The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC
Open accessAbstract
Most human coronaviruses cause mild upper respiratory tract disease but may be associated with more severe pulmonary disease in immunocompromised individuals. However, SARS coronavirus caused severe lower respiratory disease with nearly 10% mortality and evidence of systemic spread. Recently, another coronavirus (human coronavirus-Erasmus Medical Center (hCoV-EMC)) was identified in patients with severe and sometimes lethal lower respiratory tract infection. Viral genome analysis revealed close relatedness to coronaviruses found in bats. Here we identify dipeptidyl peptidase 4 (DPP4; also known as CD26) as a functional receptor for hCoV-EMC. DPP4 specifically co-purified with the receptor-binding S1 domain of the hCoV-EMC spike protein from lysates of susceptible Huh-7 cells. Antibodies directed against DPP4 inhibited hCoV-EMC infection of primary human bronchial epithelial cells and Huh-7 cells. Expression of human and bat (Pipistrellus pipistrellus) DPP4 in non-susceptible COS-7 cells enabled infection by hCoV-EMC. The use of the evolutionarily conserved DPP4 protein from different species as a functional receptor provides clues about the host range potential of hCoV-EMC. In addition, it will contribute critically to our understanding of the pathogenesis and epidemiology of this emerging human coronavirus, and may facilitate the development of intervention strategies.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Preclinical studies showed that GLP-1RAs reduce cytokine production, attenuate pulmonary inflammation and preserve lung function in rats and mice with experimental lung injury [8, 32].”
From GLP-1 receptor agonists and renal outcomes in patients with diabetes mellitus type 2 and diabetic kidney disease: state of the art (2022) · cites this paper as [32]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus
Li, W., Moore, M. J., Vasilieva, N., Sui, J., Wong, S. K., Berne, M. A., Somasundaran, M., Sullivan, J. L., Luzuriaga, K., Greenough, T. C., et al. (2003) · Nature · doi:10.1038/nature02145 · Cited by 5,923
Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia
Zaki, A. M., van Boheemen, S., Bestebroer, T. M., Osterhaus, A. D. M. E., & Fouchier, R. A. M. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1211721 · Cited by 5,677
Self-citationA crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus–induced lung injury
Kuba, K., Imai, Y., Rao, S., Gao, H., Guo, F., Guan, B., Huan, Y., Yang, P., Zhang, Y., Deng, W., et al. (2005) · Nature Medicine · doi:10.1038/nm1267 · Cited by 3,445
Bats Are Natural Reservoirs of SARS-Like Coronaviruses
Li, W., Shi, Z., Yu, M., Ren, W., Smith, C. S., Epstein, J. H., Wang, H., Crameri, G. S., Hú, Z., Zhang, H., et al. (2005) · Science · doi:10.1126/science.1118391 · Cited by 2,571
Angiotensin-converting enzyme 2 protects from severe acute lung failure
Imai, Y., Kuba, K., Rao, S., Huan, Y., Guo, F., Guan, B., Yang, P., Sarao, R., Wada, T., Leong-Poi, H., et al. (2005) · Nature · doi:10.1038/nature03712 · Cited by 2,453
Structure of SARS Coronavirus Spike Receptor-Binding Domain Complexed with Receptor
Li, F., Li, W., Farzan, M., & Harrison, S. C. (2005) · Science · doi:10.1126/science.1116480 · Cited by 2,035
