The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity
Open accessAbstract
The type I interferon (IFN) response protects cells from viral infection by inducing hundreds of interferon-stimulated genes (ISGs), some of which encode direct antiviral effectors. Recent screening studies have begun to catalogue ISGs with antiviral activity against several RNA and DNA viruses. However, antiviral ISG specificity across multiple distinct classes of viruses remains largely unexplored. Here we used an ectopic expression assay to screen a library of more than 350 human ISGs for effects on 14 viruses representing 7 families and 11 genera. We show that 47 genes inhibit one or more viruses, and 25 genes enhance virus infectivity. Comparative analysis reveals that the screened ISGs target positive-sense single-stranded RNA viruses more effectively than negative-sense single-stranded RNA viruses. Gene clustering highlights the cytosolic DNA sensor cyclic GMP-AMP synthase (cGAS, also known as MB21D1) as a gene whose expression also broadly inhibits several RNA viruses. In vitro, lentiviral delivery of enzymatically active cGAS triggers a STING-dependent, IRF3-mediated antiviral program that functions independently of canonical IFN/STAT1 signalling. In vivo, genetic ablation of murine cGAS reveals its requirement in the antiviral response to two DNA viruses, and an unappreciated contribution to the innate control of an RNA virus. These studies uncover new paradigms for the preferential specificity of IFN-mediated antiviral pathways spanning several virus families.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“For example, RNA viruses can activate the cGAS-STING pathway despite the specificity of cGAS for cytoplasmic DNA over RNA (Gao et al., 2013b; Schoggins et al., 2014).”
From Cytoplasmic DNA: sources, sensing, and role in aging and disease (2021) · cites this paper as Schoggins et al., 2014
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway
Sun, L., Wu, J., Du, F., Chen, X., & Chen, Z. J. (2013) · Science · doi:10.1126/science.1232458 · Cited by 4,996
STRING v9.1: protein-protein interaction networks, with increased coverage and integration
Franceschini, A., Szklarczyk, D., Frankild, S., Kuhn, M., Simonovic, M., Roth, A., Lin, J., Minguez, P., Bork, P., von Mering, C., et al. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks1094 · Cited by 4,398
Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA
Wu, J., Sun, L., Chen, X., Du, F., Shi, H., Chen, C., & Chen, Z. J. (2012) · Science · doi:10.1126/science.1229963 · Cited by 2,628
A diverse range of gene products are effectors of the type I interferon antiviral response
Schoggins, J. W., Wilson, S. J., Panis, M., Murphy, M. Y., Jones, C. T., Bieniasz, P. D., & Rice, C. M. (2011) · Nature · doi:10.1038/nature09907 · Cited by 2,412
Self-citationDer, S. D., Zhou, A., Williams, B. R. G., & Silverman, R. H. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.26.15623 · Cited by 1,840
Interferon-stimulated genes and their antiviral effector functions
Schoggins, J. W., & Rice, C. M. (2011) · Current Opinion in Virology · doi:10.1016/j.coviro.2011.10.008 · Cited by 1,342
Self-citationGao, P., Ascano, M., Wu, Y., Barchet, W., Gaffney, B. L., Zillinger, T., Serganov, A. A., Liu, Y., Jones, R. A., Hartmann, G., et al. (2013) · Cell · doi:10.1016/j.cell.2013.04.046 · Cited by 1,101
