Cited by 533Complement system in diseasesRetinal Diseases and TreatmentsAntioxidant Activity and Oxidative Stress

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Complement factor H binds malondialdehyde epitopes and protects from oxidative stress

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Weismann, David, Hartvigsen, Karsten, Lauer, Nadine, Bennett, Keiryn L., Scholl, Hendrik P. N., Issa, Peter Charbel, Cano, Marisol, Brandstätter, Hubert, Tsimikas, Sotirios, Skerka, Christine, Superti-Furga, Giulio, Handa, James T., Zipfel, Peter F., Witztum, Joseph L., Binder, Christoph J.·2011·Nature

DOI 10.1038/nature10449PMC PMC4826616

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Abstract

Oxidative stress and enhanced lipid peroxidation are linked to many chronic inflammatory diseases, including age-related macular degeneration (AMD). AMD is the leading cause of blindness in Western societies, but its aetiology remains largely unknown. Malondialdehyde (MDA) is a common lipid peroxidation product that accumulates in many pathophysiological processes, including AMD. Here we identify complement factor H (CFH) as a major MDA-binding protein that can block both the uptake of MDA-modified proteins by macrophages and MDA-induced proinflammatory effects in vivo in mice. The CFH polymorphism H402, which is strongly associated with AMD, markedly reduces the ability of CFH to bind MDA, indicating a causal link to disease aetiology. Our findings provide important mechanistic insights into innate immune responses to oxidative stress, which may be exploited in the prevention of and therapy for AMD and other chronic inflammatory diseases.

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Background
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Background
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Background
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BackgroundInfluential
The complement system in lipid-mediated pathologies
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Background
Association of LIPC and advanced age-related macular degeneration
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Background
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“These domains contain a glycosaminoglycan binding site [18] that mediates binding to endothelial cells [19], gangliosides [20], and malondialdehyde moieties on proteins [21].”
Background
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“Oxidative stress suppresses the expression of CFH [43] and promotes complement system activation [44], abolishing its protective function from the lipid peroxidation product [45].”
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Imaging of Oxidation-Specific Epitopes with Targeted Nanoparticles to Detect High-Risk Atherosclerotic Lesions: Progress and Future Directions
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“Cellular PRRs include MSR and toll-like receptors (TLRs) on macrophages, and soluble PPRs include NAbs and innate proteins such as C-reactive protein (CRP), other pentraxins, and the family of complement proteins [60].”
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“Similarly, CFH is able to bind immunogenic ligands such asMDA (23), DNA, histones and annexin-II (44) on the surface of apoptotic and necrotic cells and mediate their anti-inflammatory disposal.”
Background
Retinal Microenvironment Imbalance in Dry Age-Related Macular Degeneration: A Mini-Review
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“44,45 Importantly, we found OSE+ EV to be increased at the cul-prit site of coronary occlusion in AMI, 38 though their functional role in this has not been addressed.”
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“CFH binding to MDA-LDL (noted as CFHMDA-LDL) was measured by ELISA as recently described [17].”
BackgroundMethodInfluential
From compliment to insult: genetics of the complement system in physiology and disease in the human retina
Mullins, R. F., Warwick, A., Sohn, E. H., & Lotery, A. J. (2017) · Human Molecular Genetics · doi:10.1093/hmg/ddx181 · Cited by 19
“The minor allele encodes a histidine at residue 402 of the CFH molecule, which consequently has altered affinity for CRP (58), malondialdehyde (59), zinc (60) and glycos-”
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“Prior studies have reported the downregulation of CFH in retinas from glaucomatous patients and mice exposed to oxidative stress [34,46,47].”
Background
Do Statins Have a Role in the Prevention of Age-Related Macular Degeneration?
Tsao, S. W., & Fong, D. S. (2013) · Drugs & Aging · doi:10.1007/s40266-013-0061-4 · Cited by 16
“Genetic polymorphism in complement factor H, a significant risk factor for AMD [20], leads to dysregulation of the inflammatory response against peroxidized lipids, thereby exacerbating tissue destruction in the setting of AMD [21, 22].”
