The DOI matches its Crossref record; 66 of the 67 references it cites were found in a registry or an index.
Antibiotics in early life alter the murine colonic microbiome and adiposity
Open accessAbstract
Antibiotics administered in low doses have been widely used as growth promoters in the agricultural industry since the 1950s, yet the mechanisms for this effect are unclear. Because antimicrobial agents of different classes and varying activity are effective across several vertebrate species, we proposed that such subtherapeutic administration alters the population structure of the gut microbiome as well as its metabolic capabilities. We generated a model of adiposity by giving subtherapeutic antibiotic therapy to young mice and evaluated changes in the composition and capabilities of the gut microbiome. Administration of subtherapeutic antibiotic therapy increased adiposity in young mice and increased hormone levels related to metabolism. We observed substantial taxonomic changes in the microbiome, changes in copies of key genes involved in the metabolism of carbohydrates to short-chain fatty acids, increases in colonic short-chain fatty acid levels, and alterations in the regulation of hepatic metabolism of lipids and cholesterol. In this model, we demonstrate the alteration of early-life murine metabolic homeostasis through antibiotic manipulation.
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“In humans, members belonging to the Lachnospiraceae family have been shown to be protective against C. difficle (Petrof, 2013) and metabolic disorders (Cho et al., 2012).”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Cho et al., 2012
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“Subsequently, it was discovered that disruptions to the microbiome early in life can promote heightened adiposity5.”
From Gut microbiota and cardiovascular disease. (2020) · cites this paper as [5]
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“In addition, by investigating the effect of early antibiotics on intestinal microbiota, a study revealed that the composition of intestinal microbiota changed significantly and the metabolism of SCFAs was altered after treatment with subtherapeutic antibiotic therapy.56”
From The role of gut dysbiosis in Parkinson’s disease: mechanistic insights and therapeutic options (2021) · cites this paper as [56]
In the citing paper
“Difficulty in maintaining new (non-native) microbiota in recipient mice, whether germ-free or those in which gut microbiota suppression was initially performed with oral mixture of poorly absorbed antibiotics, has been reported in other studies (30-32).”
From Transmission of Atherosclerosis Susceptibility with Gut Microbial Transplantation (2015) · cites this paper as [31]
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“The use of antibiotics in early life is associated with obesity in both people and mice”
From Diet–microbiota interactions as moderators of human metabolism (2016) · cites this paper as [66]
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“Several lines of evidence support the role of gut microbiota in obesity.”
From Update on Fecal Microbiota Transplantation 2015: Indications, Methodologies, Mechanisms, and Outlook (2015) · cites this paper as [80]
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“Lean and obese individuals show marked differences in the gut microbiome.80”
From Update on Fecal Microbiota Transplantation 2015: Indications, Methodologies, Mechanisms, and Outlook (2015) · cites this paper as [80]
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“antibiotic administration increases bone density in young mice (11,12)”
From Sex steroid deficiency-associated bone loss is microbiota dependent and prevented by probiotics (2016) · cites this paper as [11]
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“Exposure to antibiotics during weaning changed gut microbial communities with increasing metabolic capacity to produce acetate, propionate, and butyrate in C57BL/6J mice.”
From Gut microbiota and cardiovascular disease. (2020) · cites this paper as [5]
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“Influx of these SCFAs to the liver resulted in substantial changes in the regulation of hepatic lipid metabolism and obese phenotype5.”