Pivotal Roles of cGAS-cGAMP Signaling in Antiviral Defense and Immune Adjuvant Effects
Li, X.-D., Wu, J., Gao, D., Wang, H., Sun, L., & Chen, Z. J. (2013) · Science · doi:10.1126/science.1244040 · Cited by 1,097
Cyclic GMP-AMP Synthase Is an Innate Immune Sensor of HIV and Other Retroviruses
Gao, D., Wu, J., Wu, Y.-T., Du, F., Aroh, C., Yan, N., Sun, L., & Chen, Z. J. (2013) · Science · doi:10.1126/science.1240933 · Cited by 1,032
Structural mechanism of cytosolic DNA sensing by cGAS
Çivril, F., Deimling, T., Mann, C. C. D. O., Ablasser, A., Moldt, M., Witte, G., Hornung, V., & Hopfner, K. (2013) · Nature · doi:10.1038/nature12305 · Cited by 916
Cited by
Sorted by citations
Items 201–300 of 885
Poliovirus intrahost evolution is required to overcome tissue-specific innate immune responses
Xiao, Y., Dolan, P., Goldstein, E. F., Li, M., Farkov, M., Brodsky, L., & Andino, R. (2017) · Nature Communications · doi:10.1038/s41467-017-00354-5 · Cited by 89
Regulation and Consequences of cGAS Activation by Self-DNA
Zierhut, C., & Funabiki, H. (2020) · Trends in Cell Biology · doi:10.1016/j.tcb.2020.05.006 · Cited by 91
Hepatic gap junctions amplify alcohol liver injury by propagating cGAS-mediated IRF3 activation
Luther, J., Khan, S. K., Gala, M. K., Kedrin, D., Sridharan, G. V., Goodman, R. P., Garber, J. J., Masia, R., Diagacomo, E., Adams, D. J., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1911870117 · Cited by 88
RNA viruses and the cGAS-STING pathway: reframing our understanding of innate immune sensing
Webb, L. G., & Fernandez-Sesma, A. (2022) · Current Opinion in Virology · doi:10.1016/j.coviro.2022.101206 · Cited by 91
Chemudupati, M., Kenney, A. D., Bonifati, S., Zani, A., McMichael, T. M., Wu, L. J., & Yount, J. S. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2018.09.012 · Cited by 92
Lin, S., Qu, L., Ettayebi, K., Crawford, S. E., Blutt, S. E., Robertson, M. J., Zeng, X., Tenge, V. R., Ayyar, B. V., Karandikar, U. C., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2010834117 · Cited by 87
A cGAS-Independent STING/IRF7 Pathway Mediates the Immunogenicity of DNA Vaccines
Suschak, J. J., Wang, S., Fitzgerald, K. A., & Lu, S. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1501836 · Cited by 87
Interferons and HIV Infection: The Good, the Bad, and the Ugly
Utay, N. S., & Douek, D. C. (2016) · Pathogens and Immunity · doi:10.20411/pai.v1i1.125 · Cited by 92
IFI44 suppresses HIV-1 LTR promoter activity and facilitates its latency
Power, D. G., Santoso, N. G., Dieringer, M., Yu, J., Huang, H., Simpson, S., Seth, I., Miao, H., & Zhu, J. K. (2015) · Virology · doi:10.1016/j.virol.2015.02.046 · Cited by 86
Sun, C., Schattgen, S., Pisitkun, P., Jørgensen, J., Hilterbrand, A. T., Wang, L. J., West, J. A., Hansen, K., Horan, K., Jakobsen, M. R., et al. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1402495 · Cited by 85
Natural Killer Cells in Viral Hepatitis
Rehermann, B. (2015) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2015.09.004 · Cited by 87
Weiss, C. M., Trobaugh, D. W., Sun, C., Lucas, T. M., Diamond, M., Ryman, K. D., & Klimstra, W. B. (2018) · mSphere · doi:10.1128/msphere.00209-18 · Cited by 85
