Integration of chemical catalysis with extractive fermentation to produce fuels
Abstract
Nearly one hundred years ago, the fermentative production of acetone by Clostridium acetobutylicum provided a crucial alternative source of this solvent for manufacture of the explosive cordite. Today there is a resurgence of interest in solventogenic Clostridium species to produce n-butanol and ethanol for use as renewable alternative transportation fuels. Acetone, a product of acetone-n-butanol-ethanol (ABE) fermentation, harbours a nucleophilic α-carbon, which is amenable to C-C bond formation with the electrophilic alcohols produced in ABE fermentation. This functionality can be used to form higher-molecular-mass hydrocarbons similar to those found in current jet and diesel fuels. Here we describe the integration of biological and chemocatalytic routes to convert ABE fermentation products efficiently into ketones by a palladium-catalysed alkylation. Tuning of the reaction conditions permits the production of either petrol or jet and diesel precursors. Glyceryl tributyrate was used for the in situ selective extraction of both acetone and alcohols to enable the simple integration of ABE fermentation and chemical catalysis, while reducing the energy demand of the overall process. This process provides a means to selectively produce petrol, jet and diesel blend stocks from lignocellulosic and cane sugars at yields near their theoretical maxima.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Another promising approach to convert ethanol (and other short-chain alcohols) to jet (or biodiesel) fuels is via extractive catalytic upgrading directly from the fermentation broth.
“Another promising approach to convert ethanol (and other short-chain alcohols) to jet (or biodiesel) fuels is via extractive catalytic upgrading directly from the fermentation broth (Anbarasan et al., 2012; Bormann et al., 2014; Sreekumar et al., 2014, 2015; Baer et al., 2016).”
From Gas Fermentation—A Flexible Platform for Commercial Scale Production of Low-Carbon-Fuels and Chemicals from Waste and Renewable Feedstocks (2016) · cites this paper as Anbarasan et al., 2012
Cites
Production of Liquid Alkanes by Aqueous-Phase Processing of Biomass-Derived Carbohydrates
Huber, G. W., Chheda, J. N., Barrett, C. J., & Dumesic, J. A. (2005) · Science · doi:10.1126/science.1111166 · Cited by 1,679 · see citing works
Dehydrogenation as a Substrate-Activating Strategy in Homogeneous Transition-Metal Catalysis
Dobereiner, G. E., & Crabtree, R. H. (2009) · Chemical Reviews · doi:10.1021/cr900202j · Cited by 1,660 · see citing works
Microbial production of fatty-acid-derived fuels and chemicals from plant biomass
Steen, E. J., Kang, Y., Bokinsky, G., Hu, Z., Schirmer, A., McClure, A., del Cardayré, S. B., & Keasling, J. D. (2010) · Nature · doi:10.1038/nature08721 · Cited by 1,338 · see citing works
Guillena, G., Ramón, D. J., & Yus, M. (2009) · Chemical Reviews · doi:10.1021/cr9002159 · Cited by 1,262 · see citing works
Borrowing Hydrogen in the Activation of Alcohols
Hamid, M. H. S. A., Slatford, P. A., & Williams, J. M. J. (2007) · Advanced Synthesis & Catalysis · doi:10.1002/adsc.200600638 · Cited by 1,136 · see citing works
Catalytic conversion of biomass to monofunctional hydrocarbons and targeted liquid-fuel classes
Kunkes, E. L., Simonetti, D. A., West, R. M., Serrano-Ruiz, J. C., Gärtner, C. A., & Dumesic, J. A. (2008) · Science · doi:10.1126/science.1159210 · Cited by 895 · see citing works
Fermentative production of butanol—the industrial perspective
Green, E. M. (2011) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2011.02.004 · Cited by 705 · see citing works
Identification and microbial production of a terpene-based advanced biofuel
Peralta‐Yahya, P., Ouellet, M., Chan, R., Mukhopadhyay, A., Keasling, J. D., & Lee, T. S. (2011) · Nature Communications · doi:10.1038/ncomms1494 · Cited by 638 · see citing works