From Gut microbiota and cardiovascular disease. (2020) · cites this paper as [5]
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Citations
Cites
Basic local alignment search tool
Altschul, S. F., Gish, W., Miller, W., Myers, E. W., & Lipman, D. J. (1990) · Journal of Molecular Biology · doi:10.1006/jmbi.1990.9999 · Cited by 98,669
Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506580102 · Cited by 53,625
QIIME allows analysis of high-throughput community sequencing data
Caporaso, J. G., Kuczynski, J., Stombaugh, J., Bittinger, K., Bushman, F. D., Costello, E. K., Fierer, N., Peña, A. G., Goodrich, J. K., Gordon, J. I., et al. (2010) · Nature Methods · doi:10.1038/nmeth.f.303 · Cited by 34,887
Search and clustering orders of magnitude faster than BLAST
Edgar, R. C. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq461 · Cited by 21,098
Naive Bayesian Classifier for Rapid Assignment of rRNA Sequences into the New Bacterial Taxonomy
Wang, Q., Garrity, G. M., Tiedje, J. M., & Cole, J. R. (2007) · Applied and Environmental Microbiology · doi:10.1128/aem.00062-07 · Cited by 20,145
FastTree 2 – Approximately Maximum-Likelihood Trees for Large Alignments
Price, M. N., Dehal, P. S., & Arkin, A. P. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009490 · Cited by 14,894
An obesity-associated gut microbiome with increased capacity for energy harvest
Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444
Bioconductor: open software development for computational biology and bioinformatics
Gentleman, R. C., Carey, V. J., Bates, D. M., Bolstad, B., Dettling, M., Dudoit, S., Ellis, B., Gautier, L., Ge, Y., Gentry, J., et al. (2004) · Genome biology · doi:10.1186/gb-2004-5-10-r80 · Cited by 12,082
Gentleman R: R: A language for data analysis and graphics
Ihaka, R., & Gentleman, R. (1996) · Journal of Computational and Graphical Statistics · doi:10.1080/10618600.1996.10474713 · Cited by 11,747
A human gut microbial gene catalogue established by metagenomic sequencing
MetaHIT Consortium, Qin, J., Li, R., Raes, J., Arumugam, M., Burgdorf, K. S., Manichanh, C., Nielsen, T., Pons, N., Levenez, F., et al. (2010) · Nature · doi:10.1038/nature08821 · Cited by 11,624
UniFrac: a New Phylogenetic Method for Comparing Microbial Communities
Lozupone, C., & Knight, R. (2005) · Applied and Environmental Microbiology · doi:10.1128/aem.71.12.8228-8235.2005 · Cited by 8,227
The gut microbiota as an environmental factor that regulates fat storage
Bäckhed, F., Ding, H., Wang, T., Hooper, L. V., Koh, G. Y., Nagy, A., Semenkovich, C. F., & Gordon, J. I. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407076101 · Cited by 6,245
Obesity alters gut microbial ecology
Ley, R. E., Bäckhed, F., Turnbaugh, P., Lozupone, C. A., Knight, R. D., & Gordon, J. I. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504978102 · Cited by 6,176
Host-Bacterial Mutualism in the Human Intestine
Bäckhed, F., Ley, R. E., Sonnenburg, J. L., Peterson, D. A., & Gordon, J. I. (2005) · Science · doi:10.1126/science.1104816 · Cited by 5,277
The Ecology of Natural Disturbance and Patch Dynamics.
Proctor, J., Pickett, S. T. A., & White, P. S. (1986) · Journal of Applied Ecology · doi:10.2307/2403105 · Cited by 3,948
PyNAST: a flexible tool for aligning sequences to a template alignment
Caporaso, J. G., Bittinger, K. L., Bushman, F. D., DeSantis, T. Z., Andersen, G. L., & Knight, R. D. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp636 · Cited by 3,449
The human microbiome: at the interface of health and disease
Cho, I., & Blaser, M. J. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3182 · Cited by 3,449
Self-citationTurnbaugh, P. J., Bäckhed, F., Fulton, L., & Gordon, J. I. (2008) · Cell Host & Microbe · doi:10.1016/j.chom.2008.02.015 · Cited by 2,915
UniFrac: an effective distance metric for microbial community comparison
Lozupone, C., Lladser, M. E., Knights, D., Stombaugh, J., & Knight, R. (2011) · The ISME Journal · doi:10.1038/ismej.2010.133 · Cited by 2,825
A Molecular View of Microbial Diversity and the Biosphere
Pace, N. R. (1997) · Science · doi:10.1126/science.276.5313.734 · Cited by 2,797
