Cited by 513Acute Myeloid Leukemia ResearchGlioma Diagnosis and TreatmentCancer, Hypoxia, and Metabolism

The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.

IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics

Open access

Sasaki, Masato, Knobbe, Christiane B., Munger, Joshua C., Lind, Evan F., Brenner, Dirk, Brüstle, Anne, Harris, Isaac S., Holmes, Roxanne, Wakeham, Andrew, Haight, Jillian, You-Ten, Annick, Li, Wanda Y., Schalm, Stefanie, Su, Shinsan M., Virtanen, Carl, Reifenberger, Guido, Ohashi, Pamela S., Barber, Dwayne L., Figueroa, Maria E., Melnick, Ari, Zúñiga-Pflücker, Juan-Carlos, Mak, Tak W.·2012·Nature

DOI 10.1038/nature11323PMC PMC4005896

Open this paper in CoChat — free account

Abstract

Mutations in the IDH1 and IDH2 genes encoding isocitrate dehydrogenases are frequently found in human glioblastomas and cytogenetically normal acute myeloid leukaemias (AML). These alterations are gain-of-function mutations in that they drive the synthesis of the ‘oncometabolite’ R-2-hydroxyglutarate (2HG). It remains unclear how IDH1 and IDH2 mutations modify myeloid cell development and promote leukaemogenesis. Here we report the characterization of conditional knock-in (KI) mice in which the most common IDH1 mutation, IDH1(R132H), is inserted into the endogenous murine Idh1 locus and is expressed in all haematopoietic cells (Vav-KI mice) or specifically in cells of the myeloid lineage (LysM-KI mice). These mutants show increased numbers of early haematopoietic progenitors and develop splenomegaly and anaemia with extramedullary haematopoiesis, suggesting a dysfunctional bone marrow niche. Furthermore, LysM-KI cells have hypermethylated histones and changes to DNA methylation similar to those observed in human IDH1- or IDH2-mutant AML. To our knowledge, our study is the first to describe the generation and characterization of conditional IDH1(R132H)-KI mice, and also the first report to demonstrate the induction of a leukaemic DNA methylation signature in a mouse model. Our report thus sheds light on the mechanistic links between IDH1 mutation and human AML.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/nature11323

Cites

34 of 34 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
Benjamini, Y., & Hochberg, Y. (1995) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1995.tb02031.x · Cited by 109,482
Linear Models and Empirical Bayes Methods for Assessing Differential Expression in Microarray Experiments
Smyth, G. K. (2004) · Statistical Applications in Genetics and Molecular Biology · doi:10.2202/1544-6115.1027 · Cited by 11,829
The control of the false discovery rate in multiple testing under dependency
Benjamini, Y., & Yekutieli, D. (2001) · The Annals of Statistics · doi:10.1214/aos/1013699998 · Cited by 10,490
Statistical significance for genomewide studies
Storey, J. D., & Tibshirani, R. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1530509100 · Cited by 9,692
An Integrated Genomic Analysis of Human Glioblastoma Multiforme
Parsons, D. W., Jones, S., Zhang, X., Lin, J. C.-H., Leary, R. J., Angenendt, P., Mankoo, P., Carter, H., Siu, I.-M., Gallia, G. L., et al. (2008) · Science · doi:10.1126/science.1164382 · Cited by 5,857
Bismark: a flexible aligner and methylation caller for Bisulfite-Seq applications
Krueger, F., & Andrews, S. (2011) · Bioinformatics · doi:10.1093/bioinformatics/btr167 · Cited by 5,275
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
Dang, L., White, D. W., Gross, S., Bennett, B. D., Bittinger, M. A., Driggers, E. M., Fantin, V. R., Jang, H. G., Jin, S., Keenan, M. C., et al. (2009) · Nature · doi:10.1038/nature08617 · Cited by 4,154
Self-citation
Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases
Xu, W., Yang, H., Liu, Y., Yang, Y., Wang, P., Kim, S.-H., Ito, S., Yang, C., Wang, P., Xiao, M.-T., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2010.12.014 · Cited by 2,875
Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation
Figueroa, M. E., Abdel-Wahab, O., Lu, C., Ward, P. S., Patel, J., Shih, A., Li, Y., Bhagwat, N., Vasanthakumar, A., Fernandez, H. F., et al. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.11.015 · Cited by 2,766
Self-citation
Identification of a CpG Island Methylator Phenotype that Defines a Distinct Subgroup of Glioma
Noushmehr, H., Weisenberger, D. J., Diefes, K., Phillips, H. S., Pujara, K., Berman, B. P., Pan, F., Pelloski, C. E., Sulman, E. P., Bhat, K. P., et al. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.03.017 · Cited by 2,337