Coronavirus Pathogenesis and the Emerging Pathogen Severe Acute Respiratory Syndrome Coronavirus
Weiss, S. R., & Navas-Martin, S. (2005) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.69.4.635-664.2005 · Cited by 1,256
Severe acute respiratory syndrome
Peiris, M. J. S., Guan, Y., & Yuen, K. (2004) · Nature Medicine · doi:10.1038/nm1143 · Cited by 1,157
Lambeir, A.-M., Durinx, C., Scharpé, S., & De Meester, I. (2003) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/713609354 · Cited by 955
Human aminopeptidase N is a receptor for human coronavirus 229E
Yeager, C. L., Ashmun, R. A., Williams, R. K., Cardellichio, C. B., Shapiro, L. H., Look, A. T., & Holmes, K. V. (1992) · Nature · doi:10.1038/357420a0 · Cited by 941
Flagged first, then by citations
Cited by
Sorted by citations
Items 901–1,000 of 1,000
The Antiviral Potential of Host Protease Inhibitors
Steinmetzer, T., & Hardes, K. (2018) · Springer eBooks · doi:10.1007/978-3-319-75474-1_11 · Cited by 26
Ezzikouri, S., Nourlil, J., Benjelloun, S., Kohara, M., & Tsukiyama–Kohara, K. (2020) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2020.1787068 · Cited by 26
COVID-19 and diabetes; Possible role of polymorphism and rise of telemedicine
Sayed, S. (2020) · Primary care diabetes · doi:10.1016/j.pcd.2020.08.018 · Cited by 26
Host Receptors of Influenza Viruses and Coronaviruses—Molecular Mechanisms of Recognition
Sriwilaijaroen, N., & Suzuki, Y. (2020) · Vaccines · doi:10.3390/vaccines8040587 · Cited by 26
Coronavirus Disease 2019 (COVID-19): Current Situation and Therapeutic Options
Singh, V., & Mishra, V. (2020) · Coronaviruses · doi:10.2174/2666796701999201005211854 · Cited by 26
Attenuation of SARS-CoV-2 infection by losartan in human kidney organoids
Rahmani, W., Chung, H., Sinha, S., Bui-Marinos, M. P., Arora, R., Jaffer, A., Corcoran, J. A., Biernaskie, J., & Chun, J. (2022) · iScience · doi:10.1016/j.isci.2022.103818 · Cited by 25
Han, H.-J., Liu, J.-W., Yu, H., & Yu, X. (2018) · Viruses · doi:10.3390/v10120680 · Cited by 25
Hong, D., Lin, L., Wang, Y., Yu, L., Tang, Y., Zhao, J. W., Song, X., He, Y., Wen, E., Zheng, L., et al. (2020) · Clinical Kidney Journal · doi:10.1093/ckj/sfaa083 · Cited by 25
Druggable targets from coronaviruses for designing new antiviral drugs
Silva, L. R., Santos-Júnior, P. F. D. S., Brandão, J. D. A., Anderson, L., Bassi, Ê. J., de Araújo‐Júnior, J. X., Cardoso, S. H., & da Silva‐Júnior, E. F. (2020) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2020.115745 · Cited by 25
Sabato, L. D., Bartolo, I. D., Marco, M. A. D., Moreno, A. M., Lelli, D., Cotti, C., Delogu, M., & Vaccari, G. (2020) · Viruses · doi:10.3390/v12121471 · Cited by 25
Kalhori, M. R., Saadatpour, F., Arefian, E., Soleimani, M., Farzaei, M. H., Aneva, I. Y., & Echeverría, J. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.616993 · Cited by 25
Park, B. K., Kim, J., Park, S., Kim, D., Kim, M., Baek, K., Bae, J., Park, M., Kim, W., Lee, Y., et al. (2021) · Theranostics · doi:10.7150/thno.55647 · Cited by 25
Kumar, S., Basu, M., Ghosh, P., Pal, U., & Ghosh, M. K. (2023) · Genes & Diseases · doi:10.1016/j.gendis.2022.12.019 · Cited by 25
Evolving sequence mutations in the Middle East Respiratory Syndrome Coronavirus (MERS-CoV)