Separation technologies for the recovery and dehydration of alcohols from fermentation broths
Vane, L. M. (2008) · Biofuels Bioproducts and Biorefining · doi:10.1002/bbb.108 · Cited by 571 · see citing works
Alcohols as Electrophiles in CC Bond‐Forming Reactions: The Hydrogen Autotransfer Process
Guillena, G., Ramón, D. J., & Yus, M. (2007) · Angewandte Chemie International Edition · doi:10.1002/anie.200603794 · Cited by 561 · see citing works
Production of High‐Quality Diesel from Biomass Waste Products
Corma, A., de la Torre, O., Renz, M., & Villandier, N. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201007508 · Cited by 422 · see citing works
Tracy, B. P., Jones, S. W., Fast, A. G., Indurthi, D. C., & Papoutsakis, E. T. (2011) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2011.10.008 · Cited by 408 · see citing works
Production of jet and diesel fuel range alkanes from waste hemicellulose-derived aqueous solutions
Xing, R., Subrahmanyam, A. V., Olcay, H., Qi, W., van Walsum, G. P., Pendse, H. P., & Huber, G. W. (2010) · Green Chemistry · doi:10.1039/c0gc00263a · Cited by 346 · see citing works
Recyclable Palladium Catalyst for Highly Selective α Alkylation of Ketones with Alcohols
Kwon, M. S., Kim, N., Seo, S. H., Park, I., Cheedarala, R. K., & Park, J. (2005) · Angewandte Chemie International Edition · doi:10.1002/anie.200502422 · Cited by 259 · see citing works
Kraemer, K., Harwardt, A., Bronneberg, R., & Marquardt, W. (2011) · Computers & Chemical Engineering · doi:10.1016/j.compchemeng.2011.01.028 · Cited by 246 · see citing works
Alsaker, K. V., Paredes, C. J., & Papoutsakis, E. T. (2009) · Biotechnology and Bioengineering · doi:10.1002/bit.22628 · Cited by 213 · see citing works
Metabolic engineering of Escherichia coli for α-farnesene production
Wang, C., Yoon, S., Jang, H., Chung, Y., Kim, J., Choi, E., & Kim, S.-W. (2011) · Metabolic Engineering · doi:10.1016/j.ymben.2011.08.001 · Cited by 208 · see citing works
Relative potential of biosynthetic pathways for biofuels and bio-based products
Dugar, D., & Stephanopoulos, G. N. (2011) · Nature Biotechnology · doi:10.1038/nbt.2055 · Cited by 179 · see citing works
Ren, C., Gu, Y., Hu, S., Wu, Y. P., Wang, P., Yang, Y., Yang, C., Yang, S., & Jiang, W. (2010) · Metabolic Engineering · doi:10.1016/j.ymben.2010.05.002 · Cited by 157 · see citing works
Selective catalytic self-condensation of acetone
Salvapati, G. S., Ramanamurty, K. V., & Janardanarao, M. (1989) · Journal of Molecular Catalysis · doi:10.1016/0304-5102(89)80134-8 · Cited by 149 · see citing works
In situ extractive fermentation of acetone and butanol
Roffler, S. R., Blanch, H. W., & Wilke, C. R. (1988) · Biotechnology and Bioengineering · doi:10.1002/bit.260310207 · Cited by 129 · see citing works
Self-citationIn-situ recovery of butanol during fermentation
Roffler, S. R., Blanch, H. W., & Wilke, C. R. (1987) · Bioprocess and Biosystems Engineering · doi:10.1007/bf00369221 · Cited by 127 · see citing works
Self-citationGürbüz, E. I., Kunkes, E. L., & Dumesic, J. A. (2010) · Green Chemistry · doi:10.1039/b920369a · Cited by 71 · see citing works
Carlini, C., Macinai, A., Galletti, A. M. R., & Sbrana, G. (2003) · Journal of Molecular Catalysis A Chemical · doi:10.1016/j.molcata.2003.10.045 · Cited by 70 · see citing works
In-situ recovery of butanol during fermentation
Roffler, S. R., Blanch, H. W., & Wilke, C. R. (1987) · Bioprocess and Biosystems Engineering · doi:10.1007/bf00387326 · Cited by 63 · see citing works
Self-citationProduction of acetone-butanol by extractive fermentation using dibutylphthalate as extractant
Wayman, M., & Parekh, R. S. (1987) · 醗酵工學雑誌 · doi:10.1016/0385-6380(87)90091-4 · Cited by 39 · see citing works
Membrane‐Assisted Extractive Butanol Fermentation
Jeon, Y.-J., & Lee, Y. Y. (1987) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1987.tb23848.x · Cited by 39 · see citing works
Catalytic conversion of sugar into conventional gasoline, diesel, jet fuel, and other hydrocarbons.