Energy contributions of volatile fatty acids from the gastrointestinal tract in various species
Bergman, E. N. (1990) · Physiological Reviews · doi:10.1152/physrev.1990.70.2.567 · Cited by 2,750
Colonic Health: Fermentation and Short Chain Fatty Acids
Wong, J. M. W., de Souza, R., Kendall, C. W. C., Emam, A., & Jenkins, D. J. A. (2006) · Journal of Clinical Gastroenterology · doi:10.1097/00004836-200603000-00015 · Cited by 2,739
Dethlefsen, L., & Relman, D. A. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000087107 · Cited by 2,421
The Ecology of Natural Disturbance and Patch Dynamics
(1985) · Elsevier eBooks · doi:10.1016/c2009-0-02903-1 · Cited by 1,588
Unravelling the effects of the environment and host genotype on the gut microbiome
Spor, A., Koren, O., & Ley, R. (2011) · Nature Reviews Microbiology · doi:10.1038/nrmicro2540 · Cited by 1,509
Developmental Origin of Fat: Tracking Obesity to Its Source
Gesta, S., Tseng, Y.-H., & Kahn, C. R. (2007) · Cell · doi:10.1016/j.cell.2007.10.004 · Cited by 1,508
Compounded Perturbations Yield Ecological Surprises
Paine, R. T., Tegner, M. J., & Johnson, E. A. (1998) · Ecosystems · doi:10.1007/s100219900049 · Cited by 1,054
Murphy, E. F., Cotter, P. D., Healy, S., Marques, T. M., O’Sullivan, Ó., Fouhy, F., Clarke, S. F., O’Toole, P. W., Quigley, E. M. M., Stanton, C., et al. (2010) · Gut · doi:10.1136/gut.2010.215665 · Cited by 964
Inhibition of gastric inhibitory polypeptide signaling prevents obesity
Miyawaki, K., Yamada, Y., Ban, N., Ihara, Y., Tsukiyama, K., Zhou, H., Fujimoto, S., Oku, A., Tsuda, K., Toyokuni, S., et al. (2002) · Nature Medicine · doi:10.1038/nm727 · Cited by 963
What are the consequences of the disappearing human microbiota?
Blaser, M. J., & Falkow, S. (2009) · Nature Reviews Microbiology · doi:10.1038/nrmicro2245 · Cited by 878
Self-citationMolecular Monitoring of Succession of Bacterial Communities in Human Neonates
Favier, C. F., Vaughan, E. E., de Vos, W. M., & Akkermans, A. D. L. (2002) · Applied and Environmental Microbiology · doi:10.1128/aem.68.1.219-226.2002 · Cited by 859
Evaluating the glucose tolerance test in mice
Andrikopoulos, S., Blair, A. R., DeLuca, N., Fam, B. C., & Proietto, J. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90617.2008 · Cited by 849
Complexity and fragility in ecological networks
Solé, R. V., & Montoya, J. M. (2001) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2001.1767 · Cited by 794
Trends in Antimicrobial Drug Prescribing Among Office-Based Physicians in the United States
McCaig, L. F. (1995) · JAMA · doi:10.1001/jama.1995.03520270048030 · Cited by 790
Butaye, P., Devriese, L. A., & Haesebrouck, F. (2003) · Clinical Microbiology Reviews · doi:10.1128/cmr.16.2.175-188.2003 · Cited by 715
Reeder, S. B., Pineda, A. R., Wen, Z., Shimakawa, A. S., Yu, H., Brittain, J. H., Gold, G. E., Beaulieu, C. F., & Pelc, N. J. (2005) · Magnetic Resonance in Medicine · doi:10.1002/mrm.20624 · Cited by 707
Acetate and Propionate Short Chain Fatty Acids Stimulate Adipogenesis via GPCR43
Hong, Y.-H., Nishimura, Y., Hishikawa, D., Tsuzuki, H., Miyahara, H., Gotoh, C., Choi, K.-C., Feng, D. D., Chen, C., Lee, H.-G., et al. (2005) · Endocrinology · doi:10.1210/en.2005-0545 · Cited by 632
TLR Signaling in the Gut in Health and Disease
Abreu, M. T., Fukata, M., & Arditi, M. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.8.4453 · Cited by 577
Depletion of Murine Intestinal Microbiota: Effects on Gut Mucosa and Epithelial Gene Expression
Reikvam, D. H., Erofeev, A. S., Sandvik, A., Grcic, V., Jahnsen, F. L., Gaustad, P., McCoy, K. D., Macpherson, A. J., Meza‐Zepeda, L. A., & Johansen, F. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017996 · Cited by 552
Zhao, G., NYMAN, M. E., & Jönsson, J. Å. (2005) · Biomedical Chromatography · doi:10.1002/bmc.580 · Cited by 531
The biology and medicine of rabbits and rodents
Whittaker, D. (1989) · British Veterinary Journal · doi:10.1016/0007-1935(89)90128-0 · Cited by 473
Absence of intestinal microbiota does not protect mice from diet-induced obesity