Balwi, M. A. A., Khan, A., Aldrees, M., Gk, U. R., Manie, B., Arabi, Y. M., Alabdulkareem, I. B., AlJohani, S. M., Alghoribi, M. F., Alaskar, A. S., et al. (2020) · Journal of Infection and Public Health · doi:10.1016/j.jiph.2020.06.030 · Cited by 25
Interaction of Severe Acute Respiratory Syndrome Coronavirus 2 and Diabetes
Shao, S., Yang, Q., Pan, R., Yu, X., & Chen, Y. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.731974 · Cited by 27
Middle East respiratory syndrome coronavirus (MERS-CoV): Impact on Saudi Arabia, 2015
Faridi, U. A. (2016) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2016.09.020 · Cited by 24
Ko, J., Müller, M. A., Seok, H., Park, G., Lee, J., Cho, S. Y., Ha, Y. E., Baek, J. Y., Kim, S.-H., Kang, J., et al. (2017) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-017-3043-3 · Cited by 24
Self-citationNakhleh, A., & Shehadeh, N. (2020) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2020.04.040 · Cited by 24
Acute kidney injury in COVID-19; a review on current knowledge
Aleebrahim‐Dehkordi, E., Reyhanian, A., Saberianpour, S., & Dehkordi, A. H. (2020) · Journal of Nephropathology · doi:10.34172/jnp.2020.31 · Cited by 24
Beyond the lung involvement in COVID-19 patients
Tuttolomondo, D., Frizzelli, A., Aiello, M., Bertorelli, G., Majori, M., & Chetta, A. A. (2021) · Minerva Medica · doi:10.23736/s0026-4806.20.06719-1 · Cited by 24
Double-Barreled CRISPR Technology as a Novel Treatment Strategy For COVID-19
Nalawansha, D. A., & Samarasinghe, K. T. G. (2020) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.0c00071 · Cited by 24
SARS-CoV-2: An Overview of Virus Genetics, Transmission, and Immunopathogenesis
Farrag, M. A., Amer, H. M., Bhat, R., Hamed, M. E., Aziz, I. M., Mubarak, A., Dawoud, T. M. S., Almalki, S. G., Alghofaili, F., Alnemare, A. K., et al. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18126312 · Cited by 28
Luk, A. O. Y., Yip, T. C., Zhang, X., Kong, A. P. S., Wong, V. W., Ronald, C. W., & Wong, G. L. (2021) · BMJ Open · doi:10.1136/bmjopen-2021-052310 · Cited by 24
COVID-19 and Diabetes Outcomes: Rationale for and Updates from the CORONADO Study
Smati, S., Tramunt, B., Wargny, M., Gourdy, P., Hadjadj, S., & Cariou, B. (2022) · Current Diabetes Reports · doi:10.1007/s11892-022-01452-5 · Cited by 27
Venkataraman, S. (2022) · Vaccines · doi:10.3390/vaccines10111805 · Cited by 24
Rong, N., & Liu, J. (2023) · Emerging Microbes & Infections · doi:10.1080/22221751.2023.2178242 · Cited by 27
Sharbatdar, Y., Mousaviyan, R., Varnosfaderani, S. M. N., Aziziyan, F., Liaghat, M., Baziyar, P., Rad, A. Y., Tavakol, C., Moeini, A. M., Nabi‐Afjadi, M., et al. (2023) · Inflammopharmacology · doi:10.1007/s10787-023-01215-y · Cited by 24
Roy, A. N., Gupta, A. M., Banerjee, D., Chakrabarti, J., & Raghavendra, P. B. (2023) · Viruses · doi:10.3390/v15102056 · Cited by 24
Yang, Y., Deng, Y. L., Wen, B., Wang, H., Meng, X., Lan, J., Gao, G. F., & Tan, W. (2014) · Viral Immunology · doi:10.1089/vim.2014.0080 · Cited by 24
Huang, C., Qi, J., Lu, G., Wang, Q., Yuan, Y., Wu, Y., Zhang, Y., Yan, J., & Gao, G. F. (2016) · Biochemistry · doi:10.1021/acs.biochem.6b00790 · Cited by 24
Biology of Viruses and Viral Diseases
Chappell, J. D., & Dermody, T. S. (2015) · Elsevier eBooks · doi:10.1016/b978-1-4557-4801-3.00134-x · Cited by 24
Wang, C., Hua, C., Xia, S., Li, W., Lu, L., & Jiang, S. (2019) · Viruses · doi:10.3390/v11010031 · Cited by 24
