The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
The global distribution and burden of dengue
Open accessAbstract
Dengue is a systemic viral infection transmitted between humans by Aedes mosquitoes. For some patients, dengue is a life-threatening illness. There are currently no licensed vaccines or specific therapeutics, and substantial vector control efforts have not stopped its rapid emergence and global spread. The contemporary worldwide distribution of the risk of dengue virus infection and its public health burden are poorly known. Here we undertake an exhaustive assembly of known records of dengue occurrence worldwide, and use a formal modelling framework to map the global distribution of dengue risk. We then pair the resulting risk map with detailed longitudinal information from dengue cohort studies and population surfaces to infer the public health burden of dengue in 2010. We predict dengue to be ubiquitous throughout the tropics, with local spatial variations in risk influenced strongly by rainfall, temperature and the degree of urbanization. Using cartographic approaches, we estimate there to be 390 million (95% credible interval 284-528) dengue infections per year, of which 96 million (67-136) manifest apparently (any level of disease severity). This infection total is more than three times the dengue burden estimate of the World Health Organization. Stratification of our estimates by country allows comparison with national dengue reporting, after taking into account the probability of an apparent infection being formally reported. The most notable differences are discussed. These new risk maps and infection estimates provide novel insights into the global, regional and national public health burden imposed by dengue. We anticipate that they will provide a starting point for a wider discussion about the global impact of this disease and will help to guide improvements in disease control strategies using vaccine, drug and vector control methods, and in their economic evaluation.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“An estimated 70% of dengue virus infections are thought to occur in Asia. (2)”
From Epidemiology of dengue reported in the World Health Organization Western Pacific Region, 2013–2019 (2023) · cites this paper as [2]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“As a result of differences in case definitions and other factors, there is likely to be underreporting and, thus, an underestimation of the true regional burden in terms of the number of cases, CFRs and incidence. (1, 2)”
From Epidemiology of dengue reported in the World Health Organization Western Pacific Region, 2013–2019 (2023) · cites this paper as [2]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Sharing information and data about dengue helps countries and areas better understand transmission patterns and supports the implementation of dengue prevention and control measures. (2)”
From Epidemiology of dengue reported in the World Health Organization Western Pacific Region, 2013–2019 (2023) · cites this paper as [2]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Greedy function approximation: A gradient boosting machine
Friedman, J. H. (2001) · The Annals of Statistics · doi:10.1214/aos/1013203451 · Cited by 30,731 · cited 1×
“India19,20 alone contributed 34% (33 [24-44] million infections) of the global total.”
Classification and Regression Trees.
Gordon, A. D., Breiman, L., Friedman, J. H., Olshen, R. A., & Stone, C. J. (1984) · Biometrics · doi:10.2307/2530946 · Cited by 23,867
Classification and Regression Trees.
Ryzin, J. V., Breiman, L., Friedman, J. H., Olshen, R. A., & Stone, C. J. (1986) · Journal of the American Statistical Association · doi:10.2307/2288003 · Cited by 21,030
Very high resolution interpolated climate surfaces for global land areas
Hijmans, R. J., Cameron, S. E., Parra, J. L., Jones, P. G., & Jarvis, A. (2005) · International Journal of Climatology · doi:10.1002/joc.1276 · Cited by 19,860
Novel methods improve prediction of species’ distributions from occurrence data
Elith*, J., H. Graham*, C., P. Anderson, R., Dudík, M., Ferrier, S., Guisan, A., J. Hijmans, R., Huettmann, F., R. Leathwick, J., Lehmann, A., et al. (2006) · Ecography · doi:10.1111/j.2006.0906-7590.04596.x · Cited by 9,088
Murray, C. J. L., Vos, T., Lozano, R., Naghavi, M., Flaxman, A. D., Michaud, C., Ezzati, M., Shibuya, K., Salomon, J. A., Abdalla, S., et al. (2012) · The Lancet · doi:10.1016/s0140-6736(12)61689-4 · Cited by 8,888 · cited 1×
“…many vaccinations are needed to avert an apparent infection) and triangulating with independent assessments of disability adjusted life years (DALYs) 21 ; (ii) elucidating the population dynamics of dengue viruses 22 ; and (iii) hypothesising about population effects of future vaccine programmes…”
Dengue and Dengue Hemorrhagic Fever
Gubler, D. J. (1998) · Clinical Microbiology Reviews · doi:10.1128/cmr.11.3.480 · Cited by 4,394
Ensemble forecasting of species distributions
ARAUJO, M., & NEW, M. (2007) · Trends in Ecology & Evolution · doi:10.1016/j.tree.2006.09.010 · Cited by 3,640 · cited 1×
“Asia bore 70% (67 [47-94] million infections) of this burden, and is characterised by large swathes of densely populated regions coinciding with very high suitability for disease transmission.”
