The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Complement factor H binds malondialdehyde epitopes and protects from oxidative stress
Open accessAbstract
Oxidative stress and enhanced lipid peroxidation are linked to many chronic inflammatory diseases, including age-related macular degeneration (AMD). AMD is the leading cause of blindness in Western societies, but its aetiology remains largely unknown. Malondialdehyde (MDA) is a common lipid peroxidation product that accumulates in many pathophysiological processes, including AMD. Here we identify complement factor H (CFH) as a major MDA-binding protein that can block both the uptake of MDA-modified proteins by macrophages and MDA-induced proinflammatory effects in vivo in mice. The CFH polymorphism H402, which is strongly associated with AMD, markedly reduces the ability of CFH to bind MDA, indicating a causal link to disease aetiology. Our findings provide important mechanistic insights into innate immune responses to oxidative stress, which may be exploited in the prevention of and therapy for AMD and other chronic inflammatory diseases.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Oxidative stress adducts and components of the complement system have been found to accumulate in drusen and sub-RPE deposits of patients with AMD (Weismann et al., 2011; Shaw et al., 2012), and mice with mutations making them prone to oxidative stress or dysregulation of the complement pathway have been presented as models of AMD (Imamura et al., 2006; Justilien et al., 2007; Hollyfield et al., 2”
From Microtubule motors transport phagosomes in the RPE, and lack of KLC1 leads to AMD-like pathogenesis (2015) · cites this paper as Weismann et al., 2011
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes
Esterbauer, H., Schaur, R. J., & Zollner, H. (1991) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(91)90192-6 · Cited by 6,672
Complement factor H polymorphism in age-related macular degeneration
Klein, R. J., Zeiss, C., Chew, E. Y., Tsai, J.-Y., Sackler, R. S., Haynes, C., Henning, A. K., SanGiovanni, J. P., Mane, S. M., Mayne, S. T., et al. (2005) · Science · doi:10.1126/science.1109557 · Cited by 4,492
Complement factor H polymorphism and age-related macular degeneration
Edwards, A. O., Ritter, R., Abel, K. J., Manning, A., Panhuysen, C., & Farrer, L. A. (2005) · Science · doi:10.1126/science.1110189 · Cited by 2,449
Complement factor H variant increases the risk of age-related macular degeneration
Haines, J. L., Hauser, M. A., Schmidt, S., Scott, W. K., Olson, L. M., Gallins, P., Spencer, K. L., Kwan, S. Y., Noureddine, M., Gilbert, J. R., et al. (2005) · Science · doi:10.1126/science.1110359 · Cited by 2,424
Hageman, G. S., Anderson, D. H., Johnson, L. V., Hancox, L. S., Taiber, A. J., Hardisty, L. I., Hageman, J. L., Stockman, H. A., Borchardt, J. D., Gehrs, K. M., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501536102 · Cited by 1,961
A blast from the past: clearance of apoptotic cells regulates immune responses
Savill, J., Dransfield, I., Gregory, C. D., & Haslett, C. (2002) · Nature reviews. Immunology · doi:10.1038/nri957 · Cited by 1,574
Age-related macular degeneration
Jager, R. D., Mieler, W. F., & Miller, J. W. (2008) · New England Journal of Medicine · doi:10.1056/nejmra0801537 · Cited by 1,379
Complement regulators and inhibitory proteins
Zipfel, P. F., & Skerka, C. (2009) · Nature reviews. Immunology · doi:10.1038/nri2620 · Cited by 1,268
Age-related macular degeneration
de Jong, P. T. V. M. (2006) · New England Journal of Medicine · doi:10.1056/nejmra062326 · Cited by 787
Age-related Macular Degeneration Histopathologic Studies
Green, W. R., & Enger, C. (1993) · Ophthalmology · doi:10.1016/s0161-6420(93)31466-1 · Cited by 757
Cited by
Sorted by citations
Items 401–500 of 533
Oxidation specific epitopes in asthma: New possibilities for treatment
Pascoe, C. D., Vaghasiya, J. M., & Halayko, A. J. (2020) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2020.105864 · Cited by 9
New Technologies to Study Functional Genomics of Age-Related Macular Degeneration
Nguyen, T., Urrutia-Cabrera, D., Liou, R. H.-C., Luu, C. D., Guymer, R. H., & Wong, R. C. B. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.604220 · Cited by 9
“This polymorphism has been demonstrated to decrease CFH binding to C reactive protein, heparin, Streptococcus M protein, malondialdehyde epitopes, oxidized phospholipids, as well as heparan sulfate and dermatan sulfate glycosaminoglycans within Bruch’s membrane (Skerka et al., 2007; Yu et al., 2007; Ormsby et al., 200…”
BackgroundÄtiologie und Pathogenese der altersabhängigen Makuladegeneration
Herrmann, P., Holz, F. G., & Issa, P. C. (2013) · Der Ophthalmologe · doi:10.1007/s00347-012-2779-5 · Cited by 9
Rodríguez‐Martínez, S., & Galván, I. (2019) · Molecular Ecology · doi:10.1111/mec.15171 · Cited by 9
“MDA is a product of the peroxi‐ dation of cellular lipids induced by ROS (e.g., Weismann et al., 2011).”