Background
A Genetic Variant in the SKIV2L Gene Is Significantly Associated With Age-Related Macular Degeneration in a Han Chinese Population
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“Of note the Y402H variant of CFH displays significantly diminished binding to heparan sulphate [9] and to MDA/ MAA modified molecules, and concurrent loss in its ability to inactivate C3b [11].”
BackgroundInfluential
Difference in the Vitreal Protein Profiles of Patients with Proliferative Diabetic Retinopathy with and without Intravitreal Conbercept Injection
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“RCA deposition and the complement system have important roles in tissue homeostasis, clearing dead cells and debris and preventing damage from oxidative stress [24].”
Background
Transcriptome analysis provides insights into the molecular mechanism of hepatocyte apoptosis in response to feeding restriction in juvenile largemouth bass Micropterus salmoides
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“As MDA is generated from the oxidation of unsaturated fatty acids, MDA is present in drusen, the extracellular deposits that accumulate in AMD eyes [24, 25].”
BackgroundMethod
Binding of Gtf2i-β/δ transcription factors to the ARMS2 gene leads to increased circulating HTRA1 in AMD patients and in vitro
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“Since the first discovery of AMD-associated susceptibility genes, namely complement factor H (CFH) on chromosome 1 and ARMS2/HTRA1 on chromosome 10, increasing GWAS sample size has so far failed to uncover any other loci of higher risk (33–35).”
BackgroundInfluential
Moss-produced human complement factor H with modified glycans has an extended half-life and improved biological activity
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“It also interacts with C-reactive protein and malondialdehyde-modi ﬁ ed proteins (87, 90).”
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Bridged emulsion gels from polymer–nanoparticle enabling large-amount biomedical encapsulation and functionalization
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“Furthermore, the CFH variant Tyr402His (rs1061170) within SCR7 that predisposes to AMD results in decreased binding to MDA-epitopes in healthy individuals and AMD patients (52, 105).”
BackgroundInfluential
Shu-Xie decoction alleviates oxidative stress and colon injury in acute sleep-deprived mice by suppressing p62/KEAP1/NRF2/HO1/NQO1 signaling
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“Malondialdehyde (MDA) is the end product of lipid peroxidation and is an effective biomarker of lipid peroxidation and an indirect index of the reactive oxygen species (ROS) levels in the plasma (Weismann et al., 2011).”
Background
Saponins of Tomato Extract Improve Non-Alcoholic Fatty Liver Disease by Regulating Oxidative Stress and Lipid Homeostasis
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“MDA is frequently used as an indicator to gauge the level of oxidative stress [37].”
Background
Purification and biochemical characterization of functional complement factor H from human plasma fractions
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“The latter has been shown to bind malondialdehyde (MDA) derived from docosahexaenoic acid [55].”
Background
Dual roles of different redox forms of complement factor H in protecting against age related macular degeneration
Krilis, M., Qi, M., Qi, J. C., Wong, J. W. H., Guymer, R. H., Liew, G., Hunyor, A. P., Madigan, M. C., McCluskey, P., Weaver, J. C., et al. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.09.034 · Cited by 14
Complement factor H binds malondialdehyde epitopes and protects from oxidative stress
Swami, M. (2011) · Nature Medicine · doi:10.1038/nm.2566 · Cited by 14
Hepatitis E Virus Induces Hepatocyte Apoptosis via Mitochondrial Pathway in Mongolian Gerbils
Yang, Y., Shi, R., Soomro, M. H., Hu, F., Du, F., & She, R. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.00460 · Cited by 14
“…to an inadequately neutralization of oxidative stress (Del Priore et al., 2002; Dunaief et al., 2002; Schutt et al., 2003; Zhou et al., 2005; Weismann et al., 2011), and mitochondrial damage has been associated with oxidative stress related diseases (Chance et al., 1979; Grivennikova et…”
Background
Immunology of age-related macular degeneration
Csaky, K. G., Mettu, P. S., & Cousins, S. W. (2012) · CRC Press eBooks · doi:10.1201/b14548-3 · Cited by 15
Complement factor H in molecular regulation of angiogenesis
Li, J., Wang, K., Starodubtseva, M. N., Nadyrov, E. A., Kapron, C. M., Hoh, J. J., & Liu, J. (2024) · Medical Review · doi:10.1515/mr-2023-0048 · Cited by 15
“The SCRs 7 and 20 facilitate the binding of CFH to MDA [13].”