Middle East Respiratory Syndrome Coronavirus Antibodies in Bactrian and Hybrid Camels from Dubai
Lau, S. K. P., Li, K. S. M., Luk, H. K. H., He, Z., Teng, J. L. L., Yuen, K., Wernery, U., & Woo, P. C. Y. (2020) · mSphere · doi:10.1128/msphere.00898-19 · Cited by 24
Highly pathogenic coronaviruses: thrusting vaccine development in the spotlight
He, C., Qin, M., & Sun, X. (2020) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2020.05.009 · Cited by 24
Hooper, N. M., Lambert, D., & Turner, A. J. (2020) · Clinical Science · doi:10.1042/cs20200476 · Cited by 24
Gao, Q., Zhang, W., Li, T., Yang, G., Zhu, W., Chen, N., & Jin, H. (2022) · Scientific Reports · doi:10.1038/s41598-021-03912-6 · Cited by 24
Du, L., Ma, C., & Jiang, S. (2013) · Journal of Infection · doi:10.1016/j.jinf.2013.05.002 · Cited by 24
Rolta, R., Salaria, D., Kumar, V., Sourirajan, A., & Dev, K. (2020) · doi:10.21203/rs.3.rs-30938/v1 · Cited by 24
Wallia, A., Prince, G., Touma, E., El Muayed, M., & Seley, J. J. (2020) · Current Diabetes Reports · doi:10.1007/s11892-020-01366-0 · Cited by 23
Rabaan, A. A., Bazzi, A. M., Al-Ahmed, S. H., & Al‐Tawfiq, J. A. (2017) · Frontiers of Medicine · doi:10.1007/s11684-017-0521-z · Cited by 23
Three Main Inducers of Alphacoronavirus Infection of Enterocytes: Sialic Acid, Proteases, and Low pH
Yuan, P., Yang, Z., Song, H. S., Wang, K., Yang, Y., Xie, L., Huang, S., Liu, J., Ran, L., & Song, Z. (2018) · Intervirology · doi:10.1159/000492424 · Cited by 23
The broad-spectrum antiviral recommendations for drug discovery against COVID-19
Hazafa, A., ur-Rahman, K., Haq, I. U., Jahan, N., Mumtaz, M., Farman, M. T., Naeem, H., Abbas, F., Naeem, M., Sadiqa, S., et al. (2020) · Drug Metabolism Reviews · doi:10.1080/03602532.2020.1770782 · Cited by 23
Kayode, A. J., Banji-Onisile, F. O., Olaniran, A. O., & Okoh, A. I. (2021) · Pathogens · doi:10.3390/pathogens10091108 · Cited by 23
Wang, H., Zhang, J., Lu, Z., Dai, W., Ma, C., Xiang, Y., & Zhang, Y. (2021) · Briefings in Bioinformatics · doi:10.1093/bib/bbab373 · Cited by 23
Converting non-neutralizing SARS-CoV-2 antibodies into broad-spectrum inhibitors
Weidenbacher, P. A. B., Waltari, E., Kobara, I. D. L. R., Bell, B. N., Morris, M. K., Cheng, Y.-C., Hanson, C. V., Pak, J. E., & Kim, P. S. (2022) · Nature Chemical Biology · doi:10.1038/s41589-022-01140-1 · Cited by 23
Nuclear translocation of spike mRNA and protein is a novel feature of SARS-CoV-2
Sattar, S., Kabát, J., Jerome, K., Feldmann, F., Bailey, K. L., & Mehedi, M. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1073789 · Cited by 23
Antiviral activity of marine sulfated glycans against pathogenic human coronaviruses
Zoepfl, M., Dwivedi, R., Kim, S. B., McVoy, M. A., & Pomin, V. H. (2023) · Scientific Reports · doi:10.1038/s41598-023-31722-5 · Cited by 23
Zhang, Y., Sun, J., Zheng, J. H., Li, S., Rao, H., Dai, J., Zhang, Z., Wang, Y., Liu, D., Chen, Z., et al. (2023) · Advanced Science · doi:10.1002/advs.202303366 · Cited by 24
Hunting Viral Receptors Using Haploid Cells
Pillay, S., & Carette, J. E. (2015) · Annual Review of Virology · doi:10.1146/annurev-virology-100114-055119 · Cited by 23
Li, Y., Li, L., Yu, S., Wang, X., Zhang, L., Yu, J., Xie, L., Li, W., Ali, R., & Qiu, H. (2016) · Viruses · doi:10.3390/v8050127 · Cited by 23
The COVID-19 pandemic – How many times were we warned before?