Hilbe, J. M. (2011) · Cambridge University Press eBooks · doi:10.1017/cbo9780511973420 · Cited by 3,352
Selecting pseudo‐absences for species distribution models: how, where and how many?
Barbet‐Massin, M., Jiguet, F., Albert, C. H., & Thuiller, W. (2012) · Methods in Ecology and Evolution · doi:10.1111/j.2041-210x.2011.00172.x · Cited by 2,716 · cited 1×
“Asia bore 70% (67 [47-94] million infections) of this burden, and is characterised by large swathes of densely populated regions coinciding with very high suitability for disease transmission.”
Flagged first, then by citations
Research works printed but not linked: 2
- Beatty, M. E., Letson, G. W. & Margolis, H. S. Estimating the global burden of dengue. Am. J. Trop. Med. Hyg. 81 (Suppl. 1). 231 (2009)
- Rodhain, F. La situation de la dengue dans le monde. Bull. Soc. Pathol. Exot. 89, 87–90 (1996)
Cited by
Sorted by citations
Items 201–300 of 1,018
RNA structures that resist degradation by Xrn1 produce a pathogenic Dengue virus RNA
Chapman, E. G., Moon, S. L., Wilusz, J., & Kieft, J. S. (2014) · eLife · doi:10.7554/elife.01892 · Cited by 205
Cross-Reactive Immunity Among Flaviviruses
Rathore, A. P. S., & John, A. L. S. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00334 · Cited by 204
“ADE occurs not only for DENV, but for other combinations of viruses from differing serocomplexes, such as DENV and ZIKV (65).”
InfluentialFibriansah, G., Tan, J. L., Smith, S. A., de Alwis, R., Ng, T., Kostyuchenko, V. A., Jadi, R., Kukkaro, P., de Silva, A. M., Crowe, J. E., et al. (2015) · Nature Communications · doi:10.1038/ncomms7341 · Cited by 203
Burkett-Cadena, N. D., & Vittor, A. Y. (2017) · Basic and Applied Ecology · doi:10.1016/j.baae.2017.09.012 · Cited by 215
“The most prevalent mosquito-borne virus, dengue virus, is estimated to infect 390 million people per year (Bhatt et al., 2013).”
Flaviviruses Exploit the Lipid Droplet Protein AUP1 to Trigger Lipophagy and Drive Virus Production
Zhang, J. S., Lan, Y., Li, M. Y., Lamers, M. M., Fusade-Boyer, M., Klemm, E. J., Thiele, C., Ashour, J., & Sanyal, S. (2018) · Cell Host & Microbe · doi:10.1016/j.chom.2018.05.005 · Cited by 206
A pan-serotype dengue virus inhibitor targeting the NS3–NS4B interaction
Kaptein, S. J. F., Goethals, O., Kiemel, D., Marchand, A., Kesteleyn, B., Bonfanti, J., Bardiot, D., Stoops, B., Jonckers, T. H. M., Dallmeier, K., et al. (2021) · Nature · doi:10.1038/s41586-021-03990-6 · Cited by 202
Antiviral drug discovery: broad-spectrum drugs from nature
Martínez, J. P., Sasse, F., Brönstrup, M., Díez, J., & Meyerhans, A. (2014) · Natural Product Reports · doi:10.1039/c4np00085d · Cited by 206
Global distribution and environmental suitability for chikungunya virus, 1952 to 2015
Nsoesie, E. O., Kraemer, M. U. G., Golding, N., Pigott, D. M., Brady, O. J., Moyes, C. L., Johansson, M. A., Gething, P. W., Velayudhan, R., Khan, K., et al. (2016) · Eurosurveillance · doi:10.2807/1560-7917.es.2016.21.20.30234 · Cited by 201
“These maps can however be used as baseline layers for future projections of CHIKV and compared with global maps of dengue [12].”
Self-citationThe Dengue Virus NS5 Protein Intrudes in the Cellular Spliceosome and Modulates Splicing
Maio, F. A. D., Risso, G., Iglesias, N. G., Shah, P. S., Pozzi, B., Gebhard, L. G., Mammi, P., Mancini, E., Yanovsky, M. J., Andino, R., et al. (2016) · PLoS Pathogens · doi:10.1371/journal.ppat.1005841 · Cited by 205
“It is responsible for about 390 million infections worldwide every year [1].”
