Clonal evolution in cancer

Hallmarks of Cancer: The Next Generation

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Cancer Statistics, 2008

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Stem cells, cancer, and cancer stem cells

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The Clonal Evolution of Tumor Cell Populations: Acquired genetic lability permits stepwise selection of variant sublines and underlies tumor progression.

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A Chromatin-Mediated Reversible Drug-Tolerant State in Cancer Cell Subpopulations

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Tumour evolution inferred by single-cell sequencing

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Distant metastasis occurs late during the genetic evolution of pancreatic cancer

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Identification of Selective Inhibitors of Cancer Stem Cells by High-Throughput Screening

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Massive genomic rearrangement acquired in a single catastrophic event during cancer development

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A Perivascular Niche for Brain Tumor Stem Cells

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CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer

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Efficient tumour formation by single human melanoma cells

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Models, mechanisms and clinical evidence for cancer dormancy

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Cancer as an evolutionary and ecological process

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Tumor heterogeneity: Causes and consequences

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Mutation selection and the natural history of cancer

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Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression

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Transformation from committed progenitor to leukaemia stem cell initiated by MLL–AF9

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Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML

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TGFβ: the molecular Jekyll and Hyde of cancer

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Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro

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Parallel progression of primary tumours and metastases

Klein, C. A. (2009) · Nature reviews. Cancer · doi:10.1038/nrc2627 · Cited by 1,161

Genome remodelling in a basal-like breast cancer metastasis and xenograft

Ding, L., Ellis, M. J., Li, S., Larson, D. E., Chen, K., Wallis, J. W., Harris, C. C., McLellan, M. D., Fulton, R. S., Fulton, L., et al. (2010) · Nature · doi:10.1038/nature08989 · Cited by 1,144

Preexistence and clonal selection of MET amplification in EGFR mutant NSCLC

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Stem cell concepts renew cancer research

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Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region

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Biological and Molecular Heterogeneity of Breast Cancers Correlates with Their Cancer Stem Cell Content

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Punctuated equilibrium comes of age

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Testicular germ-cell tumours in a broader perspective

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Adaptive Therapy

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Heterozygous Deficiency of PHD2 Restores Tumor Oxygenation and Inhibits Metastasis via Endothelial Normalization

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Comparative lesion sequencing provides insights into tumor evolution

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Accumulation of driver and passenger mutations during tumor progression

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Genetic variegation of clonal architecture and propagating cells in leukaemia

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Triple-Negative Breast Cancer: An Unmet Medical Need

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Tumor Morphology and Phenotypic Evolution Driven by Selective Pressure from the Microenvironment

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Genetic instability and darwinian selection in tumours

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The Frequency of Carcinoma and Intraepithelial Neoplasia of the Prostate in Young Male Patients

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A microenvironmental model of carcinogenesis

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The Tumor Suppressor p53 Regulates Polarity of Self-Renewing Divisions in Mammary Stem Cells

Cicalese, A., Bonizzi, G., Pasi, C. E., Faretta, M., Ronzoni, S., Giulini, B., Brisken, C., Minucci, S., Fiore, P. P. D., & Pelicci, P. G. (2009) · Cell · doi:10.1016/j.cell.2009.06.048 · Cited by 713

Exploring the Genomes of Cancer Cells: Progress and Promise

Stratton, M. R. (2011) · Science · doi:10.1126/science.1204040 · Cited by 711

The Increasing Complexity of the Cancer Stem Cell Paradigm

Rosen, J. M., & Jordan, C. T. (2009) · Science · doi:10.1126/science.1171837 · Cited by 711

Signatures of mutation and selection in the cancer genome

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Genetic clonal diversity predicts progression to esophageal adenocarcinoma

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Clonal expansion of p53 mutant cells is associated with brain tumour progression

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Cancer genomics: from discovery science to personalized medicine

Chin, L., Andersen, J. N., & Futreal, P. A. (2011) · Nature Medicine · doi:10.1038/nm.2323 · Cited by 655

The therapeutic promise of the cancer stem cell concept

Frank, N. Y., Schatton, T., & Frank, M. H. (2010) · Journal of Clinical Investigation · doi:10.1172/jci41004 · Cited by 640