Flagged first, then by citations

Show all 34 references

Sorted by citations

Items 201–300 of 512

The complex interactions between the cellular and non-cellular components of the brain tumor microenvironmental landscape and their therapeutic implications
Faisal, S. M., Comba, A., Varela, M. L., Argento, A. E., Brumley, E. K., Abel, C. C., Castro, M. G., & Lowenstein, P. R. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.1005069 · Cited by 58
Mutant IDH in Gliomas: Role in Cancer and Treatment Options
Solomou, G., Finch, A., Asghar, A., & Bardella, C. (2023) · Cancers · doi:10.3390/cancers15112883 · Cited by 62
Metabolic circuits in neural stem cells
Kim, D., Rhee, I., & Paik, J. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1686-0 · Cited by 59
Myeloproliferative neoplasms: from origins to outcomes
Nangalia, J., & Green, A. R. (2017) · Hematology · doi:10.1182/asheducation-2017.1.470 · Cited by 58
Oncometabolites at the crossroads of genetic, epigenetic and ecological alterations in cancer
Lanzetti, L. (2024) · Cell Death and Differentiation · doi:10.1038/s41418-024-01402-6 · Cited by 57
Mutations of isocitrate dehydrogenase 1 and 2 in intrahepatic cholangiocarcinoma
Grassian, A. R., Pagliarini, R. A., & Chiang, D. Y. (2014) · Current Opinion in Gastroenterology · doi:10.1097/mog.0000000000000050 · Cited by 54
DNA methylation epitypes highlight underlying developmental and disease pathways in acute myeloid leukemiaPreprint
Giacopelli, B., Wang, M., Sher, A. C., Wu, Y.-Z., Schultz, A. R., Schmutz, M., Blachly, J. S., Eisfeld, A., Mundy-Bosse, B. L., Vosberg, S., et al. (2021) · Genome Research · doi:10.1101/gr.269233.120 · Cited by 58
Preleukemic Hematopoietic Stem Cells in Human Acute Myeloid Leukemia
Corces, M. R., Chang, H. Y., & Majeti, R. (2017) · Frontiers in Oncology · doi:10.3389/fonc.2017.00263 · Cited by 56
Alterations of 5-Hydroxymethylcytosine in Human Cancers
Mariani, C. J., Madžo, J., Moen, E. L., Yesilkanal, A. E., & Godley, L. A. (2013) · Cancers · doi:10.3390/cancers5030786 · Cited by 53
Epigenetic regulators as promising therapeutic targets in acute myeloid leukemia
Gallipoli, P., Giotopoulos, G., & Huntly, B. J. P. (2015) · Therapeutic Advances in Hematology · doi:10.1177/2040620715577614 · Cited by 53
Next-Generation in vivo Modeling of Human Cancers
Gargiulo, G. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00429 · Cited by 55
Roles of IDH1/2 and TET2 mutations in myeloid disorders
Inoue, S., Lemonnier, F., & Mak, T. W. (2016) · International Journal of Hematology · doi:10.1007/s12185-016-1973-7 · Cited by 52
Self-citation
The biology and clinical impact of genetic lesions in myeloid malignancies
Lindsley, R. C., & Ebert, B. L. (2013) · Blood · doi:10.1182/blood-2013-06-460295 · Cited by 50
Hypoxia and Metabolism in Cancer
Bensaad, K., & Harris, A. L. (2013) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-5915-6_1 · Cited by 49
A Brain Penetrant Mutant IDH1 Inhibitor Provides In Vivo Survival Benefit
Kopinja, J. E., Sevilla, R. S., Levitan, D. J., Dai, D. L., Vanko, A., Spooner, E., Ware, C., Forget, R., Hu, K., Kral, A. M., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-14065-w · Cited by 49
(R) -2-Hydroxyglutarate Inhibits KDM5 Histone Lysine Demethylases to Drive Transformation in IDH -Mutant Cancers
Gunn, K., Myllykoski, M., Cao, J. Z., Ahmed, M., Huang, B., Rouaisnel, B., Diplas, B. H., Levitt, M. M., Looper, R., Doench, J. G., et al. (2023) · Cancer Discovery · doi:10.1158/2159-8290.cd-22-0825 · Cited by 57
Metabolite regulation of epigenetics in cancer
Wang, P., Chen, L., Xiong, Y., & Ye, D. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114815 · Cited by 50
Enantiomer-specific and paracrine leukemogenicity of mutant IDH metabolite 2-hydroxyglutarate
Chaturvedi, A., Cruz, M. M. A., Jyotsana, N., Sharma, A., Goparaju, R., Schwarzer, A., Görlich, K., Schottmann, R., Struys, E. A., Jansen, E. E. W., et al. (2016) · Leukemia · doi:10.1038/leu.2016.71 · Cited by 50
