The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Glucose–TOR signalling reprograms the transcriptome and activates meristems
Open accessAbstract
Meristems encompass stem/progenitor cells that sustain postembryonic growth of all plant organs. How meristems are activated and sustained by nutrient signalling remains enigmatic in photosynthetic plants. Combining chemical manipulations and chemical genetics at the photoautotrophic transition checkpoint, we reveal that shoot photosynthesis-derived glucose drives target-of-rapamycin (TOR) signalling relays through glycolysis and mitochondrial bioenergetics to control root meristem activation, which is decoupled from direct glucose sensing, growth-hormone signalling and stem-cell maintenance. Surprisingly, glucose–TOR signalling dictates transcriptional reprogramming of remarkable gene sets involved in central and secondary metabolism, cell cycle, transcription, signalling, transport and protein folding. Systems, cellular and genetic analyses uncover TOR phosphorylation of E2Fa transcription factor for an unconventional activation of S-phase genes, and glucose-signalling defects in e2fa root meristems. Our findings establish pivotal roles of glucose–TOR signalling in unprecedented transcriptional networks wiring central metabolism and biosynthesis for energy and biomass production, and integrating localized stem/progenitor-cell proliferation through inter-organ nutrient coordination to control developmental transition and growth.
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Cites
mTOR Signaling in Growth Control and Disease
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Self-citationmTOR controls mitochondrial oxidative function through a YY1–PGC-1α transcriptional complex
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Sucrose Efflux Mediated by SWEET Proteins as a Key Step for Phloem Transport
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The translational landscape of mTOR signalling steers cancer initiation and metastasis
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Cited by
Dynamic and diverse sugar signaling
Li, L., & Sheen, J. (2016) · Current Opinion in Plant Biology · doi:10.1016/j.pbi.2016.06.018 · Cited by 304
Self-citationBroeckx, T., Hulsmans, S., & Rolland, F. (2016) · Journal of Experimental Botany · doi:10.1093/jxb/erw416 · Cited by 267
Capturing the phosphorylation and protein interaction landscape of the plant TOR kinase
Van Leene, J., Han, C., Gadeyne, A., Eeckhout, D., Matthijs, C., Cannoot, B., De Winne, N., Persiau, G., Van De Slijke, E., Van de Cotte, B., et al. (2019) · Nature Plants · doi:10.1038/s41477-019-0378-z · Cited by 266
Gutierrez‐Beltran, E., Elander, P. H., Dalman, K., Dayhoff, G. W., Moschou, P. N., Uversky, V. N., Crespo, J. L., & Bozhkov, P. V. (2021) · The EMBO Journal · doi:10.15252/embj.2020105043 · Cited by 83
Alfatah, M., Wong, J. H., Krishnan, V. G., Lee, Y. C., Sin, Q. F., Goh, C. J. H., Kong, K. W., Lee, W. T., Lewis, J., Hoon, S., et al. (2021) · BMC Biology · doi:10.1186/s12915-021-01030-3 · Cited by 39
Metadata
- Authors
- Xiong, Y., McCormack, M., Li, L., Hall, Q., Xiang, C., & Sheen, J.
- Venue
- Nature
- Published
- 2013-03-31
- Volume
- 496
- Issue
- 7444
- Pages
- 181-186
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1992932809
- Cited by
- 818
- References
- 41
- FWCI
- 49.37
- Type
- journal article
- Language
- en
- Open access
- green
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- Xiong, Y., McCormack, M., Li, L., Hall, Q., Xiang, C., & Sheen, J. (2013). Glucose–TOR signalling reprograms the transcriptome and activates meristems. Nature. https://doi.org/10.1038/nature12030
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