Brief dark exposure restored ocular dominance plasticity in aging mice and after a cortical stroke
Open accessAbstract
In the primary visual cortex (V1), monocular deprivation (MD) induces a shift in the ocular dominance (OD) of binocular neurons towards the open eye (Wiesel and Hubel, 1963; Gordon and Stryker, 1996). In V1 of C57Bl/6J mice, this OD-plasticity is maximal in juveniles, declines in adults and is absent beyond postnatal day (PD) 110 (Lehmann and Löwel, 2008) if mice are raised in standard cages. Since it was recently shown that brief dark exposure (DE) restored OD-plasticity in young adult rats (PD70-100) (He et al., 2006), we wondered whether DE would restore OD-plasticity also in adult and old mice and after a cortical stroke. To this end, we raised mice in standard cages until adulthood and transferred them to a darkroom for 10-14 days. Using intrinsic signal optical imaging we demonstrate that short-term DE can restore OD-plasticity after MD in both adult (PD138) and old mice (PD535), and that OD-shifts were mediated by an increase of open eye responses in V1. Interestingly, restored OD-plasticity after DE was accompanied by a reduction of both parvalbumin expressing cells and perineuronal nets and was prevented by increasing intracortical inhibition with diazepam. DE also maintained OD-plasticity in adult mice (PD150) after a stroke in the primary somatosensory cortex. In contrast, short-term DE did not affect basic visual parameters as measured by optomotry. In conclusion, short-term DE was able to restore OD-plasticity in both adult and aging mice and even preserved plasticity after a cortical stroke, most likely mediated by reducing intracortical inhibition.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Reactivation of plasticity through dark exposure has been demonstrated in several species, including kittens, and is effective in mice up to P535 days old.
“The reactivation of plasticity through dark exposure has now been demonstrated in several species, including kittens (Duffy and Mitchell, 2013; Mitchell et al., 2016) and is effective in mice up to P535 days old (Stodieck et al., 2014).”
From Light reintroduction after dark exposure reactivates plasticity in adults via perisynaptic activation of MMP-9 (2017) · cites this paper as Stodieck et al., 2014
Cites
The Mouse Brain in Stereotaxic Coordinates
Paxinos, G. (2001) · Cited by 12,859 · see citing works
Reactivation of Ocular Dominance Plasticity in the Adult Visual Cortex
Pizzorusso, T., Medini, P., Berardi, N., Chierzi, S., Fawcett, J. W., & Maffei, L. (2002) · Science · doi:10.1126/science.1072699 · Cited by 1,679 · see citing works
Wiesel, T. N., & Hubel, D. H. (1963) · Journal of Neurophysiology · doi:10.1152/jn.1963.26.6.978 · Cited by 1,291 · see citing works
Huang, Z. J., Kirkwood, A., Pizzorusso, T., Porciatti, V., Morales, B., Bear, M. F., Maffei, L., & Tonegawa, S. (1999) · Cell · doi:10.1016/s0092-8674(00)81509-3 · Cited by 1,198 · see citing works
Induction of reproducible brain infarction by photochemically initiated thrombosis
Watson, B. D., Dietrich, W. D., Busto, R., Wachtel, M. S., & Ginsberg, M. D. (1985) · Annals of Neurology · doi:10.1002/ana.410170513 · Cited by 1,135 · see citing works
Local GABA Circuit Control of Experience-Dependent Plasticity in Developing Visual Cortex
Hensch, T. K., Fagiolini, M., Mataga, N., Stryker, M. P., Baekkeskov, S., & Kash, S. F. (1998) · Science · doi:10.1126/science.282.5393.1504 · Cited by 910 · see citing works
Experience-Dependent Plasticity of Binocular Responses in the Primary Visual Cortex of the Mouse
Gordon, J. A., & Stryker, M. P. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-10-03274.1996 · Cited by 856 · see citing works
A disinhibitory microcircuit for associative fear learning in the auditory cortex
Letzkus, J. J., Wolff, S. B. E., Meyer, E. M. M., Tovote, P., Courtin, J., Herry, C., & Lüthi, A. (2011) · Nature · doi:10.1038/nature10674 · Cited by 840 · see citing works
Rapid Quantification of Adult and Developing Mouse Spatial Vision Using a Virtual Optomotor System