Epigenetic regulators and their impact on therapy in acute myeloid leukemia
Pastore, F., & Levine, R. L. (2016) · Haematologica · doi:10.3324/haematol.2015.140822 · Cited by 49
Sensitivity of hematopoietic stem cells to mitochondrial dysfunction by SdhD gene deletion
Bejarano-García, J. A., Millán‐Uclés, Á., Rosado, I. V., Sánchez‐Abarca, L. I., Caballero‐Velázquez, T., Durán-Galván, M. J., Pérez‐Simón, J. A., & Piruat, J. I. (2016) · Cell Death and Disease · doi:10.1038/cddis.2016.411 · Cited by 54
IDH1 mutation in human glioma induces chemical alterations that are amenable to optical Raman spectroscopy
Uckermann, O., Yao, W., Juratli, T. A., Galli, R., Leipnitz, E., Meinhardt, M., Koch, E., Schackert, G., Steiner, G. R., & Kirsch, M. (2018) · Journal of Neuro-Oncology · doi:10.1007/s11060-018-2883-8 · Cited by 50
Post-translational modifications on mitochondrial metabolic enzymes in cancer
Peng, Y., Liu, H., Liu, J., & Long, J. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.12.264 · Cited by 49
From Systems to Structure: Bridging Networks and Mechanism
Fraser, J. S., Gross, J. D., & Krogan, N. J. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.01.003 · Cited by 47
Glial Progenitors as Targets for Transformation in Glioma
Ilkhanizadeh, S., Lau, J., Huang, M., Foster, D. J., Wong, R. A., Frantz, A., Wang, S., Weiss, W. A., & Persson, A. I. (2014) · Advances in cancer research · doi:10.1016/b978-0-12-800249-0.00001-9 · Cited by 47
FOXOs support the metabolic requirements of normal and tumor cells by promoting IDH1 expression
Charitou, P., Colman, M. J. R., Gerrits, J., van Triest, M. H., Koerkamp, M. J. A. G., Hornsveld, M., Holstege, F. C. P., Verhoeven‐Duif, N. M., & Burgering, B. M. T. (2015) · EMBO Reports · doi:10.15252/embr.201439096 · Cited by 47
The oncometabolite D-2-hydroxyglutarate induced by mutant IDH1 or -2 blocks osteoblast differentiation in vitro and in vivo
Suijker, J., Baelde, H. J., Roelofs, H., Cleton-Jansen, A., & Bovée, J. V. M. G. (2015) · Oncotarget · doi:10.18632/oncotarget.4024 · Cited by 47
IDH mutations in liver cell plasticity and biliary cancer
Saha, S. K., Parachoniak, C. A., & Bardeesy, N. M. (2014) · Cell Cycle · doi:10.4161/15384101.2014.965054 · Cited by 46
Elevation of Urinary 2-Hydroxyglutarate in IDH-Mutant Glioma
Fathi, A. T., Nahed, B. V., Wander, S. A., Iafrate, A. J., Borger, D. R., Hu, R., Thabet, A., Cahill, D. P., Perry, A. M., Joseph, C. P., et al. (2016) · The Oncologist · doi:10.1634/theoncologist.2015-0342 · Cited by 46
Metabolomics of oncogene-specific metabolic reprogramming during breast cancer
Dai, C., Arceo, J., Arnold, J. M., Sreekumar, A., Dovic̀hi, N. J., Li, J., & Littlepage, L. E. (2018) · Cancer & Metabolism · doi:10.1186/s40170-018-0175-6 · Cited by 46
RNA N 6-Methyladenosine Modification in Normal and Malignant Hematopoiesis
Weng, H., Huang, H., & Chen, J. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-7342-8_4 · Cited by 45
Metabolic plasticity and hematopoietic stem cell biology
Hsu, P., & Qu, C. (2013) · Current Opinion in Hematology · doi:10.1097/moh.0b013e328360ab4d · Cited by 47
Genetically Engineered Mouse Models of Gliomas: Technological Developments for Translational Discoveries
Noorani, I. (2019) · Cancers · doi:10.3390/cancers11091335 · Cited by 45
Decreased FOXJ1 expression and its ciliogenesis programme in aggressive ependymoma and choroid plexus tumours
Abedalthagafi, M., Wu, M. P., Merrill, P. H., Du, Z., Woo, T. Y. C., Sheu, S., Hurwitz, S., Ligon, K. L., & Santagata, S. (2015) · The Journal of Pathology · doi:10.1002/path.4682 · Cited by 43
Metabolic Alterations in Cancer Cells and the Emerging Role of Oncometabolites as Drivers of Neoplastic Change
Zhou, Z., Ibekwe, E., & Chornenkyy, Y. (2018) · Antioxidants · doi:10.3390/antiox7010016 · Cited by 44