Mahroum, N., Seida, I., Esirgün, S. N., & Bragazzi, N. L. (2022) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2022.07.009 · Cited by 23
Close relatives of MERS-CoV in bats use ACE2 as their functional receptorsPreprint
Xiong, Q., Cao, L., Ma, C., Liu, C., Si, J., Liu, P., Gu, M., Wang, C., Shi, L., Tong, F., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.01.24.477490 · Cited by 23
Excler, J., Delvecchio, C. J., Wiley, R. E., Williams, M., Yoon, I., Modjarrad, K., Boujelal, M., Moorthy, V., Hersi, A. S., Kim, J. H., et al. (2016) · Emerging infectious diseases · doi:10.3201/eid2208.160229 · Cited by 22
Middle East respiratory syndrome coronavirus: current knowledge and future considerations
Malik, M. R., Elkholy, A. A., Khan, W., Hassounah, S., Abubakar, A., Minh, N. N. T., & Mala, P. O. (2016) · Eastern Mediterranean Health Journal · doi:10.26719/2016.22.7.533 · Cited by 22
Yuan, Y., Qi, J., Peng, R., Li, C., Lu, G., Yan, J., Wang, Q., & Gao, G. F. (2019) · Journal of Virology · doi:10.1128/jvi.01387-19 · Cited by 22
Emameh, R. Z., Nosrati, H., & Taheri, R. A. (2020) · Biological Procedures Online · doi:10.1186/s12575-020-00121-9 · Cited by 22
COVID-19 and diabetes mellitus: implications for prognosis and clinical management
Barber, T. M. (2020) · Expert Review of Endocrinology & Metabolism · doi:10.1080/17446651.2020.1774360 · Cited by 22
Antimalarials as Antivirals for COVID-19: Believe it or Not!
Saha, B. K., Bonnier, A., & Chong, W. H. (2020) · The American Journal of the Medical Sciences · doi:10.1016/j.amjms.2020.08.019 · Cited by 22
Crosstalk Between Coronavirus Disease 2019 and Cardiovascular Disease and Its Treatment
Ye, Q., Lu, D., Shang, S., Fu, J., Gong, F., Shu, Q., & Mao, J. (2020) · ESC Heart Failure · doi:10.1002/ehf2.12960 · Cited by 24
The use of mesenchymal stromal cells in the treatment of coronavirus disease 2019
Canham, M. A., Campbell, J. D. M., & Mountford, J. C. (2020) · Journal of Translational Medicine · doi:10.1186/s12967-020-02532-4 · Cited by 22
Therapy of Type 2 Diabetes in Patients with SARS-CoV-2 Infection
Bielka, W., Przezak, A., & Pawlik, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147605 · Cited by 23
Sarker, J., Das, P., Sarker, S., Roy, A. K., & Momen, A. Z. M. R. (2021) · Scientifica · doi:10.1155/2021/2706789 · Cited by 23