BackgroundInfluential
Genetic and Epigenetic Biomarkers Linking Alzheimer’s Disease and Age-Related Macular Degeneration
Kaštelan, S., Nikuševa-Martić, T., Pašalić, D., Antunica, A. G., & Zimak, D. M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25137271 · Cited by 15
“These alterations in CFH function diminish its ability to regulate the complement pathway effectively [62].”
Background
Unravelling the therapeutic potential of IL-33 for atrophic AMD
Clare, A. J., Liu, J., Copland, D. A., Theodoropoulou, S., & Dick, A. D. (2021) · Eye · doi:10.1038/s41433-021-01725-5 · Cited by 12
Investigation of cattle plasma proteome in response to pain and inflammation using next generation proteomics technique, SWATH-MS
Ghodasara, P. D., Satake, N., Sadowski, P. G., Kopp, S. R., & Mills, P. C. (2021) · Molecular Omics · doi:10.1039/d1mo00354b · Cited by 13
Label-free and facile electrochemical biosensing using carbon nanotubes for malondialdehyde detection
Yuan, L., Lan, Y., Han, M., Bao, J., Tu, W., & Dai, Z. H. (2013) · The Analyst · doi:10.1039/c3an00041a · Cited by 14
New insight into the role of the complement in the most common types of retinopathy-current literature review
Chrzanowska, M., Modrzejewska, A., & Modrzejewska, M. (2018) · International Journal of Ophthalmology · doi:10.18240/ijo.2018.11.19 · Cited by 14
Comprehensive analysis of the cardiac proteome in a rat model of myocardial ischemia-reperfusion using a TMT-based quantitative proteomic strategy
Lim, S. H., Lee, J., & Han, M. (2020) · Proteome Science · doi:10.1186/s12953-020-00158-4 · Cited by 13
Reactive oxygen species exacerbate autoimmune hemolytic anemia in New Zealand Black mice
Konno, T., Otsuki, N., Kurahashi, T., Kibe, N., Tsunoda, S., Iuchi, Y., & Fujii, J. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.09.021 · Cited by 13
“For example, malondialdehyde, a predominant lipid peroxidation product, is a known epitope for innate immunity [12-14].”
Background
Atp11b Deletion Affects the Gut Microbiota and Accelerates Brain Aging in Mice
Liu, C., Zhang, S., Shi, H., Zhou, H., Zhuang, J., Cao, Y., Ward, N., & Wang, J. (2022) · Brain Sciences · doi:10.3390/brainsci12060709 · Cited by 13
“MDA is a common lipid peroxidation product that accumulates during many pathophysiological processes and can be used as a reliable marker of oxidative stress [43].”