PRMT1 driven PTX3 regulates ferritinophagy in glioma
Lathoria, K., Gowda, P., Umdor, S. B., Patrick, S., Suri, V. S., & Sen, E. (2023) · Autophagy · doi:10.1080/15548627.2023.2165757 · Cited by 42
The IDH1-R132H mutation aggravates cisplatin-induced acute kidney injury by promoting ferroptosis through disrupting NDUFA1 and FSP1 interaction
Lai, K., Chen, Z., Lin, S., Ye, K., Yuan, Y., Li, G., Song, Y., Ma, H., Mak, T. W., & Xu, Y. (2024) · Cell Death and Differentiation · doi:10.1038/s41418-024-01381-8 · Cited by 42
Self-citation
Enasidenib and ivosidenib in AML
Martelli, M. P., Martino, G., Cardinali, V., Falini, B., Martinelli, G., & Cerchione, C. (2020) · Minerva Medica · doi:10.23736/s0026-4806.20.07024-x · Cited by 42
Mutant IDH1 Disrupts the Mouse Subventricular Zone and Alters Brain Tumor Progression
Pirozzi, C. J., Carpenter, A. B., Waitkus, M. S., Wang, C. Y., Zhu, H., Hansen, L. J., Chen, L. H., Greer, P. K., Feng, J., Wang, Y., et al. (2017) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-16-0485 · Cited by 42
Epigenetic dysregulation: a novel pathway of oncogenesis in pediatric brain tumors
Fontebasso, A. M., Gayden, T., Nikbakht, H., Neirinck, M., Papillon‐Cavanagh, S., Majewski, J., & Jabado, N. (2014) · Acta Neuropathologica · doi:10.1007/s00401-014-1325-8 · Cited by 40
HSC commitment–associated epigenetic signature is prognostic in acute myeloid leukemia
Bartholdy, B., Christopeit, M., Will, B., Mo, Y., Barreyro, L., Yu, Y., Bhagat, T. D., Okoye-Okafor, U. C., Todorova, T. I., Greally, J. M., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci71264 · Cited by 42
Self-citation
Stem cell origin of myelodysplastic syndromes
Elias, H. K., Schinke, C., Bhattacharyya, S., Will, B., Verma, A. K., & Steidl, U. G. (2013) · Oncogene · doi:10.1038/onc.2013.520 · Cited by 40
IDH1, lipid metabolism and cancer: Shedding new light on old ideas
Bogdanovic, E. (2015) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2015.04.014 · Cited by 39
Reductive carboxylation and 2-hydroxyglutarate formation by wild-type IDH2 in breast carcinoma cells
Smolková, K., Dvořák, A., Zelenka, J., Vı́tek, L., & Ježek, P. (2015) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2015.05.012 · Cited by 39
Exosome-based strategies for diagnosis and therapy of glioma cancer
Fath, M. K., Azami, J., Masoudi, A., Mosaddeghi-Heris, R., Rahmani, E., Alavi, F., Bahrami, A. A., Payandeh, Z., Khalesi, B., Dadkhah, M., et al. (2022) · Cancer Cell International · doi:10.1186/s12935-022-02642-7 · Cited by 40
Manganese superoxide dismutase depletion in murine hematopoietic stem cells perturbs iron homeostasis, globin switching, and epigenetic control in erythrocyte precursorcells
Case, A. J., Madsen, J. M., Motto, D. G., Meyerholz, D. K., & Domann, F. E. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.11.018 · Cited by 39
L2hgdh Deficiency Accumulates l -2-Hydroxyglutarate with Progressive Leukoencephalopathy and Neurodegeneration
Ma, S., Sun, R., Jiang, B., Gao, J., Deng, W., Liu, P., He, R., Cui, J., Ji, M., Yi, W., et al. (2017) · Molecular and Cellular Biology · doi:10.1128/mcb.00492-16 · Cited by 39
Targeting of two aspects of metabolism in breast cancer treatment
Gang, B. P., Dilda, P. J., Hogg, P. J., & Blackburn, A. C. (2014) · Cancer Biology & Therapy · doi:10.4161/15384047.2014.955992 · Cited by 40
IDH1 mutation contributes to myeloid dysplasia in mice by disturbing heme biosynthesis and erythropoiesis
Gu, Y., Yang, R., Yang, Y., Zhao, Y., Wakeham, A. C., Li, W. Y., Tseng, A., Leca, J., Berger, T., Saunders, M. E., et al. (2020) · Blood · doi:10.1182/blood.2020007075 · Cited by 38
Self-citation
Molecular Imaging of Metabolic Reprograming in Mutant IDH Cells
Viswanath, P., Chaumeil, M. M., & Ronen, S. M. (2016) · Frontiers in Oncology · doi:10.3389/fonc.2016.00060 · Cited by 38