Self-citationZhao, K., Li, L., Jiang, Y., Gao, F., Zhang, Y., Zhao, W.-Y., Li, G., Yu, L., Zhou, Y., & Tong, G. (2019) · Veterinary Microbiology · doi:10.1016/j.vetmic.2019.05.003 · Cited by 84
Wang, X., Yang, C., Wang, X., Miao, J., Chen, W., Zhou, Y., Xu, Y., An, Y., Cheng, A., Ye, W., et al. (2022) · Neuron · doi:10.1016/j.neuron.2022.10.028 · Cited by 86
Knipe, D. M. (2015) · Virology · doi:10.1016/j.virol.2015.02.009 · Cited by 85
Cytosolic nucleic acid sensors and innate immune regulation
Ori, D., Murase, M., & Kawai, T. (2017) · International Reviews of Immunology · doi:10.1080/08830185.2017.1298749 · Cited by 86
Wang, J., Li, R., Lin, H., Qiu, Q., Lao, M., Zeng, S., Wang, C., Xu, S., Zou, Y., Shi, M., et al. (2019) · International Immunopharmacology · doi:10.1016/j.intimp.2019.105791 · Cited by 85
Ni, J., Guo, T., Zhou, Y., Jiang, S., Zhang, L., & Zhu, Z. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04446-3 · Cited by 83
Cox, D. J., Field, R. H., Williams, D. G., Baran, M., Bowie, A., Cunningham, C. M., & Dunne, A. (2015) · Glia · doi:10.1002/glia.22786 · Cited by 83
Innate immune escape by Dengue and West Nile viruses
Gack, M. U., & Diamond, M. (2016) · Current Opinion in Virology · doi:10.1016/j.coviro.2016.09.013 · Cited by 83
Self-citationBaculovirus as a Tool for Gene Delivery and Gene Therapy
Ono, C., Okamoto, T., Abe, T., & Matsuura, Y. (2018) · Viruses · doi:10.3390/v10090510 · Cited by 83
Viral evasion of DNA-stimulated innate immune responses
Christensen, M. H., & Paludan, S. R. (2016) · Cellular and Molecular Immunology · doi:10.1038/cmi.2016.06 · Cited by 84
Fan, W., Mar, K. B., Sari, L., Gaszek, I. K., Cheng, Q., Evers, B. M., Shelton, J. M., Wight‐Carter, M., Siegwart, D. J., Lin, M. M., et al. (2021) · Cell · doi:10.1016/j.cell.2021.04.047 · Cited by 81
Self-citationSmall molecule STING inhibition improves myocardial infarction remodeling
Rech, L., Abdellatif, M., Poettler, M., Stangl, V., Mabotuwana, N. S., Hardy, S. A., & Rainer, P. P. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.120263 · Cited by 81
Donné, R., Saroul-Aïnama, M., Cordier, P., Hammoutène, A., Kaboré, C., Stadler, M., Nemazanyy, I., Galy–Fauroux, I., Herrag, M., Riedl, T., et al. (2022) · Developmental Cell · doi:10.1016/j.devcel.2022.06.003 · Cited by 85
Nucleic Acid Sensors and Programmed Cell Death
Maelfait, J., Liverpool, L., & Rehwinkel, J. (2019) · Journal of Molecular Biology · doi:10.1016/j.jmb.2019.11.016 · Cited by 85
Influenza virus repurposes the antiviral protein IFIT2 to promote translation of viral mRNAs
Tran, V., Ledwith, M. P., Thamamongood, T., Higgins, C. A., Tripathi, S., Chang, M. W., Benner, C. W., García‐Sastre, A., Schwemmle, M., Boon, A. C. M., et al. (2020) · Nature Microbiology · doi:10.1038/s41564-020-0778-x · Cited by 80
Self-citationcGAS–STING, an important signaling pathway in diseases and their therapy
Li, Q., Wu, P., Du, Q., Hanif, U., Hu, H., & Li, K. (2024) · MedComm · doi:10.1002/mco2.511 · Cited by 83
Tomasello, E., Pollet, É., Manh, T. V., Uzé, G., & Dalod, M. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00526 · Cited by 91
Host Cell Restriction Factors that Limit Influenza A Infection
Villalón‐Letelier, F., Brööks, A. G., Saunders, P. T. K., Londrigan, S. L., & Reading, P. C. (2017) · Viruses · doi:10.3390/v9120376 · Cited by 84
Targeting STING attenuates ROS induced intervertebral disc degeneration
