for Endorphins in Exercise Effects on Adult Neurogenesis
Schoenfeld, T. J., & Swanson, C. (2021) · Biomolecules · doi:10.3390/biom11081077 · Cited by 86
Consequences of cancer treatments on adult hippocampal neurogenesis: implications for cognitive function and depressive symptoms
Pereira Dias, G., Hollywood, R., Bevilaqua, M. C. D. N., da Silveira da Luz, A. C. D., Hindges, R., Nardi, A. E., & Thuret, S. (2014) · Neuro-Oncology · doi:10.1093/neuonc/not321 · Cited by 85
Adult Neurogenesis and Stroke: A Tale of Two Neurogenic Niches
Ceangă, M., Dahab, M., Witte, O. W., & Keiner, S. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.700297 · Cited by 85
A natural carotenoid crocin exerts antidepressant action by promoting adult hippocampal neurogenesis through Wnt/β-catenin signaling
Tao, W., Ruan, J., Wu, R., Zhao, M., Zhao, T. T., Qi, M., Yau, S., Yao, G., Zhang, H., Hu, Y., et al. (2022) · Journal of Advanced Research · doi:10.1016/j.jare.2022.02.015 · Cited by 85
Sex‐dependent regulation of hippocampal neurogenesis under basal and chronic stress conditions in rats
Hillerer, K. M., Neumann, I. D., Couillard‐Després, S., Aigner, L., & Slattery, D. A. (2013) · Hippocampus · doi:10.1002/hipo.22107 · Cited by 85
Switching roles: the functional plasticity of adult tissue stem cells
Wabik, A., & Jones, P. H. (2015) · The EMBO Journal · doi:10.15252/embj.201490386 · Cited by 84
The Ontogeny of Hippocampus-Dependent Memories
Donato, F., Alberini, C. M., Amso, D., Dragoi, G., Dranovsky, A., & Newcombe, N. S. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.1651-20.2020 · Cited by 83
Characterization of cell proliferation throughout the brain of the African cichlid fish Astatotilapia burtoni and its regulation by social status
Maruska, K. P., Carpenter, R. E., & Fernald, R. D. (2012) · The Journal of Comparative Neurology · doi:10.1002/cne.23100 · Cited by 83
Cessation of voluntary wheel running increases anxiety-like behavior and impairs adult hippocampal neurogenesis in mice
Nishijima, T., Llorens-Martı́n, M., Tejeda, G. S., Inoue, K., Yamamura, Y., Soya, H., Trejo, J. L., & Torres‐Alemán, I. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.02.009 · Cited by 83
A dysphoric-like state during early withdrawal from extended access to methamphetamine self-administration in rats
Jang, C., Whitfield, T., Schulteis, G., Koob, G. F., & Wee, S. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2864-0 · Cited by 83
Local and regional heterogeneity underlying hippocampal modulation of cognition and mood
Tannenholz, L., Jimenez, J., & Kheirbek, M. A. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00147 · Cited by 83
Parity modifies the effects of fluoxetine and corticosterone on behavior, stress reactivity, and hippocampal neurogenesis
Workman, J. L., Gobinath, A. R., Kitay, N. F., Chow, C., Brummelte, S., & Galea, L. A. M. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.11.027 · Cited by 82
Baicalin promotes hippocampal neurogenesis via SGK1- and FKBP5-mediated glucocorticoid receptor phosphorylation in a neuroendocrine mouse model of anxiety/depression
Zhang, K., Pan, X., Wang, F., Ma, J., Su, G., Dong, Y., Yang, J., & Wu, C. (2016) · Scientific Reports · doi:10.1038/srep30951 · Cited by 82
Whole-brain gray matter volume abnormalities in patients with generalized anxiety disorder
Moon, C., Kim, G.-W., & Jeong, G. (2014) · Neuroreport · doi:10.1097/wnr.0000000000000100 · Cited by 81
Iptakalim confers an antidepressant effect in a chronic mild stress model of depression through regulating neuro-inflammation and neurogenesis
Lu, M., Yang, J., Geng, F., Ding, J., & Hu, G. (2014) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145714000285 · Cited by 81
Liver Soluble Epoxide Hydrolase Regulates Behavioral and Cellular Effects of Chronic Stress
