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Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells
Open accessAbstract
Macropinocytosis is a highly conserved endocytic process by which extracellular fluid and its contents are internalized into cells through large, heterogeneous vesicles known as macropinosomes. Oncogenic Ras proteins have been shown to stimulate macropinocytosis but the functional contribution of this uptake mechanism to the transformed phenotype remains unknown. Here we show that Ras-transformed cells use macropinocytosis to transport extracellular protein into the cell. The internalized protein undergoes proteolytic degradation, yielding amino acids including glutamine that can enter central carbon metabolism. Accordingly, the dependence of Ras-transformed cells on free extracellular glutamine for growth can be suppressed by the macropinocytic uptake of protein. Consistent with macropinocytosis representing an important route of nutrient uptake in tumours, its pharmacological inhibition compromises the growth of Ras-transformed pancreatic tumour xenografts. These results identify macropinocytosis as a mechanism by which cancer cells support their unique metabolic needs and point to the possible exploitation of this process in the design of anticancer therapies.
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“This especially occurs in nutrient‐deprived states and is regulated by mammalian target of rapamycin complex 1 (mTORC1), controlling protein synthesis.94”
From Hypoalbuminemia: Pathogenesis and Clinical Significance (2019) · cites this paper as [94]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“PDAC cells harboring KRAS∗ rely on increased levels of macropinocytosis for nutrient salvaging to sustain uncontrolled cell growth.14”
From Therapeutic targeting of syndecan-1 axis overcomes acquired resistance to KRAS-targeted therapy in gastrointestinal cancers (2025) · cites this paper as [14]
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In the citing paper
“a nutrient salvage process that supports oncogenic growth.14”
From Therapeutic targeting of syndecan-1 axis overcomes acquired resistance to KRAS-targeted therapy in gastrointestinal cancers (2025) · cites this paper as [14]
In the citing paper
“PDAC cells utilize macropinocytosis to obtain amino acids through the uptake and degradation of albumin and collagen230–232”
From Pancreatic cancer: Advances and challenges (2023) · cites this paper as [230]
In the citing paper
“PDAC cells can utilize macropinocytosis to obtain proline from CAF produced collagen230.”
From Pancreatic cancer: Advances and challenges (2023) · cites this paper as [230]
In the citing paper
“Through 13C-labeled isotope labeling experiments we elucidate that exosomes supply amino acids to nutrient-deprived cancer cells in a mechanism similar to macropinocytosis, albeit without the previously described dependence on oncogenic-Kras signaling.”
From Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism (2016) · cites this paper as Commisso et al., 2013
In the citing paper
“Recent studies have shown that macropinocytosis of circulating proteins (especially albumin) could supply amino acids to nutrient-deprived cancer cells (Commisso et al., 2013).”
From Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism (2016) · cites this paper as Commisso et al., 2013
In the citing paper
“These results suggested that exosomes themselves might be acting as source of metabolites in a manner similar to macropinocytosis observed recently in Kras expressing pancreatic cancer cells (Commisso et al., 2013).”
From Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism (2016) · cites this paper as Commisso et al., 2013
In the citing paper
“expression of mutant Ras or c-Src alleles provides cells with a mechanism that allows them to recover free amino acids through the lysosomal degradation of extracellular proteins”
From The emerging hallmarks of cancer metabolism (2016) · cites this paper as Commisso et al., 2013
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Citations
Cites
ras oncogenes in human cancer: a review.
