The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Generalized Lévy walks and the role of chemokines in migration of effector CD8+ T cells
Open accessAbstract
Chemokines have a central role in regulating processes essential to the immune function of T cells, such as their migration within lymphoid tissues and targeting of pathogens in sites of inflammation. Here we track T cells using multi-photon microscopy to demonstrate that the chemokine CXCL10 enhances the ability of CD8+ T cells to control the pathogen Toxoplasma gondii in the brains of chronically infected mice. This chemokine boosts T-cell function in two different ways: it maintains the effector T-cell population in the brain and speeds up the average migration speed without changing the nature of the walk statistics. Notably, these statistics are not Brownian; rather, CD8+ T-cell motility in the brain is well described by a generalized Lévy walk. According to our model, this unexpected feature enables T cells to find rare targets with more than an order of magnitude more efficiency than Brownian random walkers. Thus, CD8+ T-cell behaviour is similar to Lévy strategies reported in organisms ranging from mussels to marine predators and monkeys, and CXCL10 aids T cells in shortening the average time taken to find rare targets.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Newman (2005) · doi:10.1080/00107510500052444 · Cited by 5,749
Model selection in ecology and evolution
Johnson, J. B., & Omland, K. S. (2004) · Trends in Ecology & Evolution · doi:10.1016/j.tree.2003.10.013 · Cited by 3,838
Montoya, J., & Liesenfeld, O. (2004) · The Lancet · doi:10.1016/s0140-6736(04)16412-x · Cited by 3,232
Central Memory and Effector Memory T Cell Subsets: Function, Generation, and Maintenance
Sallusto, F., Geginat, J., & Lanzavecchia, A. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.22.012703.104702 · Cited by 3,067
Optimizing the success of random searches.
Viswanathan, G. M., Buldyrev, S. V., Havlin, S., da Luz, M. G. E., Raposo, E. P., & Stanley, H. E. (1999) · Nature · doi:10.1038/44831 · Cited by 1,359
Two-Photon Imaging of Lymphocyte Motility and Antigen Response in Intact Lymph Node
Miller, M. J., Wei, S. H., Parker, I., & Cahalan, M. D. (2002) · Science · doi:10.1126/science.1070051 · Cited by 1,207
Interferon-γ: the Major Mediator of Resistance Against Toxoplasma gondii
Suzuki, Y., Orellana, M. A., Schreiber, R. D., & Remington, J. S. (1988) · Science · doi:10.1126/science.3128869 · Cited by 1,173
Scaling laws of marine predator search behaviour
Sims, D. W., Southall, E. J., Humphries, N. E., Hays, G. C., Bradshaw, C. J. A., Pitchford, J. W., James, A., Ahmed, M. Z., Brierley, A. S., Hindell, M. A., et al. (2008) · Nature · doi:10.1038/nature06518 · Cited by 959
Environmental context explains Lévy and Brownian movement patterns of marine predators
Humphries, N. E., Queiroz, N., Dyer, J. R. M., Pade, N. G., Musyl, M. K., Schaefer, K. M., Fuller, D. W., Brunnschweiler, J. M., Doyle, T. K., Houghton, J. D. R., et al. (2010) · Nature · doi:10.1038/nature09116 · Cited by 943
Chemokines and chemokine receptors in T-cell priming and Th1/Th2-mediated responses
Sallusto, F., Lanzavecchia, A., & Mackay, C. R. (1998) · Immunology Today · doi:10.1016/s0167-5699(98)01346-2 · Cited by 897
Cited by
Microglia development and function
Nayak, D., Roth, T. L., & McGavern, D. B. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120240 · Cited by 1,154
Tissue-Resident Memory T Cells
Schenkel, J. M., & Masopust, D. (2014) · Immunity · doi:10.1016/j.immuni.2014.12.007 · Cited by 1,059
“In the brains of Toxoplasma gondii-infected mice, CXCL10 expression increases the speed of local CD8 T cells (Harris et al., 2012).”
BackgroundBachelerie, F., Ben-Baruch, A., Burkhardt, A. M., Combadiere, C., Farber, J. M., Graham, G. J., Horuk, R., Sparre-Ulrich, A. H., Locati, M., Luster, A. D., et al. (2014) · Pharmacological Reviews · doi:10.1124/pr.113.007724 · Cited by 850
Self-citationChow, M. T., Ozga, A. J., Servis, R. L., Frederick, D. T., Lo, J. A., Fisher, D. E., Freeman, G. J., Boland, G. M., & Luster, A. D. (2019) · Immunity · doi:10.1016/j.immuni.2019.04.010 · Cited by 716
“CXCR3 and its ligands guide the recruitment of effector T cells into the inflamed peripheral tissue in type 1 inflammatory responses (Dufour et al., 2002; Hancock et al., 2001; Hancock et al., 2000; Harris et al., 2012; Khan et al., 2000; Rashighi et al., 2014).”
Self-citationChromatin and lamin A determine two different mechanical response regimes of the cell nucleus
Stephens, A. D., Banigan, E. J., Adam, S. A., Goldman, R. D., & Marko, J. F. (2017) · Molecular Biology of the Cell · doi:10.1091/mbc.e16-09-0653 · Cited by 473
Self-citation
Metadata
- Authors
- Harris, T. H., Banigan, E. J., Christian, D. A., Konradt, C., Tait Wojno, E. D., Norose, K., Wilson, E. H., John, B., Weninger, W., Luster, A. D., Liu, A. J., & Hunter, C. A.
- Venue
- Nature
- Published
- 2012-05-27
- Volume
- 486
- Issue
- 7404
- Pages
- 545-548
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2019558320
- Cited by
- 512
- References
- 32
- FWCI
- 17.47
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Generalized Lévy walks and the role of chemokines in migration of effector CD8+ T cells. https://app.cochat.ai/papers/10.1038/nature11098
- The paper
- Harris, T. H., Banigan, E. J., Christian, D. A., Konradt, C., Tait Wojno, E. D., Norose, K., Wilson, E. H., John, B., Weninger, W., Luster, A. D., Liu, A. J., & Hunter, C. A. (2012). Generalized Lévy walks and the role of chemokines in migration of effector CD8+ T cells. Nature. https://doi.org/10.1038/nature11098
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
