Cited by 122Cellular transport and secretionCaveolin-1 and cellular processesAutophagy in Disease and Therapy

Spoiled for Choice: Diverse Endocytic Pathways Function at the Cell Surface

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Thottacherry, Joseph Jose, Sathe, Mugdha, Prabhakara, Chaitra, Mayor, Satyajit·2019·Annual Review of Cell and Developmental Biology

Abstract

Endocytosis has long been identified as a key cellular process involved in bringing in nutrients, in clearing cellular debris in tissue, in the regulation of signaling, and in maintaining cell membrane compositional homeostasis. While clathrin-mediated endocytosis has been most extensively studied, a number of clathrin-independent endocytic pathways are continuing to be delineated. Here we provide a current survey of the different types of endocytic pathways available at the cell surface and discuss a new classification and plausible molecular mechanisms for some of the less characterized pathways. Along with an evolutionary perspective of the origins of some of these pathways, we provide an appreciation of the distinct roles that these pathways play in various aspects of cellular physiology, including the control of signaling and membrane tension.

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Crossref · 10.1146/annurev-cellbio-100617-062710

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  • Given the physiological size of melanosomes (0.3-0.5 μm in diameter), only macropinocytosis and phagocytosis are predicted to allow internalization of such large cargo.

    “Given the physiological size of melanosomes (0.3–0.5 μm in diameter), only macropinocytosis and phagocytosis are predicted to allow the internalization of such large cargo [ 51 , 52 , 53 , 54 ].”

    From Melanin's Journey from Melanocytes to Keratinocytes: Uncovering the Molecular Mechanisms of Melanin Transfer and Processing (2023) · cites this paper as [54]

    The review’s Macropinocytosis and Phagocytosis subsections (page not provided) describe large macropinocytic vesicles and engulfment of microorganisms, both involving sizes greater than 0.5 μm. They do not give the 0.3–0.5 μm size of melanosomes or say that only these two pathways could internalize them. (LLM, conf=0.84)

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Authors
Thottacherry, J. J., Sathe, M., Prabhakara, C., & Mayor, S.
Affiliations
Tata Institute of Fundamental Research (IN)
Corresponding author
Mayor, Satyajit
Venue
Annual Review of Cell and Developmental Biology
Published
2019-10-06
Volume
35
Issue
1
Pages
55-84
ISSN
  • 1081-0706 (ISSN-L)
  • 1530-8995
OpenAlex
W2956919478
Cited by
122
References
232
Citations by year
2026: 15 · 2025: 19 · 2024: 22 · 2023: 16 · 2022: 17 · 2021: 21 · 2020: 12
FWCI
1.45
Type
journal article
Language
en
Open access
Locations
  • Annual Review of Cell and Developmental Biology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Caveolin-1 and cellular processes
  • Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
Keywords
endocytosis, clathrin-independent endocytosis, clathrin-mediated endocytosis, cell surface, membrane tension, signal transduction regulation
MeSH terms
Animals, Cell Membrane, Endocytosis, Biological Evolution, Homeostasis, Humans, Signal Transduction

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