Cited by 412Visual perception and processing mechanismsNeuroscience and Neuropharmacology ResearchNeurogenesis and neuroplasticity mechanisms

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A disinhibitory microcircuit initiates critical-period plasticity in the visual cortex

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Kuhlman, Sandra J., Olivas, Nicholas D., Tring, Elaine, Ikrar, Taruna, Xu, Xiangmin, Trachtenberg, Joshua T.·2013·Nature

DOI 10.1038/nature12485PMC PMC3962838

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Abstract

Early sensory experience instructs the maturation of neural circuitry in the cortex. This has been studied extensively in the primary visual cortex, in which loss of vision to one eye permanently degrades cortical responsiveness to that eye, a phenomenon known as ocular dominance plasticity (ODP). Cortical inhibition mediates this process, but the precise role of specific classes of inhibitory neurons in ODP is controversial. Here we report that evoked firing rates of binocular excitatory neurons in the primary visual cortex immediately drop by half when vision is restricted to one eye, but gradually return to normal over the following twenty-four hours, despite the fact that vision remains restricted to one eye. This restoration of binocular-like excitatory firing rates after monocular deprivation results from a rapid, although transient, reduction in the firing rates of fast-spiking, parvalbumin-positive (PV) interneurons, which in turn can be attributed to a decrease in local excitatory circuit input onto PV interneurons. This reduction in PV-cell-evoked responses after monocular lid suture is restricted to the critical period for ODP and appears to be necessary for subsequent shifts in excitatory ODP. Pharmacologically enhancing inhibition at the time of sight deprivation blocks ODP and, conversely, pharmacogenetic reduction of PV cell firing rates can extend the critical period for ODP. These findings define the microcircuit changes initiating competitive plasticity during critical periods of cortical development. Moreover, they show that the restoration of evoked firing rates of layer 2/3 pyramidal neurons by PV-specific disinhibition is a key step in the progression of ODP.

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Snakes, shapes, and gradient vector flow
Xu, C., & Prince, J. L. (1998) · IEEE Transactions on Image Processing · doi:10.1109/83.661186 · Cited by 4,001
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Wiesel, T. N., & Hubel, D. H. (1963) · Journal of Neurophysiology · doi:10.1152/jn.1963.26.6.1003 · Cited by 2,628
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Hensch, T. K. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1787 · Cited by 2,323
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Holtmaat, A., & Svoboda, K. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2699 · Cited by 1,934
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Stosiek, C., Garaschuk, O., Holthoff, K., & Konnerth, A. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1232232100 · Cited by 1,341
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Medini, P. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.08.022 · Cited by 24
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Hensch, T. K. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804036-2.00006-6 · Cited by 24
Neuregulin directed molecular mechanisms of visual cortical plasticity
Grieco, S. F., Holmes, T. C., & Xu, X. (2018) · The Journal of Comparative Neurology · doi:10.1002/cne.24414 · Cited by 23
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Saiepour, M. H., Rajendran, R., Omrani, A., Ma, W., Tao, H. W., Heimel, J. A., & Levelt, C. N. (2015) · Current Biology · doi:10.1016/j.cub.2015.01.024 · Cited by 21
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Voss, P., Thomas, M. E., Guercio, G. D., & de Villers‐Sidani, E. (2018) · Schizophrenia Research · doi:10.1016/j.schres.2018.04.025 · Cited by 22
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Whitelaw, B. S., Matei, E. K., & Majewska, A. K. (2020) · eNeuro · doi:10.1523/eneuro.0311-20.2020 · Cited by 20
Selective inhibition of excitatory synaptic transmission alters the emergent bursting dynamics of in vitro neural networks
Weir, J. S., Christiansen, N., Sandvig, A., & Sandvig, I. (2023) · Frontiers in Neural Circuits · doi:10.3389/fncir.2023.1020487 · Cited by 20
Nicotinic regulation of experience-dependent plasticity in visual cortex
Sadahiro, M., Sajo, M., & Morishita, H. (2016) · Journal of Physiology-Paris · doi:10.1016/j.jphysparis.2016.11.003 · Cited by 22

Authors: Kuhlman, S. J., Olivas, N. D., Tring, E., Ikrar, T., Xu, X., & Trachtenberg, J. T.
Affiliations: University of California, Los Angeles (US)
University of California, Irvine (US)
Corresponding author: Xu, Xiangmin
Trachtenberg, Joshua T.
ORCID: Kuhlman, Sandra J.
Ikrar, Taruna
Xu, Xiangmin
Trachtenberg, Joshua T.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2013-08-25
Volume: 501
Issue: 7468
Pages: 543-546
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature12485
PMC: PMC3962838
OpenAlex: W2065582606
Cited by: 412
References: 47
Citations by year: 2026: 12 · 2025: 28 · 2024: 19 · 2023: 31 · 2022: 25 · 2021: 38 · 2020: 44 · 2019: 38 · 2018: 35 · 2017: 42 · 2016: 31 · 2015: 33 · 2014: 30 · 2013: 6
FWCI: 17.95
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
RePEc: Research Papers in Economics (submittedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: National Institute on Drug Abuse (R00DA023700)
National Eye Institute (EY016052, R01EY016052, R01EY023871)
National Institute of Neurological Disorders and Stroke (R01NS078434, NS078434)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords: ocular dominance plasticity, parvalbumin interneurons, critical period, primary visual cortex, monocular deprivation, cortical inhibition, disinhibition, fast-spiking interneurons, sensory deprivation, inhibitory interneurons, eye development
MeSH terms: Animals, Critical Period, Psychological, Female, Interneurons, Lasers, Male, Neural Inhibition, Neuronal Plasticity, Parvalbumins, Photic Stimulation, Sensory Deprivation, Visual Cortex, Vision, Binocular, Vision, Monocular, Dominance, Ocular, Mice

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A disinhibitory microcircuit initiates critical-period plasticity in the visual cortex

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