Prusky, G. T., Alam, N. M., Beekman, S., & Douglas, R. M. (2004) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.04-0541 · Cited by 777 · see citing works
Inhibitory threshold for critical-period activation in primary visual cortex
Fagiolini, M., & Hensch, T. K. (2000) · Nature · doi:10.1038/35004582 · Cited by 716 · see citing works
Development and plasticity of the primary visual cortex
Espinosa, J. S., & Stryker, M. P. (2012) · Neuron · doi:10.1016/j.neuron.2012.06.009 · Cited by 672 · see citing works
Experience-dependent modification of synaptic plasticity in visual cortex
Kirkwood, A., Rioult, M., & Bear, M. (1996) · Nature · doi:10.1038/381526a0 · Cited by 666 · see citing works
Rapid, experience-dependent expression of synaptic NMDA receptors in visual cortex in vivo
Quinlan, E., Philpot, B. D., Huganir, R., & Bear, M. (1999) · Nature Neuroscience · doi:10.1038/7263 · Cited by 614 · see citing works
A synaptic memory trace for cortical receptive field plasticity
Froemke, R. C., Merzenich, M. M., & Schreiner, C. E. (2007) · Nature · doi:10.1038/nature06289 · Cited by 600 · see citing works
Removing brakes on adult brain plasticity: From molecular to behavioral interventions
Bavelier, D., Levi, D. M., Li, R. W., Dan, Y., & Hensch, T. K. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4812-10.2010 · Cited by 589 · see citing works
New Paradigm for Optical Imaging
Kalatsky, V. A., & Stryker, M. P. (2003) · Neuron · doi:10.1016/s0896-6273(03)00286-1 · Cited by 571 · see citing works
Moon, L. D. F., Asher, R. A., Rhodes, K. E., & Fawcett, J. W. (2001) · Nature Neuroscience · doi:10.1038/87415 · Cited by 563 · see citing works
Animals lacking link protein have attenuated perineuronal nets and persistent plasticity
Carulli, D., Pizzorusso, T., Kwok, J. C. F., Putignano, E., Poli, A., Forostyak, S., Andrews, M. R., Deepa, S. S., Glant, T. T., & Fawcett, J. W. (2010) · Brain · doi:10.1093/brain/awq145 · Cited by 495 · see citing works
Sale, A., Maya Vetencourt, J. F., Medini, P., Cenni, M. C., Baroncelli, L., De Pasquale, R., & Maffei, L. (2007) · Nature Neuroscience · doi:10.1038/nn1899 · Cited by 492 · see citing works
Sugiyama, S., Di Nardo, A. A., Aizawa, S., Matsuo, I., Volovitch, M., Prochiantz, A., & Hensch, T. K. (2008) · Cell · doi:10.1016/j.cell.2008.05.054 · Cited by 491 · see citing works
Critical periods during sensory development
Berardi, N., Pizzorusso, T., & Maffei, L. (2000) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(99)00047-1 · Cited by 490 · see citing works
NMDA Receptor-Dependent Ocular Dominance Plasticity in Adult Visual Cortex
Sawtell, N. B., Frenkel, M. Y., Philpot, B. D., Nakazawa, K., Tonegawa, S., & Bear, M. F. (2003) · Neuron · doi:10.1016/s0896-6273(03)00323-4 · Cited by 482 · see citing works
Specific GABA <sub>A</sub> Circuits for Visual Cortical Plasticity
Fagiolini, M., Fritschy, J.-M., Löw, K., Möhler, H., Rudolph, U., & Hensch, T. K. (2004) · Science · doi:10.1126/science.1091032 · Cited by 471 · see citing works
Receptive fields of single cells and topography in mouse visual cortex
Dräger, U. C. (1975) · The Journal of Comparative Neurology · doi:10.1002/cne.901600302 · Cited by 415 · see citing works
A disinhibitory microcircuit initiates critical-period plasticity in the visual cortex
Kuhlman, S. J., Olivas, N. D., Tring, E., Ikrar, T., Xu, X., & Trachtenberg, J. T. (2013) · Nature · doi:10.1038/nature12485 · Cited by 412 · see citing works
How Monocular Deprivation Shifts Ocular Dominance in Visual Cortex of Young Mice
Frenkel, M. Y., & Bear, M. F. (2004) · Neuron · doi:10.1016/j.neuron.2004.12.003 · Cited by 412 · see citing works
Critical-Period Plasticity in the Visual Cortex
Levelt, C. N., & Hübener, M. (2012) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-061010-113813 · Cited by 402 · see citing works
Otx2 Binding to Perineuronal Nets Persistently Regulates Plasticity in the Mature Visual Cortex
Beurdeley, M., Spatazza, J., Lee, H. H. C., Sugiyama, S., Bernard, C., Di Nardo, A. A., Hensch, T. K., & Prochiantz, A. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0394-12.2012 · Cited by 398 · see citing works