Background
Nucleocytoplasmic transport at the crossroads of proteostasis, neurodegeneration and neuroprotection
Ferreira, P. A. (2023) · FEBS Letters · doi:10.1002/1873-3468.14722 · Cited by 12
Short-term exposure to silver nano-particles alters the physiology and induces stress-related gene expression in Nelumbo nucifera
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Development and application of a nonradioactive binding assay of oxidized low-density lipoprotein to macrophage scavenger receptors
Montano, E. N., Boullier, A., Almazan, F., Binder, C. J., Witztum, J. L., & Hartvigsen, K. (2013) · Journal of Lipid Research · doi:10.1194/jlr.d040923 · Cited by 12
Age-Related Maculopathy Susceptibility 2 and Complement Factor H Polymorphism and Intraocular Complement Activation in Neovascular Age-Related Macular Degeneration
Kato, Y., Oguchi, Y., Omori, T., Kasai, A., Ogasawara, M., Sugano, Y., Itagaki, K., Ojima, A., Ishida, Y., Machida, T., et al. (2022) · Ophthalmology Science · doi:10.1016/j.xops.2022.100167 · Cited by 11
“Besides, CFH is a major malondialdehydebinding protein and an innate defense protein against malondialdehyde, a marker of oxidative stress.(38) The CFH H402 variant binds malondialdehyde less efficiently than the CFH Y402 variant, suggesting that patients with the CFH H402 variant have weak resistance to oxidative”
Background
New insight of complement system in the process of vascular calcification
Liu, A., Luo, P., & Huang, H. (2023) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17732 · Cited by 10
Litchi Pericarp Extract Treats Type 2 Diabetes Mellitus by Regulating Oxidative Stress, Inflammatory Response, and Energy Metabolism
Yang, Z., Zhang, L., Liu, J., & Li, D. (2024) · Antioxidants · doi:10.3390/antiox13040495 · Cited by 11
“…where PEPCK is the key rate-limiting enzyme in the process, and its expression determines the rate of gluconeogenesis [42,43]. rate-limiting enzyme in the process, and its expression determines the rate of gluconeogenesis [42,43 Thus, managing gluconeogenesis is vital for treating type 2 diabetes.”
Tipping the Scale: Atheroprotective IgM-Producing B Cells in Atherosclerosis
Ransegnola, B. P., Pattarabanjird, T., & McNamara, C. A. (2024) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.124.319847 · Cited by 11
Pheomelanin molecular vibration is associated with mitochondrial ROS production in melanocytes and systemic oxidative stress and damage
Galván, I., Jorge, A., & Gil, M. G. (2017) · Integrative Biology · doi:10.1039/c7ib00107j · Cited by 11
Isotypes of autoantibodies against novel differential 4-hydroxy-2-nonenal-modified peptide adducts in serum is associated with rheumatoid arthritis in Taiwanese women
Tsai, K.-L., Chang, C., Chang, Y., Lu, Y., Tsai, I.-J., Chen, J., Lin, S.-H., Tai, C.-C., Lin, Y.-F., Chang, H., et al. (2021) · BMC Medical Informatics and Decision Making · doi:10.1186/s12911-020-01380-y · Cited by 11
“Moreover, it was reported that the HNE modification was unbound by CFAH [59].”
Background
Clinical relevance of nitrated beta 2-glycoprotein I in antiphospholipid syndrome: Implications for thrombosis risk
Krilis, M., Qi, M., Ioannou, Y., Zhang, J. Y., Ahmadi, Z., Wong, J. W. H., Vlachoyiannopoulos, P. G., Moutsopoulos, H. Μ., Koike, T., Sturgess, A. D., et al. (2021) · Journal of Autoimmunity · doi:10.1016/j.jaut.2021.102675 · Cited by 11
Curcumin reduces oxidative stress and fat deposition in longissimus dorsi muscle of intrauterine growth‐retarded finishing pigs
Zhang, J., Yan, E., Zhang, L., Wang, T. Z., & Wang, C. (2022) · Animal Science Journal · doi:10.1111/asj.13741 · Cited by 11
Therapeutic Potential of Targeting Lipid Aldehydes and Lipoxidation End-Products in the Treatment of Ocular Disease
McDowell, R. E., McGeown, J. G., Stitt, A. W., & Curtis, T. M. (2013) · Future Medicinal Chemistry · doi:10.4155/fmc.12.202 · Cited by 11
Probucol Protects Rats from Cardiac Dysfunction Induced by Oxidative Stress following Cardiopulmonary Resuscitation
Xu, X., Hou, H., Lin, V. S. ‐., Ho, D., Tran, K., Che, B., May, A., Zhang, J., Lu, Z., Lu, Z., et al. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/1284804 · Cited by 11
Retracted
A source of exogenous oxidative stress improves oxidative status and favors pheomelanin synthesis in zebra finches
Rodríguez‐Martínez, S., & Galván, I. (2019) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/j.cbpc.2019.108667 · Cited by 11
Sweet turning bitter: Carbohydrate sensing of complement in host defence and disease
Hevey, R., Pouw, R. B., Harris, C. L., & Ricklin, D. (2020) · British Journal of Pharmacology · doi:10.1111/bph.15307 · Cited by 11
“GAGs are proteoglycans with related but distinct structures that can be classified into several groups, including heparin, heparan sulfate and chondroitin sulfate, with particular sulfation patterns affecting their biological activity (Whitelock & Iozzo, 2005).”