Guo, Q., Zhu, D., Wang, Y., Miao, Z. H., Chen, Z., Lin, Z., Lin, J., Huang, C., Pan, L., Wang, L., et al. (2021) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2021.04.017 · Cited by 79
Wang, S., Chi, X., Wei, H., Chen, Y., Chen, Z., Huang, S., & Chen, J. (2014) · Journal of Virology · doi:10.1128/jvi.00126-14 · Cited by 79
Feng, H., Zhang, Q.-M., Zhang, Y.-B., Li, Z., Zhang, J., Xiong, Y.-W., Wu, M., & Gui, J. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1600159 · Cited by 79
Koenig, A., & Buskiewicz, I. A. (2022) · Antioxidants and Redox Signaling · doi:10.1089/ars.2021.0073 · Cited by 78
Wang, F., Zhao, M., Chang, B., Zhou, Y., Wu, X., Ma, M., Liu, S., Cao, Y., Zheng, M., Dang, Y., et al. (2022) · Molecular Cell · doi:10.1016/j.molcel.2022.03.034 · Cited by 79
A key anti-viral protein, RSAD2/VIPERIN, restricts the release of measles virus from infected cells
Kurokawa, C., Iankov, I. D., & Galanis, E. (2019) · Virus Research · doi:10.1016/j.virusres.2019.01.014 · Cited by 77
Mitochondrial control of innate immune responses
Chen, S., Liao, Z., & Xu, P. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1166214 · Cited by 87
Cui, S., Yu, Q., Chu, L., Cui, Y., Ding, M., Wang, Q., Wang, H., Chen, Y. Z., Liu, X., & Wang, C. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108490 · Cited by 77
Nucleic Acid–Sensing Receptors: Rheostats of Autoimmunity and Autoinflammation
Sharma, S., Fitzgerald, K. A., Cancro, M. P., & Marshak‐Rothstein, A. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1500964 · Cited by 77
Guo, F., Tang, L., Shu, S., Sehgal, M., Sheraz, M. A., Liu, B., Zhao, Q., Cheng, J., Zhao, X., Zhou, T., et al. (2017) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00771-17 · Cited by 81
A NIK–SIX signalling axis controls inflammation by targeted silencing of non-canonical NF-κB
Liu, Z., Mar, K. B., Hanners, N. W., Perelman, S. S., Kanchwala, M., Xing, C., Schoggins, J. W., & Alto, N. M. (2019) · Nature · doi:10.1038/s41586-019-1041-6 · Cited by 79
Self-citationHancks, D. C., Hartley, M. K., Hagan, C., Clark, N. L., & Elde, N. C. (2015) · PLoS Genetics · doi:10.1371/journal.pgen.1005203 · Cited by 76
Infection, Inflammation, and Immunity in Sepsis
Das, U. N. (2023) · Biomolecules · doi:10.3390/biom13091332 · Cited by 75
Xue, B., Yang, D., Wang, J., Xu, Y., Wang, X., Qin, Y., Tian, R., Chen, S., Xie, Q., Liu, N., et al. (2016) · Journal of Virology · doi:10.1128/jvi.00352-16 · Cited by 75
Human Type I Interferon Antiviral Effects in Respiratory and Reemerging Viral Infections
Acosta, P. L., Byrne, A. B., Hijano, D. R., & Talarico, L. B. (2020) · Journal of Immunology Research · doi:10.1155/2020/1372494 · Cited by 75
Induced antiviral innate immunity in Drosophila
Lamiable, O., & Imler, J. (2014) · Current Opinion in Microbiology · doi:10.1016/j.mib.2014.05.006 · Cited by 75
Intracellular STING inactivation sensitizes breast cancer cells to genotoxic agents
Gaston, J., Cheradame, L., Yvonnet, V., Déas, O., Poupon, M., Judde, J., Cairo, S., & Goffin, V. (2016) · Oncotarget · doi:10.18632/oncotarget.12858 · Cited by 75
Lucas, T. M., Richner, J. M., & Diamond, M. S. (2015) · Journal of Virology · doi:10.1128/jvi.02463-15 · Cited by 77
Self-citationMicroglial cGAS drives neuroinflammation in the MPTP mouse models of Parkinson's disease