Perspectives for therapeutic targeting of gene mutations in acute myeloid leukaemia with normal cytogenetics
Falini, B., Sportoletti, P., Brunetti, L., & Martelli, M. P. (2015) · British Journal of Haematology · doi:10.1111/bjh.13409 · Cited by 38
IGFBP2 expression predicts IDH-mutant glioma patient survival
Huang, L. E., Cohen, A. L., Colman, H., Jensen, R. L., Fults, D. W., & Couldwell, W. T. (2016) · Oncotarget · doi:10.18632/oncotarget.13329 · Cited by 37
Pathogenic Mechanisms in Acute Myeloid Leukemia
Chakraborty, S., & Park, C. Y. (2022) · Current Treatment Options in Oncology · doi:10.1007/s11864-022-01021-8 · Cited by 36
The mechanistic role of DNA methylation in myeloid leukemogenesis
Jasielec, J. K., Saloura, V., & Godley, L. A. (2014) · Leukemia · doi:10.1038/leu.2014.163 · Cited by 37
Non‐genetic heterogeneity, altered cell fate and differentiation therapy
Lewis, A. C., & Kats, L. M. (2021) · EMBO Molecular Medicine · doi:10.15252/emmm.202012670 · Cited by 36
Inhibitors of Mutant Isocitrate Dehydrogenases 1 and 2 (mIDH1/2): An Update and Perspective
Ma, T., Zou, F., Pusch, S., Xu, Y., von Deimling, A., & Zha, X. (2018) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.8b00159 · Cited by 35
Unraveling the mystery of cancer metabolism in the genesis of tumor-initiating cells and development of cancer
Zhang, G., Yang, P., Guo, P.-D., Miele, L., Sarkar, F. H., Wang, Z. P., & Zhou, Q. (2013) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2013.03.001 · Cited by 34
Emergence of heterogeneity in acute leukemias
Stiehl, T., Lutz, C., & Marciniak-Czochra, A. K. (2016) · Biology Direct · doi:10.1186/s13062-016-0154-1 · Cited by 34
IDH1 Mutation Promotes Tumorigenesis by Inhibiting JNK Activation and Apoptosis Induced by Serum Starvation
Jiang, B., Zhang, J., Xia, J., Zhao, W., Wu, Y., Shi, M., Luo, L., Zhou, H., Chen, A., Ma, H., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.03.053 · Cited by 33
Self-citation
Genetic profiling of intrahepatic cholangiocarcinoma and its clinical implication in targeted therapy.
Xie, D., Ren, Z., Fan, J., & Gao, Q. (2016) · PubMed Central · Cited by 34
Targeting STAT5 Signaling Overcomes Resistance to IDH Inhibitors in Acute Myeloid Leukemia through Suppression of Stemness
Liu, A. C. H., Cathelin, S., Yang, Y., Dai, D. L., Ayyathan, D. M., Hosseini, M., Minden, M. D., Tierens, A. M., & Chan, S. M. (2022) · Cancer Research · doi:10.1158/0008-5472.can-22-1293 · Cited by 33
Extramedullary Hematopoiesis (EMH) in Laboratory Animals: Offering an Insight into Stem Cell Research
Chiu, S., Liu, H.-H., Chen, C., Chen, P.-R., Liu, M.-C., Lin, S., & Chang, K. (2015) · Cell Transplantation · doi:10.3727/096368915x686850 · Cited by 36
Pediatric high-grade astrocytomas: a distinct neuro-oncological paradigm
Gerges, N., Fontebasso, A. M., Albrecht, S., Faury, D., & Jabado, N. (2013) · Genome Medicine · doi:10.1186/gm470 · Cited by 33
Small molecule activation of NOTCH signaling inhibits acute myeloid leukemia
Qi, Y., Jiang, J., Zhan, G., Yan, W., Huang, L., Hu, Y., Su, H., Tong, Q., Yue, M., Li, H., et al. (2016) · Scientific Reports · doi:10.1038/srep26510 · Cited by 33
Molecular and Genomic Landscape of Peripheral T-Cell Lymphoma
Iqbal, J., Amador, C., McKeithan, T. W., & Chan, W. C. (2018) · Cancer treatment and research · doi:10.1007/978-3-319-99716-2_2 · Cited by 35
Transcriptional networks in acute myeloid leukemia
Thoms, J. A. I., Beck, D., & Pimanda, J. E. (2019) · Genes Chromosomes and Cancer · doi:10.1002/gcc.22794 · Cited by 33
A Critical Review of Animal Models Used in Acute Myeloid Leukemia Pathophysiology
Skayneh, H., Jishi, B., Hleihel, R., Hamieh, M., Darwiche, N., Bazarbachi, A. A., El-Sabban, M. E., & Hajj, H. E. (2019) · Genes · doi:10.3390/genes10080614 · Cited by 32
Contribution of metabolic abnormalities to acute myeloid leukemia pathogenesis