Qin, X.-H., Wu, Z., Dong, J.-H., Zeng, Y.-N., Xiong, W.-C., Liu, C., Wang, M.-Y., Zhu, M.-Z., Chen, W.-J., Zhang, Y., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.11.006 · Cited by 80
Experience-Dependent Regulation of Dentate Gyrus Excitability by Adult-Born Granule Cells
Park, E., Burghardt, N. S., Dvořák, D., Hen, R., & Fenton, A. A. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.0885-15.2015 · Cited by 80
AKT and MAPK signaling pathways in hippocampus reveals the pathogenesis of depression in four stress-induced models
Li, X., Teng, T., Yan, W., Fan, L., Liu, X., Clarke, G. A., Zhu, D., Jiang, Y., Xiang, Y., Yu, Y., et al. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02486-3 · Cited by 80
Depression and treatment response: dynamic interplay of signaling pathways and altered neural processes
Đurić, V., & Duman, R. S. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1020-7 · Cited by 80
Early Activation of Microglia Triggers Long-Lasting Impairment of Adult Neurogenesis in the Olfactory Bulb
Lazarini, F., Gabellec, M., Torquet, N., & Lledo, P. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.6394-11.2012 · Cited by 80
The protective effects of Ghrelin/GHSR on hippocampal neurogenesis in CUMS mice
Huang, H., Chen, X., Han, Q.-Q., Wang, J., Pilot, A., Yu, R., Liu, Q., Li, B., Wu, G.-C., Wang, Y., et al. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.05.013 · Cited by 79
cAMP-PKA cascade: An outdated topic for depression?
Gao, F., Yang, S., Wang, J., & Zhu, G. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113030 · Cited by 83
Neurotrophic factor-α1 prevents stress-induced depression through enhancement of neurogenesis and is activated by rosiglitazone
Cheng, Y., Rodriguiz, R. M., Murthy, S. R. K., Senatorov, V. V., Thouënnon, E., Cawley, N. X., Aryal, D. K., Ahn, S., Lecka‐Czernik, B., Wetsel, W. C., et al. (2014) · Molecular Psychiatry · doi:10.1038/mp.2014.136 · Cited by 79
Synaptic Zn2+ homeostasis and its significance
Takeda, A., Nakamura, M., Fujii, H., & Tamano, H. (2013) · Metallomics · doi:10.1039/c3mt20269k · Cited by 79
GABAergic Regulation of Adult Hippocampal Neurogenesis
Sibbe, M., & Kulik, Á. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0072-3 · Cited by 79

Authors: Snyder, J. S., Soumier, A., Brewer, M., Pickel, J., & Cameron, H. A.
Affiliations: National Institutes of Health (US)
Corresponding author: Cameron, Heather A.
ORCID: Snyder, Jason S.
Soumier, Amélie
Brewer, Michelle
Pickel, James
Cameron, Heather A.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2011-08
Volume: 476
Issue: 7361
Pages: 458-461
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature10287
PMC: PMC3162077
OpenAlex: W2023343492
Cited by: 1,473
References: 34
Citations by year: 2026: 59 · 2025: 61 · 2024: 87 · 2023: 79 · 2022: 96 · 2021: 109 · 2020: 107 · 2019: 93 · 2018: 87 · 2017: 109 · 2016: 132 · 2015: 123 · 2014: 118 · 2013: 97 · 2012: 95
FWCI: 34.57
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Funders: National Science Foundation
GlaxoSmithKline
National Institutes of Health (Z01‐MH002784)
National Institute of Mental Health (ZIAMH002784)
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: adult hippocampal neurogenesis, stress response, depression, glucocorticoids, hypothalamic-pituitary-adrenal axis, dentate gyrus, anhedonia, food avoidance, behavioural despair, dexamethasone
MeSH terms: Animals, Behavior, Animal, Corticosterone, Depression, Dexamethasone, Glucocorticoids, Hippocampus, Hypothalamo-Hypophyseal System, Male, Mice, Inbred C57BL, Mice, Transgenic, Pituitary-Adrenal System, Receptors, Glucocorticoid, Restraint, Physical, Stress, Physiological, Swimming, Dentate Gyrus, Mice, Neurogenesis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Adult hippocampal neurogenesis buffers stress responses and depressive behaviour

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks