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Autistic-like behaviour in Scn1a+/− mice and rescue by enhanced GABA-mediated neurotransmission
Open accessAbstract
Haploinsufficiency of the SCN1A gene encoding voltage-gated sodium channel Na(V)1.1 causes Dravet's syndrome, a childhood neuropsychiatric disorder including recurrent intractable seizures, cognitive deficit and autism-spectrum behaviours. The neural mechanisms responsible for cognitive deficit and autism-spectrum behaviours in Dravet's syndrome are poorly understood. Here we report that mice with Scn1a haploinsufficiency exhibit hyperactivity, stereotyped behaviours, social interaction deficits and impaired context-dependent spatial memory. Olfactory sensitivity is retained, but novel food odours and social odours are aversive to Scn1a(+/-) mice. GABAergic neurotransmission is specifically impaired by this mutation, and selective deletion of Na(V)1.1 channels in forebrain interneurons is sufficient to cause these behavioural and cognitive impairments. Remarkably, treatment with low-dose clonazepam, a positive allosteric modulator of GABA(A) receptors, completely rescued the abnormal social behaviours and deficits in fear memory in the mouse model of Dravet's syndrome, demonstrating that they are caused by impaired GABAergic neurotransmission and not by neuronal damage from recurrent seizures. These results demonstrate a critical role for Na(V)1.1 channels in neuropsychiatric functions and provide a potential therapeutic strategy for cognitive deficit and autism-spectrum behaviours in Dravet's syndrome.
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“Loss of function variants of NaV1.1 cause Dravet syndrome [48], generalized epilepsy with febrile seizures plus [49], and have also been associated with ASD [50,51].”
From Progress in Understanding and Treating SCN2A-Mediated Disorders (2018) · cites this paper as [51]
In the citing paper
“Low doses of clonazepam completely rescued the abnormal social behaviors and deficits in fear memory typically presented by Scn1a+/- mice (Han et al., 2012), demonstrating the impact of restoring the proper coordination of inhibitory transmissions.”
From Unifying Views of Autism Spectrum Disorders: A Consideration of Autoregulatory Feedback Loops (2016) · cites this paper as Han et al., 2012
In the citing paper
“Low doses of clonazepam completely rescued the abnormal social behaviors and deficits in fear memory typically presented by Scn1a+/- mice (Han et al., 2012), demonstrating the impact of restoring the proper coordination of inhibitory transmissions.”
From Unifying Views of Autism Spectrum Disorders: A Consideration of Autoregulatory Feedback Loops (2016) · cites this paper as Han et al., 2012
In the citing paper
“In mice haploinsufficient for Scn1a , treatment with low-dose clonazepam, a positive allosteric modulator of GABAA receptors, completely reversed the abnormal social behaviors and deficits in fear memory 77 .”
From Progress toward treatments for synaptic defects in autism (2013) · cites this paper as [77]
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Cites
Model of autism: increased ratio of excitation/inhibition in key neural systems
Rubenstein, J. L. R., & Merzenich, M. M. (2003) · Genes, Brain and Behavior · doi:10.1034/j.1601-183x.2003.00037.x · Cited by 2,768
Self-citationNeocortical excitation/inhibition balance in information processing and social dysfunction
Yizhar, O., Fenno, L. E., Prigge, M., Schneider, F., Davidson, T. J., O’Shea, D. J., Sohal, V. S., Goshen, I., Finkelstein, J., Paz, J. T., et al. (2011) · Nature · doi:10.1038/nature10360 · Cited by 2,454
Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations
O’Roak, B. J., Vives, L., Girirajan, S., Karakoc, E., Krumm, N., Coe, B. P., Levy, R., Ko, A., Lee, C., Smith, J. D., et al. (2012) · Nature · doi:10.1038/nature10989 · Cited by 2,165
From Ionic Currents to Molecular Mechanisms
Catterall, W. A. (2000) · Neuron · doi:10.1016/s0896-6273(00)81133-2 · Cited by 2,124
Self-citationAdvances in autism genetics: on the threshold of a new neurobiology
Abrahams, B. S., & Geschwind, D. H. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2346 · Cited by 1,866
Paraganglioma of the filum terminale internum
Kamalian, N., Abbassioun, K., Amirjamshidi, A., & Shams-Shahrabadi, M. (1987) · Journal of Neurology · doi:10.1007/bf00314201 · Cited by 1,595
Report of a case and review of the literature
Kamalian, N., Abbassioun, K., Amirjamshidi, A., et al. (1987) · Cited by 1,576
Behavioural phenotyping assays for mouse models of autism
Silverman, J. L., Yang, M., Lord, C., & Crawley, J. N. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2851 · Cited by 1,462
De Novo Mutations in the Sodium-Channel Gene SCN1A Cause Severe Myoclonic Epilepsy of Infancy
Claes, L., Del-Favero, J., Ceulemans, B., Lagae, L., Van Broeckhoven, C., & De Jonghe, P. (2001) · The American Journal of Human Genetics · doi:10.1086/320609 · Cited by 1,292
Exome sequencing in sporadic autism spectrum disorders identifies severe de novo mutations
O'Roak, B. J., Deriziotis, P., Lee, C., Vives, L., Schwartz, J. J., Girirajan, S., Karakoc, E., MacKenzie, A. P., Ng, S. B., Baker, C., et al. (2011) · Nature Genetics · doi:10.1038/ng.835 · Cited by 1,203
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Cheong, E., & Lee, C. J. (2025) · Handbook of clinical neurology · doi:10.1016/b978-0-443-19104-6.00003-6 · Cited by 6
Dysregulation of the Cannabinoid System in Childhood Epilepsy: From Mechanisms to Therapy
Montebello, G., & Giovanni, G. D. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26136234 · Cited by 6
Epilepsy and Intellectual and Developmental Disabilities
Oguni, H. (2013) · Journal of Policy and Practice in Intellectual Disabilities · doi:10.1111/jppi.12035 · Cited by 5
Neural Network Excitation/Inhibition: A Key to Empathy and Empathy Impairment
Tang, Y., Wang, C., Li, Q., Liu, G., Song, D. F., Quan, Z., Yan, Y., & Qing, H. (2024) · The Neuroscientist · doi:10.1177/10738584231223119 · Cited by 9
Isom, L. L. (2014) · Epiliepsy currents/Epilepsy currents · doi:10.5698/1535-7597-14.6.350 · Cited by 5
Properties of Calmodulin Binding to NaV1.2 IQ Motif and Its Autism-Associated Mutation R1902C
Jia, W., Liu, J., Yu, Z., Zhang, X., Xu, X., Wang, Y., Gao, Q., Feng, R., Wan, Y., Xu, J., et al. (2021) · Neurochemical Research · doi:10.1007/s11064-020-03189-7 · Cited by 5
Structure-function relationship of new peptides activating human Nav1.1
Lopez, L., Waard, S. D., Meudal, H., Caumes, C., Khakh, K., Peigneur, S., Oliveira-Mendes, B. B. R., Lin, S., Waele, J. D., Montnach, J., et al. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115173 · Cited by 5
Transcriptional Regulation of Cortical Interneuron Development
Pai, E. L.-L., Vogt, D. L., Hu, J. S., & Rubenstein, J. L. R. (2024) · Oxford University Press eBooks · doi:10.1093/med/9780197549469.003.0047 · Cited by 6
Self-citationMutations of Ion Channels in Genetic Epilepsies
Mantegazza, M., Rusconi, R., & Cestèle, S. (2014) · Contemporary clinical neuroscience · doi:10.1007/978-3-319-12283-0_2 · Cited by 5
Alabdali, A. N., Bacha, A. G. B., Alonazi, M. A., Abuaish, S., Almotairi, A. R., AL-Ayadhi, L. Y., & El-Ansary, A. K. (2025) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2025.1553438 · Cited by 4
Yu, Y., Zhao, Y., Feng, J., Lian, N., Yu, J., Yang, Y., Yao, J., & Yu, Y. (2025) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70376 · Cited by 4
Nakakubo, S., Hiramatsu, Y., Goto, T., Kimura, S., Narugami, M., Nakajima, M., Ueda, Y., Shiraishi, H., Manabe, A., Sharmin, D., et al. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1273633 · Cited by 4
Li, X., Fu, Q., Zhong, M., Long, Y., Zhao, F., Huang, Y., Zhang, Z., Wen, M., Chen, K., Chen, R., et al. (2024) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2024.102136 · Cited by 4
Specchio, N., & Auvin, S. (2025) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2025.110271 · Cited by 4
Zhang, Q., Martin‐Caraballo, M., & Hsia, S. V. (2020) · Cell & Bioscience · doi:10.1186/s13578-020-00430-2 · Cited by 4
Epilepsies in Children with 2q24.3 Deletion/Duplication
Yamamoto, T., Kurahashi, H., Takasu, M., & Okumura, A. (2015) · Journal of Pediatric Epilepsy · doi:10.1055/s-0035-1554786 · Cited by 4
Haploinsufficiency of hnRNP U Changes Activity Pattern and Metabolic Rhythms
Lai, B., Zou, J., Lin, Z., Qu, Z., Song, A., Xu, Y., & Gao, X. (2017) · American Journal Of Pathology · doi:10.1016/j.ajpath.2017.09.017 · Cited by 4
The Autistic Spectrum Disorders (ASD): From the Clinics to the Molecular Analysis
Roubertoux, P. L., & Tordjman, S. (2014) · Neuromethods · doi:10.1007/978-1-4939-2250-5_2 · Cited by 4
Serotonin Disturbance in Mouse Models of Autism Spectrum Disorders
Tamada, K., & Takumi, T. (2014) · Neuromethods · doi:10.1007/978-1-4939-2250-5_9 · Cited by 4
Early hippocampal hyperexcitability followed by disinhibition in a mouse model of Dravet syndromePreprint
Almog, Y., Brusel, M., Anderson, K., & Rubinstein, M. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/790170 · Cited by 4
Physiological and molecular impairment of PV circuit homeostasis in mouse models of autismPreprint
Monday, H. R., Nieto, A. M., Yohannes, S., Luxu, S., Wong, K. G., Bolio, F. E., & Feldman, D. E. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.01.08.632056 · Cited by 4
Ion Channels in Odor Information Processing of Neural Circuits of the Vertebrate Olfactory Bulb
Yu, Y.-Q., Liao, P. S., & Jiang, R. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252413259 · Cited by 3
Voltage-Gated Sodium Channel Dysfunction in Epilepsy: Zebrafish Models for Therapeutics
Gyamfi, A., Manikandan, P., Cisneros, W. A., Cummins, T., & Marrs, J. A. (2025) · Biomedicines · doi:10.3390/biomedicines13092078 · Cited by 3
The First 30 Days Postnatal of the GABA Receptor: A Comprehensive Overview
Falsaperla, R., Collotta, A. D., Sortino, V., Malaventura, C., Spatuzza, M., Romano, C., & Suppiej, A. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05326-1 · Cited by 3
Xiang, L.-Y., Chen, X.-Y., Lu, L., Kong, M.-H., Ji, Q., Xiong, Y., Xie, M.-M., Jian, X.-L., & Zhu, Z.-R. (2024) · Neuroscience · doi:10.1016/j.neuroscience.2024.05.030 · Cited by 3
Current Trends in Dravet syndrome Research
Higurashi, N. (2013) · Journal of Neurology & Neurophysiology · doi:10.4172/2155-9562.1000152 · Cited by 3
Disease Modification in Epilepsy: Behavioural Accompaniments
Russo, E., & Citraro, R. (2021) · Current topics in behavioral neurosciences · doi:10.1007/7854_2020_216 · Cited by 3
Hernández, A. V. M., Caro‐Llopis, A., Rubio-Sanchez, P., Martı́nez, J. C., Vila, M. T., Monfort, S., & Martı́nez, F. (2022) · Journal of Child Neurology · doi:10.1177/08830738211072694 · Cited by 3
Before the first seizure: The developmental imprint of infant epilepsy on neurodevelopment
Milh, M. (2023) · Revue Neurologique · doi:10.1016/j.neurol.2023.01.725 · Cited by 3
Ho, S., Chen, I., Tsai, C., Chang, K., Lin, C., Chern, Y., & Liou, H. (2023) · Hippocampus · doi:10.1002/hipo.23584 · Cited by 3
Turkalj, L., Mehta, M., Matteson, P. G., Prem, S., Williams, M., Connacher, R., DiCicco-Bloom, E. M., & Millonig, J. H. (2020) · Advances in neurobiology · doi:10.1007/978-3-030-45493-7_4 · Cited by 3
Rosch, R. E., & Goldberg, E. M. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-89932-1.00015-9 · Cited by 3
White, H. S., & Barker‐Haliski, M. L. (2015) · Wiley eBooks · doi:10.1002/9781118936979.ch4 · Cited by 3
Dey, S., & Das, A. (2026) · Brain Research · doi:10.1016/j.brainres.2026.150164 · Cited by 2
Differential GABA dynamics across brain functional networks in autism
Huang, Q., Chen, D., Pereira, A. C., Leonard, A., Ellis, C. L., Velthuis, H., Dimitrov, M., Ponteduro, F. M., Wong, N. M. L., Kowalewski, Ł., et al. (2026) · Communications Biology · doi:10.1038/s42003-026-09563-5 · Cited by 2
Targeting notch signaling to restore neural development and behavior in mouse models of ASD
Hanno, Y., Nakanishi, M., Takase, A., Nomura, J., Tanaka, M., Iida, Y., Tanaka, M., Hosokawa, H., Ito, M., Mikami, K., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-70321-6 · Cited by 2
Cestèle, S., Harper, A. J., Marra, S., Leroudier, N., Rusconi, R., Dhifallah, S., Horrocks, I. A., Kirkham, F. J., Morgan, I. M. R., Singh, J., et al. (2026) · Neurology Genetics · doi:10.1212/nxg.0000000000200352 · Cited by 2
Higurashi, N., Okano, H., & Hirose, S. (2013) · Future Neurology · doi:10.2217/fnl.13.34 · Cited by 2
Takechi, K. (2019) · YAKUGAKU ZASSHI · doi:10.1248/yakushi.19-00159 · Cited by 2
The Genetic Facets of Dravet Syndrome: Recent Insights
Mouhi, H. E., Abbassi, M., Jalte, M., Natiq, A., Bouguenouch, L., & Chaouki, S. (2024) · Annals of Child Neurology · doi:10.26815/acn.2023.00367 · Cited by 2
Ma, D., & Gu, C. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105897 · Cited by 2
Abnormalities in the functional activity of neural networks in a human iPSC model of Dravet syndrome
Mzezewa, R., Hyvärinen, T., Kulta, O., Vinogradov, A., Pesu, E., Isosaari, L., Vuolanto, V., Kapucu, F. E., Schuster, J., Dahl, N., et al. (2025) · Neuroscience Research · doi:10.1016/j.neures.2025.104958 · Cited by 2
Neuroinflammation in the Pathogenesis of Early Life Epileptic Encephalopathies
Salar, S., & Galanopoulou, A. S. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-53088-0.00005-1 · Cited by 2
What Rodent Models Teach Us about the Association of Autism and Epilepsy
Golshani, P. (2024) · Oxford University Press eBooks · doi:10.1093/med/9780197549469.003.0059 · Cited by 2
Lee, K. S., Lee, T., Kim, M., Ignatova, E., Ban, H., Sung, M. K., Kim, Y., Kim, Y., Han, J., & Choi, J. K. (2025) · Scientific Reports · doi:10.1038/s41598-024-83839-w · Cited by 2
Xu, Z., Liu, Z., He, X., Shu, H., Wang, X., Liu, T., Chen, L., Zhang, W., Xu, P., & Liu, Y. (2025) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2025.03.016 · Cited by 2
Zhu, L., Demetriou, Y., Barden, J., Disla, J., Zhao, M., & Mattis, J. (2025) · Epilepsia · doi:10.1111/epi.18532 · Cited by 2
Autism and Medical Comorbidities
Schiff, M., & Asato, M. R. (2015) · Key issues in mental health (Online)/Key issues in mental health (Print) · doi:10.1159/000363562 · Cited by 2
[Research advances in candidate genes for autism spectrum disorder].
Yang, Z., & Sun, G. (2016) · PubMed Central · doi:10.7499/j.issn.1008-8830.2016.03.018 · Cited by 2
Emery, B. A., Everett, M., Dunn, L. R., Lau, B. Y. B., & Krishnan, K. (2026) · Frontiers in Neuroscience · doi:10.3389/fnins.2026.1769195 · Cited by 2
Enhanced cross-modal activation of sensory cortex in mouse models of autismPreprint
Hattori, R., Südhof, T. C., Yamakawa, K., & Hensch, T. K. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/150839 · Cited by 2
Pernici, C. D., Spink, A., Dahle, E. J., Johnson, K. J., Metcalf, C. S., West, P. J., & Wilcox, K. S. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.06.16.448684 · Cited by 2
Li, W., He, S., Chen, J., Ma, J., Wu, Y., Yang, R., Chen, M., Li, X., Sun, Z., Chu, C., et al. (2026) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2026.111765 · Cited by 1
Catterall, W. A. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802002-9.00004-2 · Cited by 1
Self-citationDissecting Epileptic and Cognitive Network Dysfunction in Epilepsy
Lenck‐Santini, P., & Holmes, G. L. (2024) · Oxford University Press eBooks · doi:10.1093/med/9780197549469.003.0057 · Cited by 1
Establishment of Neurodevelopment in the First 1000 Days of Life
Mazaheri‐Tehrani, S., Bemanalizadeh, M., Poursafa, P., & Kelishadi, R. (2024) · Springer eBooks · doi:10.1007/978-981-97-7433-3_1 · Cited by 2
Odierna, G. L., Stednitz, S. J., Pruitt, A., Arnold, J., Hoffman, E. J., & Scott, E. K. (2025) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2025.110426 · Cited by 1
Hu, Z., Liu, W.-T., Li, Y., Hu, L., Huang, Y., Liu, X.-Y., Zhang, Q., Wang, Y., Chen, J., Li, Z.-X., et al. (2025) · Acta Pharmacologica Sinica · doi:10.1038/s41401-025-01588-6 · Cited by 1
Reed, S. L., Aiani, L. M., Faiz, E., Adediran, E. O., Benveniste, M., Murnane, K. S., D’Souza, M. J., Escayg, A., & Wong, J. C. (2025) · Epilepsia · doi:10.1111/epi.18649 · Cited by 1
Development of Novel Small-Molecule Targeting SCN1A-Associated Severe Myoclonic Epilepsy of Infancy
Kim, D. G., Hwang, K.-S., Ahn, S. H., Kim, S. S., Son, Y., Park, S. B., Jung, W. H., Shin, D., Cho, S. H., Choi, B. W., et al. (2026) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5c03293 · Cited by 1
Varman, D. R., Sivamaruthi, B. S., Kesika, P., Martínez‐Torres, A., Reyes‐Haro, D., & Chaiyasut, C. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1840553 · Cited by 1
[Advances on GABAergic interneurons in autism spectrum disorders].
Li, J., Xu, J., & Luo, J. (2020) · PubMed Central · doi:10.3785/j.issn.1008-9292.2020.08.10 · Cited by 1
Букина, Е. С., Kondratyev, N. V., Kozin, S. V., Голимбет, В. Е., Artyuhov, A., & Dashinimaev, E. B. (2021) · Neurochemical Journal · doi:10.1134/s1819712421040048 · Cited by 1
Rodent Models for ASD Biomarker Development
Lee, H. H. C., & Şahin, M. (2024) · Advances in neurobiology · doi:10.1007/978-3-031-69491-2_8 · Cited by 2
Alabdali, A. N. (2025) · International journal for autism challenges & solution. · doi:10.54878/sgp7fp60 · Cited by 1
Altered motor activity and social behavior in zebrafish lacking the Hcn2b ion channel
Rodríguez-Ortiz, R., Fernández-Rosales, J. P., García-Peña, M. F., Hernández, A., Espino-Saldaña, Á. E., & Martínez‐Torres, A. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.09.020 · Cited by 1
Neurobehavioral Comorbidities of Epilepsy: Lessons from Animal Models
Mazarati, A. M. (2015) · Neuropsychiatric symptoms of neurological disease · doi:10.1007/978-3-319-22159-5_1 · Cited by 1
ISDN2014_0117: Brain morphometry of Dravet Syndrome
Pérez, A., García‐Pentón, L., Canales-Rodríguez, E. J., Lerma‐Usabiaga, G., Davidson, D. J., Alemán‐Gómez, Y., Iturria‐Medina, Y., Acha, J., & Carreiras, M. (2015) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2015.04.096 · Cited by 1
Richards, K., & Petrou, S. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804066-9.00053-5 · Cited by 1
Imaging Synapse Formation and Remodeling In Vitro and In Vivo
Okabe, S. (2019) · Springer eBooks · doi:10.1007/978-981-13-7908-6_19 · Cited by 2
Neural Mechanisms Underlying the Establishment of Unimodality in Mouse Primary Visual Cortex
Hattori, R. (2016) · Digital Access to Scholarship at Harvard (DASH) (Harvard University) · Cited by 1
β-catenin signaling via astrocyte-encoded TCF7L2 regulates neuronal excitability and social behaviorPreprint
Szewczyk, Ł. M., Lipiec, M. A., Liszewska, E., Urban‐Ciećko, J., Kondrakiewicz, L., Puścian, A., Knapska, E., Hiromi, I., Jan, N. T., Molofsky, A. V., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.11.28.402099 · Cited by 1
Broadening Neurologic Manifestations in Adult Patients With Dravet Syndrome
Tsuji, S. (2022) · Neurology · doi:10.1212/wnl.0000000000200753 · Cited by 1
Shih, Y.-C., Nelson, L., Janeček, M., & Peixoto, R. T. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.11.23.568500 · Cited by 3
Walker, H., Kwak, D., Devaraju, P., Curd, B. C., Chikuni, A. M., & Frost, N. A. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.07.15.664892 · Cited by 1
Regulation of synaptic function and plasticity by cyclin-dependent kinase 5
Su, S. C. (2012) · DSpace@MIT (Massachusetts Institute of Technology)
Human iPSC Models: A Platform for Investigating Neurodevelopmental Diseases
McKinney, C. E. (2014) · Journal of Molecular and Genetic Medicine · doi:10.4172/1747-0862.1000122
ANALYSIS OF THE CENTRAL NERVOUS SYSTEM IN A MOUSE MODEL OF HSAN TYPE III
Waller, H. R. (2013) · Montana State University ScholarWorks (Montana State University)
Towards Understanding the Neural Mechanism of Behavioral Phenotypes Seen in Psychiatric Disorders
Nakai, N., Yizhar, O., & Takumi, T. (2015) · Springer eBooks · doi:10.1007/978-4-431-55516-2_23
Genetic basis of neurological disorder with human induced pluripotent stem cells
