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Clonal evolution in cancer
Open accessAbstract
Cancers evolve by a reiterative process of clonal expansion, genetic diversification and clonal selection within the adaptive landscapes of tissue ecosystems. The dynamics are complex, with highly variable patterns of genetic diversity and resulting clonal architecture. Therapeutic intervention may destroy cancer clones and erode their habitats, but it can also inadvertently provide a potent selective pressure for the expansion of resistant variants. The inherently Darwinian character of cancer is the primary reason for this therapeutic failure, but it may also hold the key to more effective control.
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“There is increasing evidence that cancers undergo clonal evolution under the selective pressure of chemotherapy 22.”
From Role of TP53 mutations in the origin and evolution of therapy-related acute myeloid leukaemia (2015) · cites this paper as [22]
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Metadata
- Authors
- Greaves, M., & Maley, C. C.
- Affiliations
- University of California, San Francisco (US)
- ORCID
- Maley, Carlo C.
- Venue
- Nature
- Published
- 2012-01
- Volume
- 481
- Issue
- 7381
- Pages
- 306-313
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC3367003
- OpenAlex
- W2023560061
- Cited by
- 3,162
- References
- 104
- Citations by year
- 2026: 180 · 2025: 160 · 2024: 181 · 2023: 225 · 2022: 204 · 2021: 253 · 2020: 229 · 2019: 211 · 2018: 247 · 2017: 296 · 2016: 247 · 2015: 238 · 2014: 221 · 2013: 164 · 2012: 101
- FWCI
- 17.27
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- National Cancer Institute (R01CA149566, P01CA091955, U54CA143803, P01CA91955, R01CA140657)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Keywords
- clonal evolution, cancer, clonal expansion, genetic diversification, clonal selection, fitness landscape, tumor microenvironment, clonal architecture, drug resistance
- MeSH terms
- Animals, Clone Cells, Humans, Mutation, Neoplasms, Neoplastic Stem Cells, Genomics, Tumor Microenvironment, Clonal Evolution
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