Blommel, P. G., Keenan, G. R., Rozmiarek, R. T., & Cortright, R. D. (2008) · International sugar journal · Cited by 28 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Nonenzymatic Sugar Production from Biomass Using Biomass-Derived γ-Valerolactone
Luterbacher, J. S., Rand, J. M., Alonso, D. M., Han, J., Youngquist, J. T., Maravelias, C. T., Pfleger, B. F., & Dumesic, J. A. (2014) · Science · doi:10.1126/science.1246748 · Cited by 705 · see citing works
A comprehensive metabolic map for production of bio-based chemicals
Lee, S. Y., Kim, H. U., Chae, T. U., Cho, J. S., Kim, J. W., Shin, J. H., Kim, D. I., Ko, Y., Jang, W. D., & Jang, Y. (2019) · Nature Catalysis · doi:10.1038/s41929-018-0212-4 · Cited by 614 · see citing works
Fuelling the future: microbial engineering for the production of sustainable biofuels
Liao, J. C., Mi, L., Pontrelli, S., & Luo, S. (2016) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2016.32 · Cited by 597 · see citing works
Systems strategies for developing industrial microbial strains
Lee, S. Y., & Kim, H. U. (2015) · Nature Biotechnology · doi:10.1038/nbt.3365 · Cited by 589 · see citing works
Bio-jet fuel conversion technologies
Wang, W.-C., & Tao, L. (2016) · Renewable and Sustainable Energy Reviews · doi:10.1016/j.rser.2015.09.016 · Cited by 564 · see citing works
Sun, Z., Bottari, G., Afanasenko, A. M., Stuart, M. C. A., Deuss, P. J., Fridrich, B., & Barta, K. (2018) · Nature Catalysis · doi:10.1038/s41929-017-0007-z · Cited by 517 · see citing works
Review of old chemistry and new catalytic advances in the on-purpose synthesis of butadiene
Makshina, E. V., Dusselier, M., Janssens, W., Degrève, J., Jacobs, P. A., & Sels, B. F. (2014) · Chemical Society Reviews · doi:10.1039/c4cs00105b · Cited by 514 · see citing works
A review on commercial-scale high-value products that can be produced alongside cellulosic ethanol
Rosales‐Calderon, O., & Arantes, V. (2019) · Biotechnology for Biofuels · doi:10.1186/s13068-019-1529-1 · Cited by 501 · see citing works
Carbon-negative production of acetone and isopropanol by gas fermentation at industrial pilot scale
Liew, F. E., Nogle, R., Abdalla, T., Rasor, B. J., Canter, C. E., Jensen, R. O., Wang, L., Strutz, J., Chirania, P., Tissera, S. L. D., et al. (2022) · Nature Biotechnology · doi:10.1038/s41587-021-01195-w · Cited by 487 · see citing works
Liew, F., Martin, M. E., Tappel, R. C., Heijstra, B. D., Mihalcea, C., & Köpke, M. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00694 · Cited by 485 · see citing works
Production of Fuels and Chemicals from Biomass: Condensation Reactions and Beyond
Wu, L., Moteki, T., Gokhale, A. A., Flaherty, D. W., & Toste, F. D. (2016) · Chem · doi:10.1016/j.chempr.2016.05.002 · Cited by 375 · see citing works
Self-citationManganese-Catalyzed Upgrading of Ethanol into 1-Butanol
Fu, S., Shao, Z., Wang, Y., & Liu, Q. (2017) · Journal of the American Chemical Society · doi:10.1021/jacs.7b05939 · Cited by 338 · see citing works
Biomass-derived aviation fuels: Challenges and perspective
Wang, M., Dewil, R., Maniatis, K., Wheeldon, J. M., Tan, T., Baeyens, J., & Fang, Y. (2019) · Progress in Energy and Combustion Science · doi:10.1016/j.pecs.2019.04.004 · Cited by 334 · see citing works
Qiu, B., Tao, X., Wang, J., Liu, Y., Li, S., & Chu, H. (2022) · Energy Conversion and Management · doi:10.1016/j.enconman.2022.115647 · Cited by 314 · see citing works
Gabriëls, D., Hernández, W. Y., Sels, B. F., Voort, P. V. D., & Verberckmoes, A. A. (2015) · Catalysis Science & Technology · doi:10.1039/c5cy00359h · Cited by 297 · see citing works
Hybrid bioinorganic approach to solar-to-chemical conversion
Nichols, E. M., Gallagher, J. J., Liu, C., Su, Y., Resasco, J., Yu, Y., Sun, Y., Yang, P., Chang, M. C. Y., & Chang, C. J. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1508075112 · Cited by 291 · see citing works