Vigensh, M., & Balachandar, V. (2017) · International Journal of Current Advanced Research · doi:10.24327/ijcar.2017.3886.0387
Dravet Syndrome and Psychiatric Comorbidity
van Gemert, L., & Gunning, W. B. (2018) · Journal of Pediatric Epilepsy · doi:10.1055/s-0038-1676858
Comprehensive Ontology Design for Autism Spectrum Disorder
Janatimasaoom, B. (2016) · Knowledge Commons (Lakehead University)
Townsend, L. (2017) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/1g4n-6f83
Early EEG and behavioral alterations in Dravet micePreprint
Fadila, S., Quinn, S., Maia, A. T., Yakubovich, D., Anderson, K. L., & Rubinstein, M. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.01.13.904557
Preclinical validation of endocannabinoid system drug targets for the treatment of Dravet syndrome
Bahceci, D. (2020) · The Sydney eScholarship Repository (The University of Sydney)
Hull, J. M. (2019) · Deep Blue (University of Michigan)
The Role of Synaptic Activity in Neocortical Seizure State Transitions
Breton, V. L. (2020) · TSpace (University of Toronto)
Richards, K., Coulthard, L. I., Rome, C., Collyer, T. A., Karle, T. J., Beare, R. J., & Petrou, S. (2021) · Neuroimage Reports · doi:10.1016/j.ynirp.2021.100023
Mini biopsies point to source of lethal seizures in model mice
Askham, A. V. (2022) · The Transmitter · doi:10.53053/dotz9841
Ardhanareeswaran, K. (2021) · Springer eBooks · doi:10.1007/978-3-319-91280-6_102062
Hollander, E., & Uzunova, G. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.734899881.793557220
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Metadata
- Authors
- Han, S., Tai, C., Westenbroek, R. E., Yu, F. H., Cheah, C. S., Potter, G. B., Rubenstein, J. L., Scheuer, T., de la Iglesia, H. O., & Catterall, W. A.
- Affiliations
- University of Washington (US)
- University of California, San Francisco (US)
- Corresponding author
- Catterall, William A.
- ORCID
- Venue
- Nature
- Published
- 2012-08-22
- Volume
- 489
- Issue
- 7416
- Pages
- 385-390
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC3448848
- OpenAlex
- W2050659319
- Cited by
- 643
- References
- 47
- Citations by year
- 2026: 23 · 2025: 35 · 2024: 43 · 2023: 57 · 2022: 39 · 2021: 62 · 2020: 54 · 2019: 48 · 2018: 37 · 2017: 55 · 2016: 49 · 2015: 47 · 2014: 44 · 2013: 48 · 2012: 2
- FWCI
- 31.70
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institute of Mental Health (R01MH075016, R37MH049428)
- National Institute of Neurological Disorders and Stroke (R01NS025704)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Epilepsy research and treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Keywords
- SCN1A, haploinsufficiency, GABAergic neurotransmission, GABAA receptor, clonazepam, social interaction deficits, hyperactivity, stereotypy, fear memory, spatial memory, interneurons, epilepsy, cognitive impairment
- MeSH terms
- Animals, Anxiety, Autistic Disorder, Clonazepam, Epilepsies, Myoclonic, gamma-Aminobutyric Acid, Heterozygote, Hippocampus, Hyperkinesis, Interneurons, Male, Memory, Nerve Tissue Proteins, Synaptic Transmission, Social Behavior, Space Perception, Syndrome, Transcription Factors, Sodium Channels, Homeodomain Proteins, GABA Modulators, Stereotypic Movement Disorder, Mice, Haploinsufficiency, GABAergic Neurons, NAV1.1 Voltage-Gated Sodium Channel
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