Ma, C., Liu, Y., Li, S., Ma, C., Huang, J., Wen, S., Yang, S., & Wang, B. (2023) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14157 · Cited by 76
Wang, Y., Wang, W., Xu, L., Zhou, X., Shokrollahi, E., Felczak, K., van der Laan, L. J. W., Pankiewicz, K. W., Sprengers, D., Raat, N. J. H., et al. (2016) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.02700-15 · Cited by 74
Identification of Interferon-Stimulated Gene Proteins That Inhibit Human Parainfluenza Virus Type 3
Rabbani, M. A. G., Ribaudo, M. R., Guo, J., & Barik, S. (2016) · Journal of Virology · doi:10.1128/jvi.01551-16 · Cited by 74
Triggering Intracellular Receptors for Vaccine Adjuvantation
Gutjahr, A., Tiraby, G., Pérouzel, É., Verrier, B., & Paul, S. (2016) · Trends in Immunology · doi:10.1016/j.it.2016.07.001 · Cited by 73
RBP–RNA interactions in the control of autoimmunity and autoinflammation
Liu, J., & Cao, X. (2023) · Cell Research · doi:10.1038/s41422-022-00752-5 · Cited by 74
The Peculiar Characteristics of Fish Type I Interferons
Boudinot, P., Langevin, C., Secombes, C. J., & Levraud, J. (2016) · Viruses · doi:10.3390/v8110298 · Cited by 73
Deb, P., Dai, J., Singh, S., Kalyoussef, E., & Fitzgerald-Bocarsly, P. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.1800933 · Cited by 72
IFI16: At the Interphase between Innate DNA Sensing and Genome Regulation
Jakobsen, M. R., & Paludan, S. R. (2014) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2014.06.004 · Cited by 72
Innate Immune Sensing of Viruses and Its Consequences for the Central Nervous System
Singh, H., Koury, J., & Kaul, M. (2021) · Viruses · doi:10.3390/v13020170 · Cited by 75
The Emerging Role of Nuclear Viral DNA Sensors
Diner, B. A., Lum, K. K., & Cristea, I. M. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.r115.652289 · Cited by 74
Hepatitis C Virus NS4B Can Suppress STING Accumulation To Evade Innate Immune Responses
Yi, G., Wen, Y., Shu, C., Han, Q., Konan, K. V., Li, P., & Kao, C. C. (2015) · Journal of Virology · doi:10.1128/jvi.01720-15 · Cited by 74
Innate Immune Mechanisms and Herpes Simplex Virus Infection and Disease
Kurt‐Jones, E. A., Orzalli, M. H., & Knipe, D. M. (2017) · Advances in anatomy, embryology and cell biology · doi:10.1007/978-3-319-53168-7_3 · Cited by 71
Crosstalk between nucleocytoplasmic trafficking and the innate immune response to viral infection
Shen, Q., Wang, Y. E., & Palazzo, A. F. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.100856 · Cited by 71
A defective viral genome strategy elicits broad protective immunity against respiratory viruses
Xiao, Y., Lidsky, P. V., Shirogane, Y., Aviner, R., Wu, C.-T., Li, W., Zheng, W., Talbot, D., Catching, A., Doitsh, G., et al. (2021) · Cell · doi:10.1016/j.cell.2021.11.023 · Cited by 75
Mitochondrial DNA Release Contributes to Intestinal Ischemia/Reperfusion Injury
Liao, S., Luo, J., Kadier, T., Ding, K., Chen, R., & Meng, Q. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.854994 · Cited by 74
Regulation of the Trafficking and Antiviral Activity of IFITM3 by Post-Translational Modifications
Chesarino, N. M., McMichael, T. M., & Yount, J. S. (2014) · Future Microbiology · doi:10.2217/fmb.14.65 · Cited by 70
Mitochondria and Viral Infection: Advances and Emerging Battlefronts
Sorouri, M., Chang, T., & Hancks, D. C. (2022) · mBio · doi:10.1128/mbio.02096-21 · Cited by 72