Bos, J. L. (1989) · PubMed · Cited by 5,061
Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses
Jones, S., Zhang, X., Parsons, D. W., Lin, J. C.-H., Leary, R. J., Angenendt, P., Mankoo, P., Carter, H., Kamiyama, H., Jimeno, A., et al. (2008) · Science · doi:10.1126/science.1164368 · Cited by 3,969
Hingorani, S. R., Wang, L., Multani, A. S., Combs, C., Deramaudt, T. B., Hruban, R. H., Rustgi, A. K., Chang, S., & Tuveson, D. A. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.04.023 · Cited by 2,609
Wise, D. R., DeBerardinis, R. J., Mancuso, A., Sayed, N., Zhang, X.-Y., Pfeiffer, H. K., Nissim, I., Daikhin, E., Yudkoff, M., McMahon, S. B., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810199105 · Cited by 2,001
Self-citationReductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia
Metallo, C. M., Gameiro, P. A., Bell, E. L., Mattaini, K. R., Yang, J., Hiller, K., Jewell, C. M., Johnson, Z. R., Irvine, D. J., Guarente, L., et al. (2012) · Nature · doi:10.1038/nature10602 · Cited by 1,791
Self-citationComplete nucleotide sequences of the T24 human bladder carcinoma oncogene and its normal homologue
Capon, D. J., Chen, E. Y., Levinson, A. D., Seeburg, P. H., & Goeddel, D. V. (1983) · Nature · doi:10.1038/302033a0 · Cited by 997
Induction of Membrane Ruffling and Fluid-Phase Pinocytosis in Quiescent Fibroblasts by ras Proteins
Bar-Sagi, D., & Feramisco, J. R. (1986) · Science · doi:10.1126/science.3090687 · Cited by 734
Self-citationPharmacological Inhibition of Endocytic Pathways: Is It Specific Enough to Be Useful?
Ivanov, A. I. (2008) · Methods in molecular biology · doi:10.1007/978-1-59745-178-9_2 · Cited by 615
Oncogenic K‐Ras decouples glucose and glutamine metabolism to support cancer cell growth
Gaglio, D., Metallo, C. M., Gameiro, P. A., Hiller, K., Danna, L. S., Balestrieri, C., Alberghina, L., Stephanopoulos, G., & Chiaradonna, F. (2011) · Molecular Systems Biology · doi:10.1038/msb.2011.56 · Cited by 492
Self-citationGLUTAMINE METABOLISM IN LYMPHOCYTES: ITS BIOCHEMICAL, PHYSIOLOGICAL AND CLINICAL IMPORTANCE
Newsholme, E. A., Crabtree, B., & Ardawi, M. S. M. (1985) · Quarterly Journal of Experimental Physiology · doi:10.1113/expphysiol.1985.sp002935 · Cited by 465
Cited by
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Items 201–300 of 1,002
Kim, H. S., Mendiratta, S., Kim, J., Pecot, C. V., Larsen, J. E., Zubovych, I., Seo, B. Y., Kim, J., Eskiocak, B., Chung, H., et al. (2013) · Cell · doi:10.1016/j.cell.2013.09.041 · Cited by 172
Pancreatic cancer: Stroma and its current and emerging targeted therapies
Kota, J., Hancock, J., Kwon, J. J., & Korc, M. (2017) · Cancer Letters · doi:10.1016/j.canlet.2016.12.035 · Cited by 177
EGFR-Pak signaling selectively regulates glutamine deprivation-induced macropinocytosis
Lee, S.-W., Zhang, Y., Jung, M., Cruz, N., Alas, B., & Commisso, C. (2019) · Developmental Cell · doi:10.1016/j.devcel.2019.05.043 · Cited by 172
Self-citationMechanisms of Carrier Formation during Clathrin-Independent Endocytosis