Toward low-cost biological and hybrid biological/catalytic conversion of cellulosic biomass to fuels
Lynd, L. R., Beckham, G. T., Guss, A. M., Jayakody, L. N., Karp, E. M., Maranas, C. D., McCormick, R. L., Amador‐Noguez, D., Bomble, Y. J., Davison, B. H., et al. (2022) · Energy & Environmental Science · doi:10.1039/d1ee02540f · Cited by 269 · see citing works
Cellulose solvent-based pretreatment for enhanced second-generation biofuel production: a review
Satari, B., Karimi, K., & Kumar, R. (2018) · Sustainable Energy & Fuels · doi:10.1039/c8se00287h · Cited by 250 · see citing works
Li, G., Wang, R., Pang, J., Wang, A., Li, N., & Zhang, T. (2024) · Chemical Reviews · doi:10.1021/acs.chemrev.2c00756 · Cited by 225 · see citing works
Barriers and opportunities in bio-based production of hydrocarbons
Zhou, Y. J., Kerkhoven, E. J., & Nielsen, J. (2018) · Nature Energy · doi:10.1038/s41560-018-0197-x · Cited by 213 · see citing works
Selective Hydrodeoxygenation of Aromatics to Cyclohexanols over Ru Single Atoms Supported on CeO 2
Zhang, K., Meng, Q., Wu, H., Yan, J., Mei, X., An, P., Zheng, L., Zhang, J., He, M., & Han, B. (2022) · Journal of the American Chemical Society · doi:10.1021/jacs.2c08992 · Cited by 213 · see citing works
Novel Strategies for the Production of Fuels, Lubricants, and Chemicals from Biomass
Shylesh, S., Gokhale, A. A., Ho, C. R., & Bell, A. T. (2017) · Accounts of Chemical Research · doi:10.1021/acs.accounts.7b00354 · Cited by 212 · see citing works
Boot, M. D., Tian, M., Hensen, E. J. M., & Sarathy, S. M. (2016) · Progress in Energy and Combustion Science · doi:10.1016/j.pecs.2016.12.001 · Cited by 210 · see citing works
Wang, S., Zhang, Z., Liu, B., & Li, J. (2013) · Catalysis Science & Technology · doi:10.1039/c3cy00223c · Cited by 207 · see citing works
Recent Advances in Catalytic Conversion of Glycerol
Zhou, C. H., Zhao, H., Tong, D. S., Wu, L. M., & Yu, W. H. (2013) · Catalysis Reviews · doi:10.1080/01614940.2013.816610 · Cited by 200 · see citing works
Mascal, M., Dutta, S., & Gandarias, I. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201308143 · Cited by 202 · see citing works
cis,cis-Muconic acid: separation and catalysis to bio-adipic acid for nylon-6,6 polymerization
Vardon, D. R., Rorrer, N. A., Salvachúa, D., Settle, A. E., Johnson, C. W., Menart, M. J., Cleveland, N. S., Ciesielski, P. N., Steirer, K. X., Dorgan, J. R., et al. (2016) · Green Chemistry · doi:10.1039/c5gc02844b · Cited by 196 · see citing works
Integrated Conversion of Cellulose to High-Density Aviation Fuel
Liu, Y., Li, G., Hu, Y., Wang, A., Lü, F., Zou, J., Cong, Y., Li, N., & Zhang, T. (2019) · Joule · doi:10.1016/j.joule.2019.02.005 · Cited by 187 · see citing works
The Application of Fermentation Technology in Traditional Chinese Medicine: A Review
Li, L., Wang, L., Fan, W., Jiang, Y., Zhang, C., Li, J., Peng, W., & Wu, C. (2020) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x20500433 · Cited by 185 · see citing works
Transition-metal catalyzed valorization of lignin: the key to a sustainable carbon-neutral future
Kärkäs, M. D., Matsuura, B. S., Monos, T. M., Magallanes, G., & Stephenson, C. R. J. (2015) · Organic & Biomolecular Chemistry · doi:10.1039/c5ob02212f · Cited by 184 · see citing works
McCormick, R. L., Fioroni, G. M., Fouts, L., Christensen, E., Yanowitz, J., Polikarpov, E., Albrecht, K. O., Gaspar, D. J., Gladden, J. M., & George, A. (2017) · SAE international journal of fuels and lubricants · doi:10.4271/2017-01-0868 · Cited by 181 · see citing works
Synthesis of renewable high-density fuels using cyclopentanone derived from lignocellulose
Yang, J., Li, N., Li, G., Wang, W., Wang, A., Wang, X., Cong, Y., & Zhang, T. (2013) · Chemical Communications · doi:10.1039/c3cc46588h · Cited by 178 · see citing works
Expanding chemistry through in vitro and in vivo biocatalysis
Kissman, E. N., Sosa, M. B., Millar, D. C., Koleski, E. J., Thevasundaram, K., & Chang, M. C. Y. (2024) · Nature · doi:10.1038/s41586-024-07506-w · Cited by 178 · see citing works
Schwartz, T. J., O’Neill, B. J., Shanks, B. H., & Dumesic, J. A. (2014) · ACS Catalysis · doi:10.1021/cs500364y · Cited by 175 · see citing works
Liu, B., & Zhang, Z. (2016) · ChemSusChem · doi:10.1002/cssc.201600507 · Cited by 174 · see citing works
Separation and purification of biobutanol during bioconversion of biomass
Huang, H., Ramaswamy, S., & Liu, Y. (2014) · Separation and Purification Technology · doi:10.1016/j.seppur.2014.06.013 · Cited by 168 · see citing works
Recent updates on lignocellulosic biomass derived ethanol - A review
Kumar, R., Tabatabaei, M., Karimi, K., & Horváth, I. S. (2016) · Biofuel Research Journal · doi:10.18331/brj2016.3.1.4 · Cited by 162 · see citing works
Review of Biojet Fuel Conversion Technologies
National Renewable Energy Lab. (NREL), G., Wang, W., Bioenergy Technologies Office (EE-3B) USDOE Office of Energy Efficiency and Renewable Energy (EERE), Tao, L., Markham, J. N., Zhang, Y., Tan, E., Batan, L., Warner, E., & Biddy, M. J. (2016) · doi:10.2172/1278318 · Cited by 149 · see citing works
Making JP‐10 Superfuel Affordable with a Lignocellulosic Platform Compound
Li, G., Hou, B., Wang, A., Xin, X., Cong, Y., Wang, X., Li, N., & Zhang, T. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201906744 · Cited by 148 · see citing works
Highly Selective Condensation of Biomass‐Derived Methyl Ketones as a Source of Aviation Fuel
Sacia, E. R., Balakrishnan, M., Deaner, M. H., Goulas, K. A., Toste, F. D., & Bell, A. T. (2015) · ChemSusChem · doi:10.1002/cssc.201500002 · Cited by 143 · see citing works
Self-citationCatalytic Total Hydrodeoxygenation of Biomass‐Derived Polyfunctionalized Substrates to Alkanes
Nakagawa, Y., Liu, S., Tamura, M., & Tomishige, K. (2015) · ChemSusChem · doi:10.1002/cssc.201403330 · Cited by 139 · see citing works
Stress-tolerant non-conventional microbes enable next-generation chemical biosynthesis
Thorwall, S., Schwartz, C., Chartron, J. W., & Wheeldon, I. R. (2020) · Nature Chemical Biology · doi:10.1038/s41589-019-0452-x · Cited by 131 · see citing works
Solvent‐Free Synthesis of C10 and C11 Branched Alkanes from Furfural and Methyl Isobutyl Ketone
Yang, J., Li, N., Li, G., Wang, W., Wang, A., Wang, X., Cong, Y., & Zhang, T. (2013) · ChemSusChem · doi:10.1002/cssc.201300318 · Cited by 134 · see citing works
Butanol Synthesis Routes for Biofuel Production: Trends and Perspectives
Kolesińska, B., Frączyk, J., Binczarski, M. J., Modelska, M., Berłowska, J., Dziugan, P., Antolak, H., Kaminski, Z. J., Witońska, I., & Kręgiel, D. (2019) · Materials · doi:10.3390/ma12030350 · Cited by 130 · see citing works
Renewable Unsaturated Polyesters from Muconic Acid
Rorrer, N. A., Dorgan, J. R., Vardon, D. R., Martinez, C. R., Yang, Y., & Beckham, G. T. (2016) · ACS Sustainable Chemistry & Engineering · doi:10.1021/acssuschemeng.6b01820 · Cited by 128 · see citing works
Synthesis of renewable diesel with hydroxyacetone and 2-methyl-furan
Li, G., Li, N., Li, S., Wang, A., Cong, Y., Wang, X., & Zhang, T. (2013) · Chemical Communications · doi:10.1039/c3cc42296h · Cited by 127 · see citing works
Influence of functional groups on low-temperature combustion chemistry of biofuels
Rotavera, B. M., & Taatjes, C. A. (2021) · Progress in Energy and Combustion Science · doi:10.1016/j.pecs.2021.100925 · Cited by 122 · see citing works
Goulas, K. A., Sreekumar, S., Song, Y., Kharidehal, P., Gunbas, G. E., Dietrich, P. J., Johnson, G. R., Wang, Y. C., Grippo, A. M., Grabow, L. C., et al. (2016) · Journal of the American Chemical Society · doi:10.1021/jacs.6b02247 · Cited by 122 · see citing works
Self-citationLi, G., Li, N., Wang, X., Sheng, X., Li, S., Wang, A., Cong, Y., Wang, X., & Zhang, T. (2014) · Energy & Fuels · doi:10.1021/ef500676z · Cited by 121 · see citing works
