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The global distribution and burden of dengue
Open accessAbstract
Dengue is a systemic viral infection transmitted between humans by Aedes mosquitoes. For some patients, dengue is a life-threatening illness. There are currently no licensed vaccines or specific therapeutics, and substantial vector control efforts have not stopped its rapid emergence and global spread. The contemporary worldwide distribution of the risk of dengue virus infection and its public health burden are poorly known. Here we undertake an exhaustive assembly of known records of dengue occurrence worldwide, and use a formal modelling framework to map the global distribution of dengue risk. We then pair the resulting risk map with detailed longitudinal information from dengue cohort studies and population surfaces to infer the public health burden of dengue in 2010. We predict dengue to be ubiquitous throughout the tropics, with local spatial variations in risk influenced strongly by rainfall, temperature and the degree of urbanization. Using cartographic approaches, we estimate there to be 390 million (95% credible interval 284-528) dengue infections per year, of which 96 million (67-136) manifest apparently (any level of disease severity). This infection total is more than three times the dengue burden estimate of the World Health Organization. Stratification of our estimates by country allows comparison with national dengue reporting, after taking into account the probability of an apparent infection being formally reported. The most notable differences are discussed. These new risk maps and infection estimates provide novel insights into the global, regional and national public health burden imposed by dengue. We anticipate that they will provide a starting point for a wider discussion about the global impact of this disease and will help to guide improvements in disease control strategies using vaccine, drug and vector control methods, and in their economic evaluation.
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“An estimated 70% of dengue virus infections are thought to occur in Asia. (2)”
From Epidemiology of dengue reported in the World Health Organization Western Pacific Region, 2013–2019 (2023) · cites this paper as [2]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
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“As a result of differences in case definitions and other factors, there is likely to be underreporting and, thus, an underestimation of the true regional burden in terms of the number of cases, CFRs and incidence. (1, 2)”
From Epidemiology of dengue reported in the World Health Organization Western Pacific Region, 2013–2019 (2023) · cites this paper as [2]
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“Sharing information and data about dengue helps countries and areas better understand transmission patterns and supports the implementation of dengue prevention and control measures. (2)”
From Epidemiology of dengue reported in the World Health Organization Western Pacific Region, 2013–2019 (2023) · cites this paper as [2]
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Cites
Greedy function approximation: A gradient boosting machine
Friedman, J. H. (2001) · The Annals of Statistics · doi:10.1214/aos/1013203451 · Cited by 30,731 · cited 1×
“India19,20 alone contributed 34% (33 [24-44] million infections) of the global total.”
Classification and Regression Trees.
Gordon, A. D., Breiman, L., Friedman, J. H., Olshen, R. A., & Stone, C. J. (1984) · Biometrics · doi:10.2307/2530946 · Cited by 23,867
Classification and Regression Trees.
Ryzin, J. V., Breiman, L., Friedman, J. H., Olshen, R. A., & Stone, C. J. (1986) · Journal of the American Statistical Association · doi:10.2307/2288003 · Cited by 21,030
Very high resolution interpolated climate surfaces for global land areas
Hijmans, R. J., Cameron, S. E., Parra, J. L., Jones, P. G., & Jarvis, A. (2005) · International Journal of Climatology · doi:10.1002/joc.1276 · Cited by 19,860
Novel methods improve prediction of species’ distributions from occurrence data
Elith*, J., H. Graham*, C., P. Anderson, R., Dudík, M., Ferrier, S., Guisan, A., J. Hijmans, R., Huettmann, F., R. Leathwick, J., Lehmann, A., et al. (2006) · Ecography · doi:10.1111/j.2006.0906-7590.04596.x · Cited by 9,088
Murray, C. J. L., Vos, T., Lozano, R., Naghavi, M., Flaxman, A. D., Michaud, C., Ezzati, M., Shibuya, K., Salomon, J. A., Abdalla, S., et al. (2012) · The Lancet · doi:10.1016/s0140-6736(12)61689-4 · Cited by 8,888 · cited 1×
“…many vaccinations are needed to avert an apparent infection) and triangulating with independent assessments of disability adjusted life years (DALYs) 21 ; (ii) elucidating the population dynamics of dengue viruses 22 ; and (iii) hypothesising about population effects of future vaccine programmes…”
Dengue and Dengue Hemorrhagic Fever
Gubler, D. J. (1998) · Clinical Microbiology Reviews · doi:10.1128/cmr.11.3.480 · Cited by 4,394
Ensemble forecasting of species distributions
ARAUJO, M., & NEW, M. (2007) · Trends in Ecology & Evolution · doi:10.1016/j.tree.2006.09.010 · Cited by 3,640 · cited 1×
“Asia bore 70% (67 [47-94] million infections) of this burden, and is characterised by large swathes of densely populated regions coinciding with very high suitability for disease transmission.”
Hilbe, J. M. (2011) · Cambridge University Press eBooks · doi:10.1017/cbo9780511973420 · Cited by 3,352
Selecting pseudo‐absences for species distribution models: how, where and how many?
Barbet‐Massin, M., Jiguet, F., Albert, C. H., & Thuiller, W. (2012) · Methods in Ecology and Evolution · doi:10.1111/j.2041-210x.2011.00172.x · Cited by 2,716 · cited 1×
“Asia bore 70% (67 [47-94] million infections) of this burden, and is characterised by large swathes of densely populated regions coinciding with very high suitability for disease transmission.”
Research works printed but not linked: 2
- Beatty, M. E., Letson, G. W. & Margolis, H. S. Estimating the global burden of dengue. Am. J. Trop. Med. Hyg. 81 (Suppl. 1). 231 (2009)
- Rodhain, F. La situation de la dengue dans le monde. Bull. Soc. Pathol. Exot. 89, 87–90 (1996)
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Osorio, J. E., Vélez, I. D., Thomson, C., López, L., Jimenez, A., Haller, A. A., Silengo, S. J., Scott, J. C., Boroughs, K. L., Stovall, J. L., et al. (2014) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(14)70811-4 · Cited by 158
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Guerra, C. A., Reiner, R. C., Perkins, T. A., Lindsay, S. W., Midega, J. T., Brady, O. J., Barker, C. M., Reisen, W. K., Harrington, L. C., Takken, W., et al. (2014) · Parasites & Vectors · doi:10.1186/1756-3305-7-276 · Cited by 154
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“For instance, dengue incidence has increased by 30 times over the last 50 years, with about 390 million infections reported annually worldwide [14,15].”
Global research priorities for infections that affect the nervous system
John, C. C., Carabin, H., Montano, S. M., Bangirana, P., Zunt, J. R., & Peterson, P. K. (2015) · Nature · doi:10.1038/nature16033 · Cited by 158
“Dengue, and to a lesser extent chikungunya, viruses will probably become leading global causes of arboviral encephalitis in the next decade 2,11,12 .”
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Martín-Acebes, M. A., Vázquez-Calvo, Á., & Sáiz, J. (2016) · Progress in Lipid Research · doi:10.1016/j.plipres.2016.09.005 · Cited by 150
“year, of which 100 million result in symptomatic disease [22].”
Liu, B., Gao, X., Ma, J., Jiao, Z., Xiao, J., Hayat, M. A., & Wang, H. (2019) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2019.01.301 · Cited by 146
Tay, M. Y. F., Saw, W. G., Zhao, Y., Chan, K. W. K., Singh, D., Chong, Y., Forwood, J. K., Ooi, E. E., Grüber, G., Lescar, J., et al. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.607341 · Cited by 147
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Baidaliuk, A., Miot, E. F., Lequime, S., Moltini-Conclois, I., Delaigue, F., Dabo, S., Dickson, L. B., Aubry, F., Merkling, S. H., Cao‐Lormeau, V., et al. (2019) · Journal of Virology · doi:10.1128/jvi.00705-19 · Cited by 146
Cheong, Y. L., Leitão, P. J., & Lakes, T. (2014) · Spatial and Spatio-temporal Epidemiology · doi:10.1016/j.sste.2014.05.002 · Cited by 145
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Self-citationKlema, V. J., Ye, M., Hindupur, A., TERAMOTO, T., Gottipati, K., Padmanabhan, R., & Choi, K. H. (2016) · PLoS Pathogens · doi:10.1371/journal.ppat.1005451 · Cited by 150
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Liu-Helmersson, J., Brännström, Å., Sewe, M. O., Semenza, J. C., & Rocklöv, J. (2019) · Frontiers in Public Health · doi:10.3389/fpubh.2019.00148 · Cited by 145
“Almost half of the world’s population is now at risk from these diseases (9).”
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InfluentialVazquez‐Prokopec, G. M., Montgomery, B. L., Horne, P., Clennon, J. A., & Ritchie, S. A. (2017) · Science Advances · doi:10.1126/sciadv.1602024 · Cited by 140
Pan, X., Pike, A., Joshi, D., Bian, G., McFadden, M. J., Lü, P., Liang, X., Zhang, F., Raikhel, A. S., & Xi, Z. (2017) · The ISME Journal · doi:10.1038/ismej.2017.174 · Cited by 143
Fraser, J. E., Bruyne, J. T. D., Iturbe‐Ormaetxe, I., Stepnell, J., Burns, R. L., Flores, H. A., & O’Neill, S. L. (2017) · PLoS Pathogens · doi:10.1371/journal.ppat.1006751 · Cited by 143
Lee, C.-H. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/6208067 · Cited by 142
“Dengue virus (DENV) is an arthropodborne tropical virus responsible for the development of dengue fever and related diseases [109, 110].”
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Montoya, M., Collins, M. H., Dejnirattisai, W., Katzelnick, L. C., Puerta-Guardo, H. N., Jadi, R., Schildhauer, S., Supasa, P., Vasanawathana, S., Malasit, P., et al. (2018) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiy164 · Cited by 141
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Shi, Y., Liu, X., Kok, S. Y., Rajarethinam, J., Liang, S., Yap, G., Chong, C., Lee, K.-S., Tan, S. S. Y., Chin, C. K. Y., et al. (2015) · Environmental Health Perspectives · doi:10.1289/ehp.1509981 · Cited by 140
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Jiang, M., Sheng, F., Zhang, Z., Ma, X., Gao, T., Fu, C., & Li, P. (2021) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2021.113954 · Cited by 139
Sang, S., Gu, S., Bi, P., Yang, W., Yang, Z., Xu, L., Yang, J., Liu, X., Jiang, T., Wu, H., et al. (2015) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0003808 · Cited by 139
The citrus flavanone naringenin impairs dengue virus replication in human cells
Frabasile, S., Koishi, A. C., Kuczera, D., Silveira, G. F., Verri, W. A., Jr., dos Santos, C. N. D., & Bordignon, J. (2017) · Scientific Reports · doi:10.1038/srep41864 · Cited by 138
Modelling the effects of global climate change on Chikungunya transmission in the 21st century
Tjaden, N. B., Suk, J. E., Fischer, D., Thomas, S. M., Beierkuhnlein, C., & Semenza, J. C. (2017) · Scientific Reports · doi:10.1038/s41598-017-03566-3 · Cited by 146
Flavonoid from Carica papaya inhibits NS2B-NS3 protease and prevents Dengue 2 viral assembly
Senthilvel, P., Lavanya, P., Kumar, K. M., Swetha, R. G., Anitha, P., Bag, S., Sarveswari, S., Vijayakumar, V., Ramaiah, S., & Anbarasu, A. (2013) · Bioinformation · doi:10.6026/97320630009889 · Cited by 137
The Complex Relationship between Weather and Dengue Virus Transmission in Thailand
Campbell, K. M., Lin, C., Iamsirithaworn, S., & Scott, T. W. (2013) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.13-0321 · Cited by 137
Self-citationLuteolin restricts dengue virus replication through inhibition of the proprotein convertase furin
Peng, M., Watanabe, S., Chan, K. W. K., He, Q., Zhao, Y., Zhang, Z., Lai, X., Luo, D., Vasudevan, S. G., & Li, G. (2017) · Antiviral Research · doi:10.1016/j.antiviral.2017.03.026 · Cited by 137
Chen, H.-R., Lai, Y., & Yeh, T. (2018) · Journal of Biomedical Science · doi:10.1186/s12929-018-0462-0 · Cited by 137
Structure mapping of dengue and Zika viruses reveals functional long-range interactions
Huber, R. G., Lim, X. N., Ng, W. C., Sim, A. Y. L., Poh, H. X., Shen, Y., Lim, S. Y., Sundstrom, K. B., Sun, A. X., Aw, J. G. A., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09391-8 · Cited by 139
“The viruses were then separated into three reactions: (1) we added 1:20 the volume of 1M NAI (03-310, Merck, 25 μl of NAI in 500 μl of virus in cell media) and incubated the reaction for 15 min at 37 °C for structure probing; (2) we added 1:20 volume of dimethyl sulfoxide (DMSO) to the virus and incubated the reaction…”
Dengue Virus Impairs Mitochondrial Fusion by Cleaving Mitofusins
Yu, C.-Y., Liang, J., Li, J., Lee, Y.-L., Chang, B.-L., Su, C.-I., Huang, W.-J., Lai, M. M. C., & Lin, Y. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1005350 · Cited by 138
“The virus is transmitted by mosquitos, with possibly 390 million DENV infections every year [28].”
Flipse, J., Toro, M. D., Hoornweg, T. E., van de Pol, D. P. I., Inchima, S. U., & Smit, J. M. (2016) · Scientific Reports · doi:10.1038/srep29201 · Cited by 136
“DENV infection is the most prevalent arthropod-borne viral infection worldwide with approximately 390 million infections and 96 million symptomatic cases in 2010 11 .”
Angleró-Rodríguez, Y., MacLeod, H. J., Kang, S., Carlson, J. S., Jupatanakul, N., & Dimopoulos, G. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.02050 · Cited by 133
“DENV causes 400 million infections and 12,500 deaths per year, and ZIKV recently emerged as another arbovirus of major public health concern (Guzman et al., 2010; WHO, 2012; Bhatt et al., 2013; Weaver et al., 2016).”
Qamar, M. T. U., Maryam, A., Muneer, I., Feng, X., Ashfaq, U. A., Khan, F. A., Anwar, F., Geesi, M. H., Khalid, R. R., Rauf, S. A., et al. (2019) · Scientific Reports · doi:10.1038/s41598-018-38450-1 · Cited by 139
Prediction of dengue outbreaks based on disease surveillance, meteorological and socio-economic data
Jain, R., Sontisirikit, S., Iamsirithaworn, S., & Prendinger, H. (2019) · BMC Infectious Diseases · doi:10.1186/s12879-019-3874-x · Cited by 141
Zhao, N., Charland, K., Carabalí, M., Nsoesie, E. O., Maheu‐Giroux, M., Rees, E. E., Yuan, M., García-Balaguera, C., Jaramillo, G. I., & Zinszer, K. (2020) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0008056 · Cited by 136
Population bottlenecks and founder effects: implications for mosquito-borne arboviral emergence
Weaver, S. C., Forrester, N. L., Liu, J., & Vasilakis, N. (2021) · Nature Reviews Microbiology · doi:10.1038/s41579-020-00482-8 · Cited by 132
Current Trends and Limitations in Dengue Antiviral Research
Obi, J. O., Gutiérrez-Barbosa, H., Chua, J. V., & Deredge, D. J. (2021) · Tropical Medicine and Infectious Disease · doi:10.3390/tropicalmed6040180 · Cited by 145
Weiskopf, D., Cerpas, C., Angelo, M. A., Bangs, D. J., Sidney, J., Paul, S., Peters, B., Sanches, F. P. S., Silvera, C. G. T., Costa, P. R., et al. (2015) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiv289 · Cited by 135
Predicting outcome from dengue
Yacoub, S., & Wills, B. A. (2014) · BMC Medicine · doi:10.1186/s12916-014-0147-9 · Cited by 135
Dicer-2-Dependent Activation of Culex Vago Occurs via the TRAF-Rel2 Signaling Pathway
Paradkar, P. N., Duchemin, J., Voysey, R., & Walker, P. J. (2014) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0002823 · Cited by 138
Role of the Vector in Arbovirus Transmission
Conway, M. J., Colpitts, T. M., & Fikrig, E. (2014) · Annual Review of Virology · doi:10.1146/annurev-virology-031413-085513 · Cited by 138
Dendritic Cells in Dengue Virus Infection: Targets of Virus Replication and Mediators of Immunity
Schmid, M., Diamond, M., & Harris, E. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00647 · Cited by 140
Jumping species—a mechanism for coronavirus persistence and survival
Menachery, V. D., Graham, R. L., & Baric, R. S. (2017) · Current Opinion in Virology · doi:10.1016/j.coviro.2017.01.002 · Cited by 135
Hafirassou, M. L., Meertens, L., Umaña-Diaz, C., Labeau, A., Dejarnac, O., Bonnet‐Madin, L., Kümmerer, B. M., Delaugerre, C., Roingeard, P., Vidalain, P., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.11.094 · Cited by 141
Harrington, L. C., Fleisher, A. E., Ruiz-Moreno, D., Vermeylen, F., Wa, C. V., Poulson, R. L., Edman, J. D., Clark, J. M., Jones, J. W., Kitthawee, S., et al. (2014) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0003048 · Cited by 132
Self-citationPathogenesis and virulence of flavivirus infections
van Leur, S. W., Heunis, T. D. J., Munnur, D., & Sanyal, S. (2021) · Virulence · doi:10.1080/21505594.2021.1996059 · Cited by 135
“100 million symptomatic cases every year[2].”
Immune-Mediated Pathogenesis in Dengue Virus Infection
Khanam, A., Gutiérrez-Barbosa, H., Lyke, K. E., & Chua, J. V. (2022) · Viruses · doi:10.3390/v14112575 · Cited by 134
“Dengue, caused by the dengue virus (DENV), is one of the most prevalent tropical infectious diseases affecting close to 400 million people worldwide annually [1].”
Dengue disease surveillance: an updated systematic literature review
Runge‐Ranzinger, S., McCall, P. J., Kroeger, A., & Horstick, O. (2014) · Tropical Medicine & International Health · doi:10.1111/tmi.12333 · Cited by 133
Air Travel Is Associated with Intracontinental Spread of Dengue Virus Serotypes 1–3 in Brazil
Nunes, M. R. T., Palacios, G. F., Faria, N. R., Sousa, E. C., Pantoja, J. A. D. S., Rodrigues, S. G., Carvalho, V. L., Medeiros, D. B. D. A., Savji, N., Baele, G., et al. (2014) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0002769 · Cited by 133
Exploiting Intimate Relationships: Controlling Mosquito-Transmitted Disease with Wolbachia
Caragata, E. P., Dutra, H. L. C., & Moreira, L. A. (2015) · Trends in Parasitology · doi:10.1016/j.pt.2015.10.011 · Cited by 133
“The situation has been exacerbated by the global expansion in range of the primary vector Aedes aegypti, and the secondary vector Aedes albopictus, aided by increased urbanization in developing nations and climate change, which have provided more favorable niches through increased access to breeding sites and human ho…”
Soto-Acosta, R., Bautista‐Carbajal, P., Cervantes-Salazar, M., Angel-Ambrocio, A. H., & del Ángel, R. M. (2017) · PLoS Pathogens · doi:10.1371/journal.ppat.1006257 · Cited by 133
Pompon, J., Manuel, M., Ng, G. G. K., Wong, B., Shan, C., Manokaran, G., Soto-Acosta, R., Bradrick, S. S., Ooi, E. E., Missé, D., et al. (2017) · PLoS Pathogens · doi:10.1371/journal.ppat.1006535 · Cited by 127
“Dengue viruses (DENV), members of the flavivirus genus, infect about 390 million people annually and threaten one third of the world population [1] making them the most important arboviruses in the world.”
Innate Immune Responses to Acute Viral Infection During Pregnancy
Cornish, E. F., Filipovic, I., Åsenius, F., Williams, D. J., & McDonnell, T. C. R. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.572567 · Cited by 149
“Dengue virus Flaviviridae ssRNA 390 million cases annually (46) 1.”
Hagenlocher, M., Delmelle, E., Casas, I., & Kienberger, S. (2013) · International Journal of Health Geographics · doi:10.1186/1476-072x-12-36 · Cited by 136
International Dispersal of Dengue through Air Travel: Importation Risk for Europe
Semenza, J. C., Súdre, B., Miniota, J., Rossi, M., Hu, W., Kossowsky, D., Suk, J. E., Bortel, W. V., & Khan, K. (2014) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0003278 · Cited by 132
A global compendium of human dengue virus occurrence
Messina, J. P., Brady, O. J., Pigott, D. M., Brownstein, J. S., Hoen, A. G., & Hay, S. I. (2014) · Scientific Data · doi:10.1038/sdata.2014.4 · Cited by 132
Self-citationKushwah, R. B. S., Dykes, C. L., Kapoor, N., Adak, T., & Singh, O. P. (2015) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0003332 · Cited by 129
Plasmodium vivax Transmission in Africa
Howes, R. E., Reiner, R. C., Battle, K. E., Longbottom, J., Mappin, B., Ordanovich, D., Tatem, A. J., DRAKELEY, C. J., Gething, P. W., Zimmerman, P. A., et al. (2015) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0004222 · Cited by 134
“Although there were additional surveys reporting “zero Pv”, these were not incorporated into the evidence synthesis as they could not be interpreted as “absolute absences” [43], particularly given the lower sensitivity of conventional microscopy and RDT methods to Pv than Pf Fig 9.”
Self-citationDeming, R., Manrique-Saide, P. C., Medina‐Barreiro, A., Koyoc-Cardeña, E., Che‐Mendoza, A., Jones, B., Liebman, K. A., Vizcaino, L., Vazquez‐Prokopec, G. M., & Lenhart, A. E. (2016) · Parasites & Vectors · doi:10.1186/s13071-016-1346-3 · Cited by 134
Metadata
- Authors
- Bhatt, S., Gething, P. W., Brady, O. J., Messina, J. P., Farlow, A. W., Moyes, C. L., Drake, J. M., Brownstein, J. S., Hoen, A. G., Sankoh, O., Myers, M. F., George, D. B., Jaenisch, T., Wint, G. R. W., Simmons, C. P., Scott, T. W., Farrar, J. J., & Hay, S. I.
- Affiliations
- University of Oxford (GB)
- University of Georgia (US)
- Boston Children's Hospital (US)
- Dartmouth College (US)
- University of the Witwatersrand (ZA)
- National Institutes of Health (US)
- University Hospital Heidelberg (DE)
- Churchill Hospital (GB)
- National University of Singapore (SG)
- Corresponding author
- Hay, Simon I.
- ORCID
- Venue
- Nature
- Published
- 2013-04
- Volume
- 496
- Issue
- 7446
- Pages
- 504-507
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC3651993
- OpenAlex
- W2131222241
- Cited by
- 10,037
- References
- 52
- Citations by year
- 2026: 615 · 2025: 704 · 2024: 830 · 2023: 846 · 2022: 816 · 2021: 943 · 2020: 946 · 2019: 922 · 2018: 777 · 2017: 724 · 2016: 744 · 2015: 551 · 2014: 467 · 2013: 141
- FWCI
- 650.37
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- LSHTM Research Online (London School of Hygiene and Tropical Medicine) (acceptedVersion)
- Minerva Access (University of Melbourne) (submittedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- RePEc: Research Papers in Economics (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Spiral (Imperial College London) (submittedVersion)
- Funders
- U.S. Department of Homeland Security
- Wellcome Trust (089276, 095066, 084368, 097318)
- European Commission (261504)
- National Institutes of Health (5r01ai069341-05)
- Biotechnology and Biological Sciences Research Council (1090403)
- National Institute of General Medical Sciences (R01GM083224)
- National Institute of Allergy and Infectious Diseases (R01-AI069341, R01AI091980)
- Fogarty International Center
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Mosquito-borne diseases and control
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Dengue and Mosquito Control Research
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Climate Change and Health Impacts
- Keywords
- dengue, global burden of disease, dengue incidence, dengue risk mapping, Aedes, mosquito-borne viral disease, temperature and precipitation effects, urbanization, dengue prevention, dengue control, tropical and subtropical regions, dengue vaccine
- MeSH terms
- Dengue, Dengue Virus, Humans, Public Health, Quality Control, Rain, Risk Factors, Temperature, Tropical Climate, Urbanization, Global Health, World Health Organization, Cohort Studies, Incidence, Databases, Factual
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