Chromosome translocations and covert leukemic clones are generated during normal fetal development

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Leukemia in twins: lessons in natural history

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Inferring tumor progression from genomic heterogeneityPreprint

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Radiation and the microenvironment – tumorigenesis and therapy

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Evolution of human BCR–ABL1 lymphoblastic leukaemia-initiating cells

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Genetic Interactions in Cancer Progression and Treatment

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DNA Damage-Mediated Induction of a Chemoresistant Niche

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Genetic Progression and the Waiting Time to Cancer

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Human cancers express mutator phenotypes: origin, consequences and targeting

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Barrett's oesophagus and oesophageal adenocarcinoma: time for a new synthesis

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Subclonal phylogenetic structures in cancer revealed by ultra-deep sequencing

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Cellular and genetic diversity in the progression of in situ human breast carcinomas to an invasive phenotype

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Ductal Carcinoma In situ and the Emergence of Diversity during Breast Cancer Evolution

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Temporal Dissection of Tumorigenesis in Primary Cancers

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Deadly Teamwork: Neural Cancer Stem Cells and the Tumor Microenvironment

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Effective Targeting of Quiescent Chronic Myelogenous Leukemia Stem Cells by Histone Deacetylase Inhibitors in Combination with Imatinib Mesylate

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Human Chromosomal Translocations at CpG Sites and a Theoretical Basis for Their Lineage and Stage Specificity

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How and Why Species Multiply

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Selectively Advantageous Mutations and Hitchhikers in Neoplasms

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Individual crypt genetic heterogeneity and the origin of metaplastic glandular epithelium in human Barrett’s oesophagus

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BCL6 enables Ph+ acute lymphoblastic leukaemia cells to survive BCR–ABL1 kinase inhibition

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Clonal selection in xenografted human T cell acute lymphoblastic leukemia recapitulates gain of malignancy at relapse

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Metapopulation dynamics and spatial heterogeneity in cancer

González-Garcı́a, I., Solé, R. V., & Costa, J. C. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.202139299 · Cited by 201

Identifying cancer driver genes in tumor genome sequencing studies

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Distinct pools of cancer stem-like cells coexist within human glioblastomas and display different tumorigenicity and independent genomic evolution

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Carcinogen-specific induction of genetic instability

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Long-term haematopoietic reconstitution by Trp53-/-p16Ink4a-/-p19Arf-/- multipotent progenitors

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Competitive release and facilitation of drug-resistant parasites after therapeutic chemotherapy in a rodent malaria model

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Ecological Therapy for Cancer: Defining Tumors Using an Ecosystem Paradigm Suggests New Opportunities for Novel Cancer Treatments

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Statistical Analysis of Pathogenicity of Somatic Mutations in Cancer

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Inactivation of p53 in breast cancers correlates with stem cell transcriptional signatures

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The relationship between growth rate, labelling index and histological type of human solid tumours

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Inferring clonal expansion and cancer stem cell dynamics from DNA methylation patterns in colorectal cancers

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A Comprehensive Survey of Clonal Diversity Measures in Barrett's Esophagus as Biomarkers of Progression to Esophageal Adenocarcinoma

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Complex patterns of ETS gene alteration arise during cancer development in the human prostate

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The molecular basis of common and rare fragile sites

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Cancer stem cells: Back to Darwin?

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Rapid growth of a hepatocellular carcinoma and the driving mutations revealed by cell-population genetic analysis of whole-genome data

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Clonal Interference and the Periodic Selection of New Beneficial Mutations in Escherichia coli

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Cancer: the evolutionary legacy

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How and Why Species Multiply

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Acquisition of genome-wide copy number alterations in monozygotic twins with acute lymphoblastic leukemia

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Overlooking Evolution: A Systematic Analysis of Cancer Relapse and Therapeutic Resistance Research

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Shifting paradigms: the seeds of oncogene addiction

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Xenografts of highly resistant leukemia recapitulate the clonal composition of the leukemogenic compartment

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Immunologically silent cancer clone transmission from mother to offspring

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Solving the Puzzle of Metastasis: The Evolution of Cell Migration in Neoplasms

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