Background
Early Transcriptomic Response to OxLDL in Human Retinal Pigment Epithelial Cells
Koirala, D., Beranová-Giorgianni, Š., & Giorgianni, F. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228818 · Cited by 11
“stress-induced protein modifications [17].”
A nasal double DNA adjuvant system induces atheroprotective IgM antibodies via dendritic cell-B-1a B cell interactions
Yoshimatsu, H., Kataoka, K., Fujihashi, K., Miyake, T., & Ono, Y. (2022) · Vaccine · doi:10.1016/j.vaccine.2022.01.027 · Cited by 11
Atypical hemolytic uremic syndrome
Walsh, P. R., & Kavanagh, D. (2025) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2025.05.010 · Cited by 10
Levels of the oxidative stress biomarker malondialdehyde in tears of patients with central serous chorioretinopathy relate to disease activity.
Daruich, A., Sauvain, J., Matet, A., Eperon, S., Schweizer, C., Berthet, A., Danuser, B., & Béhar‐Cohen, F. (2020) · PubMed Central · Cited by 10
Cysteamine-supplemented diet for cashmere goats: A potential strategy to inhibit rumen biohydrogenation and enhance plasma antioxidant capacity
Wu, T., Liang, J., Wang, T., Zhao, R., Ma, Y., Gao, Y., Zhao, S., Chen, G., & Liu, B. (2022) · Frontiers in Veterinary Science · doi:10.3389/fvets.2022.997091 · Cited by 10
“The MDA levels are commonly used as a proxy for lipid peroxidation and cellular damage in vivo (61, 62).”
Method
Human Complement Factor H and Factor H-Like Protein 1 Are Expressed in Human Retinal Pigment Epithelial Cells
Weinberger, A. W. A., Eddahabi, C., Carstesen, D., Zipfel, P. F., Walter, P., & Skerka, C. (2013) · Ophthalmic Research · doi:10.1159/000351624 · Cited by 10
Molecular Mechanisms of Macular Degeneration Associated with the Complement Factor H Y402H Mutation
Harrison, R. E. S., & Morikis, D. (2018) · Biophysical Journal · doi:10.1016/j.bpj.2018.12.007 · Cited by 11
Is Turkish coffee protects Drosophila melanogaster on cadmium acetate toxicity by promoting antioxidant enzymes?
Güneş, E., & Şensoy, E. (2022) · Chemosphere · doi:10.1016/j.chemosphere.2022.133972 · Cited by 10
Bruch’s membrane heparan sulfate retains lipoproteins in the early stages of age-related macular degeneration
Toomey, C. B., Pflugmacher, S., Park, K., Pihl, J., Novak, S. W., Rodriguez, J. W., Jalali, M., Jung, J., Mozafari, M., Omran, S. P., et al. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2500727122 · Cited by 10
“It is noteworthy that drusen are characterized by high concentrations of oxidized lipoproteins and hydroxyapatite, which are believed to contribute to inflammation and serve as a focal point for the pathobiology of AMD ( 16 , 17 ).”
Early development conditions and the oxidative cost of social context in adulthood: an experimental study in birds
Romero‐Haro, A. Á., Canelo, T., & Alonso‐Álvarez, C. (2015) · Frontiers in Ecology and Evolution · doi:10.3389/fevo.2015.00035 · Cited by 9
“…molecule in the lipid peroxidation cascade (Halliwell and Gutteridge, 2007), it has also been shown that MDA molecules form adducts with proteins, promoting inflammatory responses and even mutations leading to different diseases in humans (Tuma, 2002; Del Rio et al., 2005; Weismann et al., 2011).”