Chao, C.-H., Wu, W.-C., Lai, Y., Tsai, P.-J., Perng, G., Lin, Y.-S., & Yeh, T. (2019) · PLoS Pathogens · doi:10.1371/journal.ppat.1007625 · Cited by 205
Whitfield, Z. J., Dolan, P., Kunitomi, M., Tassetto, M., Seetin, M. G., Oh, S. D., Heiner, C. R., Paxinos, E. E., & Andino, R. (2017) · Current Biology · doi:10.1016/j.cub.2017.09.067 · Cited by 193
Epidemiological Trends of Dengue Disease in Thailand (2000–2011): A Systematic Literature Review
Limkittikul, K., Brett, J., & L’Azou, M. (2014) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0003241 · Cited by 198
Bhattacharyya, S., Zagórska, A., Lew, E. D., Shrestha, B., Rothlin, C. V., Naughton, J., Diamond, M., Lemke, G., & Young, J. A. T. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.07.005 · Cited by 202
Human to Mosquito Transmission of Dengue Viruses
Carrington, L. B., & Simmons, C. P. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00290 · Cited by 200
Self-citationKatzelnick, L. C., Montoya, M., Gresh, L., Balmaseda, Á., & Harris, E. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1522136113 · Cited by 196
“D virus (DENV) is a mosquito-borne flavivirus that infects up to 390 million individuals each year (1).”
Economic Impact of Dengue: Multicenter Study across Four Brazilian Regions
Martelli, C. M. T., Siqueira, J. B., Parente, M. P. P. D., Zara, A. L. D. S. A., de Oliveira, C. S., Braga, C., Pimenta, F. G., Cortés, F., López, J. G., Bahia, L., et al. (2015) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0004042 · Cited by 196
Flavivirus NS1 protein in infected host sera enhances viral acquisition by mosquitoes
Liu, J., Liu, Y., Nie, K., Du, S., Qiu, J., Pang, X., Wang, P., & Cheng, G. (2016) · Nature Microbiology · doi:10.1038/nmicrobiol.2016.87 · Cited by 196
Brugueras, S., Fernández-Martínez, B., la Puente, J. M., Figuerola, J., Montalvo, T., Rius, C., Larrauri, A., & Gómez‐Barroso, D. (2020) · Environmental Research · doi:10.1016/j.envres.2020.110038 · Cited by 207
de Alwis, R., Williams, K. L., Schmid, M., Lai, C.-Y., Patel, B., Smith, S. A., Crowe, J. E., Wang, W., Harris, E., & de Silva, A. M. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1004386 · Cited by 196
A review of dengue diagnostics and implications for surveillance and control
Raafat, N., Blacksell, S. D., & Maude, R. J. (2019) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1093/trstmh/trz068 · Cited by 195
Neurological Complications of Dengue Fever
Trivedi, S., & Chakravarty, A. (2022) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-022-01213-7 · Cited by 195
Grange, L. J., Simon‐Lorière, E., Sakuntabhai, A., Gresh, L., Paul, R. E. L., & Harris, E. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00280 · Cited by 198
Disease and economic burdens of dengue
Castro, M. C., Wilson, M. E., & Bloom, D. E. (2017) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(16)30545-x · Cited by 194
Platelet activation determines the severity of thrombocytopenia in dengue infection
Ojha, A., Nandi, D., Batra, H., Singhal, R., Annarapu, G. K., Bhattacharyya, S., Seth, T., Dar, L., Medigeshi, G. R., Vrati, S., et al. (2017) · Scientific Reports · doi:10.1038/srep41697 · Cited by 193
Lim, S. P., Noble, C. G., Seh, C. C., Soh, T. S., Sahili, A. E., Chan, G. K. Y., Lescar, J., Arora, R., Benson, T. E., Nilar, S., et al. (2016) · PLoS Pathogens · doi:10.1371/journal.ppat.1005737 · Cited by 193
“The mosquito-borne DENV causes widespread epidemics in over 100 countries, with*390 million infections each year [2].”
Global risk model for vector-borne transmission of Zika virus reveals the role of El Niño 2015
Caminade, C., Turner, J., Metelmann, S., Hesson, J. C., Blagrove, M. S. C., Solomon, T., Morse, A. P., & Baylis, M. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1614303114 · Cited by 199
A CRISPR toolbox to study virus–host interactions
Puschnik, A. S., Majzoub, K., Ooi, Y. S., & Carette, J. E. (2017) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2017.29 · Cited by 185
Rapid antigen tests for dengue virus serotypes and Zika virus in patient serum
Bosch, I., de Puig, H., Hiley, M., Carré-Camps, M., Perdomo-Celis, F., Narváez, C. F., Salgado, D. M., Senthoor, D., O’Grady, M., Phillips, E., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aan1589 · Cited by 193
“DENV, ZIKV, and chikungunya (an alphavirus) infections exhibit common symptoms including varying degrees of fever, headache, myalgia, arthralgia, nausea, and rash, with hemorrhagic fevers as outcomes of severe infections in about 1% of infected individuals (22).”
Eisen, L., Monaghan, A. J., Lozano-Fuentes, S., Steinhoff, D. F., Hayden, M. H., & Bieringer, P. E. (2014) · Journal of Medical Entomology · doi:10.1603/me13214 · Cited by 176
Ding, Q., Gaska, J. M., Douam, F., Wei, L., Kim, D., Balev, M., Heller, B. L., & Ploß, A. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1803406115 · Cited by 200
“Approximately 390 million people contract dengue virus (DENV) annually, with roughly 96 million developing clinically symptomatic disease (2).”
The immune response against flaviviruses
Slon-Campos, J., Mongkolsapaya, J., & Screaton, G. R. (2018) · Nature Immunology · doi:10.1038/s41590-018-0210-3 · Cited by 191
Evaluation of Dengue NS1 Antigen Rapid Tests and ELISA Kits Using Clinical Samples
Pal, S., Dauner, A. L., Mitra, I., Forshey, B. M., García, P., Morrison, A. C., Halsey, E. S., Kochel, T. J., & Wu, S.-J. L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0113411 · Cited by 188
Hunsperger, E. A., Yoksan, S., Buchy, P., Nguyen, V. C., Sekaran, S. D., Enria, D. A., Vázquez, S., Elizabeth, C., Pelegrino, J. L., Artsob, H., et al. (2014) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0003171 · Cited by 188
Platelets in Immune Response to Virus and Immunopathology of Viral Infections
Hottz, E. D., Bozza, F. A., & Bozza, P. T. (2018) · Frontiers in Medicine · doi:10.3389/fmed.2018.00121 · Cited by 185
“5 billion people live in high-risk transmission areas with more than 90 million symptomatic infections occurring annually (134).”
Targeting proprotein convertase subtilisin/kexin type 9 (PCSK9): From bench to bedside
Bao, X., Liang, Y., Chang, H., Cai, T., Feng, B., Gordon, K., Zhu, Y., Shi, H., He, Y., & Xie, L. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01690-3 · Cited by 187
The overlapping global distribution of dengue, chikungunya, Zika and yellow fever
Lim, A., Shearer, F. M., Sewalk, K. C., Pigott, D. M., Clarke, J., Ghouse, A., Judge, C., Kang, H., Messina, J. P., Kraemer, M. U. G., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-58609-5 · Cited by 187
Self-citationMosquito Immunity against Arboviruses
Sim, S., Jupatanakul, N., & Dimopoulos, G. (2014) · Viruses · doi:10.3390/v6114479 · Cited by 184
Parallel shRNA and CRISPR-Cas9 screens enable antiviral drug target identification
Deans, R. M., Morgens, D. W., Ökesli, A., Pillay, S., Horlbeck, M. A., Kampmann, M., Gilbert, L. A., Li, A., Mateo, R., Smith, M. A., et al. (2016) · Nature Chemical Biology · doi:10.1038/nchembio.2050 · Cited by 182
CRISPR-Cas systems for diagnosing infectious diseases
Kostyusheva, A., Brezgin, S., Babin, Y. Y., Vasilyeva, I., Glebe, D., Kostyushev, D. S., & Chulanov, V. (2021) · Methods · doi:10.1016/j.ymeth.2021.04.007 · Cited by 197
“Thus, laboratory diagnosis of dengue fever is crucial for rapid management of patients with severe infection [119].”
Economic and Disease Burden of Dengue Illness in India
Shepard, D. S., Halasa, Y. A., Tyagi, B. K., Adhish, V., Nandan, D., Karthiga, K. S., Chellaswamy, V., Gaba, M., Arora, N. K., & _, _. (2014) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.14-0002 · Cited by 183
Laporta, G. Z., Potter, A. M., Oliveira, J. F. A., Bourke, B. P., Pecor, D. B., & Linton, Y. (2023) · Insects · doi:10.3390/insects14010049 · Cited by 204
Faucon, F., Dusfour, I., Gaude, T., Navratil, V., Boyer, F., Chandre, F., Sirisopa, P., Thanispong, K., Juntarajumnong, W., Poupardin, R., et al. (2015) · Genome Research · doi:10.1101/gr.189225.115 · Cited by 191
Challenges and opportunities in controlling mosquito-borne infections
Ferguson, N. M. (2018) · Nature · doi:10.1038/s41586-018-0318-5 · Cited by 188
Clinical predictors of severe dengue: a systematic review and meta-analysis
Tsheten, T., Clements, A., Gray, D. J., Adhikary, R. K., Furuya‐Kanamori, L., & Wangdi, K. (2021) · Infectious Diseases of Poverty · doi:10.1186/s40249-021-00908-2 · Cited by 201
Bogoch, I. I., Brady, O. J., Kraemer, M. U. G., German, M. L., Creatore, M. I., Brent, S. E., Watts, A., Hay, S. I., Kulkarni, M. A., Brownstein, J. S., et al. (2016) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(16)30270-5 · Cited by 174
Self-citationWeiskopf, D., Angelo, M. A., Bangs, D. J., Sidney, J., Paul, S., Peters, B., Silva, A. D. D., Lindow, J. C., Diehl, S. A., Whitehead, S. S., et al. (2014) · Journal of Virology · doi:10.1128/jvi.02129-14 · Cited by 178
Dengue during pregnancy and adverse fetal outcomes: a systematic review and meta-analysis
Paixão, E. S., Teixeira, M. G., Costa, M. D. C. N., & Rodrigues, L. C. (2016) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(16)00088-8 · Cited by 190
Murugesan, A., & Mythreyee, M. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-819400-3.00016-8 · Cited by 195
The Role of Temperature in Shaping Mosquito-Borne Viruses Transmission
Bellone, R., & Failloux, A. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.584846 · Cited by 197
“DENV is one of the most widespread MBV with nearly half of the world’s population (128 countries) at risk of infection (Brady et al., 2012; Messina et al., 2014); it affects annually 50–100 million people (Bhatt et al., 2013) at a cost of US$ 8–9 billion (Shepard et al., 2016).”