Shin, H. J., Ku, K. B., Kim, H. S., Moon, H.-W., Jeong, G. U., Hwang, I., Yoon, G. Y., Lee, S.-H., Lee, S., Ahn, D., et al. (2021) · International Journal of Biological Sciences · doi:10.7150/ijbs.61320 · Cited by 22
Abuhasira, R., Ayalon‐Dangur, I., Zaslavsky, N., Koren, R., Keller, M., Dicker, D., & Grossman, A. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.794382 · Cited by 23
Comprehensive Oncogenic Features of Coronavirus Receptors in Glioblastoma Multiforme
Chen, A., Zhao, W., Li, X., Sun, G., Ma, Z., Peng, L., Shi, Z., Li, X., & Yan, J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.840785 · Cited by 23
DPP-4 Inhibitors as a Savior for COVID-19 Patients with Diabetes
Nag, S., Mandal, S., Mukherjee, O., Mukherjee, S., & Kundu, R. (2023) · Future Virology · doi:10.2217/fvl-2022-0112 · Cited by 22
2-thiouridine is a broad-spectrum antiviral nucleoside analogue against positive-strand RNA viruses
Uemura, K., Nobori, H., Sato, A., Toba, S., Kusakabe, S., Sasaki, M., Tabata, K., Matsuno, K., Maeda, N., Ito, S., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2304139120 · Cited by 23
Lee, N. L. S., & Qureshi, S. T. (2013) · Critical Care Clinics · doi:10.1016/j.ccc.2013.07.003 · Cited by 22
Cardiovascular safety of dipeptidyl peptidase-4 inhibitors: recent evidence on heart failure.
Kankanala, S., Syed, R. M., Gong, Q., Ren, B., Rao, X., & Zhong, J. (2016) · PubMed Central · Cited by 22
Te, N., Vergara‐Alert, J., Lehmbecker, A., Pérez, M., Haagmans, B. L., Baumgärtner, W., Bensaïd, A., & Segalés, J. (2018) · Transboundary and Emerging Diseases · doi:10.1111/tbed.13092 · Cited by 22
Self-citationCoronavirus Receptors as Immune Modulators
Devarakonda, C. K. V., Meredith, E. K., Ghosh, M., & Shapiro, L. H. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.2001062 · Cited by 22
Roy, S., Ghani, K., de Campos-Lima, P. O., & Caruso, M. (2021) · Virus Research · doi:10.1016/j.virusres.2021.198305 · Cited by 23
Niu, X., Hou, Y. J., Jung, K., Kong, F., Saif, L. J., & Wang, Q. (2021) · Viruses · doi:10.3390/v13010122 · Cited by 22
Coronaviruses Associated with the Superfamily Musteloidea
Stout, A. E., Guo, Q., Millet, J. K., de Matos, R., & Whittaker, G. R. (2021) · mBio · doi:10.1128/mbio.02873-20 · Cited by 22
Chemokine Regulation During Epidemic Coronavirus Infection
Majumdar, S., & Murphy, P. M. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.600369 · Cited by 22
Can cilia provide an entry gateway for SARS-CoV-2 to human ciliated cells?