Reviving the Weizmann process for commercial n-butanol production
Nguyen, N.-P.-T., Raynaud, C., Meynial‐Salles, I., & Soucaille, P. (2018) · Nature Communications · doi:10.1038/s41467-018-05661-z · Cited by 117 · see citing works
Yang, J., Li, N., Li, S., Wang, W., Li, L., Wang, A., Wang, X., Cong, Y., & Zhang, T. (2014) · Green Chemistry · doi:10.1039/c4gc01314j · Cited by 115 · see citing works
Moteki, T., & Flaherty, D. W. (2016) · ACS Catalysis · doi:10.1021/acscatal.6b00556 · Cited by 115 · see citing works
Elsayed, I., Mashaly, M. M., El‐Taweel, F. M. A. A., Jackson, M. A., & Hassan, E. B. (2018) · Fuel · doi:10.1016/j.fuel.2018.02.135 · Cited by 114 · see citing works
Balakrishnan, M., Sacia, E. R., Sreekumar, S., Gunbas, G. E., Gokhale, A. A., Scown, C. D., Toste, F. D., & Bell, A. T. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1508274112 · Cited by 113 · see citing works
Self-citationMetabolic engineering of Escherichia coli for the production of phenol from glucose
Kim, B., Park, H., Na, D., & Lee, S. Y. (2013) · Biotechnology Journal · doi:10.1002/biot.201300263 · Cited by 111 · see citing works
Jatoi, A. S., Abbasi, S. A., Hashmi, Z., Shah, A. K., Alam, M. S., Bhatti, Z. A., Maitlo, G., Hussain, S., Khandro, G. A., Usto, M. A., et al. (2021) · Biomass Conversion and Biorefinery · doi:10.1007/s13399-021-01853-8 · Cited by 115 · see citing works
Hydrodeoxygenation of furans over Pd-FeOx/SiO2 catalyst under atmospheric pressure
Yang, J., Li, S., Zhang, L., Liu, X., Wang, J., Pan, X., Li, N., Wang, A., Cong, Y., Wang, X., et al. (2016) · Applied Catalysis B: Environmental · doi:10.1016/j.apcatb.2016.08.045 · Cited by 110 · see citing works
More Sustainable Formation of CN and CC Bonds for the Synthesis of N‐Heterocycles
Schranck, J., Tlili, A., & Beller, M. (2013) · Angewandte Chemie International Edition · doi:10.1002/anie.201303015 · Cited by 107 · see citing works
Liu, X., Xiao, J., Ding, H., Zhong, W., Xu, Q., Su, S., & Yin, D. (2015) · Chemical Engineering Journal · doi:10.1016/j.cej.2015.08.022 · Cited by 107 · see citing works
Huang, X., Men, Y., Wang, J., An, W., & Wang, Y. (2016) · Catalysis Science & Technology · doi:10.1039/c6cy02091g · Cited by 102 · see citing works
Zaheer, M., Hermannsdörfer, J., Kretschmer, W., Motz, G., & Kempe, R. (2013) · ChemCatChem · doi:10.1002/cctc.201300763 · Cited by 101 · see citing works
Cao, Z., Engelhardt, J., Dierks, M., Clough, M. T., Wang, G., Heracleous, E., Lappas, A. A., Rinaldi, R., & Schüth, F. (2017) · Angewandte Chemie International Edition · doi:10.1002/anie.201610405 · Cited by 100 · see citing works
He, C., Christensen, P. R., Seguin, T. J., Dailing, E. A., Wood, B. M., Walde, R. K., Persson, K. A., Russell, T. P., & Helms, B. A. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201912223 · Cited by 101 · see citing works
Jing, Y., Yu, X., Guo, Y. Q., Liu, X., & Wang, Y. (2019) · CHINESE JOURNAL OF CATALYSIS (CHINESE VERSION) · doi:10.1016/s1872-2067(19)63371-1 · Cited by 99 · see citing works
Synthesis of Diesel and Jet Fuel Range Alkanes with Furfural and Angelica Lactone
Xu, J., Li, N., Yang, X., Li, G., Wang, A., Cong, Y., Wang, X., & Zhang, T. (2017) · ACS Catalysis · doi:10.1021/acscatal.7b01992 · Cited by 98 · see citing works
Sreekumar, S., Baer, Z. C., Anbarasan, P., Gunbas, G. E., Grippo, A. M., Blanch, H. W., Clark, D. S., & Toste, F. D. (2015) · Nature Protocols · doi:10.1038/nprot.2015.029 · Cited by 97 · see citing works
Self-citationLiang, G., Wang, A., Zhao, X., Lei, N., & Zhang, T. (2016) · Green Chemistry · doi:10.1039/c6gc00118a · Cited by 96 · see citing works
Guan, W., Shi, S., Tu, M., & Lee, Y. Y. (2015) · Bioresource Technology · doi:10.1016/j.biortech.2015.10.102 · Cited by 95 · see citing works
Awasthi, M. K., Singh, E., Binod, P., Sindhu, R., Sarsaiya, S., Kumar, A., Chen, H., Duan, Y., Pandey, A., Kumar, S., et al. (2021) · Renewable and Sustainable Energy Reviews · doi:10.1016/j.rser.2021.111987 · Cited by 95 · see citing works