Kittayapong, P., Ninphanomchai, S., Limohpasmanee, W., Chansang, C., Chansang, U., & Mongkalangoon, P. (2019) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0007771 · Cited by 173
“In particular, dengue is causing important public health problems and high economic burdens globally [5,6].”
Predicting the risk of avian influenza A H7N9 infection in live-poultry markets across Asia
Gilbert, M., Golding, N., Zhou, H., Wint, W., Robinson, T. P., Tatem, A. J., Lai, S., Zhou, S., Jiang, H., Guo, D., et al. (2014) · Nature Communications · doi:10.1038/ncomms5116 · Cited by 176
Self-citationRašić, G., Filipović, I., Weeks, A. R., & Hoffmann, A. A. (2014) · BMC Genomics · doi:10.1186/1471-2164-15-275 · Cited by 168
Properties and Functions of the Dengue Virus Capsid Protein
Byk, L. A., & Gamarnik, A. V. (2016) · Annual Review of Virology · doi:10.1146/annurev-virology-110615-042334 · Cited by 176
“DENV is estimated to cause around 390 million infections per year, placing over 3 billion people at risk of infection (1).”
Ishikawa, T., Yamanaka, A., & Konishi, E. (2014) · Vaccine · doi:10.1016/j.vaccine.2014.01.040 · Cited by 175
Dengue vaccine: hypotheses to understand CYD-TDV-induced protection
Guy, B., & Jackson, N. (2015) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2015.2 · Cited by 174
Platelet Activation and Apoptosis Modulate Monocyte Inflammatory Responses in Dengue
Hottz, E. D., de Moraes, I. M. M., Vieira‐de‐Abreu, A., de Assis, E. F., de Souza, R. V., Castro-Faria-Neto, H. C., Weyrich, A. S., Zimmerman, G. A., Bozza, F. A., & Bozza, P. T. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1400091 · Cited by 174
Region-wide synchrony and traveling waves of dengue across eight countries in Southeast Asia
van Panhuis, W. G., Choisy, M., Xiong, X., Chok, N. S., Akarasewi, P., Iamsirithaworn, S., Lam, S. K., Chong, C. K., Lam, F. C., Phommasack, B., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1501375112 · Cited by 173
“The virus causes an estimated 390 million infections per year, resulting in 96 million clinically symptomatic cases (1).”
Development of the Sanofi Pasteur tetravalent dengue vaccine: One more step forward
Guy, B., Briand, O., Lang, J., Saville, M. K., & Jackson, N. M. (2015) · Vaccine · doi:10.1016/j.vaccine.2015.09.108 · Cited by 170
Designing improved active peptides for therapeutic approaches against infectious diseases
Gomes, B., Augusto, M. T., Felício, M. R., Hollmann, A., Franco, O. L., Gonçalves, S., & Santos, N. C. (2018) · Biotechnology Advances · doi:10.1016/j.biotechadv.2018.01.004 · Cited by 183
Contributions from the silent majority dominate dengue virus transmission
ten Bosch, Q. A., Clapham, H., Lambrechts, L., Duong, V., Buchy, P., Althouse, B. M., Lloyd, A. L., Waller, L. A., Morrison, A. C., Kitron, U. D., et al. (2018) · PLoS Pathogens · doi:10.1371/journal.ppat.1006965 · Cited by 173
“Of the 390 million dengue virus (DENV) infections that occur globally each year, an estimated 300 million do not result in symptoms severe enough for a person to seek treatment [7,8], meaning that they likely go undetected by most surveillance systems.”
Self-citationDengue virus infection – a review of pathogenesis, vaccines, diagnosis and therapy
Kok, B. H., Lim, H. T., Lim, C. P., Lai, N. S., Leow, C. Y., & Leow, C. Y. (2022) · Virus Research · doi:10.1016/j.virusres.2022.199018 · Cited by 173
Dengue virus binding and replication by platelets
Simon, A. Y., Sutherland, M. R., & Pryzdial, E. L. G. (2015) · Blood · doi:10.1182/blood-2014-09-598029 · Cited by 172
Characterization of Dengue Virus NS4A and NS4B Protein Interaction
Zou, J., Xie, X., Wang, Q.-Y., Dong, H., Lee, M. Y., Kang, C., Yuan, Z., & Shi, P. (2015) · Journal of Virology · doi:10.1128/jvi.03453-14 · Cited by 172
Epidemiological Scenario of Dengue in Brazil
Fares‐Gusmao, R., de Souza, K. P. R., Áñez, G., & Rios, M. (2015) · BioMed Research International · doi:10.1155/2015/321873 · Cited by 168
Advances and Limitations of Disease Biogeography Using Ecological Niche Modeling
Escobar, L. E., & Craft, M. E. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01174 · Cited by 168
Dengue fever and insecticide resistance in Aedes mosquitoes in Southeast Asia: a review
Gan, S. J., Leong, Y. Q., bin Barhanuddin, M. F. H., Wong, S. T., Wong, S. F., Mak, J. W., & Ahmad, R. B. (2021) · Parasites & Vectors · doi:10.1186/s13071-021-04785-4 · Cited by 182
Pathologic highlights of dengue hemorrhagic fever in 13 autopsy cases from Myanmar
Aye, K. S., Charngkaew, K., Win, K. M., Wai, K. Z., Moe, K. K., Punyadee, N., Thiemmeca, S., Suttitheptumrong, A., Sukpanichnant, S., Malasit, P., et al. (2014) · Human Pathology · doi:10.1016/j.humpath.2014.01.022 · Cited by 170
Selvarajoo, S., Liew, J. W. K., Tan, W., Lim, X. Y., Refai, W. F., Zaki, R. A., Sethi, N., Sulaiman, W. Y. W., Lim, Y. A. L., Vadivelu, J., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-66212-5 · Cited by 170
Emerging Role of Zika Virus in Adverse Fetal and Neonatal Outcomes
Panchaud, A., Stojanov, M., Ammerdorffer, A., Vouga, M., & Baud, D. (2016) · Clinical Microbiology Reviews · doi:10.1128/cmr.00014-16 · Cited by 171
“Recent estimations indicate that 40 to 50% of the human population is exposed to Aedes mosquitoes (159, 160) and potentially to arbovirus infections, including ZIKV.”
Moureau, G., Cook, S., Lemey, P., Nougairede, A., Forrester, N. L., Khasnatinov, M., Charrel, R. N., Firth, A. E., Gould, E. A., & de Lamballerie, X. (2015) · PLOS ONE · doi:10.1371/journal.pone.0117849 · Cited by 169
Fibriansah, G., Tan, J. L., Smith, S. A., de Alwis, A. R., Ng, T., Kostyuchenko, V. A., Ibarra, K. D., Wang, J., Harris, E., de Silva, A., et al. (2014) · EMBO Molecular Medicine · doi:10.1002/emmm.201303404 · Cited by 169
Wilder‐Smith, A., Hombach, J., Ferguson, N. M., Selgelid, M. J., O’Brien, K. L., Vannice, K., Barrett, A. D. T., Ferdinand, E., Flasche, S., Guzmán, M. G., et al. (2018) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(18)30494-8 · Cited by 169
Self-citationStruchiner, C. J., Rocklöv, J., Wilder‐Smith, A., & Massad, E. (2015) · PLoS ONE · doi:10.1371/journal.pone.0136286 · Cited by 168
Mapping the zoonotic niche of Lassa fever in Africa
Mylne, A., Pigott, D. M., Longbottom, J., Shearer, F. M., Duda, K. A., Messina, J. P., Weiss, D. J., Moyes, C. L., Golding, N., & Hay, S. I. (2015) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1093/trstmh/trv047 · Cited by 168
Self-citationAutochthonous case of dengue in France, October 2013
Marchand, E., Prat, C. M. A., Jeannin, C., Lafont, E., Bergmann, T., Flusin, O., Rizzi, J., le Roux, N., Busso, V., Deniau, J., et al. (2013) · Eurosurveillance · doi:10.2807/1560-7917.es2013.18.50.20661 · Cited by 168
Serological cross-reactivity among common flaviviruses
Chan, K. R., Ismail, A. A., Thergarajan, G., Raju, C. S., Chai, Y. H., Manikam, R., & Sekaran, S. D. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.975398 · Cited by 168
“These pathogens represent a significant burden of disease, causing about 400 million cases with 100 million symptomatic cases each year with dengue alone (Bhatt et al., 2013).”
Hotez, P. J., Bottazzi, M. E., Strych, U., Chang, L.-Y., Lim, Y. A. L., Goodenow, M. M., & AbuBakar, S. (2015) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0003575 · Cited by 167
Huber, J. H., Childs, M. L., Caldwell, J. M., & Mordecai, E. A. (2018) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0006451 · Cited by 167
Patterns, Drivers, and Challenges of Vector-Borne Disease Emergence
Swei, A., Couper, L., Coffey, L. L., Kapan, D. D., & Bennett, S. N. (2019) · Vector-Borne and Zoonotic Diseases · doi:10.1089/vbz.2018.2432 · Cited by 184
“In the case of dengue, Africa was found to be particularly at risk for transmission due to high levels of precipitation and temperature suitability for dengue, as well as abundant and highly connected low-income urban and peri-urban centers to facilitate human movement (Bhatt et al. 2013).”
Wolbachia Reduces the Transmission Potential of Dengue-Infected Aedes aegypti
Ye, Y. H., Carrasco, A. M., Frentiu, F. D., Chenoweth, S. F., Beebe, N. W., van den Hurk, A. F., Simmons, C. P., O’Neill, S. L., & McGraw, E. A. (2015) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0003894 · Cited by 160
Self-citationCardiovascular manifestations of the emerging dengue pandemic
Yacoub, S., Wertheim, H. F. L., Simmons, C. P., Screaton, G. R., & Wills, B. A. (2014) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2014.40 · Cited by 168
Self-citationPerumalsamy, H., Jang, M. J., Kim, J., Murugan, K., & Ahn, Y. (2015) · Parasites & Vectors · doi:10.1186/s13071-015-0848-8 · Cited by 165
Genes involved in virulence of the entomopathogenic fungus Beauveria bassiana
Valero‐Jiménez, C. A., Wiegers, H., Zwaan, B. J., Koenraadt, C. J. M., & van Kan, J. A. L. (2015) · Journal of Invertebrate Pathology · doi:10.1016/j.jip.2015.11.011 · Cited by 165
Zanini, F., Robinson, M., Croote, D., Sahoo, M. K., Sanz, A. M., Ortiz-Lasso, E., Albornóz, L. L., Rosso, F., Montoya, J. G., Goo, L., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1813819115 · Cited by 160
“D virus (DENV) is a major threat to global health, estimated to infect 400 million people annually in over 100 countries (1).”
Label-free electrochemical DNA biosensor for zika virus identification
Faria, H. A. M., & Zucolotto, V. (2019) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2019.02.018 · Cited by 165
Mathematical models for dengue fever epidemiology: A 10-year systematic review
Aguiar, M., Anam, V., Blyuss, K. B., Estadilla, C. D. S., Guerrero, B. V., Knopoff, D. A., Kooi, B. W., Srivastav, A. K., Steindorf, V., & Stollenwerk, N. (2022) · Physics of Life Reviews · doi:10.1016/j.plrev.2022.02.001 · Cited by 178
Microbiota-Dependent Priming of Antiviral Intestinal Immunity in Drosophila
Sansone, C. L., Cohen, J. A., Yasunaga, A., Xu, J., Osborn, G., Subramanian, H. E., Gold, B., Buchon, N., & Cherry, S. R. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.10.010 · Cited by 164
“In particular, dengue virus (DENV), a member of the Flaviviridae family, is a re-emerging arbovirus that infects >300 million people and causes 250,000 deaths annually (Bhatt et al., 2013).”
Genetic control of Aedes mosquitoes
Alphey, L., McKemey, A. R., Nimmo, D. D., Neira, M., Lacroix, R., Matzen, K. J., & Beech, C. (2013) · Pathogens and Global Health · doi:10.1179/2047773213y.0000000095 · Cited by 163
Autochthonous dengue outbreak in Nîmes, South of France, July to September 2015
Succo, T., Leparc-Goffart, I., Ferré, J.-B., Roiz, D., Broche, B., Maquart, M., Noël, H., Catelinois, O., Entezam, F., Caire, D., et al. (2016) · Eurosurveillance · doi:10.2807/1560-7917.es.2016.21.21.30240 · Cited by 163
Environmental and Social Change Drive the Explosive Emergence of Zika Virus in the Americas
Ali, S., Gugliemini, O., Harber, S., Harrison, A., Houle, L., Ivory, J., Kersten, S., Khan, R., Kim, J. R., LeBoa, C., et al. (2017) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0005135 · Cited by 163
Bartlow, A. W., Manore, C. A., Xu, C., Kaufeld, K., Valle, S. Y. D., Ziemann, A., Fairchild, G. C., & Fair, J. M. (2019) · Veterinary Sciences · doi:10.3390/vetsci6020040 · Cited by 169
“While yearly dengue epidemics continue [4,95,96], the chikungunya virus and Zika virus have recently emerged and caused large outbreaks in the Americas, spreading rapidly across the continent after introduction and causing long-term effects, including Zika-related birth defects.”
A mosquito salivary protein promotes flavivirus transmission by activation of autophagy
Sun, P., Nie, K., Zhu, Y., Liu, Y., Wu, P., Liu, Z., Du, S., Fan, H., Chen, C., Zhang, R., et al. (2020) · Nature Communications · doi:10.1038/s41467-019-14115-z · Cited by 163
Nitsche, C., Schreier, V. N., Behnam, M. A. M., Kumar, A., Bartenschlager, R. F. W., & Klein, C. D. P. (2013) · Journal of Medicinal Chemistry · doi:10.1021/jm400828u · Cited by 163
Biochemistry and Medicinal Chemistry of the Dengue Virus Protease
Nitsche, C., Holloway, S., Schirmeister, T., & Klein, C. D. P. (2014) · Chemical Reviews · doi:10.1021/cr500233q · Cited by 159
Unexpected outbreaks of arbovirus infections: lessons learned from the Pacific and tropical America
Musso, D., Rodriguez-Morales, A. J., Levi, J. E., Cao‐Lormeau, V., & Gubler, D. J. (2018) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(18)30269-x · Cited by 162
Salje, H., Lessler, J., Berry, I. M., Melendrez, M. C., Endy, T. P., Kalayanarooj, S., A-nuegoonpipat, A., Chanama, S., Sangkijporn, S., Klungthong, C., et al. (2017) · Science · doi:10.1126/science.aaj9384 · Cited by 150
Benelli, G., Maggi, F., Pavela, R., Murugan, K., Govindarajan, M., Vaseeharan, B., Petrelli, R., Cappellacci, L., Kumar, S. S., Hofer, A., et al. (2017) · Environmental Science and Pollution Research · doi:10.1007/s11356-017-9752-4 · Cited by 162
Human T Cell Response to Dengue Virus Infection
Tian, Y., Grifoni, A., Sette, A., & Weiskopf, D. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02125 · Cited by 160
Smith, S. A., de Alwis, A. R., Kose, N., Harris, E., Ibarra, K. D., Kahle, K. M., Pfaff, J. M., Xiang, X., Doranz, B. J., de Silva, A. M., et al. (2013) · mBio · doi:10.1128/mbio.00873-13 · Cited by 159
Structural basis for antibody inhibition of flavivirus NS1–triggered endothelial dysfunction
Biering, S. B., Akey, D. L., Wong, M. P., Brown, W. C., Lo, N. T. N., Puerta-Guardo, H. N., de Sousa, F. T. G., Wang, C., Konwerski, J. R., Espinosa, D. A., et al. (2021) · Science · doi:10.1126/science.abc0476 · Cited by 159
Metadata
- Authors
- Bhatt, S., Gething, P. W., Brady, O. J., Messina, J. P., Farlow, A. W., Moyes, C. L., Drake, J. M., Brownstein, J. S., Hoen, A. G., Sankoh, O., Myers, M. F., George, D. B., Jaenisch, T., Wint, G. R. W., Simmons, C. P., Scott, T. W., Farrar, J. J., & Hay, S. I.
- Affiliations
- University of Oxford (GB)
- University of Georgia (US)
- Boston Children's Hospital (US)
- Dartmouth College (US)
- University of the Witwatersrand (ZA)
- National Institutes of Health (US)
- University Hospital Heidelberg (DE)
- Churchill Hospital (GB)
- National University of Singapore (SG)
- Corresponding author
- Hay, Simon I.
- ORCID
- Venue
- Nature
- Published
- 2013-04
- Volume
- 496
- Issue
- 7446
- Pages
- 504-507
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC3651993
- OpenAlex
- W2131222241
- Cited by
- 10,037
- References
- 52
- Citations by year
- 2026: 615 · 2025: 704 · 2024: 830 · 2023: 846 · 2022: 816 · 2021: 943 · 2020: 946 · 2019: 922 · 2018: 777 · 2017: 724 · 2016: 744 · 2015: 551 · 2014: 467 · 2013: 141
- FWCI
- 650.37
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- LSHTM Research Online (London School of Hygiene and Tropical Medicine) (acceptedVersion)
- Minerva Access (University of Melbourne) (submittedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- RePEc: Research Papers in Economics (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Spiral (Imperial College London) (submittedVersion)
- Funders
- U.S. Department of Homeland Security
- Wellcome Trust (089276, 095066, 084368, 097318)
- European Commission (261504)
- National Institutes of Health (5r01ai069341-05)
- Biotechnology and Biological Sciences Research Council (1090403)
- National Institute of General Medical Sciences (R01GM083224)
- National Institute of Allergy and Infectious Diseases (R01-AI069341, R01AI091980)
- Fogarty International Center
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Mosquito-borne diseases and control
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Dengue and Mosquito Control Research
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Climate Change and Health Impacts
- Keywords
- dengue, global burden of disease, dengue incidence, dengue risk mapping, Aedes, mosquito-borne viral disease, temperature and precipitation effects, urbanization, dengue prevention, dengue control, tropical and subtropical regions, dengue vaccine
- MeSH terms
- Dengue, Dengue Virus, Humans, Public Health, Quality Control, Rain, Risk Factors, Temperature, Tropical Climate, Urbanization, Global Health, World Health Organization, Cohort Studies, Incidence, Databases, Factual
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