BackgroundWang, D., Wang, X., Han, J., You, C., Liu, Z., & Wu, Z. (2024) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-024-10312-5 · Cited by 8
““**” and “*” denote P 0.01 and P 0.05, respectively generated during metabolic processes [24, 25].”
InfluentialVelázquez-Soto, H., Groman-Lupa, S., Cruz‐Aguilar, M., Salazar, A., Zenteno, J. C., & Martínez, M. D. C. J. (2023) · Antioxidants · doi:10.3390/antiox12081540 · Cited by 8
Complement Activation and Inhibition in Retinal Diseases
Kleinman, M. E., & Ambati, J. (2015) · Developments in ophthalmology · doi:10.1159/000431141 · Cited by 8
“Y402H has also been linked to other downstream molecular events, including decreased neutralization of the proinflammatory lipid peroxidation product, malondialdehyde, leading to IL-8 and TNF-α induction [18].”
BackgroundChen, B., Aredo, B., Zhu, Y., Ding, Y., Wang, C. X.-Z., & Ufret-Vincenty, R. L. (2019) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.18-25751 · Cited by 9
Yu, P., Teng, X., Liu, T., Li, Y., Ni, J., Xue, S., & Wang, J. (2022) · Functional Foods in Health and Disease · doi:10.31989/ffhd.v12i7.944 · Cited by 14
Busch, C., Rau, S., Sekulic, A., Pèrié, L., Huber, C., Gehrke, M., Joussen, A. M., Zipfel, P. F., Wildner, G., Skerka, C., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1200725 · Cited by 8
“This might be explained by CD59, which inactivates MAC formation (7, 44) and represents a target for further therapeutic approaches (26).”
BackgroundNovel Immune Assay for Quantification of Plasma Protective Capacity Against Oxidized Phospholipids
Bochkov, V. N., Schoenenberger, A. W., Oskolkova, O., Toth, U., Stöckl, J., Majdic, O., Daci, A., Resink, T. J., Erné, P., & Philippova, M. (2016) · Biomarkers in Medicine · doi:10.2217/bmm-2016-0096 · Cited by 8
Zipfel, P. F., & Heidenreich, K. (2025) · The Journal of Immunology · doi:10.1093/jimmun/vkaf065 · Cited by 7
Vataja, E., Ratti, G., Safa, A., Pagano, M., Ferrante, L., Meri, S., & Haapasalo, K. (2025) · Inflammation Research · doi:10.1007/s00011-025-02069-6 · Cited by 7
“On HDL, FH binds to ApoE to confer protection against complement, but on oxLDL, FH binds to malondialdehyde (MDA)-modified epitopes, which in atherosclerotic lesions are generated as a response to inflammation [ 103].”
The Benefits of Complement Measurements for the Clinical Practice
Grünenwald, A., & Roumenina, L. T. (2021) · Methods in molecular biology · doi:10.1007/978-1-0716-1016-9_1 · Cited by 7
Hartley, A., Magapu, P., van den Berg, V. J., Khan, A. H. A., Shah, H. A., Allaf, M., Chow, A., Caga‐Anan, M., Shalhoub, J., Köenig, W., et al. (2022) · Antioxidants · doi:10.3390/antiox11020271 · Cited by 7
“However, C3/MDA-LDL complexes themselves may not be solely proinflammatory, as they may remain under regulatory control by both complement factor H and decay accelerating factor in plasma, preventing progress beyond the level of C3 in the complement cascade [22,23].”