Background
Wnt2 overexpression protects against PINK1 mutant‑induced mitochondrial dysfunction and oxidative stress
Xia, S., Wen, X., Fan, X., Chen, X., Wei, Z., Li, Q., & Sun, L. (2020) · Molecular Medicine Reports · doi:10.3892/mmr.2020.11066 · Cited by 9
AAV Gene Augmentation of Truncated Complement Factor H Differentially Rescues Ocular Complement Dysregulation in a Mouse Model
Grigsby, D., Klingeborn, M., Kelly, U., Chew, L. A., Asokan, A., Devlin, G. W., Smith, S. M. R., Keyes, L. R., Timmers, A. M., Scaria, A., et al. (2023) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.64.10.25 · Cited by 8
Cisplatin‐induced oxPAPC release enhances MDSCs infiltration into LL2 tumour tissues through MCP‐1/CCL2 and LTB4/LTB4R pathways
Nie, J. S., Ai, J., Hong, W., Bai, Z., Wang, B., Yang, J., Zhang, Z., Mo, F., Yang, J., Sun, Q., et al. (2023) · Cell Proliferation · doi:10.1111/cpr.13570 · Cited by 8
Scavenger Receptor A Mediates the Clearance and Immunological Screening of MDA-Modified Antigen by M2-Type Macrophages
Warnecke, A., Abele, S., Musunuri, S., Bergquist, J., & Harris, R. A. (2017) · NeuroMolecular Medicine · doi:10.1007/s12017-017-8461-y · Cited by 9
IgM natural antibody T15/E06 in atherosclerosis
Zou, J., Wang, G., Li, H., Yu, X.-H., & Tang, C. (2020) · Clinica Chimica Acta · doi:10.1016/j.cca.2020.01.024 · Cited by 9

Authors: Weismann, D., Hartvigsen, K., Lauer, N., Bennett, K. L., Scholl, H. P. N., Issa, P. C., Cano, M., Brandstätter, H., Tsimikas, S., Skerka, C., Superti-Furga, G., Handa, J. T., Zipfel, P. F., Witztum, J. L., & Binder, C. J.
Affiliations: Austrian Academy of Sciences (AT)
Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Knöll-Institut (HKI) (DE)
Johns Hopkins University (US)
University of Oxford (GB)
Octapharma (Austria) (AT)
University of California San Diego (US)
Corresponding author: Binder, Christoph J.
ORCID: Bennett, Keiryn L.
Scholl, Hendrik P. N.
Issa, Peter Charbel
Tsimikas, Sotirios
Skerka, Christine
Handa, James T.
Zipfel, Peter F.
Witztum, Joseph L.
Binder, Christoph J.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2011-10
Volume: 478
Issue: 7367
Pages: 76-81
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature10449
PMC: PMC4826616
OpenAlex: W2062097745
Cited by: 533
References: 42
Citations by year: 2026: 16 · 2025: 24 · 2024: 25 · 2023: 30 · 2022: 29 · 2021: 42 · 2020: 36 · 2019: 29 · 2018: 33 · 2017: 31 · 2016: 39 · 2015: 42 · 2014: 44 · 2013: 66 · 2012: 44
FWCI: 22.28
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Funders: National Heart, Lung, and Blood Institute (R01-HL086599, HL-088093, P01HL088093)
National Eye Institute (EY14005, R01EY014005, EY019044, R01EY019904)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Complement system in diseases
Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Keywords: complement factor H, malondialdehyde, lipid peroxidation, oxidative stress, age-related macular degeneration, macrophage uptake, pro-inflammatory effects, innate immunity, chronic inflammation, retina
MeSH terms: Animals, Epitopes, Binding Sites, Complement System Proteins, Complement Inactivator Proteins, Enzyme-Linked Immunosorbent Assay, Female, Humans, Inflammation, Macular Degeneration, Male, Malondialdehyde, Mice, Inbred C57BL, Mutation, Necrosis, Protein Binding, Retina, Lipid Peroxidation, Apoptosis, Complement Factor H, Protein Structure, Tertiary, Macrophages, Peritoneal, Oxidative Stress, Mice

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Complement factor H binds malondialdehyde epitopes and protects from oxidative stress

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