Egan, G., & Schimmer, A. D. (2022) · Trends in Cell Biology · doi:10.1016/j.tcb.2022.11.004 · Cited by 35
The epigenetic landscape of T-cell acute lymphoblastic leukemia
der Meulen, J. V., Roy, N. V., Vlierberghe, P. V., & Speleman, F. (2014) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2014.04.015 · Cited by 35
IDH1 deficiency attenuates gluconeogenesis in mouse liver by impairing amino acid utilization
Ye, J., Gu, Y., Zhang, F., Zhao, Y., Yuan, Y., Hao, Z., Sheng, Y., Li, W. Y., Wakeham, A. C., Cairns, R. A., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1618605114 · Cited by 32
Self-citation
Innovative Medicine
Nakao, K., Minato, N., & Üemoto, S. (2015) · Springer eBooks · doi:10.1007/978-4-431-55651-0 · Cited by 34
Mutant IDH1 confers resistance to energy stress in normal biliary cells through PFKP-induced aerobic glycolysis and AMPK activation
Fujiwara, H., Tateishi, K., Misumi, K., Hayashi, A., Igarashi, K., Kato, H., Nakatsuka, T., Suzuki, N., Yamamoto, K., Kudo, Y., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-55211-w · Cited by 32
Focal disruption of DNA methylation dynamics at enhancers in IDH-mutant AML cells
Wilson, E. R., Helton, N., Heath, S. E., Fulton, R. S., Payton, J. E., Welch, J. S., Walter, M. J., Westervelt, P., DiPersio, J. F., Link, D. C., et al. (2021) · Leukemia · doi:10.1038/s41375-021-01476-y · Cited by 31
2-Hydroxyglutarate in Acute Myeloid Leukemia: A Journey from Pathogenesis to Therapies
Raimondi, V., Ciotti, G., Gottardi, M., & Ciccarese, F. (2022) · Biomedicines · doi:10.3390/biomedicines10061359 · Cited by 35
Cancer metabolomics in basic science perspective
Kwon, H. N., Oh, S., Jin, X., An, Y., & Park, S. (2015) · Archives of Pharmacal Research · doi:10.1007/s12272-015-0552-4 · Cited by 32
Systematic Analysis Reveals that Cancer Mutations Converge on Deregulated Metabolism of Arachidonate and Xenobiotics
Gatto, F., Schulze, A., & Nielsen, J. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.06.038 · Cited by 30
Epigenetic Modifiers in Normal and Malignant Hematopoiesis
Haladyna, J. N., Yamauchi, T., Neff, T., & Bernt, K. M. (2015) · Epigenomics · doi:10.2217/epi.14.88 · Cited by 30
Clonal evolution of preleukemic hematopoietic stem cells in acute myeloid leukemia
Sykes, S. M., Kokkaliaris, K. D., Milsom, M. D., Levine, R. L., & Majeti, R. (2015) · Experimental Hematology · doi:10.1016/j.exphem.2015.08.012 · Cited by 32
Polycomb repressive complex 2 in the driver’s seat of childhood and young adult brain tumours
Krug, B., Harutyunyan, A. S., Deshmukh, S., & Jabado, N. (2021) · Trends in Cell Biology · doi:10.1016/j.tcb.2021.05.006 · Cited by 29
Genetic dissection of leukemia-associated IDH1 and IDH2 mutants and D-2-hydroxyglutarate in Drosophila
Reitman, Z. J., Sinenko, S. A., Spana, E. P., & Yan, H. (2014) · Blood · doi:10.1182/blood-2014-05-577940 · Cited by 29
IDH1 Arg-132 mutant promotes tumor formation through down-regulating p53
Jiang, B., Zhao, W., Shi, M., Zhang, J., Chen, A., Ma, H., Suleman, M., Lin, F., Zhou, L., Wang, J., et al. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra117.001385 · Cited by 29
Deconvoluting clonal and cellular architecture in IDH-mutant acute myeloid leukemia
Sirenko, M., Lee, S., Sun, Z., Chaligne, R., Loghavi, S., Asimomitis, G., Brierley, C. K., Bernard, E., Cai, S. F., Myers, R. M., et al. (2025) · Cell Stem Cell · doi:10.1016/j.stem.2025.04.012 · Cited by 28
Enigmas of IDH mutations in hematology/oncology
Heuser, M., Cruz, M. M. A., Goparaju, R., & Chaturvedi, A. (2015) · Experimental Hematology · doi:10.1016/j.exphem.2015.05.005 · Cited by 28
Isocitrate dehydrogenase 1 mutation enhances 24(S)-hydroxycholesterol production and alters cholesterol homeostasis in glioma
Yang, R., Zhao, Y., Gu, Y., Yang, Y., Gao, X., Yuan, Y., Xiao, L., Zhang, J., Sun, C., Yang, H. K., et al. (2020) · Oncogene · doi:10.1038/s41388-020-01439-0 · Cited by 29