BackgroundCoated cysteamine, a potential feed additive for ruminants — An updated review
Yaqoob, M. U., Hou, J., Li, Z., Qi, Y., Wu, P., Zhu, X., Cao, X., & Li, Z. (2023) · Animal Bioscience · doi:10.5713/ab.23.0245 · Cited by 7
“…which was reduced to 26.77% in lambs (fed 50 mg/kg BW of ≥99% CSHCl [68]) and 2.64% in goats (fed 120 mg/kg BW of 30% coated CSHCl for 40 days [48]) using CS. MAD is a biochemical marker of oxidative stress which is used as a procurator for lipid peroxidation and cellular damage in vivo [75,76].”
MethodInfluentialLiang, Y. S., Dai, D., Chang, W.-Q., WANG, Y., Zhang, Z., Li, D., Zhang, B., & Li, Y. (2024) · Journal of Fungi · doi:10.3390/jof10060380 · Cited by 7
Salivary IgA antibody to malondialdehyde–acetaldehyde associates with mild periodontal pocket depth
Akhi, R., Nissinen, A. E. T., Wang, C., Kyrklund, M., Paju, S., Mäntylä, P., Buhlin, K., Sinisalo, J. P., Pussinen, P. J., & Hörkkö, S. (2021) · Oral Diseases · doi:10.1111/odi.13936 · Cited by 7
Regulation of C3 Activation by the Alternative Complement Pathway in the Mouse Retina
Williams, J. A. E., Stampoulis, D., Gunter, C. E., Greenwood, J., Adamson, P., & Moss, S. E. (2016) · PLoS ONE · doi:10.1371/journal.pone.0161898 · Cited by 7
“Recently it has been shown that the Y402H SNP in CFH affects its binding to the lipid peroxidation product malondialdehyde, which accumulates with age [8].”
BackgroundNext-Generation Therapeutic Solutions for Age-Related Macular Degeneration
Cunnusamy, K., Ufret-Vincenty, R. L., & Wang, S. (2012) · Pharmaceutical Patent Analyst · doi:10.4155/ppa.12.12 · Cited by 7
“Among the complement factors, CFH was recently discovered as a major peroxidation product Malondialdehyde binding protein which protects against oxidative stress-induced inflammatory response (32).”
BackgroundKerboua, K. E., Boumédiène, A., Haiba, F., & Batouche, D. D. (2016) · The Egyptian Rheumatologist · doi:10.1016/j.ejr.2016.02.003 · Cited by 7
Complement Inhibition in Age-Related Macular Degeneration—Treat Early!
Scholl, H. P. N. (2022) · JAMA Ophthalmology · doi:10.1001/jamaophthalmol.2021.6068 · Cited by 6
van den Beukel, M. D., Zhang, L., van der Meulen, S., Borggreven, N. V., Nugteren, S., Brouwer, M. C., Pouw, R. B., Gelderman, K. A., de Ru, A. H., Janssen, G. M. C., et al. (2025) · Journal of Autoimmunity · doi:10.1016/j.jaut.2025.103444 · Cited by 6
Lipid Peroxidation in Subretinal Fluid: Some Light on the Prognosis Factors
Bosch‐Morell, F., García-Gen, E., Mérida, S., Penadés, M., Desco, C., & Návea, A. (2021) · Biomolecules · doi:10.3390/biom11040514 · Cited by 6
“There are many toxic biological effects they can cause on proteins [20], such as proinflammatory alterations of components of the complement system factor H, the main regulator of the alternative pathway [21] and C3a, a proinflammatory complement component [22]; activation of a specific isoform of protein kinase C (PK…”
BackgroundRetinal function and CFH-ARMS2 polymorphisms analysis: a pilot study in Italian AMD patients
Capoluongo, E., Concolino, P., Piccardi, M., Marangoni, D., Mello, E., Minnella, A. M., Savastano, M. C., Fadda, A., Zuppi, C., Bisti, S., et al. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.03.008 · Cited by 6
Densen, P., & Ram, S. (2015) · Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases · doi:10.1016/b978-1-4557-4801-3.00009-6 · Cited by 6
Wang, L., Kaya, K. D., Kim, S.-J., Brooks, M. J., Wang, J., Xin, Y., Qian, J. X., Swaroop, A., & Handa, J. T. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.06.004 · Cited by 7
