Cited by 175Catalysis for Biomass ConversionEnzyme Catalysis and ImmobilizationMicrobial Metabolic Engineering and Bioproduction

Bridging the Chemical and Biological Catalysis Gap: Challenges and Outlooks for Producing Sustainable Chemicals

Schwartz, Thomas J., O’Neill, Brandon J., Shanks, Brent H., Dumesic, James A.·2014·ACS Catalysis

Abstract

Recent advances in metabolic engineering have allowed for the production of a wide array of molecules via biocatalytic routes. The high selectivity of biocatalysis to remove functionality from biomass can be used to produce platform molecules that are suitable for subsequent upgrading over heterogeneous catalysts. Accordingly, the more robust continuous processing allowed by chemical catalysis could be leveraged to upgrade biologically derived platform molecules to produce direct or functional replacements for petroleum products. Herein, we highlight recent results that utilize a combination of chemical and biological catalysis, and using the perspective of heterogeneous chemical catalysis, we identify challenges that need to be addressed to bridge the gap between the two catalytic approaches. Specifically, studies are required to address the effects on catalyst performance of impurities that originate during bioprocessing. In addition, new generations of heterogeneous catalysts are required for stable operation under liquid phase reaction conditions in the presence of biogenic impurities. Finally, the design and syntheses of new catalysts are required to tailor the active sites and the environment around these sites to achieve selective conversion of the functional groups present in biologically derived platform molecules.

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Crossref · 10.1021/cs500364y

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115 of 115 references verified0 citation errors · 0 not checkable

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  • The role of catalysis in these conversions is critical and many research efforts are focusing on developing green catalytic processes with high efficiency and low cost.

    “The role of catalysis in these conversions is critical and many research efforts are focusing on developing green catalytic processes with high efficiency and low cost.[84][85][86]”

    From Catalysis as an Enabling Science for Sustainable Polymers (2018) · cites this paper as [86]

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Authors
Schwartz, T. J., O’Neill, B. J., Shanks, B. H., & Dumesic, J. A.
Affiliations
  • University of Wisconsin–Madison (US)
  • Iowa State University (US)
Corresponding author
Dumesic, James A.
Venue
ACS Catalysis
Published
2014-05-28
Volume
4
Issue
6
Pages
2060-2069
ISSN
2155-5435 (ISSN-L)
OpenAlex
W2950816365
Cited by
175
References
115
Citations by year
2026: 5 · 2025: 7 · 2024: 3 · 2023: 9 · 2022: 12 · 2021: 14 · 2020: 12 · 2019: 17 · 2018: 24 · 2017: 24 · 2016: 25 · 2015: 16 · 2014: 7
FWCI
12.47
Type
journal article
Language
en
Open access
closed
Locations
ACS Catalysis (publishedVersion)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Catalysis for Biomass Conversion
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Enzyme Catalysis and Immobilization
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
Keywords
biocatalysis, heterogeneous catalysis, metabolic engineering, sustainable chemicals, biomass conversion, platform molecules, catalyst stability, liquid-phase catalysis, active site design

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