Nurturing brain plasticity: Impact of environmental enrichment
Baroncelli, L., Braschi, C., Spolidoro, M., Begenisic, T., Sale, A., & Maffei, L. (2010) · Cell Death & Differentiation · doi:10.1038/cdd.2009.193 · Cited by 330 · see citing works
Homeostatic Regulation of Eye-Specific Responses in Visual Cortex during Ocular Dominance Plasticity
Mrsic-Flogel, T. D., Hofer, S. B., Ohki, K., Reid, R. C., Bonhoeffer, T., & Hübener, M. (2007) · Neuron · doi:10.1016/j.neuron.2007.05.028 · Cited by 330 · see citing works
Development of precise maps in visual cortex requires patterned spontaneous activity in the retina
Cang, J., Rentería, R. C., Kaneko, M., Liu, X., Copenhagen, D. R., & Stryker, M. P. (2005) · Neuron · doi:10.1016/j.neuron.2005.09.015 · Cited by 306 · see citing works
Visual Deprivation Reactivates Rapid Ocular Dominance Plasticity in Adult Visual Cortex
He, H., Hodos, W., & Quinlan, E. M. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.5554-05.2006 · Cited by 263 · see citing works
Distinctive Features of Adult Ocular Dominance Plasticity
Sato, M., & Stryker, M. P. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.2451-08.2008 · Cited by 263 · see citing works
Bidirectional synaptic plasticity: from theory to reality
Bear, M. F. (2003) · Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences · doi:10.1098/rstb.2002.1255 · Cited by 260 · see citing works
Critical Periods in the Visual System: Changing Views for a Model of Experience-Dependent Plasticity
Hooks, B. M., & Chen, C. (2007) · Neuron · doi:10.1016/j.neuron.2007.10.003 · Cited by 254 · see citing works
Mechanism for a sliding synaptic modification threshold
Bear, M. F. (1995) · Neuron · doi:10.1016/0896-6273(95)90056-x · Cited by 237 · see citing works
Multiple periods of functional ocular dominance plasticity in mouse visual cortex
Tagawa, Y., Kanold, P. O., Majdan, M., & Shatz, C. J. (2005) · Nature Neuroscience · doi:10.1038/nn1410 · Cited by 235 · see citing works
Critical Period Mechanisms in Developing Visual Cortex
Hensch, T. K. (2005) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(05)69008-4 · Cited by 226 · see citing works
Prior experience enhances plasticity in adult visual cortex
Hofer, S. B., Mrsic‐Flogel, T. D., Bonhoeffer, T., & Hübener, M. (2005) · Nature Neuroscience · doi:10.1038/nn1610 · Cited by 223 · see citing works
Observations on monocular deprivation in mice
Dräger, U. C. (1978) · Journal of Neurophysiology · doi:10.1152/jn.1978.41.1.28 · Cited by 213 · see citing works
Elimination of Inhibitory Synapses Is a Major Component of Adult Ocular Dominance Plasticity
van Versendaal, D., Rajendran, R., Saiepour, M. H., Klooster, J., Smit‐Rigter, L. A., Sommeijer, J.-P., Zeeuw, C. I. D., Hofer, S. B., Heimel, J. A., & Levelt, C. N. (2012) · Neuron · doi:10.1016/j.neuron.2012.03.015 · Cited by 187 · see citing works
Age-Dependent Ocular Dominance Plasticity in Adult Mice
Lehmann, K., & Löwel, S. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003120 · Cited by 175 · see citing works
Self-citationOptical imaging of the intrinsic signal as a measure of cortical plasticity in the mouse
Cang, J., Kalatsky, V. A., Löwel, S., & Stryker, M. P. (2005) · Visual Neuroscience · doi:10.1017/s0952523805225178 · Cited by 152 · see citing works
Self-citationYe, Q., & Miao, Q.-L. (2013) · Matrix Biology · doi:10.1016/j.matbio.2013.04.001 · Cited by 146 · see citing works
Greifzu, F., Pielecka-Fortuna, J., Kalogeraki, E., Krempler, K., Favaro, P. D., Schlüter, O. M., & Löwel, S. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1313385111 · Cited by 144 · see citing works
Self-citationA semi-persistent adult ocular dominance plasticity in visual cortex is stabilized by activated CREBPreprint
Pham, T. A., Graham, S. J., Suzuki, S., Barco, Á., Kandel, E. R., Gordon, B., & Lickey, M. E. (2004) · Learning & Memory · doi:10.1101/lm.75304 · Cited by 136 · see citing works
Enhancement of Vision by Monocular Deprivation in Adult Mice
Prusky, G. T., Alam, N. M., & Douglas, R. M. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.3396-06.2006 · Cited by 112 · see citing works