Annamalai, B., Parsons, N., Nicholson, C., Joseph, K., Coughlin, B. A., Yang, X., Jones, B. W., Tomlinson, S., & Rohrer, B. (2021) · Experimental Eye Research · doi:10.1016/j.exer.2021.108583 · Cited by 6
Whitcomb, E. A., Shang, F., & Taylor, A. (2013) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.13-12808 · Cited by 6
Park, D. H., Shin, J. P., & Kim, I. T. (2013) · Retina · doi:10.1097/iae.0000000000000047 · Cited by 6
“Furthermore, CFH polymorphism H402, which is strongly associated with AMD, markedly reduces the ability of CFH to bind MDA indicating a causal link to disease etiology.(8) ARMS2 messenger RNA encodes a protein that seems to localize to the outer mitochondrial membrane and mitochondrial dysfunction can cause oxidative…”
BackgroundLi, X., Guo, D., Zhou, H., Hu, Y., Fang, X., Chen, Y., & Zhang, F. (2019) · Mediators of Inflammation · doi:10.1155/2019/7147652 · Cited by 6
“MDA was a reliable marker of oxidative stress response and was related to atherosclerosis [30].”
BackgroundGuo, Z., Zhang, L., Liu, J., & Yang, Z. (2025) · Current Issues in Molecular Biology · doi:10.3390/cimb47020076 · Cited by 5
“MDA is the final product of lipid peroxidation and is frequently utilized as a biomarker to assess MDA is the fi nal product of lipid peroxidation and is frequently utilized as a biomarker to assess the degree of oxidative stress [34]. the degree of oxidative stress [34].”
Zhang, X., Shi, S., Li, X., Li, C., & Li, Q. (2025) · Life · doi:10.3390/life15040600 · Cited by 5
“ASA can increase the antioxidant capacity during plant growth and development, it can also affect plant carbon metabolism, cell division, growth, stress response, ion absorption, and other physiological functions [64].”
Xiao, Y., Li, Q., Yang, Y., Zhang, Y., Shen, Y., Wei, R., Xiu, Y., Liu, Y., Lei, N., & Zhang, W. (2025) · Environmental Chemistry and Ecotoxicology · doi:10.1016/j.enceco.2025.10.016 · Cited by 5
Delrue, C., Speeckaert, R., & Speeckaert, M. M. (2026) · Biomolecules · doi:10.3390/biom16020234 · Cited by 5
“Ad-ditionally, improving mitophagy may promote the removal of damaged mitochondria, thus reducing oxidative stress, decreasing inflammatory signals, stopping the cycle of mitochondrial dysfunction, and preventing complement activation [12,19].”
InfluentialIqbal, M., Hussain, I., Habib, A., Ashraf, M. A., & Rasheed, R. (2015) · Journal of Chemistry · doi:10.1155/2015/318506 · Cited by 5
“One of the major and most toxic by-products of lipid peroxidation is MDA [24, 67].”
BackgroundLi, Y., Lei, K., Xu, X., Rajput, I. R., DongYou, Y., & WeiFen, L. (2013) · International Journal of Agriculture and Biology · Cited by 5
Lin, X., Wang, J., Hou, Z., Ren, S., Wang, W., Yang, Y., Yi, Y., Zhang, Y., & Li, R. (2024) · Current Microbiology · doi:10.1007/s00284-024-03858-8 · Cited by 5
Jokesch, P., Holzer, L., Jantscher, L., Guttzeit, S., Übelhart, R., Oskolkova, O., Bochkov, V. N., & Gesslbauer, B. (2024) · Journal of Lipid Research · doi:10.1016/j.jlr.2024.100704 · Cited by 5
Gureeva, M. V., Kirillova, M. S., Trandina, V. A., Kryukova, V. A., Eremina, A. A., Alimova, A. A., Grabovich, M. Y., & Gureev, A. P. (2025) · Microorganisms · doi:10.3390/microorganisms13020334 · Cited by 5
“It was previously shown that Pb at 585 mg/kg significantly inhibited the germination of wheat seedlings compared to the uninoculated control [29], and at a concentration of 50 µ M, it reduced the root growth of Vicia faba L. var. minor Harz. and caused significant damage to them [8].”