Fleissner, C. K., Huebel, N., Abd El-Bary, M. M., Loh, G., Klaus, S., & Blaut, M. (2010) · British Journal of Nutrition · doi:10.1017/s0007114510001303 · Cited by 436
The biology and medicine of rabbits and rodents
Harkness, J. E., & Wagner, J. E. (1977) · Andalas University Repository (Andalas University) · Cited by 394
Wlodarska, M., Willing, B., Keeney, K. M., Menendez, A., Bergstrom, K. S., Gill, N., Russell, S. L., Vallance, B. A., & Finlay, B. B. (2011) · Infection and Immunity · doi:10.1128/iai.01104-10 · Cited by 382
Reshaping the gut microbiome with bacterial transplantation and antibiotic intakePreprint
Manichanh, C., Reeder, J., Gibert, P., Varela, E., Llopis, M., Antolı́n, M., Guigó, R., Knight, R. D., & Guarner, F. (2010) · Genome Research · doi:10.1101/gr.107987.110 · Cited by 338
Increased risk of childhood asthma from antibiotic use in early life
Kozyrskyj, A. L., Ernst, P., & Becker, A. B. (2007) · Chest · doi:10.1378/chest.06-3008 · Cited by 272
The equilibria that allow bacterial persistence in human hosts
Blaser, M. J., & Kirschner, D. E. (2007) · Nature · doi:10.1038/nature06198 · Cited by 239
Self-citationFunctional GIP Receptors Are Present on Adipocytes
Yip, R. G.-C., Boylan, M. O., Kieffer, T. J., & Wolfe, M. M. (1998) · Endocrinology · doi:10.1210/endo.139.9.6288 · Cited by 237
Pavoine, S., Dufour, A., & Chessel, D. (2004) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2004.02.014 · Cited by 213
Hong, F., Radaeva, S., Pan, H., Tian, Z., Veech, R. L., & Gao, B. (2004) · Hepatology · doi:10.1002/hep.20400 · Cited by 202
GIP and GLP-1 as incretin hormones: lessons from single and double incretin receptor knockout mice
Hansotia, T., & Drucker, D. J. (2004) · Regulatory Peptides · doi:10.1016/j.regpep.2004.07.019 · Cited by 187
Antibiotic administration alters the community structure of the gastrointestinal microbiota
Robinson, C. J., & Young, V. B. (2010) · Gut Microbes · doi:10.4161/gmic.1.4.12614 · Cited by 161
Martı́nez-Murcia, A., Acinas, S. G., & Rodríguez‐Valera, F. (1995) · FEMS Microbiology Ecology · doi:10.1111/j.1574-6941.1995.tb00149.x · Cited by 156
McCracken, V. J., Simpson, J. M., Mackie, R. I., & Gaskins, H. R. (2001) · Journal of Nutrition · doi:10.1093/jn/131.6.1862 · Cited by 136
Identification of the intestinal cell storing gastric inhibitory peptide
Buffa, R., Polak, J. M., Pearse, A. G. E., Solcia, E., Grimelius, L., & Capella, C. (1975) · Histochemistry and Cell Biology · doi:10.1007/bf00499706 · Cited by 117
Henderson, G., Naylor, G. E., Leahy, S. C., & Janssen, P. H. (2010) · Applied and Environmental Microbiology · doi:10.1128/aem.02580-09 · Cited by 86
Gastric inhibitory polypeptide modulates adiposity and fat oxidation under diminished insulin action
Zhou, H., Yamada, Y., Tsukiyama, K., Miyawaki, K., Hosokawa, M., Nagashima, K., Toyoda, K., Naitoh, R., Mizunoya, W., Fushiki, T., et al. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.07.164 · Cited by 77
Physiology of GIP - A Lesson from GIP Receptor Knockout Mice
Yamada, Y., & Seino, Y. (2004) · Hormone and Metabolic Research · doi:10.1055/s-2004-826162 · Cited by 49
Community‐Level Analysis: Key Genes of CO2‐Reductive Acetogenesis
Lovell, C. R., & Leaphart, A. B. (2005) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(05)97028-6 · Cited by 46
ANDES: Statistical tools for the ANalyses of DEep Sequencing
Li, K., Venter, E., Yooseph, S., Stockwell, T. B., Eckerle, L. D., Denison, M. R., Spiro, D. J., & Methé, B. A. (2010) · BMC Research Notes · doi:10.1186/1756-0500-3-199 · Cited by 23
Self-citationJukes, T. H. (1970) · New England Journal of Medicine · doi:10.1056/nejm197001012820116 · Cited by 23
Pavoine, S., & Bailly, X. (2007) · BMC Evolutionary Biology · doi:10.1186/1471-2148-7-156 · Cited by 14
Gastric inhibitory polypeptide is the major insulinotropic factor in K(ATP) null mice
Tsukiyama, K., Yamada, Y., Miyawaki, K., Hamasaki, A., Nagashima, K., Hosokawa, M., Fujimoto, S., Takahashi, A., Toyoda, K., Toyokuni, S., et al. (2004) · European Journal of Endocrinology · doi:10.1530/eje.0.1510407 · Cited by 11
Studies on growth promotion by antibiotics. I. Effects of chlortetracycline on growth.