CpG Island Methylator Phenotype—A Hope for the Future or a Road to Nowhere?
Karpiński, P., & Sasiadek, M. M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020830 · Cited by 30
Neoantigen-specific TCR-T cell-based immunotherapy for acute myeloid leukemia
Zhou, W., Yu, J., Li, Y., & Wang, K. (2022) · Experimental Hematology and Oncology · doi:10.1186/s40164-022-00353-3 · Cited by 27
Functions of idh1 and its mutation in the regulation of developmental hematopoiesis in zebrafish
Shi, X. E., He, A. B.-L., Ma, A. C. H., Guo, Y., Chi, Y., Man, C. H., Zhang, W., Zhang, Y., Wen, Z., Cheng, T., et al. (2015) · Blood · doi:10.1182/blood-2014-09-601187 · Cited by 27
Functions of TET Proteins in Hematopoietic Transformation
Han, J., An, J., & Ko, M. (2015) · Molecules and Cells · doi:10.14348/molcells.2015.0294 · Cited by 26
Cofactors As Metabolic Sensors Driving Cell Adaptation in Physiology and Disease
Rabhi, N., Hannou, S. A., Froguel, P., & Annicotte, J. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00304 · Cited by 27
Isocitrate Dehydrogenase Mutations in Myelodysplastic Syndromes and in Acute Myeloid Leukemias
Testa, U., Castelli, G., & Pelosi, E. (2020) · Cancers · doi:10.3390/cancers12092427 · Cited by 26
Mutant IDH : A Targetable Driver of Leukemic Phenotypes Linking Metabolism, Epigenetics and Transcriptional Regulation
Garrett-Bakelman, F. E., & Melnick, A. M. (2016) · Epigenomics · doi:10.2217/epi-2016-0008 · Cited by 25
Self-citation
Novel epigenetic therapies in hematological malignancies: Current status and beyond
Gallipoli, P., & Huntly, B. J. P. (2017) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2017.07.005 · Cited by 25
Role of Isocitrate Dehydrogenase 2 on DNA Hydroxymethylation in Human Airway Smooth Muscle Cells
Yeung, B. H. Y., Huang, J., An, S. S., Solway, J., Mitzner, W., & Tang, W. (2020) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2019-0323oc · Cited by 25
Dissecting TET2 Regulatory Networks in Blood Differentiation and Cancer
Lazarenkov, A., & Sardina, J. L. (2022) · Cancers · doi:10.3390/cancers14030830 · Cited by 26
Inhibition of mutant IDH1 promotes cycling of acute myeloid leukemia stem cells
Gruber, E., So, J., Lewis, A. C., Franich, R. L., Cole, R., Martelotto, L. G., Rogers, A. J., Vidacs, E., Fraser, P., Stanley, K. L., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111182 · Cited by 28
HDAC1 and HDAC6 are essential for driving growth in IDH1 mutant glioma
Garrett, M. C., Albano, R., Carnwath, T., Elahi, L. S., Behrmann, C. A., Pemberton, M., Woo, D., O'Brien, E. J., VanCauwenbergh, B., Perentesis, J. P., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-33889-3 · Cited by 27
Clonal dynamics in a single AML case tracked for 9 years reveals the complexity of leukemia progression
Kim, T., Yoshida, K., Kim, Y. K., Tyndel, M. S., Park, H. J., Choi, S., Ahn, J., Jung, S.-H., Yang, D.-H., Lee, J.-J., et al. (2015) · Leukemia · doi:10.1038/leu.2015.264 · Cited by 24
Epigenetic Changes as a Target in Aging Haematopoietic Stem Cells and Age-Related Malignancies
Buisman, S. C., & de Haan, G. (2019) · Cells · doi:10.3390/cells8080868 · Cited by 24
The molecular basis of myeloid malignancies
Kitamura, T., Inoue, D., Okochi, N., Kato, N., Komeno, Y., Yang, L. U., Enomoto, Y., Doki, N., UCHIDA, T., Kagiyama, Y., et al. (2014) · Proceedings of the Japan Academy Series B · doi:10.2183/pjab.90.389 · Cited by 26
Mutant IDH1 promotes phagocytic function of microglia/macrophages in gliomas by downregulating ICAM1
Ma, D., Zhan, D., Fu, Y., Wei, S., Lal, B., Wang, J., Li, Y.-Q., López-Bertoni, H., Yalçın, F., Dzaye, O. D. A., et al. (2021) · Cancer Letters · doi:10.1016/j.canlet.2021.05.038 · Cited by 23
Impact of DNA methylation programming on normal and pre-leukemic hematopoiesis
Langstein, J., Milsom, M. D., & Lipka, D. B. (2017) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2017.09.008 · Cited by 25