Swan, J., Toomey, C. B., Bergstrand, M., Cuello, H., Robie, J., Yu, H., Yuan, Y. H., Kooner, A. S., Chen, X., Shaughnessy, J., et al. (2025) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.66.6.81 · Cited by 5
“55 We hypothesize that a reduced amount of sialic acid would result in less inhibition of microglia (Siglec 1, 3, 11, and 16) and macrophages (Siglec 3, 7, and 9), however, immune regulation was beyond the scope of this study.”
InfluentialPrecision medicine for age-related macular degeneration: current developments and prospects
Biarnés, M., Vassilev, V., Nogoceke, E., Emri, E., Rodríguez‐Bocanegra, E., Ferraro, L. L., Garcia, M., Fauser, S., Monés, J., Lengyel, I., et al. (2018) · Expert Review of Precision Medicine and Drug Development · doi:10.1080/23808993.2018.1502037 · Cited by 5
Zipfel, P. F., & Lauer, N. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-4118-2_11 · Cited by 5
Molins, B., Mesquida, M., & Adán, A. (2022) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2022.101097 · Cited by 5
RetractedChen, Y.-J., Yu, H., Tsai, C., & Tiao, M. (2025) · APOPTOSIS · doi:10.1007/s10495-025-02111-2 · Cited by 4
“MDA is a reliable marker of oxidative stress and has been implicated in various disorders, including liver injury [ 52, 53].”
Lipoprotein oxidation biomarkers for cardiovascular risk: what does the future hold?
Taleb, A., & Tsimikas, S. (2012) · Expert Review of Cardiovascular Therapy · doi:10.1586/erc.12.32 · Cited by 4
Free Radical Biology of Eye Diseases
Kisić, B., Miric, D. J., & Zoric, L. D. (2014) · Springer eBooks · doi:10.1007/978-3-642-30018-9_192 · Cited by 4
Li, X., Shi, S., Zhang, X., Li, C., Wang, H., Kang, W., & Yin, G. (2022) · Life · doi:10.3390/life12122140 · Cited by 4
“At the same time, the accumulation of ROS can lead to peroxidation or delipidation of unsaturated fatty acids in cell membranes, which are degraded to small molecules MDA step by step [66].”
BackgroundLi, Z., Li, Y., Xie, E., & Yuchun, S. (2024) · Frontiers in Plant Science · doi:10.3389/fpls.2024.1371818 · Cited by 4
Qian, W., Yu, H., Zhang, C., Zhang, H., Fu, S., & Xia, C. (2021) · Frontiers in Veterinary Science · doi:10.3389/fvets.2021.723898 · Cited by 4
“Complement factor H is a major MDA binding protein that can induce the proinflammatory effects of MDA (35).”
BackgroundComplement Regulatory Proteins and Related Diseases
Meri, S., & Jarva, H. (2013) · Encyclopedia of Life Sciences · doi:10.1002/9780470015902.a0001434.pub3 · Cited by 4
Xue, J., Jia, H., Du, K., Pang, Y., Guo, X., Zhang, Y. L., Liu, Y., Luo, X., & Tang, Z. (2025) · Small · doi:10.1002/smll.202510416 · Cited by 3
Advances in Complement Research: from Pathophysiology to Precision Medicine
Thurman, J. M. (2025) · Physiology · doi:10.1152/physiol.00037.2025 · Cited by 4
Skerka, C., Cochlovius, B., Hüllebrand, J. P., Goel, D., Sood, P., Pal, N., Chakravarti, A., Muth, D. R., Zeitz, O., & Zipfel, P. F. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1814415 · Cited by 3
Blood levels of antioxidants during age-related macular degeneration treatment by rheohaemapheresis
Aufartová, J., Blaha, M., Kasalová, E., Honegrova, B., Červinková, B., Krčmová, L. K., Plíšek, J., Lánská, M., Sobotka, L., & Solichová, D. (2015) · Biomedical Papers · doi:10.5507/bp.2015.028 · Cited by 3
Making sense of the spectrum of glomerular disease associated with complement dysregulation
Johnson, S. A., Wong, E. K. S., & Taylor, C. M. (2013) · Pediatric Nephrology · doi:10.1007/s00467-013-2559-8 · Cited by 3
“2) [8, 9].”