Interferons: Reprogramming the Metabolic Network against Viral Infection
Raniga, K., & Liang, C. (2018) · Viruses · doi:10.3390/v10010036 · Cited by 74
The cGas–Sting Signaling Pathway Is Required for the Innate Immune Response Against Ectromelia Virus
Cheng, W., He, X., Jia, H., Chen, G.-H., Jin, Q., Long, Z.-L., & Jing, Z. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01297 · Cited by 69
Innate recognition of microbial-derived signals in immunity and inflammation
Zhang, Y., & Liang, C. (2016) · Science China Life Sciences · doi:10.1007/s11427-016-0325-6 · Cited by 69
Wu, X., Wang, J., Wang, S., Wu, F., Chen, Z., Li, C., Cheng, G., & Qin, F. X.-F. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.00344 · Cited by 69
Riegger, D., Hai, R., Dornfeld, D., Mänz, B., Leyva-Grado, V. H., Sánchez-Aparicio, M. T., Albrecht, R. A., Palese, P., Haller, O., Schwemmle, M., et al. (2014) · Journal of Virology · doi:10.1128/jvi.02406-14 · Cited by 67
Self-citationChen, W., Li, S., Yu, H., Liu, X., Huang, L., Wang, Q., Liu, H., Cui, Y., Tang, Y., Zhang, P., et al. (2016) · PLoS Pathogens · doi:10.1371/journal.ppat.1005462 · Cited by 67
Stavrou, S., Aguilera, A. N., Blouch, K., & Ross, S. R. (2018) · mBio · doi:10.1128/mbio.00923-18 · Cited by 67
Activation of Stimulation of Interferon Genes (STING) Signal and Cancer Immunotherapy
Luo, K.-W., Li, N., Ye, W., Gao, H., Luo, X., & Cheng, B. (2022) · Molecules · doi:10.3390/molecules27144638 · Cited by 68
Grünvogel, O., Esser‐Nobis, K., Reustle, A., Schult, P., Müller, B., Metz, P., Trippler, M., Windisch, M. P., Frese, M., Binder, M., et al. (2015) · Journal of Virology · doi:10.1128/jvi.01297-15 · Cited by 65
Growing tumors induce a local STING dependent Type I IFN response in dendritic cells
Andzinski, L., Spanier, J., Kasnitz, N., Kröger, A., Jin, L., Brinkmann, M. M., Kalinke, U., Weiß, S., Jabłońska, J., & Lienenklaus, S. (2016) · International Journal of Cancer · doi:10.1002/ijc.30159 · Cited by 67
Age-related alterations in immune responses to West Nile virus infection
Montgomery, R. R. (2016) · Clinical & Experimental Immunology · doi:10.1111/cei.12863 · Cited by 67
Deciphering the pathways to antiviral innate immunity and inflammation
Yang, Q., & Shu, H. (2019) · Advances in immunology · doi:10.1016/bs.ai.2019.11.001 · Cited by 66
The MAVS Immune Recognition Pathway in Viral Infection and Sepsis
Sharma, A., Kontodimas, K., & Bosmann, M. (2021) · Antioxidants and Redox Signaling · doi:10.1089/ars.2021.0167 · Cited by 65
Coevolution pays off: Herpesviruses have the license to escape the DNA sensing pathway
Stempel, M., Chan, B., & Brinkmann, M. M. (2019) · Medical Microbiology and Immunology · doi:10.1007/s00430-019-00582-0 · Cited by 65
Boys, I. N., Xu, E., Mar, K. B., Cruz-Rivera, P. C. D. L., Eitson, J. L., Moon, B., & Schoggins, J. W. (2020) · Cell Host & Microbe · doi:10.1016/j.chom.2020.09.014 · Cited by 63
Self-citationFlaviviruses: Innate Immunity, Inflammasome Activation, Inflammatory Cell Death, and Cytokines
Pan, Y., Cai, W., Cheng, A., Wang, M., Yin, Z., & Jia, R. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.829433 · Cited by 68
Xu, L., Zhou, X., Wang, W., Wang, Y., Yin, Y., van der Laan, L. J. W., Sprengers, D., Metselaar, H. J., Peppelenbosch, M. P., & Pan, Q. (2016) · The FASEB Journal · doi:10.1096/fj.201600356r · Cited by 63