Frontiers in microbial 1-butanol and isobutanol production
Chen, C.-T., & Liao, J. C. (2016) · FEMS Microbiology Letters · doi:10.1093/femsle/fnw020 · Cited by 94 · see citing works
Direct α‐Alkylation of Ketones with Alcohols in Water
Xu, G., Li, Q., Feng, J., Liu, Q., Zhang, Z., Wang, X., Zhang, X., & Mu, X. (2013) · ChemSusChem · doi:10.1002/cssc.201300815 · Cited by 93 · see citing works
de Souza, A. J., Hull, P. A., Gille, S., & Pauly, M. (2014) · Planta · doi:10.1007/s00425-014-2139-6 · Cited by 90 · see citing works
An NAD(P)H-Dependent Artificial Transfer Hydrogenase for Multienzymatic Cascades
Okamoto, Y., Köhler, V., & Ward, T. R. (2016) · Journal of the American Chemical Society · doi:10.1021/jacs.6b02470 · Cited by 90 · see citing works
Hellier, P., Talibi, M., Eveleigh, A., & Ladommatos, N. (2017) · Proceedings of the Institution of Mechanical Engineers Part D Journal of Automobile Engineering · doi:10.1177/0954407016687453 · Cited by 90 · see citing works
Yang, Y., Ren, Z., Zhou, S., & Wei, M. (2021) · ACS Catalysis · doi:10.1021/acscatal.1c00699 · Cited by 87 · see citing works
Li, G., Li, N., Yang, J., Li, L., Wang, A., Wang, X., Cong, Y., & Zhang, T. (2013) · Green Chemistry · doi:10.1039/c3gc41356j · Cited by 86 · see citing works
Alkane production from biomass: chemo-, bio- and integrated catalytic approaches
Deneyer, A., Renders, T., Aelst, J. V., den Bosch, S. V., Gabriëls, D., & Sels, B. F. (2015) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2015.08.010 · Cited by 85 · see citing works
Zheng, M., Pang, J., Wang, A., & Zhang, T. (2014) · CHINESE JOURNAL OF CATALYSIS (CHINESE VERSION) · doi:10.1016/s1872-2067(14)60013-9 · Cited by 85 · see citing works
Liu, Y., Guo, L., Wang, L., Wang, Z., & Zhou, H. (2017) · Bioresource Technology · doi:10.1016/j.biortech.2017.01.061 · Cited by 85 · see citing works
Harvey, B. G., Meylemans, H. A., Gough, R. V., Quintana, R. L., Garrison, M. D., & Bruno, T. J. (2014) · Physical Chemistry Chemical Physics · doi:10.1039/c3cp55349c · Cited by 83 · see citing works
Sacia, E. R., Deaner, M. H., Louie, L., & Bell, A. T. (2015) · Green Chemistry · doi:10.1039/c4gc02292k · Cited by 81 · see citing works
Coupling chemical and biological catalysis: a flexible paradigm for producing biobased chemicals
Schwartz, T. J., Shanks, B. H., & Dumesic, J. A. (2016) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2015.12.017 · Cited by 82 · see citing works
Hussain, I., Ganiyu, S. A., Alasiri, H. S., & Alhooshani, K. R. (2022) · Energy Conversion and Management · doi:10.1016/j.enconman.2022.116433 · Cited by 79 · see citing works
Recognition and Site‐Selective Transformation of Monosaccharides by Using Copper(II) Catalysis
Chen, I., Kou, K. G. M., Le, D. N., Rathbun, C. M., & Dong, V. M. (2014) · Chemistry - A European Journal · doi:10.1002/chem.201400133 · Cited by 76 · see citing works
One-pot transformation of polysaccharides via multi-catalytic processes
Li, H., Bhadury, P. S., Riisager, A., & Yang, S. (2014) · Catalysis Science & Technology · doi:10.1039/c4cy00711e · Cited by 73 · see citing works
Production of Adipic Acid from Sugar Beet Residue by Combined Biological and Chemical Catalysis
Zhang, H., Li, X., Su, X., Ang, E. L., Zhang, Y., & Zhao, H. (2016) · ChemCatChem · doi:10.1002/cctc.201600069 · Cited by 72 · see citing works
Renewable high-density spiro-fuels from lignocellulose-derived cyclic ketones
Xie, J., Zhang, X., Pan, L., Nie, G., Xiu‐tian‐feng, E., Liu, Q., Wang, P., Li, Y., & Zou, J. (2017) · Chemical Communications · doi:10.1039/c7cc05101h · Cited by 72 · see citing works
Sun, Z., & Barta, K. (2018) · Chemical Communications · doi:10.1039/c8cc02937g · Cited by 72 · see citing works