BackgroundInfluentialChen, H., Zhen, J., Wu, Z., Li, X., Liu, S., Tang, Z., & Sun, Z. (2019) · Animal Production Science · doi:10.1071/an17152 · Cited by 3
Mano, F., Sakata, S., Chang, K.-C., & Mano, T. (2021) · Journal of Ocular Pharmacology and Therapeutics · doi:10.1089/jop.2021.0031 · Cited by 3
“18,19 20–22 Thus, MDA is a useful biological marker of oxidative stress.”
Automated Quantification and Network Analysis of Redox Dynamics in Neuronal Mitochondria
Kurz, F. T., & Breckwoldt, M. O. (2022) · Methods in molecular biology · doi:10.1007/978-1-0716-1831-8_12 · Cited by 3
Lee, Y., Lin, Y., Liao, C., Chang, Y., Huang, Y.-H., Tsai, I.-J., Chen, J., Lin, S.-H., Lin, Y.-F., Hsieh, T.-W., et al. (2022) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2022.07.002 · Cited by 3
Navneet, S., Ishii, M., & Rohrer, B. (2024) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.65.8.34 · Cited by 3
“19,23 While neoepitope production and concomitant antibody binding to the RPE/BrM have been reported for other epitopes such as malondialdehyde, 45 the results here provide genotype-specific results.”
Lee, Y., Ahn, E. J., & Hussain, A. A. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.96818 · Cited by 3
The Role of Inflammation in Age-Related Macular Degeneration
Harris, J. M., & Wu, D. M. (2025) · International Ophthalmology Clinics · doi:10.1097/iio.0000000000000578 · Cited by 2
Superior Oxidative Status in Leucistic Cinereous Vultures
Galván, I., Alvarado-Piqueras, A., Apruzzese, A., González, F., & Negro, J. J. (2025) · Ecological and Evolutionary Physiology · doi:10.1086/737629 · Cited by 2
Factor H and Factor H-like Protein 1
Barlow, P. N. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-810420-0.00030-4 · Cited by 2
Extrarenal manifestations in inherited kidney diseases
Hoefele, J., Eble, J., Hermle, T. F., Wuttke, M., & Schultheiß, U. T. (2024) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfae176 · Cited by 2
Du, K., Zhang, Y., Zhao, C., Luo, X., Wang, H., Guo, X., & Tang, Z. (2025) · ACS Agricultural Science & Technology · doi:10.1021/acsagscitech.5c00252 · Cited by 2
WITHDRAWN: Complement dysregulation in AMD: RPE-Bruch’s membrane-choroid
Sparrow, J. R., Ueda, K., & Zhou, J. (2012) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2012.03.011 · Cited by 2
Philippova, M., Oskolkova, O., & Bochkov, V. N. (2019) · European Journal of Lipid Science and Technology · doi:10.1002/ejlt.201800511 · Cited by 2
Du, Y., Feng, L., Tang, J.-H., Qin, X., Bai, B., & Liang, L. (2025) · Investigative Ophthalmology and Visual Science · doi:10.1167/iovs.66.9.44 · Cited by 1
“26,27 C5a, a potent activation fragment derived from the complement system, has been extensively implicated in the pathogenesis and progression of AMD.”
Sambhariya, W. S., Rickman, C. B., D'Amore, P. A., Corradetti, G., Hageman, G. S., Howell, G. R., Marola, O. J., Phatnani, H. P., Philp, N. J., Sinha, D., et al. (2026) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2026.101449 · Cited by 1
Heat stress: an environmental challenge to immune resilience and health in dairy cows
Tariq, A., & Bromfield, J. J. (2026) · Frontiers in Animal Science · doi:10.3389/fanim.2026.1755098 · Cited by 2
“Oxidative stress, caused by excessive production offree radicals and ROS or a decline in antioxidant defenses, results in cellular damage and promotes tissue in fl ammation (Khor et al., 2011; Weismann et al., 2011).”