Rozas, C., Frank, H., Heynen, A. J., Morales, B., Bear, M. F., & Kirkwood, A. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-17-06791.2001 · Cited by 90 · see citing works
Montey, K. L., & Quinlan, E. M. (2011) · Nature Communications · doi:10.1038/ncomms1312 · Cited by 88 · see citing works
Screening mouse vision with intrinsic signal optical imaging
Heimel, J. A., Hartman, R. J., Hermans, J. M., & Levelt, C. N. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05333.x · Cited by 78 · see citing works
From brain formation to plasticity: Insights on Otx2 homeoprotein
Sugiyama, S., Prochiantz, A., & Hensch, T. K. (2009) · Development, Growth & Differentiation · doi:10.1111/j.1440-169x.2009.01093.x · Cited by 77 · see citing works
Huang, S., Gu, Y., Quinlan, E. M., & Kirkwood, A. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4384-10.2010 · Cited by 67 · see citing works
Vision and visual plasticity in ageing mice
Lehmann, K., Schmidt, K.-F., & Löwel, S. (2012) · Restorative Neurology and Neuroscience · doi:10.3233/rnn-2012-110192 · Cited by 59 · see citing works
Self-citationDark Exposure Extends the Integration Window for Spike-Timing-Dependent Plasticity
Guo, Y., Huang, S., Pasquale, R. D., McGehrin, K., Lee, H., Zhao, K., & Kirkwood, A. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.2545-12.2012 · Cited by 57 · see citing works
Greifzu, F., Schmidt, S., Schmidt, K.-F., Kreikemeier, K., Witte, O. W., & Löwel, S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016458108 · Cited by 51 · see citing works
Self-citationA rich environmental experience reactivates visual cortex plasticity in aged rats
Scali, M., Baroncelli, L., Cenni, M. C., Sale, A., & Maffei, L. (2012) · Experimental Gerontology · doi:10.1016/j.exger.2012.01.007 · Cited by 48 · see citing works
Highly Specific Structural Plasticity of Inhibitory Circuits in the Adult Neocortex
Chen, J. L., & Nedivi, E. (2013) · The Neuroscientist · doi:10.1177/1073858413479824 · Cited by 36 · see citing works
Network influences on cortical plasticity
Greifzu, F., Wolf, F., & Löwel, S. (2012) · e-Neuroforum · doi:10.1007/s13295-012-0030-0 · Cited by 7 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Murase, S., Lantz, C. L., & Quinlan, E. M. (2017) · eLife · doi:10.7554/elife.27345 · Cited by 87 · see citing works
Enhancement of visual cortex plasticity by dark exposure
Erchova, I., Vasalauskaite, A., Longo, V., & Sengpiel, F. (2017) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2016.0159 · Cited by 32 · see citing works
Optimization of visual training for full recovery from severe amblyopia in adults
Eaton, N. C., Sheehan, H. M., & Quinlan, E. M. (2016) · Learning & Memory · doi:10.1101/lm.040295.115 · Cited by 28 · see citing works
- Authors
- Stodieck, S. K., Greifzu, F., Goetze, B., Schmidt, K.-F., & Löwel, S.
- Affiliations
- University of Göttingen (DE)
- Corresponding author
- Greifzu, Franziska
- ORCID
- Löwel, Siegrid
- Venue
- Experimental Gerontology
- Publisher
- Elsevier BV
- Published
- 2014-12
- Volume
- 60
- Pages
- 1-11
- ISSN
- 0531-5565 (ISSN-L)
- OpenAlex
- W1971604198
- Cited by
- 43
- References
- 58
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 2 · 2023: 1 · 2022: 1 · 2020: 3 · 2019: 6 · 2018: 7 · 2017: 9 · 2016: 5 · 2015: 4
- FWCI
- 3.34
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Experimental Gerontology (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- GRO (submittedVersion)
- Funders
- Federal Ministry of Education and Research, Germany (01GQ0921, 01GQ0810)
- Deutsche Forschungsgemeinschaft
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- ocular dominance plasticity, monocular deprivation, dark exposure, aging, cortical stroke, primary visual cortex, intracortical inhibition, parvalbumin interneurons, perineuronal nets, diazepam, somatosensory cortex, adult mice
- MeSH terms
- Aging, Animals, Darkness, Diazepam, Female, Male, Mice, Inbred C57BL, Neuronal Plasticity, Parvalbumins, Sensory Deprivation, Somatosensory Cortex, Visual Acuity, Visual Cortex, Contrast Sensitivity, Stroke, Dominance, Ocular, Mice, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