Schwartz, T. J., Johnson, R. L., Cárdenas, J., Okerlund, A. L., Silva, N. A. D., Schmidt‐Rohr, K., & Dumesic, J. A. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201407615 · Cited by 71 · see citing works
Visible light mediated upgrading of biomass to biofuel
Verma, S., Baig, R. B. N., Nadagouda, M. N., & Varma, R. S. (2016) · Green Chemistry · doi:10.1039/c5gc02951a · Cited by 69 · see citing works
Wheeldon, I. R., Christopher, P., & Blanch, H. W. (2017) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2017.02.019 · Cited by 69 · see citing works
Self-citationAllen, J. W., Scheer, A. M., Gao, C. W., Merchant, S. S., Vasu, S., Welz, O., Savee, J. D., Osborn, D. L., Changyoul Lee, E., Vranckx, S., et al. (2013) · Combustion and Flame · doi:10.1016/j.combustflame.2013.10.019 · Cited by 69 · see citing works
Wallace, S., & Balskus, E. P. (2016) · Angewandte Chemie International Edition · doi:10.1002/anie.201600966 · Cited by 69 · see citing works
Highly efficient separation of 5-hydroxymethylfurfural from imidazolium-based ionic liquids
Wang, H., Cui, J., Zhao, Y., Li, Z., & Wang, J. (2020) · Green Chemistry · doi:10.1039/d0gc03557b · Cited by 68 · see citing works
Conversion of biomass derived valerolactone into high octane number gasoline with an ionic liquid
Xin, J., Yan, D., Ayodele, O. O., Zhang, Z., Lü, X., & Zhang, S. (2014) · Green Chemistry · doi:10.1039/c4gc01792g · Cited by 68 · see citing works
Selective Catalysis for Cellulose Conversion to Lactic Acid and Other α-Hydroxy Acids
Dusselier, M., & Sels, B. F. (2014) · Topics in current chemistry · doi:10.1007/128_2014_540 · Cited by 67 · see citing works
Shylesh, S., Sreekumar, S., Gomes, J., Grippo, A. M., Arab, G., Head‐Gordon, M., Toste, F. D., & Bell, A. T. (2015) · Angewandte Chemie International Edition · doi:10.1002/anie.201412470 · Cited by 66 · see citing works
Self-citationLiu, J., Chan, S. H. J., Brock‐Nannestad, T., Chen, J., Lee, S. Y., Solem, C., & Jensen, P. R. (2016) · Metabolic Engineering · doi:10.1016/j.ymben.2016.02.008 · Cited by 65 · see citing works
Chemocatalytic upgrading of tailored fermentation products toward biodiesel
Sreekumar, S., Baer, Z. C., Gross, E., Padmanaban, S., Goulas, K., Gunbas, G., Alayoglu, S., Blanch, H. W., Clark, D. S., & Toste, F. D. (2014) · ChemSusChem · doi:10.1002/cssc.201402244 · Cited by 64 · see citing works
Self-citationRenewable fuels from biomass: Technical hurdles and economic assessment of biological routes
Klein‐Marcuschamer, D., & Blanch, H. W. (2015) · AIChE Journal · doi:10.1002/aic.14755 · Cited by 64 · see citing works
Self-citation
- Authors
- Anbarasan, P., Baer, Z. C., Sreekumar, S., Gross, E., Binder, J. B., Blanch, H. W., Clark, D. S., & Toste, F. D.
- Affiliations
- Energy Biosciences Institute (US)
- Lawrence Berkeley National Laboratory (US)
- Corresponding author
- Toste, F. Dean
- Venue
- Nature
- Published
- 2012-11-07
- Volume
- 491
- Issue
- 7423
- Pages
- 235-239
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1995815598
- Cited by
- 385
- References
- 28
- Citations by year
- 2026: 8 · 2025: 20 · 2024: 21 · 2023: 22 · 2022: 29 · 2021: 24 · 2020: 26 · 2019: 32 · 2018: 30 · 2017: 36 · 2016: 56 · 2015: 33 · 2014: 26 · 2013: 21 · 2012: 1
- FWCI
- 14.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Catalysis for Biomass Conversion
- Physical Sciences › Engineering › Biomedical Engineering › Biofuel production and bioconversion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
- Keywords
- acetone-butanol-ethanol fermentation, ketone production, biofuels, jet fuel precursors, Clostridium acetobutylicum, lignocellulosic biomass, cane sugar, C–C bond formation, renewable transportation fuels
- MeSH terms
- Acetone, Ethanol, Alkylation, Catalysis, Fermentation, Gasoline, Ketones, Lignin, Models, Chemical, Palladium, Time Factors, Triglycerides, Biomass, 1-Butanol, Saccharum, Clostridium acetobutylicum, Biofuels
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review