Ferreira, A. P. A., & Boucrot, E. (2017) · Trends in Cell Biology · doi:10.1016/j.tcb.2017.11.004 · Cited by 175
Altered cancer metabolism in mechanisms of immunotherapy resistance
Ramapriyan, R., Caetano, M. S., Barsoumian, H. B., Mafra, A. C. P., Zambalde, É. P., Menon, H., Tsouko, E., Welsh, J. W., & Cortez, M. A. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.11.004 · Cited by 173
Fan, Z., Liu, H., Xue, Y., Lin, J., Fu, Y., Xia, Z., Pan, D.-M., Zhang, J., Qiao, K., Zhang, Z., et al. (2020) · Bioactive Materials · doi:10.1016/j.bioactmat.2020.08.005 · Cited by 171
The role of lysosomes in cancer development and progression
Tang, T., Yang, Z., Wang, D., Yang, X., Wang, J., Li, L., Wen, Q., Gao, L., Bian, X., & Yu, S. (2020) · Cell & Bioscience · doi:10.1186/s13578-020-00489-x · Cited by 173
Plasma membrane V-ATPase controls oncogenic RAS-induced macropinocytosis
Ramírez, C., Hauser, A. D., Vucic, E., & Bar‐Sagi, D. (2019) · Nature · doi:10.1038/s41586-019-1831-x · Cited by 169
Self-citationA plasma membrane template for macropinocytic cups
Veltman, D. M., Williams, T. D., Bloomfield, G., Chen, B., Betzig, E., Insall, R. H., & Kay, R. R. (2016) · eLife · doi:10.7554/elife.20085 · Cited by 164
Serine and Functional Metabolites in Cancer
Newman, A. C., & Maddocks, O. D. K. (2017) · Trends in Cell Biology · doi:10.1016/j.tcb.2017.05.001 · Cited by 168
Direct control of lysosomal catabolic activity by mTORC1 through regulation of V-ATPase assembly
Ratto, E., Chowdhury, S., Siefert, N., Schneider, M., Wittmann, M., Helm, D., & Palm, W. (2022) · Nature Communications · doi:10.1038/s41467-022-32515-6 · Cited by 175
Leveraging Physiology for Precision Drug Delivery
Sun, W., Hu, Q., Ji, W., Wright, G., & Gu, Z. (2017) · Physiological Reviews · doi:10.1152/physrev.00015.2016 · Cited by 169
MYC Mediates Large Oncosome-Induced Fibroblast Reprogramming in Prostate Cancer
Minciacchi, V. R., Spinelli, C., Reis-Sobreiro, M., Cavallini, L., You, S., Zandian, M., Li, X., Mishra, R., Chiarugi, P., Adam, R. M., et al. (2017) · Cancer Research · doi:10.1158/0008-5472.can-16-2942 · Cited by 168
Ahmed, N., Escalona, R. M., Leung, D. T. H., Chan, E., & Kannourakis, G. (2018) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2018.10.002 · Cited by 166
Nitrogen Metabolism in Cancer and Immunity
Kurmi, K., & Haigis, M. C. (2020) · Trends in Cell Biology · doi:10.1016/j.tcb.2020.02.005 · Cited by 167
Regulation and function of autophagy in pancreatic cancer
Li, J., Chen, X., Kang, R., Zeh, H. J., Klionsky, D. J., & Tang, D. (2020) · Autophagy · doi:10.1080/15548627.2020.1847462 · Cited by 167
Uridine-derived ribose fuels glucose-restricted pancreatic cancer
Nwosu, Z. C., Ward, M. H., Sajjakulnukit, P., Poudel, P., Ragulan, C., Kasperek, S., Radyk, M. D., Sutton, D., Menjivar, R. E., Andren, A. C., et al. (2023) · Nature · doi:10.1038/s41586-023-06073-w · Cited by 170
Nanoparticle-siRNA: A potential cancer therapy?
