Absence of intestinal microbiota does not protect mice from diet-induced obesity
Open accessAbstract
The gut microbiota has been implicated in host nutrient absorption and energy homeostasis. We studied the influence of different diets on body composition in germ-free (GF) and conventional (CV) mice. GF and CV male adult C3H mice were fed ad libitum a semi-synthetic low-fat diet (LFD; carbohydrate–protein–fat ratio: 41:42:17; 19·8 kJ/g), a high-fat diet (HFD; 41:16:43; 21·4 kJ/g) or a commercial Western diet (WD; 41:19:41; 21·5 kJ/g). There was no difference in body weight gain between GF and CV mice on the LFD. On the HFD, GF mice gained more body weight and body fat than CV mice, and had lower energy expenditure. GF mice on the WD gained significantly less body fat than GF mice on the HFD. GF mice on both HFD and WD showed increased intestinal mRNA expression of fasting-induced adipose factor/angiopoietin-like protein 4 ( Fiaf/Angptl4 ), but they showed no major changes in circulating Fiaf/Angptl4 compared with CV mice. The faecal microbiota composition of the CV mice differed between diets: the proportion of Firmicutes increased on both HFD and WD at the expense of the Bacteroidetes. This increase in the Firmicutes was mainly due to the proliferation of one family within this phylum: the Erysipelotrichaceae. We conclude that the absence of gut microbiota does not provide a general protection from diet-induced obesity, that intestinal production of Fiaf/Angptl4 does not play a causal role in gut microbiota-mediated effects on fat storage and that diet composition affects gut microbial composition to larger extent than previously thought.
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Protection from microbiota-dependent obesity is lost when sucrose is omitted from the diet.
“all protection from obesity (that is, microbiota-dependent obesity) is lost when sucrose is omitted from the diet45.”
From Diet–microbiota interactions as moderators of human metabolism (2016) · cites this paper as [45]
Among families of the phylum Firmicutes, Erysipelotrichaceae has been found to increase several fold in mice exposed to a high-fat or Western diet.
“among families of the phylum Firmicutes, specifically Erysipelotrichaceae has instead been found to increase several fold in mice exposed to both a high-fat or Western diet [56].”
From Gut microbiota and glucometabolic alterations in response to recurrent partial sleep deprivation in normal-weight young individuals (2016) · cites this paper as [56]
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- Authors
- Fleissner, C. K., Huebel, N., Abd El-Bary, M. M., Loh, G., Klaus, S., & Blaut, M.
- Affiliations
- German Institute of Human Nutrition (DE)
- ORCID
- Klaus, Susanne
- Venue
- British Journal of Nutrition
- Publisher
- Cambridge University Press (CUP)
- Published
- 2010-05-05
- Volume
- 104
- Issue
- 6
- Pages
- 919-929
- ISSN
- 0007-1145 (ISSN-L)
- 1475-2662
- OpenAlex
- W1994366077
- Cited by
- 436
- References
- 34
- Citations by year
- 2026: 12 · 2025: 14 · 2024: 11 · 2023: 23 · 2022: 27 · 2021: 39 · 2020: 25 · 2019: 29 · 2018: 28 · 2017: 28 · 2016: 37 · 2015: 30 · 2014: 39 · 2013: 28 · 2012: 33
- FWCI
- 12.24
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal Of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- gut microbiota, germ-free mice, diet-induced obesity, high-fat diet, Western diet, low-fat diet, fat mass, energy expenditure, Firmicutes, Bacteroidetes, Erysipelotrichaceae, intestinal gene expression, host-microbe interactions
- MeSH terms
- Adipose Tissue, Animals, Bacteria, Colon, Dietary Fats, Energy Metabolism, Feces, Male, Mice, Inbred Strains, Obesity, RNA, Messenger, Weight Gain, Diet, Fat-Restricted, Angiopoietins, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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