Yang, J., Tian, B., Sun, H., Garofalo, R., & Brasier, A. R. (2017) · Nature Microbiology · doi:10.1038/nmicrobiol.2017.86 · Cited by 64
Interruption of post-Golgi STING trafficking activates tonic interferon signaling
Tu, X., Chu, T., Jeltema, D., Abbott, K., Yang, K., Xing, C., Han, J., Dobbs, N., & Yan, N. (2022) · Nature Communications · doi:10.1038/s41467-022-33765-0 · Cited by 63
Wu, N. N., Wang, L., Wang, L., Xu, X., Lopaschuk, G. D., Zhang, Y., & Ren, J. T. (2023) · Experimental & Molecular Medicine · doi:10.1038/s12276-022-00923-9 · Cited by 63
Mahjoor, M., Mahmoudvand, G., Farokhi, S., Shadab, A., Kashfi, M., & Afkhami, H. (2023) · Cell Communication and Signaling · doi:10.1186/s12964-023-01240-y · Cited by 63
Norovirus replication, host interactions and vaccine advances
Prasad, B. V. V., Atmar, R. L., Ramani, S., Palzkill, T. G., Song, Y., Crawford, S. E., & Estes, M. K. (2025) · Nature Reviews Microbiology · doi:10.1038/s41579-024-01144-9 · Cited by 62
Evasion of Innate and Intrinsic Antiviral Pathways by the Zika Virus
Serman, T. M., & Gack, M. U. (2019) · Viruses · doi:10.3390/v11100970 · Cited by 63
Danziger, O., Patel, R. S., DeGrace, E. J., Rosen, M. R., & Rosenberg, B. R. (2022) · PLoS Pathogens · doi:10.1371/journal.ppat.1010464 · Cited by 62
Mucolipin-2 Cation Channel Increases Trafficking Efficiency of Endocytosed Viruses
Rinkenberger, N., & Schoggins, J. W. (2018) · mBio · doi:10.1128/mbio.02314-17 · Cited by 63
Self-citationA molecular arms race between host innate antiviral response and emerging human coronaviruses
Wong, L.-Y. R., Lui, P., & Jin, D. (2016) · Virologica Sinica · doi:10.1007/s12250-015-3683-3 · Cited by 59
Anghelina, D., Lam, E., & Falck-Pedersen, E. (2016) · Journal of Virology · doi:10.1128/jvi.00500-16 · Cited by 59
Post-Translational Modifications of cGAS-STING: A Critical Switch for Immune Regulation
Yu, Y., Liu, J., Liu, C., Liu, R., Liu, L., Yu, Z., Zhuang, J., & Sun, C. (2022) · Cells · doi:10.3390/cells11193043 · Cited by 59
Schisandrin C enhances cGAS-STING pathway activation and inhibits HBV replication
Jia, Z., Xu, G., Hou, X., Mu, W., Yang, H., Shi, W., Wen, J., Liu, T., Wu, Z., Jun, B., et al. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.116427 · Cited by 58
Skin innate immune response to flaviviral infection
Garcia, M., Wehbe, M., Lévêque, N., & Bodet, C. (2017) · European Cytokine Network · doi:10.1684/ecn.2017.0394 · Cited by 65
STING induces ZBP1-mediated necroptosis independently of TNFR1 and FADD
Kelepouras, K., Saggau, J., Bonasera, D., Kiefer, C., Locci, F., Rakhsh-Khorshid, H., Grauvogel, L., Varanda, A. B., Peifer, M., Loricchio, E., et al. (2025) · Nature · doi:10.1038/s41586-025-09536-4 · Cited by 64
The role of cGAS in innate immunity and beyond
Ablasser, A., & Gulen, M. F. (2016) · Journal of Molecular Medicine · doi:10.1007/s00109-016-1423-2 · Cited by 57
Okamoto, M., Tsukamoto, H., Kouwaki, T., Seya, T., & Oshiumi, H. (2017) · Viral Immunology · doi:10.1089/vim.2016.0178 · Cited by 58
Caspases control antiviral innate immunity
Chen, H., Ning, X., & Jiang, Z. (2017) · Cellular and Molecular Immunology · doi:10.1038/cmi.2017.44 · Cited by 59
Do Human Endogenous Retroviruses Contribute to Multiple Sclerosis, and if So, How?