Li, L., Lu, Q., Chen, Z., Zhang, L., Jian, Y., Lv, J., Yang, M., Gao, J., Li, H., Li, H., et al. (2026) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2026.140159 · Cited by 1
Intracellular complement factor H protects neurons during CNS inflammation
Mayer, C., Woo, M. S., Sonner, J. K., Binkle-Ladisch, L., Fischbach, F., Sekol, P., Smith, M. D., Lucas‐Ruiz, F., Manteufel, D., Mattern, K. M.-J., et al. (2026) · Nature · doi:10.1038/s41586-026-10981-y · Cited by 1
“Consistent with this, the SCR7 region, which contains the AMD-associated Y402H variant, was dispensable for neuroprotection against oxidative stress 40,56 , whereas SCR20 was essential.”
InfluentialRole of genetic factors in the pathogenesis of exudative age-related macular degeneration
Zhou, P., & Li, X. (2014) · Taiwan Journal of Ophthalmology · doi:10.1016/j.tjo.2014.03.007 · Cited by 1
Anterior Chamber and Retina (Structure, Function and Immunology)
Rhoades, W. R., Kump, L. I., & Margalit, E. (2016) · Springer eBooks · doi:10.1007/978-3-319-44022-4_4 · Cited by 1
ISSAC, M. D. N. A. F. M. S. M., & El-ESSAWY, M. D. M. A. Z. R. A. (2019) · The Medical Journal of Cairo University/The Medical Journal of Cairo University · doi:10.21608/mjcu.2019.52412 · Cited by 1
Knowledge mapping of B cell and atherosclerosis over the past 20 years: A bibliometric analysis
Cheng, T., You, Y., Jia, B., Wang, H., Lv, M., Zhu, X., & Hu, Y. (2023) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2023.2277567 · Cited by 1
“19,20 In addition, his team is studying the role and function of B cell subsets and natural antibodies.”
Neovascular Age-Related Macular Degeneration: Rationale for Current Treatment Guidelines
Chen, C. J., & Bressler, N. M. (2013) · Essentials in ophthalmology/Essentials ophthalmology · doi:10.1007/978-3-642-36324-5_8 · Cited by 1
Yasukawa, T. (2013) · Expert Review of Ophthalmology · doi:10.1586/17469899.2013.814960 · Cited by 1
Complement: The Alternative Pathway
Zipfel, P. F., & Skerka, C. (2015) · Encyclopedia of Life Sciences · doi:10.1002/9780470015902.a0000509.pub3 · Cited by 1
Witztum, J. L. (2015) · Circulation Research · doi:10.1161/circresaha.115.306928 · Cited by 1
Dalai, A. K. (2011) · Cited by 1
WITHDRAWN: Early development of normative mind for the students - Stress management approach
Wei, F., Seetharaman, T., & Sivakumar, V. (2021) · Aggression and Violent Behavior · doi:10.1016/j.avb.2021.101627 · Cited by 1
RetractedNissilä, E., Syed, S., Uvarov, P., Lokki, A. I., Laivuori, M., Chernyaeva, L., Roininen, E., Vataja, E., Tuhkala, A., Keskitalo, S., et al. (2025) · Research Square · doi:10.21203/rs.3.rs-6828685/v1 · Cited by 1
Complement: new therapies and emergence of the complotype
Morgan, B. P. (2013) · ISBT Science Series · doi:10.1111/voxs.12030
Challenges for Atrophic Age-Related Macular Degeneration Research
Qin, S. (2012) · Anatomy & Physiology · doi:10.4172/2161-0940.1000e119
“Whether CFH interacts with other oxidized lipid-protein adducts such as carboxyethylpyrrole-adducts in a similar way to the MDA–CFH paradigm, remains to be addressed.”
BackgroundInfluentialCellular and Humoral Responses following Minimally Invasive Surgery: Role of Reactive Oxygen Species
Leaver, H. A., Rotondo, D., & Walker, W. S. G. (2015) · Current Metabolomics · doi:10.2174/2213235x03666150128200126
“Complement Factor H was recently shown to protect against oxidative stress by binding lipoxidation products [40].”
