Cited by 319Olfactory and Sensory Function StudiesIon Channels and ReceptorsBiochemical Analysis and Sensing Techniques

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Molecular organization of vomeronasal chemoreception

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Isogai, Yoh, Si, Sheng, Pont-Lezica, Lorena, Tan, Taralyn, Kapoor, Vikrant, Murthy, Venkatesh N., Dulac, Catherine·2011·Nature

DOI 10.1038/nature10437PMC PMC3192931

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Abstract

The vomeronasal organ (VNO) has a key role in mediating the social and defensive responses of many terrestrial vertebrates to species- and sex-specific chemosignals. More than 250 putative pheromone receptors have been identified in the mouse VNO, but the nature of the signals detected by individual VNO receptors has not yet been elucidated. To gain insight into the molecular logic of VNO detection leading to mating, aggression or defensive responses, we sought to uncover the response profiles of individual vomeronasal receptors to a wide range of animal cues. Here we describe the repertoire of behaviourally and physiologically relevant stimuli detected by a large number of individual vomeronasal receptors in mice, and define a global map of vomeronasal signal detection. We demonstrate that the two classes (V1R and V2R) of vomeronasal receptors use fundamentally different strategies to encode chemosensory information, and that distinct receptor subfamilies have evolved towards the specific recognition of certain animal groups or chemical structures. The association of large subsets of vomeronasal receptors with cognate, ethologically and physiologically relevant stimuli establishes the molecular foundation of vomeronasal information coding, and opens new avenues for further investigating the neural mechanisms underlying behaviour specificity.

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The Vomeronasal Organ
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Authors: Isogai, Y., Si, S., Pont-Lezica, L., Tan, T., Kapoor, V., Murthy, V. N., & Dulac, C.
Affiliations: Harvard University (US)
Howard Hughes Medical Institute (US)
Corresponding author: Dulac, Catherine
ORCID: Isogai, Yoh
Si, Sheng
Tan, Taralyn
Kapoor, Vikrant
Murthy, Venkatesh N.
Dulac, Catherine
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2011-09-21
Volume: 478
Issue: 7368
Pages: 241-245
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature10437
PMC: PMC3192931
OpenAlex: W2152243497
Cited by: 317
References: 34
Citations by year: 2026: 10 · 2025: 8 · 2024: 22 · 2023: 21 · 2022: 15 · 2021: 25 · 2020: 24 · 2019: 19 · 2018: 27 · 2017: 16 · 2016: 27 · 2015: 21 · 2014: 31 · 2013: 25 · 2012: 21
FWCI: 13.80
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
RePEc: Research Papers in Economics (submittedVersion)
UCL Discovery (University College London) (submittedVersion)
Funders: Howard Hughes Medical Institute
National Institute on Deafness and Other Communication Disorders (R01DC003903, R01DC009019)
Topics: Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Health Sciences › Nursing › Nutrition and Dietetics › Biochemical Analysis and Sensing Techniques
Keywords: vomeronasal organ, vomeronasal receptors, pheromone receptors, V1R, V2 receptor, kairomones, pheromones, innate behavior, social behavior, aggression, mating behavior, mice
MeSH terms: Animals, Birds, Chemoreceptor Cells, Cues, Female, Gene Expression Regulation, Male, Mammals, Pheromones, Predatory Behavior, Sex Characteristics, Species Specificity, Receptors, Odorant, Vomeronasal Organ, Mice, Early Growth Response Protein 1

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Molecular organization of vomeronasal chemoreception

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