Morris, G., Maes, M. H. J., Murdjeva, M., & Puri, B. K. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1255-x · Cited by 60
Metadata
- Authors
- Schoggins, J. W., MacDuff, D. A., Imanaka, N., Gainey, M. D., Shrestha, B., Eitson, J. L., Mar, K. B., Richardson, R. B., Ratushny, A. V., Litvak, V., Dabelic, R., Manicassamy, B., Aitchison, J. D., Aderem, A., Elliott, R. M., García-Sastre, A., Racaniello, V., Snijder, E. J., Yokoyama, W. M., Diamond, M. S., Virgin, H. W., & Rice, C. M.
- Affiliations
- MRC University of Glasgow Centre for Virus Research (GB)
- Washington University in St. Louis (US)
- Rockefeller University (US)
- Howard Hughes Medical Institute (US)
- The University of Texas Southwestern Medical Center (US)
- Center for Infectious Disease Research (US)
- Columbia University (US)
- University of Chicago (US)
- University of St Andrews (GB)
- Leiden University Medical Center (NL)
- Corresponding author
- Schoggins, John W.
- Rice, Charles M.
- ORCID
- Venue
- Nature
- Published
- 2013-11-27
- Volume
- 505
- Issue
- 7485
- Pages
- 691-695
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC4077721
- OpenAlex
- W2058277625
- Cited by
- 896
- References
- 39
- Citations by year
- 2026: 41 · 2025: 49 · 2024: 51 · 2023: 80 · 2022: 76 · 2021: 79 · 2020: 92 · 2019: 74 · 2018: 82 · 2017: 58 · 2016: 74 · 2015: 87 · 2014: 52
- FWCI
- 39.24
- Type
- journal article
- Language
- en
- Update notices
- erratum (2015-07-08)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Leiden Repository (Leiden University) (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- U.S. Department of Veterans Affairs (HHSN272200900041CU19)
- Wellcome Trust (099220)
- National Institutes of Health (5t32ai005284-45)
- National Institute of General Medical Sciences (U54GM103511, GM103511, GM 076547, P50GM076547)
- National Institute of Allergy and Infectious Diseases (T32-AI005284, AI 057160, AI091707, U01AI095611, HHSN266200700010C, AI057158, R01AI091707, AI104972, U19AI083025, R01AI032972, AI095611, U54AI057160, R01AI025032, R00AI095320, AI083025, U54AI057158, R01AI102597, R01AI104972, HHSN272200900041C)
- National Institute of Diabetes and Digestive and Kidney Diseases (K01DK095031, DK095031)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (T32AR007279)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
- Keywords
- cGAS, interferon-stimulated genes, antiviral innate immunity, positive-sense single-stranded RNA viruses, negative-sense RNA viruses, DNA viruses, STING, IRF3, type I interferon
- MeSH terms
- STING Protein, Cyclic Guanosine Monophosphate-Adenosine Monophosphate Synthase, Animals, DNA Viruses, Flow Cytometry, Immunity, Innate, Interferons, Membrane Proteins, Nucleotidyltransferases, RNA Viruses, Substrate Specificity, Viruses, Gene Library, Cluster Analysis, Mice, Knockout, STAT1 Transcription Factor, Interferon Regulatory Factor-3, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review