Backgroundhemolytic uremic syndrome Complement activation by heme as a secondary hit for atypical
Frémeaux‐Bacchi, V., Roumenina, L. T., Frimat, M., Tabarin, F., Dimitrov, J. D., Poitou, C., & Halbwachs‐Mecarelli, L. (2013)
Development of a Functional Contrast Agent for Targeting Lipid-derived Radicals
Yamada, K. (2016) · YAKUGAKU ZASSHI · doi:10.1248/yakushi.15-00234-4
Genetics and Pathology of Inflammatory Components on AMD
Li, X., Huang, L., Zhou, P., & Chan, C. (2017) · Essentials in ophthalmology/Essentials ophthalmology · doi:10.1007/978-4-431-56511-6_15
Molecular, Cellular, and Animal Experiments in Formaldehyde Study
Qiang, M., Su, T., Wu, B., & He, R. (2017) · Springer eBooks · doi:10.1007/978-94-024-1177-5_13
Endogenous DAMPs, Category II: Constitutively Expressed, Injury-Modified Molecules (Cat. II DAMPs)
Land, W. G. (2018) · Springer eBooks · doi:10.1007/978-3-319-78655-1_13
Detection and inhibition of redox reaction and lipid derived radicals
Yamada, K. (2018) · Drug Delivery System · doi:10.2745/dds.33.197
Koirala, D. (2018) · doi:10.21007/etd.cghs.2018.0466
“demonstrated this clearly by showing a mechanistic link between CFH polymorphism, the highest genetic risk for developing AMD, and oxidative stress-induced protein modification [148].”
BackgroundOxidative stress in viral HEPATITIS B and C
Namıduru, E. S., & Namıduru, M. (2019) · Asian Pacific Journal of Health Sciences · doi:10.21276/apjhs.2019.6.4.10
Complement Factor H-Related 3 induces inflammation and complosome activation in human RPE cellsPreprint
Schäfer, N., Rasras, A. J., Ceteras, D., Amslinger, S., Enzmann, V., Jägle, H., & Pauly, D. (2021) · Research Square · doi:10.21203/rs.3.rs-344659/v1
Metadata
- Authors
- Weismann, D., Hartvigsen, K., Lauer, N., Bennett, K. L., Scholl, H. P. N., Issa, P. C., Cano, M., Brandstätter, H., Tsimikas, S., Skerka, C., Superti-Furga, G., Handa, J. T., Zipfel, P. F., Witztum, J. L., & Binder, C. J.
- Affiliations
- Austrian Academy of Sciences (AT)
- Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Knöll-Institut (HKI) (DE)
- Johns Hopkins University (US)
- University of Oxford (GB)
- Octapharma (Austria) (AT)
- University of California San Diego (US)
- Corresponding author
- Binder, Christoph J.
- ORCID
- Venue
- Nature
- Published
- 2011-10
- Volume
- 478
- Issue
- 7367
- Pages
- 76-81
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC4826616
- OpenAlex
- W2062097745
- Cited by
- 533
- References
- 42
- Citations by year
- 2026: 16 · 2025: 24 · 2024: 25 · 2023: 30 · 2022: 29 · 2021: 42 · 2020: 36 · 2019: 29 · 2018: 33 · 2017: 31 · 2016: 39 · 2015: 42 · 2014: 44 · 2013: 66 · 2012: 44
- FWCI
- 22.28
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01-HL086599, HL-088093, P01HL088093)
- National Eye Institute (EY14005, R01EY014005, EY019044, R01EY019904)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Complement system in diseases
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Keywords
- complement factor H, malondialdehyde, lipid peroxidation, oxidative stress, age-related macular degeneration, macrophage uptake, pro-inflammatory effects, innate immunity, chronic inflammation, retina
- MeSH terms
- Animals, Epitopes, Binding Sites, Complement System Proteins, Complement Inactivator Proteins, Enzyme-Linked Immunosorbent Assay, Female, Humans, Inflammation, Macular Degeneration, Male, Malondialdehyde, Mice, Inbred C57BL, Mutation, Necrosis, Protein Binding, Retina, Lipid Peroxidation, Apoptosis, Complement Factor H, Protein Structure, Tertiary, Macrophages, Peritoneal, Oxidative Stress, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