Buqaileh, R., Saternos, H. C., Ley, S. T., Aranda, A., Forero, K. V., & AbouAlaiwi, W. A. (2021) · Physiological Genomics · doi:10.1152/physiolgenomics.00015.2021 · Cited by 22
Influenza Virus and SARS-CoV-2 Vaccines
Sandor, A., Sturdivant, M. S., & Ting, J. P. ‐. (2021) · The Journal of Immunology · doi:10.4049/jimmunol.2001287 · Cited by 23
El-Kafrawy, S. A., Abbas, A. T., Sohrab, S. S., Tabll, A. A., Hassan, A. M., Iwata‐Yoshikawa, N., Nagata, N., & Azhar, E. I. (2021) · Pharmaceuticals · doi:10.3390/ph14060511 · Cited by 22
ACE2 interaction with cytoplasmic PDZ protein enhances SARS-CoV-2 invasion
Zhang, Q., Gefter, J. V., Sneddon, W. B., Mamonova, T., & Friedman, P. A. (2021) · iScience · doi:10.1016/j.isci.2021.102770 · Cited by 22
The Role of Post-Translational Modifications of Chemokines by CD26 in Cancer
Zutter, A. D., Damme, J. V., & Struyf, S. (2021) · Cancers · doi:10.3390/cancers13174247 · Cited by 22
Coronaviruses fusion with the membrane and entry to the host cell
Wędrowska, E., Wandtke, T., Senderek, T., Piskorska, E., & Kopiński, P. (2020) · Annals of Agricultural and Environmental Medicine · doi:10.26444/aaem/122079 · Cited by 21
Al-Kuraishy, H. M., Al‐Niemi, M. S., Hussain, N. R., Al-Gareeb, A. I., Al‐Harchan, N. A., & Al-Kurashi, A. H. (2020) · IntechOpen eBooks · doi:10.5772/intechopen.92837 · Cited by 21
The COVID-19 pandemic: biological evolution, treatment options and consequences
Das, S., Das, S., & Ghangrekar, M. M. (2020) · Innovative Infrastructure Solutions · doi:10.1007/s41062-020-00325-8 · Cited by 21
Ji, X., Tan, W., Zhang, C., Zhai, Y., Hsueh, Y.-C., Zhang, Z., Zhang, C., Lu, Y., Duan, B., Tan, G., et al. (2020) · Drug Development Research · doi:10.1002/ddr.21717 · Cited by 21
Jha, N. K., Jeyaraman, M., Rachamalla, M., Ojha, S. K., Dua, K., Chellappan, D. K., Muthu, S., Sharma, A., Jha, S. K., Jain, R., et al. (2021) · Immuno · doi:10.3390/immuno1010004 · Cited by 21
Management of Patients With Glucocorticoid-Related Diseases and COVID-19
Chifu, I. O., Detomas, M., Dischinger, U., Kimpel, O., Megerle, F., Hahner, S., Faßnacht, M., & Altieri, B. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.705214 · Cited by 21
Toxoplasma gondii SAG1 targeting host cell S100A6 for parasite invasion and host immunity
Zhou, L.-J., Peng, J., Chen, M., Yao, L.-J., Zou, W., He, C. Y., & Peng, H. (2021) · iScience · doi:10.1016/j.isci.2021.103514 · Cited by 21
Risk Factors for COVID-19: Diabetes, Hypertension, and Obesity
Buscemi, S., Corleo, D., & Randazzo, C. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-85113-2_7 · Cited by 24
COVID-19 and diabetes—Two giants colliding: From pathophysiology to management
Pelle, M. C., Zaffina, I., Provenzano, M., Moirano, G., & Arturi, F. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.974540 · Cited by 22
Speranskaya, A. S., Artyushin, I. V., Samoilov, A. E., Korneenko, E. V., Khabudaev, K. V., Ilina, E. N., Yuzefovich, A. P., Safonova, M. V., Dolgova, A. S., Gladkikh, A. S., et al. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20043702 · Cited by 21
Tai, W., Zheng, J. H., Zhang, X., Shi, J., Wang, G., Guan, X., Zhu, J., Perlman, S. M., & Du, L. (2023) · Virus Research · doi:10.1016/j.virusres.2023.199156 · Cited by 21
An update on Middle East respiratory syndrome: 2 years later
Al‐Tawfiq, J. A., & Memish, Z. A. (2015) · Expert Review of Respiratory Medicine · doi:10.1586/17476348.2015.1027689 · Cited by 21
The receptor binding domain of MERS-CoV: The dawn of vaccine and treatment development