Authors: Sasaki, M., Knobbe, C. B., Munger, J. C., Lind, E. F., Brenner, D., Brüstle, A., Harris, I. S., Holmes, R., Wakeham, A., Haight, J., You-Ten, A., Li, W. Y., Schalm, S., Su, S. M., Virtanen, C., Reifenberger, G., Ohashi, P. S., Barber, D. L., Figueroa, M. E., Melnick, A., Zúñiga-Pflücker, J.-C., & Mak, T. W.
Affiliations: University Health Network (CA)
University of Rochester Medicine (US)
University of Toronto (CA)
Agios Pharmaceuticals (United States) (US)
Heinrich Heine University Düsseldorf (DE)
Cornell University (US)
Corresponding author: Mak, Tak W.
ORCID: Sasaki, Masato
Munger, Joshua C.
Lind, Evan F.
Brenner, Dirk
Harris, Isaac S.
Holmes, Roxanne
Haight, Jillian
Li, Wanda Y.
Schalm, Stefanie
Virtanen, Carl
Reifenberger, Guido
Ohashi, Pamela S.
Barber, Dwayne L.
Melnick, Ari
Mak, Tak W.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2012-07-04
Volume: 488
Issue: 7413
Pages: 656-659
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature11323
PMC: PMC4005896
OpenAlex: W2035409103
Cited by: 513
References: 34
Citations by year: 2026: 5 · 2025: 20 · 2024: 16 · 2023: 27 · 2022: 26 · 2021: 31 · 2020: 28 · 2019: 34 · 2018: 33 · 2017: 44 · 2016: 55 · 2015: 55 · 2014: 53 · 2013: 64 · 2012: 21
FWCI: 41.37
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
RePEc: Research Papers in Economics (submittedVersion)
ANU Open Research (Australian National University) (submittedVersion)
Funders: Canadian Institutes of Health Research
National Institute of Allergy and Infectious Diseases (R56AI081773, R01AI081773)
Topics: Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
Health Sciences › Medicine › Oncology › Glioma Diagnosis and Treatment
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Keywords: IDH1 R132H mutation, isocitrate dehydrogenase, 2-hydroxyglutarate, acute myeloid leukemia, hematopoietic progenitor cells, epigenetics, DNA methylation, histone methylation, conditional knock-in mice, extramedullary hematopoiesis, splenomegaly, anemia
MeSH terms: Aging, Animals, Bone Marrow, Disease Models, Animal, Female, Glioma, Hematopoiesis, Hematopoietic Stem Cells, Histones, Humans, Isocitrate Dehydrogenase, Male, Mutation, Spleen, Leukemia, Myeloid, Acute, CpG Islands, Cell Lineage, DNA Methylation, Myeloid Cells, Epigenesis, Genetic, Mutant Proteins, Mice, Gene Knock-In Techniques

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks