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Exosomes: A New Hope for Angiogenesis-Mediated Bone Regeneration

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A Jack of All Trades: Impact of Glucocorticoids on Cellular Cross-Talk in Osteoimmunology

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Substance P blocks ovariectomy-induced bone loss by modulating inflammation and potentiating stem cell function

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When a House Is Not a Home: A Survey of Antimetastatic Niches and Potential Mechanisms of Disseminated Tumor Cell Suppression

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Chimeric Peptides Quickly Modify the Surface of Personalized 3D Printing Titanium Implants to Promote Osseointegration

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Bone morphogenetic protein 9 enhances osteogenic and angiogenic responses of human amniotic mesenchymal stem cells cocultured with umbilical vein endothelial cells through the PI3K/AKT/m-TOR signaling pathway

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Exploring the effect of the “quaternary regulation” theory of “peripheral nerve-angiogenesis-osteoclast-osteogenesis” on osteoporosis based on neuropeptides

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Preparation and Biocompatibility of Core‐Shell Microspheres for Sequential, Sustained Release of BMP‐2 and VEGF

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Caffeic Acid‐Deferoxamine Self‐Polymerization Coating on Ti Implant Promotes Osteointegration by Synergetic Regulation of Multi‐Pathways in ONFH Mechanism

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Review on Additives in Hydrogels for 3D Bioprinting of Regenerative Medicine: From Mechanism to Methodology

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Geometric Angles and Gene Expression in Cells for Structural Bone Regeneration

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Reassessing endothelial-to-mesenchymal transition in mouse bone marrow: insights from lineage tracing models

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Pericytes as the Orchestrators of Vasculature and Adipogenesis

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ETV2 regulating PHD2-HIF-1α axis controls metabolism reprogramming promotes vascularized bone regeneration

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ABCG2-Expressing Clonal Repopulating Endothelial Cells Serve to Form and Maintain Blood Vessels

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Lack of endogenous parathyroid hormone delays fracture healing by inhibiting vascular endothelial growth factor‑mediated angiogenesis

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Collagen XIII-derived ectodomain regulates bone angiogenesis and intracortical remodeling

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BMP9 exhibits dual and coupled roles in inducing osteogenic and angiogenic differentiation of mesenchymal stem cells

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Mechanisms Supporting the Use of Beta-Blockers for the Management of Breast Cancer Bone Metastasis

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Antagonism Between PEDF and TGF-β Contributes to Type VI Osteogenesis Imperfecta Bone and Vascular Pathogenesis

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HIF-1α and periodontitis: Novel insights linking host-environment interplay to periodontal phenotypes

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Hyperbaric oxygen promotes bone regeneration by activating the mechanosensitive Piezo1 pathway in osteogenic progenitors

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Fenestrated Endothelial Cells across Organs: Insights into Kidney Function and Disease

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Revolutionizing Bone Regeneration: Vascularized Bone Tissue Engineering with Advanced 3D Printing Technology

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Advancement in smart bone implants: the latest multifunctional strategies and synergistic mechanisms for tissue repair and regeneration

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Osteoinductive Activity of Bone Scaffold Bioceramic Companied with Control Release of VEGF Protein Treated Dental stem cells as A New Concept for Bone Regeneration: Part II

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Calcification of lower extremity arteries is related to the presence of osteoporosis in postmenopausal women with type 2 diabetes mellitus: a cross-sectional observational study

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A Review Into the Insights of the Role of Endothelial Progenitor Cells on Bone Biology

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Single-cell spatiotemporal analysis reveals cell fates and functions of transplanted mesenchymal stromal cells during bone repair

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Identification of fecal microbiome signatures associated with familial longevity and candidate metabolites for healthy aging

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Endothelial-derived angiocrine factors as instructors of embryonic development

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Black phosphorus quantum dot-modified ADSCs as a novel therapeutic for periodontitis bone loss coupling of osteogenesis and osteoimmunomodulation

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3D Printed O2-Generating Scaffolds Enhance Osteoprogenitor- and Type H Vessel Recruitment During Bone Healing

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Isolation and Culture Expansion of Tumor-specific Endothelial Cells

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Intrafibrillar silicified collagen scaffold promotes in-situ bone regeneration by activating the monocyte p38 signaling pathway

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Regulation of bone blood flow in humans: The role of nitric oxide, prostaglandins, and adenosine

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Bone‐targeted delivery of TGF‐β type 1 receptor inhibitor rescues uncoupled bone remodeling in Camurati–Engelmann disease

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Parathyroid Hormone (PTH) Increases Skeletal Tumour Growth and Alters Tumour Distribution in an In Vivo Model of Breast Cancer

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Cellular senescence mediates the detrimental effect of prenatal dexamethasone exposure on postnatal long bone growth in mouse offspring

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Increased Osteoblastic Cxcl9 Contributes to the Uncoupled Bone Formation and Resorption in Postmenopausal Osteoporosis

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MicroRNA-205 mediates endothelial progenitor functions in distraction osteogenesis by targeting the transcription regulator NOTCH2

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Restoring Tissue Homeostasis at Metastatic Sites: A Focus on Extracellular Vesicles in Bone Metastasis

Giannandrea, D., Citro, V., Lesma, E. A., Bignotto, M., Platonova, N., & Chiaramonte, R. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.644109 · Cited by 20

Pulsed electromagnetic fields attenuate glucocorticoid-induced bone loss by targeting senescent LepR+ bone marrow mesenchymal stromal cells

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Efficacy of Honeycomb TCP-induced Microenvironment on Bone Tissue Regeneration in Craniofacial Area

Watanabe, S., Takabatake, K., Tsujigiwa, H., Watanabe, T., Tokuyama, E., Ito, S., Nagatsuka, H., & Kimata, Y. (2016) · International Journal of Medical Sciences · doi:10.7150/ijms.15560 · Cited by 20

Erratum: Corrigendum: Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone

Kusumbe, A. P., Ramasamy, S. K., & Adams, R. H. (2014) · Nature · doi:10.1038/nature13720 · Cited by 20

Microenvironment-responsive injectable hydrogel for neuro-vascularized bone regeneration

Wang, W., Hu, C., Xiao, J., Luo, D., Hou, Y., Zhan, J., Hou, Y., Li, X., Yang, H., Chen, S., et al. (2024) · Materials Today Bio · doi:10.1016/j.mtbio.2024.101369 · Cited by 19

Bionic Nanostructures Create Mechanical Signals to Mediate the Composite Structural Bone Regeneration Through Multi‐System Regulation

Pei, Y., Wang, Y., Chen, J., Zhou, J., Han, Y., Liu, X., Chen, S., Chen, S., He, D., Wu, Y., et al. (2025) · Advanced Science · doi:10.1002/advs.202502299 · Cited by 24

Insufficient blood supply of fovea capitis femoris, a risk factor of femoral head osteonecrosis

Zhao, K., Zhang, F., Quan, K., Zhu, B., Li, G., & Mei, J. (2021) · Journal of Orthopaedic Surgery and Research · doi:10.1186/s13018-021-02564-6 · Cited by 19

The Cellular Choreography of Osteoblast Angiotropism in Bone Development and Homeostasis

Neag, G., Finlay, M., & Naylor, A. J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147253 · Cited by 19

Interrod spacing dependent angiogenesis and osseointegration of Na2TiO3 nanorods-patterned arrays via immunoregulation

Yu, D., Guo, S., Yang, D. S., Li, B., Guo, Z., & Han, Y. N. (2021) · Chemical Engineering Journal · doi:10.1016/j.cej.2021.131187 · Cited by 19

Metabolic effects of CoCr-enriched medium on shear-stressed endothelial cell and osteoblasts: A possible mechanism involving a hypoxic condition on bone healing

Fernandes, C. J. D. C., de Almeida, G. S., Pinto, T. S., Teixeira, S. A., Bezerra, F., & Zambuzzi, W. F. (2021) · Materials Science and Engineering C · doi:10.1016/j.msec.2021.112353 · Cited by 19

Tanshinol Alleviates Microcirculation Disturbance and Impaired Bone Formation by Attenuating TXNIP Signaling in GIO Rats

Lai, W., Mo, Y., Wang, D., Zhong, Y., Lu, L., Wang, J., Cui, L., Liu, Y., & Yang, Y. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.722175 · Cited by 19

HA-g-CS Implant and Moderate-intensity Exercise Stimulate Subchondral Bone Remodeling and Promote Repair of Osteochondral Defects in Mice

Shen, K., Liu, X., Qin, H., Chai, Y., Wang, L., & Yu, B. (2021) · International Journal of Medical Sciences · doi:10.7150/ijms.63401 · Cited by 19

Bone marrow sinusoidal endothelium controls terminal erythroid differentiation and reticulocyte maturation

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Extracellular Vesicles in Osteosarcoma: Antagonists or Therapeutic Agents?

Martino, V. D., Rossi, M., Battafarano, G., Pepe, J., Minisola, S., & Fattore, A. D. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222212586 · Cited by 19

A Brief Review on Hydroxyapatite Nanoparticles Interactions with Biological Constituents

Torres, F. C. L., de Sousa, E. M. B., & Cipreste, M. F. (2022) · Journal of Biomaterials and Nanobiotechnology · doi:10.4236/jbnb.2022.131002 · Cited by 19

To improve the angiogenesis of endothelial cells on Ti-Cu alloy by the synergistic effects of Cu ions release and surface nanostructure

Zhang, Y., Cui, S., Cao, S., Yang, L. J., Qin, G. W., & Zhang, E. (2022) · Surface and Coatings Technology · doi:10.1016/j.surfcoat.2022.128116 · Cited by 19

MicroRNAs: Emerging Regulators of Metastatic Bone Disease in Breast Cancer

Haider, M., Smit, D. J., & Taipaleenmäki, H. (2022) · Cancers · doi:10.3390/cancers14030729 · Cited by 19

Nanohydroxyapatite‐Blasted Bioactive Surface Drives Shear‐Stressed Endothelial Cell Growth and Angiogenesis

Pinto, T. S., Martins, B. R., Ferreira, M. R., Bezerra, F., & Zambuzzi, W. F. (2022) · BioMed Research International · doi:10.1155/2022/1433221 · Cited by 19

Bevacizumab‐Laden Nanofibers Simulating an Antiangiogenic Niche to Improve the Submuscular Stability of Stem Cell Engineered Cartilage

Zhu, X., Xu, Y., Xu, X., Zhu, J., Chen, L., Xu, Y., Yang, Y., & Song, N. (2022) · Small · doi:10.1002/smll.202201874 · Cited by 19

WHIM Syndrome-linked CXCR4 mutations drive osteoporosis

Anginot, A., Nguyen, J., Nader, Z. A., Rondeau, V., Bonaud, A., Kalogeraki, M., Boutin, A., Lemos, J. P., Bisio, V., Koenen, J., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-37791-4 · Cited by 20

Iron accumulation and its impact on osteoporotic fractures in postmenopausal women

Cai, H., Zhang, H., He, W., & Zhang, H. (2023) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b2200519 · Cited by 19

Multimodality imaging reveals angiogenic evolution in vivo during calvarial bone defect healing

Ren, Y., Chu, X., Senarathna, J., Bhargava, A., Grayson, W. L., & Pathak, A. P. (2023) · Angiogenesis · doi:10.1007/s10456-023-09899-0 · Cited by 19

Transforming the Niche: The Emerging Role of Extracellular Vesicles in Acute Myeloid Leukaemia Progression

Mendes, M., Monteiro, A. C., Neto, E., Barrias, C. C., Simões, M. S., Duarte, D., & Caires, H. R. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25084430 · Cited by 19

Porous metal materials for applications in orthopedic field: A review on mechanisms in bone healing

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Antibacterial bioadaptive scaffold promotes vascularized bone regeneration by synergistical action of intrinsic stimulation and immunomodulatory activity

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A multifunctional bioactive material that stimulates osteogenesis and promotes the vascularization bone marrow stem cells and their resistance to bacterial infection

Ma, C., Wei, Q., Cao, B. W., Cheng, X., Tian, J., Pu, H., Yusufu, A., & Cao, L. (2017) · PLoS ONE · doi:10.1371/journal.pone.0172499 · Cited by 19

miRNA‐21 deficiency impairs alveolar socket healing in mice

Strauß, F. J., Stähli, A., Kobatake, R., Tangl, S., Heimel, P., Alccayhuaman, K. A. A., Schosserer, M., Hackl, M., Grillari, J., & Gruber, R. (2020) · Journal of Periodontology · doi:10.1002/jper.19-0567 · Cited by 19

Heparinized chitosan/hydroxyapatite scaffolds stimulate angiogenesis

Nájera-Romero, G. V., Yar, M., & Rehman, I. U. (2020) · Functional Composite Materials · doi:10.1186/s42252-020-00012-y · Cited by 19

New Insights to the Crosstalk between Vascular and Bone Tissue in Chronic Kidney Disease–Mineral and Bone Disorder

Mace, M. L., Egstrand, S., Morevati, M., Ølgaard, K., & Lewin, E. (2021) · Metabolites · doi:10.3390/metabo11120849 · Cited by 19

Identification of a prolonged action molecular GLP-1R agonist for the treatment of femoral defects

Wang, N., Liu, X., Shi, L., Liu, Y., Guo, S., Liu, W., Li, X., Meng, J., Ma, X., & Guo, Z. (2020) · Biomaterials Science · doi:10.1039/c9bm01426h · Cited by 18

Self-assembled peptide hydrogel loaded with functional peptide Dentonin accelerates vascularized bone tissue regeneration in critical-size bone defects

Liu, Y., Li, L., He, M., Xu, Y., Wu, Z., Xu, X., Luo, K., & Lv, H. (2024) · Regenerative Biomaterials · doi:10.1093/rb/rbae106 · Cited by 19

Single-cell transcriptomics identifies PDGFRA+ progenitors orchestrating angiogenesis and periodontal tissue regeneration

Liu, J., He, J., Zhang, Z., Liu, L. N., Cao, Y., Zhang, X., Cai, X., Luo, X., Lei, X., Zhang, N., et al. (2025) · International Journal of Oral Science · doi:10.1038/s41368-025-00384-6 · Cited by 18

Long non-coding RNA HCAR promotes endochondral bone repair by upregulating VEGF and MMP13 in hypertrophic chondrocyte through sponging miR-15b-5p

Bai, Y., Gong, X., Dong, R., Cao, Z., Dou, C., Liu, C., Li, J., Kang, F., Dai, J., Zhao, C., et al. (2020) · Genes & Diseases · doi:10.1016/j.gendis.2020.07.013 · Cited by 18

Graphene Oxide Framework Structures and Coatings: Impact on Cell Adhesion and Pre-Vascularization Processes for Bone Grafts

Wang, F., Saure, L. M., Schütt, F., Lorich, F., Rasch, F., Nia, A. S., Feng, X., Seekamp, A., Klüter, T., Naujokat, H., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23063379 · Cited by 18

Controlled mechanical loading improves bone regeneration by regulating type H vessels in a S1Pr1 ‐dependent manner

Yang, C., Liu, Y., Wang, Z., Lin, M., & Liu, C. (2022) · The FASEB Journal · doi:10.1096/fj.202200339rrr · Cited by 18

ROS Scavenging Graphene‐Based Hydrogel Enhances Type H Vessel Formation and Vascularized Bone Regeneration via ZEB1/Notch1 Mediation

Zhou, J., Li, Y., He, J., Liu, L., Hu, S., Guo, M., Liu, T., Liu, J., Wang, J., Guo, B., et al. (2023) · Macromolecular Bioscience · doi:10.1002/mabi.202200502 · Cited by 20

Hollow Hydroxyapatite Microspheres Loaded with rhCXCL13 to Recruit BMSC for Osteogenesis and Synergetic Angiogenesis to Promote Bone Regeneration in Bone Defects

Zeng, J., Xiong, S., Zhou, J., Peng, W., Guo, K., Wang, F., Ouyang, M., Long, Z., Yao, A., Li, J., et al. (2023) · International Journal of Nanomedicine · doi:10.2147/ijn.s408905 · Cited by 18