Young, S. W. S., Stenzel, M. H., & Jia-Lin, Y. (2015) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2015.10.015 · Cited by 161
Zhang, N., Zhao, F., Zou, Q., Li, Y., Ma, G., & Yan, X. (2016) · Small · doi:10.1002/smll.201602339 · Cited by 161
Stromal epigenetic alterations drive metabolic and neuroendocrine prostate cancer reprogramming
Mishra, R., Haldar, S., Placencio, V. R., Madhav, A., Rohena-Rivera, K., Agarwal, P., Duong, F. L., Angara, B., Tripathi, M., Liu, Z., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci99397 · Cited by 167
Direct inhibition of oncogenic KRAS by hydrocarbon-stapled SOS1 helices
Leshchiner, E. S., Parkhitko, A. A., Bird, G. H., Luccarelli, J., Bellairs, J. A., Escudero, S., Opoku-Nsiah, K., Godes, M., Perrimon, N., & Walensky, L. D. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1413185112 · Cited by 159
The key role of extracellular vesicles in the metastatic process
Zhao, H., Achreja, A., Iessi, E., Logozzi, M., Mizzoni, D., Raimo, R. D., Nagrath, D., & Fais, S. (2017) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2017.11.005 · Cited by 164
MiT/TFE Family of Transcription Factors, Lysosomes, and Cancer
Perera, R. M., Malta, C. D., & Ballabio, A. (2018) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-030518-055835 · Cited by 162
Tumor Microenvironment Remodeling Enables Bypass of Oncogenic KRAS Dependency in Pancreatic Cancer
Hou, P., Kapoor, A., Zhang, Q., Li, J., Wu, C.-J., Li, J., Lan, Z., Tang, M., Ma, X., Ackroyd, J. J., et al. (2020) · Cancer Discovery · doi:10.1158/2159-8290.cd-19-0597 · Cited by 154
Harguindey, S., Arranz, J. A., Orozco, J. D. P., Rauch, C., Fais, S., Cardone, R. A., & Reshkin, S. J. (2013) · Journal of Translational Medicine · doi:10.1186/1479-5876-11-282 · Cited by 158
Developing dietary interventions as therapy for cancer
Taylor, S. R., Falcone, J. N., Cantley, L. C., & Goncalves, M. D. (2022) · Nature reviews. Cancer · doi:10.1038/s41568-022-00485-y · Cited by 168
Chatterjee, M., Ben‐Josef, E., Robb, R. N., Vedaie, M., Seum, S., Thirumoorthy, K., Palanichamy, K., Harbrecht, M. T., Chakravarti, A., & Williams, T. M. (2017) · Cancer Research · doi:10.1158/0008-5472.can-17-0604 · Cited by 156
The origins and evolution of macropinocytosis
King, J., & Kay, R. R. (2018) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2018.0158 · Cited by 152
Metabolic Adaptations in Cancer Stem Cells
Yadav, U. P., Singh, T., Kumar, P., Sharma, P., Kaur, H., Sharma, S., Singh, S., Kumar, S., & Mehta, K. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.01010 · Cited by 158
Drugging the addict: non‐oncogene addiction as a target for cancer therapy
Nagel, R., Semenova, E. A., & Berns, A. J. M. (2016) · EMBO Reports · doi:10.15252/embr.201643030 · Cited by 161
The plasticity of pancreatic cancer metabolism in tumor progression and therapeutic resistance
Biancur, D. E., & Kimmelman, A. C. (2018) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2018.04.011 · Cited by 152
Hyun, H., Park, J., Willis, K., Park, J. E., Lyle, L. T., Lee, W., & Yeo, Y. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.07.024 · Cited by 153
PIKfyve Regulates Vacuole Maturation and Nutrient Recovery following Engulfment
Krishna, S., Palm, W., Lee, Y., Yang, W., Bandyopadhyay, U., Xu, H., Florey, O., Thompson, C. B., & Overholtzer, M. (2016) · Developmental Cell · doi:10.1016/j.devcel.2016.08.001 · Cited by 140
Self-citationCanton, J., Schlam, D., Breuer, C., Gütschow, M., Glogauer, M., & Grinstein, S. (2016) · Nature Communications · doi:10.1038/ncomms11284 · Cited by 148
Qian, Y., Wang, X., Liu, Y., Li, Y., Colvin, R. A., Tong, L., Wu, S., & Chen, X. (2014) · Cancer Letters · doi:10.1016/j.canlet.2014.06.008 · Cited by 149
Starvation and Pseudo-Starvation as Drivers of Cancer Metastasis through Translation Reprogramming
García‐Jiménez, C., & Goding, C. R. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.11.018 · Cited by 157
A Small Molecule with Big Impact: MRTX1133 Targets the KRASG12D Mutation in Pancreatic Cancer
Wei, D., Wang, L., Zuo, X., Maitra, A., & Bresalier, R. S. (2023) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-23-2098 · Cited by 177
Hu, H.-F., Ye, Z., Qin, Y., Xu, X.-W., Yu, X.-J., Zhuo, Q.-F., & Ji, S.-R. (2021) · Acta Pharmacologica Sinica · doi:10.1038/s41401-020-00584-2 · Cited by 149
The redox requirements of proliferating mammalian cells
Hosios, A. M., & Heiden, M. G. V. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.tm117.000239 · Cited by 157
Drp1 Promotes KRas-Driven Metabolic Changes to Drive Pancreatic Tumor Growth
Nagdas, S., Kashatus, J. A., Nascimento, A., Hussain, S. S., Trainor, R. E., Pollock, S. R., Adair, S. J., Michaels, A. D., Sesaki, H., Stelow, E. B., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.07.031 · Cited by 151
The development of human serum albumin-based drugs and relevant fusion proteins for cancer therapy
Tao, H., Wang, R. L., Sheng, W., & Zhen, Y. (2021) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2021.07.080 · Cited by 148
Reprogramming tumour-associated macrophages to outcompete cancer cells
Zhang, X., Li, S., Malik, I., Do, M. H., Ji, L., Chou, C., Shi, W., Capistrano, K. J., Zhang, J., Hsu, T.-W., et al. (2023) · Nature · doi:10.1038/s41586-023-06256-5 · Cited by 154
The metabolic landscape of lung cancer: New insights in a disturbed glucose metabolism
Vanhove, K., Graulus, G.-J., Mesotten, L., Thomeer, M., Derveaux, E., Noben, J.-P., Guedens, W., & Adriaensens, P. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.01215 · Cited by 147
Phosphoinositides in phagocytosis and macropinocytosis
Levin‐Konigsberg, R., Grinstein, S., & Schlam, D. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.09.005 · Cited by 151
Exploiting Metabolic Vulnerabilities of Cancer with Precision and Accuracy
Wolpaw, A. J., & Dang, C. V. (2017) · Trends in Cell Biology · doi:10.1016/j.tcb.2017.11.006 · Cited by 150
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DeNicola, G. M., & Cantley, L. C. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.10.018 · Cited by 149
Perez, V. M., Kearney, J. F., & Yeh, J. J. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.751311 · Cited by 143
Lipid-gated monovalent ion fluxes regulate endocytic traffic and support immune surveillance
Freeman, S. A., Uderhardt, S., Sarić, A., Collins, R. F., Buckley, C. M. F., Mylvaganam, S., Boroumand, P., Plumb, J. D., Germain, R. N., Ren, D., et al. (2019) · Science · doi:10.1126/science.aaw9544 · Cited by 141
Zhao, H., Atkinson, J. E., Gulesserian, S., Zeng, Z., Nater, J., Ou, J. W., Yang, P., Morrison, K. J. M., Coleman, J. D., Malik, F., et al. (2018) · Cancer Research · doi:10.1158/0008-5472.can-17-3202 · Cited by 144
Barriers and opportunities for gemcitabine in pancreatic cancer therapy
Beutel, A. K., & Halbrook, C. J. (2023) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00331.2022 · Cited by 150
Egami, Y., Taguchi, T., Maekawa, M., Arai, H., & Araki, N. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00374 · Cited by 145
Influence of the Tumor Microenvironment on Cancer Cells Metabolic Reprogramming
Gouirand, V., Guillaumond, F., & Vasseur, S. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00117 · Cited by 140
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Pupo, E., Avanzato, D., Middonti, E., Bussolino, F., & Lanzetti, L. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00848 · Cited by 151
Lin, H., Singla, B., Ghoshal, P., Faulkner, J., Cherian‐Shaw, M., O'Connor, P. M., She, J., de Chantemèle, E. J. B., & Csányi, G. (2018) · British Journal of Pharmacology · doi:10.1111/bph.14429 · Cited by 144
CD9 identifies pancreatic cancer stem cells and modulates glutamine metabolism to fuel tumour growth
Wang, V. M.-Y., Ferreira, R. M. M., Almagro, J., Evan, T., Legrave, N. M., Thin, M. Z., Frith, D., Carvalho, J., Barry, D. J., Snijders, A. P., et al. (2019) · Nature Cell Biology · doi:10.1038/s41556-019-0407-1 · Cited by 142
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Fang, D., & Maldonado, E. N. (2018) · Advances in cancer research · doi:10.1016/bs.acr.2018.02.002 · Cited by 142
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Liu, J., Wu, Y., Sha, M., Xu, P., Li, S., Li, Y., Hu, X., Ouyang, L., & Wang, G. (2024) · Molecular Cancer · doi:10.1186/s12943-024-01934-y · Cited by 151
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Zafra, M. P., Parsons, M. J., Kim, J., Alonso-Curbelo, D., Goswami, S., Schatoff, E. M., Han, T., Katti, A., Fernandez, M. T. C., Wilkinson, J. E., et al. (2020) · Cancer Discovery · doi:10.1158/2159-8290.cd-20-0442 · Cited by 139
Drinking problems: mechanisms of macropinosome formation and maturation
Buckley, C. M. F., & King, J. (2017) · FEBS Journal · doi:10.1111/febs.14115 · Cited by 140
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Fu, Y., Liu, S., Zeng, S., & Shen, H. (2018) · Molecular Cancer · doi:10.1186/s12943-018-0815-z · Cited by 137
Petan, T. (2020) · Reviews of physiology, biochemistry and pharmacology · doi:10.1007/112_2020_51 · Cited by 145
Cancer metabolism and tumor microenvironment: fostering each other?
Yuan, Y., Li, H., Wang, P., Chen, L., Guo, D. S., Jiang, H., He, B., Qin, S., Wang, K., Li, N., et al. (2021) · Science China Life Sciences · doi:10.1007/s11427-021-1999-2 · Cited by 140
Metabolic requirements for cancer cell proliferation
Keibler, M. A., Wasylenko, T. M., Kelleher, J. K., Iliopoulos, O., Heiden, M. G. V., & Stephanopoulos, G. N. (2016) · Cancer & Metabolism · doi:10.1186/s40170-016-0156-6 · Cited by 141
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Anastasiou, D. (2016) · British Journal of Cancer · doi:10.1038/bjc.2016.412 · Cited by 138
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Kawada, K., Toda, K., & Sakai, Y. (2017) · International Journal of Clinical Oncology · doi:10.1007/s10147-017-1156-4 · Cited by 140
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Peck, B., & Schulze, A. (2019) · Trends in cancer · doi:10.1016/j.trecan.2019.09.007 · Cited by 138
The biological underpinnings of therapeutic resistance in pancreatic cancerPreprint
Beatty, G. L., Werba, G., Lyssiotis, C. A., & Simeone, D. M. (2021) · Genes & Development · doi:10.1101/gad.348523.121 · Cited by 139
Hopefully devoted to Q: targeting glutamine addiction in cancer
Still, E. R., & Yuneva, M. O. (2017) · British Journal of Cancer · doi:10.1038/bjc.2017.113 · Cited by 142
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Keenan, M. M., & Chi, J.-T. (2015) · The Cancer Journal · doi:10.1097/ppo.0000000000000104 · Cited by 131
Foster, D. A., Salloum, D., Menon, D., & Frías, M. A. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.r114.566091 · Cited by 131
Stock, C. M., & Pedersen, S. F. (2016) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2016.12.001 · Cited by 132
IRE1α RNase–dependent lipid homeostasis promotes survival in Myc-transformed cancers
Xie, H. J., Tang, C.-H. A., Song, J. H., Mancuso, A., Valle, J. R. D., Cao, J., Xiang, Y., Dang, C. V., Lan, R., Sanchez, D. J., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci95864 · Cited by 132
Kong, C., Li, Y., Liu, Z., Ye, J., Wang, Z., Zhang, L., Kong, W., Liu, H., Liu, C., Pang, H., et al. (2019) · ACS Nano · doi:10.1021/acsnano.8b08246 · Cited by 127
Regulation of antioxidants in cancer
Hecht, F., Zocchi, M., Alimohammadi, F., & Harris, I. S. (2023) · Molecular Cell · doi:10.1016/j.molcel.2023.11.001 · Cited by 138
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Parodi, A., Miao, J., Soond, S. M., Rudzińska, M., & Zamyatnin, A. A. (2019) · Biomolecules · doi:10.3390/biom9060218 · Cited by 129
Neurofibromin controls macropinocytosis and phagocytosis in Dictyostelium
Bloomfield, G., Traynor, D., Sander, S. P., Veltman, D. M., Pachebat, J. A., & Kay, R. R. (2015) · eLife · doi:10.7554/elife.04940 · Cited by 126
Lysosomes in cancer — living on the edge (of the cell)
Hämälistö, S., & Jäättelä, M. (2016) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2016.02.009 · Cited by 129
Yang, Y., Gabra, M. B. I., Hanse, E. A., Lowman, X. H., Tran, T. Q., Li, H., Milman, N., Liu, J., Reid, M. A., Locasale, J. W., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-08759-0 · Cited by 129
Shao, X., Cao, G., Chen, D., Liu, J., Yu, B., Liu, M., Li, Y., Cao, B., Sadovsky, Y., & Wang, Y. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2017092118 · Cited by 128
Gong, Z., Li, Q., Shi, J., Liu, E. T., Shultz, L. D., & Ren, G. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.11.003 · Cited by 129
Metabolic requirement for GOT2 in pancreatic cancer depends on environmental context
Kerk, S. A., Lin, L., Myers, A. L., Sutton, D. J., Andren, A., Sajjakulnukit, P., Zhang, L., Zhang, Y., Jiménez, J. A., Nelson, B. S., et al. (2022) · eLife · doi:10.7554/elife.73245 · Cited by 108
MAL2 drives immune evasion in breast cancer by suppressing tumor antigen presentation
Fang, Y., Wang, L., Wan, C., Sun, Y., der Jeught, K. V., Zhou, Z., Dong, T., So, K. M., Yu, T., Li, Y., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci140837 · Cited by 134
Dai, M., Yan, G., Wang, N., Daliah, G., Edick, A. M., Poulet, S., Boudreault, J., Ali, S., Burgos, S. A., & Lebrun, J. J. (2021) · Nature Communications · doi:10.1038/s41467-021-23316-4 · Cited by 130
Sarett, S. M., Werfel, T. A., Lee, L., Jackson, M. A., Kilchrist, K. V., Brantley‐Sieders, D. M., & Duvall, C. L. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1621240114 · Cited by 126
Ligand-Occupied Integrin Internalization Links Nutrient Signaling to Invasive Migration
Rainero, E., Howe, J. D., Caswell, P. T., Jamieson, N. B., Anderson, K. I., Critchley, D. R., Machesky, L. M., & Norman, J. C. (2015) · Cell Reports · doi:10.1016/j.celrep.2014.12.037 · Cited by 126
Recent insights into the biology of pancreatic cancer
Yao, W., Maitra, A., & Ying, H. (2020) · EBioMedicine · doi:10.1016/j.ebiom.2020.102655 · Cited by 127
Li, R., Ng, T. S. C., Wang, S. J., Prytyskach, M., Rodell, C. B., Mikula, H., Köhler, R. H., Garlin, M. A., Lauffenburger, D. A., Parangi, S., et al. (2021) · Nature Nanotechnology · doi:10.1038/s41565-021-00897-1 · Cited by 130
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Freeman, S. A., Grinstein, S., & Orlowski, J. (2022) · Physiological Reviews · doi:10.1152/physrev.00009.2022 · Cited by 127
Lipid sensing by mTOR complexes via de novo synthesis of phosphatidic acid
Menon, D., Salloum, D., Bernfeld, E., Sher, E. F., Akselrod, A., Frías, M. A., Sudderth, J., Chen, P.-H., DeBerardinis, R. J., & Foster, D. A. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.772988 · Cited by 127
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Seshacharyulu, P., Baine, M. J., Souchek, J. J., Menning, M., Kaur, S., Yan, Y., Ouellette, M. M., Jain, M., Lin, C. H., & Batra, S. K. (2017) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2017.02.003 · Cited by 127
HNF4A and GATA6 Loss Reveals Therapeutically Actionable Subtypes in Pancreatic Cancer
Brunton, H., Caligiuri, G., Cunningham, R., Upstill‐Goddard, R., Bailey, U., Garner, I., Nourse, C., Dreyer, S. B., Jones, M. D., Moran‐Jones, K., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107625 · Cited by 121
Chen, N., Brachmann, C. B., Liu, X., Pierce, D. W., Dey, J., Kerwin, W. S., Li, Y., Zhou, S. Y., Hou, S., Carleton, M. O., et al. (2015) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-015-2833-5 · Cited by 127
Cancer Metabolism Drives a Stromal Regenerative Response
Schwörer, S., Vardhana, S. A., & Thompson, C. B. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.01.015 · Cited by 125
Self-citationGlucose Metabolism in Pancreatic Cancer
Liang, Y., Raj, P. S., Yao, W., & Ying, H. (2019) · Cancers · doi:10.3390/cancers11101460 · Cited by 127
Spoiled for Choice: Diverse Endocytic Pathways Function at the Cell Surface
Thottacherry, J. J., Sathe, M., Prabhakara, C., & Mayor, S. (2019) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100617-062710 · Cited by 122
Genome scale metabolic modeling of cancer
Nilsson, A., & Nielsen, J. (2016) · Metabolic Engineering · doi:10.1016/j.ymben.2016.10.022 · Cited by 121
Cong, V. T., Houng, J. L., Kavallaris, M., Chen, X., Tilley, R. D., & Gooding, J. J. (2022) · Chemical Society Reviews · doi:10.1039/d1cs00707f · Cited by 129
Targeting cancer cell metabolism in pancreatic adenocarcinoma
Cohen, R., Neuzillet, C., Tijeras‐Raballand, A., Faivre, S. J., Gramont, A. D. E., & Raymond, É. (2015) · Oncotarget · doi:10.18632/oncotarget.4160 · Cited by 119
Stromal reengineering to treat pancreas cancer
Stromnes, I. M., DelGiorno, K. E., Greenberg, P. D., & Hingorani, S. R. (2014) · Carcinogenesis · doi:10.1093/carcin/bgu115 · Cited by 119
Metadata
- Authors
- Commisso, C., Davidson, S. M., Soydaner-Azeloglu, R. G., Parker, S. J., Kamphorst, J. J., Hackett, S., Grabocka, E., Nofal, M., Drebin, J. A., Thompson, C. B., Rabinowitz, J. D., Metallo, C. M., Vander Heiden, M. G., & Bar-Sagi, D.
- Affiliations
- New York University (US)
- Koch Institute for Integrative Cancer Research At MIT (US)
- University of California San Diego (US)
- Princeton University (US)
- Hospital of the University of Pennsylvania (US)
- Memorial Sloan Kettering Cancer Center (US)
- ORCID
- Venue
- Nature
- Published
- 2013-05-12
- Volume
- 497
- Issue
- 7451
- Pages
- 633-637
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC3810415
- OpenAlex
- W2129917557
- Cited by
- 1,683
- References
- 31
- Citations by year
- 2026: 120 · 2025: 130 · 2024: 130 · 2023: 136 · 2022: 162 · 2021: 186 · 2020: 166 · 2019: 135 · 2018: 129 · 2017: 113 · 2016: 119 · 2015: 79 · 2014: 56 · 2013: 20
- FWCI
- 52.97
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
- Funders
- National Cancer Institute (R01CA055360, P01CA104838, R01CA105463, P30CA014051, P01CA117969, P30CA016087, R01CA163591)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
- Keywords
- macropinocytosis, oncogenic Ras, amino acid supply, glutamine addiction, cancer metabolism, macropinosomes, protein degradation, pancreatic tumours, nutrient uptake, cancer therapy
- MeSH terms
- Amino Acids, Animals, Biological Transport, Carbon, Cell Line, Transformed, Cell Transformation, Neoplastic, Disease Models, Animal, Female, Glutamine, Mice, Nude, Pancreatic Neoplasms, Pinocytosis, Oncogene Protein p21(ras), NIH 3T3 Cells, Cell Line, Tumor, Cell Proliferation, Mice, Proteolysis
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