Ozawa, E. (1955) · PubMed · Cited by 10
Studies on growth promotion by antibiotics
小澤, 英. (1957) · Medical Entomology and Zoology · Cited by 8
Jukes, T. H. (1979) · Science · doi:10.1126/science.204.4388.8 · Cited by 6
Research works printed but not linked: 2
- Ley, R. E. et al. Obesity alters gut microbial ecology. Proc. Natl Acad. Sci. USA 102, 11070–11075 (2005) · DOI · Paper page
- Gentleman, R. C. et al. Bioconductor: open software development for computational biology and bioinformatics. Genome Biol. 5, R80 (2004) · DOI
Cited by
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Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286
Richness of human gut microbiome correlates with metabolic markers
Le Chatelier, E., Nielsen, T., Qin, J., Prifti, E., Hildebrand, F., Falony, G., Almeida, M., Arumugam, M., Batto, J.-M., Kennedy, S., et al. (2013) · Nature · doi:10.1038/nature12506 · Cited by 4,662
The Human Intestinal Microbiome in Health and Disease
Lynch, S. V., & Pedersen, O. (2016) · New England Journal of Medicine · doi:10.1056/nejmra1600266 · Cited by 3,637
Human Genetics Shape the Gut Microbiome
Goodrich, J. K., Waters, J. L., Poole, A. C., Sutter, J. L., Koren, O., Blekhman, R., Beaumont, M., Van Treuren, W., Knight, R., Bell, J. T., et al. (2014) · Cell · doi:10.1016/j.cell.2014.09.053 · Cited by 3,164
Gut–brain axis: How the microbiome influences anxiety and depression
Foster, J. A., & McVey Neufeld, K.-A. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2013.01.005 · Cited by 2,460
Metadata
- Authors
- Cho, I., Yamanishi, S., Cox, L., Methé, B. A., Zavadil, J., Li, K., Gao, Z., Mahana, D., Raju, K., Teitler, I., Li, H., Alekseyenko, A. V., & Blaser, M. J.
- Affiliations
- New York University (US)
- J. Craig Venter Institute (US)
- VA NY Harbor Healthcare System (US)
- Corresponding author
- Blaser, Martin J.
- ORCID
- Venue
- Nature
- Published
- 2012-08
- Volume
- 488
- Issue
- 7413
- Pages
- 621-626
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC3553221
- OpenAlex
- W2003836872
- Cited by
- 1,613
- References
- 67
- Citations by year
- 2026: 29 · 2025: 65 · 2024: 94 · 2023: 92 · 2022: 109 · 2021: 158 · 2020: 191 · 2019: 142 · 2018: 139 · 2017: 162 · 2016: 122 · 2015: 106 · 2014: 98 · 2013: 88 · 2012: 15
- FWCI
- 39.50
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Rutgers University Community Repository (Rutgers University) (submittedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- National Institutes of Health (UL1TR000038)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK090989, T-R01 DK090989)
- National Center for Research Resources (UL1RR029893)
- National Center for Advancing Translational Sciences
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- growth promoters, gut microbiota, colonic microbiota, adiposity, short-chain fatty acids, carbohydrate metabolism, lipid metabolism, cholesterol metabolism, metabolic homeostasis, livestock feed additives
- MeSH terms
- Age Factors, Animals, Anti-Bacterial Agents, Body Composition, Body Weight, Bone Development, Cecum, Cholesterol, Colon, Fatty Acids, Volatile, Feces, Female, Gastric Inhibitory Polypeptide, Liver, Male, Mice, Inbred C57BL, Weaning, Bone Density, Polymerase Chain Reaction, Adiposity, Lipid Metabolism, Mice, Metagenome
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