Zhou, N., Zhang, Y., Zhang, J.-C., Feng, L., & Bao, J. (2013) · Journal of the Formosan Medical Association · doi:10.1016/j.jfma.2013.11.006 · Cited by 21
Possible mechanisms of direct cardiovascular impact of GLP-1 agonists and DPP4 inhibitors
Bistola, V., Lambadiari, V., Dimitriadis, G., Ioannidis, I., Makrilakis, K., Tentolouris, N., Τσάπας, Α., & Parissis, J. (2018) · Heart Failure Reviews · doi:10.1007/s10741-018-9674-3 · Cited by 21
Heightened ACE Activity and Unfavorable Consequences in COVID-19 Diabetic Subjects
Sandooja, R., Vura, N. V. R. K., & Morocco, M. (2020) · International Journal of Endocrinology · doi:10.1155/2020/7847526 · Cited by 21
SARS-CoV-2 infection in patients with diabetes mellitus and hypertension: a systematic review
Deravi, N., Fathi, M., Vakili, K. G., Yaghoobpoor, S., Pirzadeh, M., Mokhtari, M., Fazel, T., Ahsan, E., & Ghaffari, S. (2020) · Reviews in Cardiovascular Medicine · doi:10.31083/j.rcm.2020.03.78 · Cited by 21
Souza, P. F. N., Mesquita, F. P., Amaral, J. L., Landim, P. G. C., Lima, K. R. P., Costa, M. B., Farias, I. R., Lima, L. B., & Montenegro, R. C. (2021) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2021.02.203 · Cited by 21
Barth, R. F., Buja, L. M., Barth, A. L., Carpenter, D. E., & Parwani, A. V. (2021) · Archives of Pathology & Laboratory Medicine · doi:10.5858/arpa.2020-0820-sa · Cited by 23
Rais, Y., Fu, Z., & Drabovich, A. P. (2021) · Clinical Proteomics · doi:10.1186/s12014-021-09325-x · Cited by 23
Chen, H., Peng, J., Wang, T., Wen, J., Chen, S., Huang, Y., & Zhang, Y. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2022.115370 · Cited by 19
Metadata
- Authors
- Raj, V. S., Mou, H., Smits, S. L., Dekkers, D. H. W., Müller, M. A., Dijkman, R., Muth, D., Demmers, J. A. A., Zaki, A., Fouchier, R. A. M., Thiel, V., Drosten, C., Rottier, P. J. M., Osterhaus, A. D. M. E., Bosch, B. J., & Haagmans, B. L.
- Affiliations
- Erasmus MC (NL)
- Utrecht University (NL)
- University of Bonn (DE)
- Kantonsspital St. Gallen (CH)
- Soliman Fakeeh Hospital (SA)
- University of Zurich (CH)
- Corresponding author
- Bosch, Berend Jan
- Haagmans, Bart L.
- ORCID
- Venue
- Nature
- Published
- 2013-03
- Volume
- 495
- Issue
- 7440
- Pages
- 251-254
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC7095326
- OpenAlex
- W2119111857
- Cited by
- 2,061
- References
- 25
- Citations by year
- 2026: 41 · 2025: 64 · 2024: 97 · 2023: 130 · 2022: 199 · 2021: 358 · 2020: 609 · 2019: 74 · 2018: 59 · 2017: 61 · 2016: 93 · 2015: 101 · 2014: 86 · 2013: 87
- FWCI
- 89.49
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, other-oa)
- Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
- Funders
- National Science Foundation
- European Commission (223498, 278976)
- Deutsche Forschungsgemeinschaft (DR 772/3-1, KA1241/18-1, 772/3)
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (132898)
- Bundesministerium für Bildung und Forschung
- China Scholarship Council
- Stiftung Forschung 3R (128-11)
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Virus Infections Studies
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Keywords
- MERS-CoV, dipeptidyl peptidase IV, CD26, viral receptor, host range, lower respiratory tract infection, SARS-CoV, receptor binding domain, Huh7 cells, bronchial epithelial cells
- MeSH terms
- Animals, Chlorocebus aethiops, Chiroptera, Epithelial Cells, Humans, Molecular Sequence Data, Receptors, Virus, Coronavirus, Coronavirus Infections, Dipeptidyl Peptidase 4, COS Cells, Bronchioles, Host Specificity
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review