11β-Hydroxysteroid Dehydrogenase Type 1 Facilitates Osteoporosis by Turning on Osteoclastogenesis through Hippo Signaling

Li, H., Hu, S., Wu, R., Zhou, H., Zhang, K., Li, K., Lin, W., Shi, Q., Chen, H., & Lv, S. (2023) · International Journal of Biological Sciences · doi:10.7150/ijbs.82933 · Cited by 18

Region-specific sympatho-adrenergic regulation of specialized vasculature in bone homeostasis and regeneration

Xu, H., Liu, J.-X., Zheng, C., Liu, L., Ma, C., Tian, J.-Y., Yuan, Y., Cao, Y., Xing, S., Liu, S., et al. (2023) · iScience · doi:10.1016/j.isci.2023.107455 · Cited by 18

Cellular Scale Curvature in Bioceramic Scaffolds Enhanced Bone Regeneration by Regulating Skeletal Stem Cells and Vascularization

Liu, Y., Wang, Y., Lin, M., Liu, H., Pan, Y., Wu, J., Guo, Z., Li, J., Yan, B., Zhou, H., et al. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202401667 · Cited by 18

Vascular niches: endothelial cells as tissue‐ and site‐specific multifunctional team players in health and disease

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The anabolic action of intermittent parathyroid hormone on cortical bone depends partly on its ability to induce nitric oxide‐mediated vasorelaxation in BALB/c mice

Gohin, S., Carriero, A., Chenu, C., Pitsillides, A. A., Arnett, T. R., & Marenzana, M. (2016) · Cell Biochemistry and Function · doi:10.1002/cbf.3164 · Cited by 18

Notch signaling represses hypoxia-inducible factor-1α-induced activation of Wnt/β-catenin signaling in osteoblasts under cobalt-mimicked hypoxia

LI, C.-T., LIU, J.-X., Yu, B., Liu, R., Dong, C., & Li, S. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.5324 · Cited by 18

Is subchondral bone cyst formation in non-load-bearing region of osteoarthritic knee a vascular problem?

Chan, P. M., Wen, C., Yang, W. C., Yan, C., & Chiu, P. (2017) · Medical Hypotheses · doi:10.1016/j.mehy.2017.09.027 · Cited by 18

Osteoinductivity of nanostructured hydroxyapatite‐functionalized gelatin modulated by human and endogenous mesenchymal stromal cells

Bella, E. D., Parrilli, A., Bigi, A., Panzavolta, S., Amadori, S., Giavaresi, G., Martini, L., Borsari, V., & Fini, M. (2017) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.36295 · Cited by 18

The Instructive Role of the Bone Marrow Niche in Aging and Leukemia

Lazzari, E., & Butler, J. M. (2018) · Current Stem Cell Reports · doi:10.1007/s40778-018-0143-7 · Cited by 20

Critical Considerations for Regeneration of Vascularized Composite Tissues

Mohammadi, M. S., Buchen, J. T., Pasquina, P. F., Niklason, L. E., Alvarez, L. M., & Jariwala, S. H. (2020) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2020.0223 · Cited by 19

Endothelial Notch activity promotes angiogenesis and osteogenesis in bone

Ramasamy, S. K., Kusumbe, A. P., Wang, L., & Adams, R. H. (2014) · Nature · doi:10.1038/nature13146 · Cited by 1,071

Angiogenesis-osteogenesis coupling: a key element in bone physiology and regeneration

Boston, B., Ipe, D. S., Căpitănescu, B., Hamlet, S. M., Love, R. M., Nusem, I., Miroiu, R. I., Warnke, P. H., & Petcu, E. B. (2021) · Vascular Cell · doi:10.24238/13221-13-1-203 · Cited by 8

Unique bone marrow blood vessels couple angiogenesis and osteogenesis in bone homeostasis and diseases

Zhao, Y., & Xie, L. (2020) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14348 · Cited by 57

Endothelial diversity in bone vasculature coordinates osteogenesis and hematopoiesis

Iga, T. (2026) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-026-01702-6

1018 – HETEROGENEITY AND FUNCTIONAL SPECIALIZATION OF THE BONE MICROVASCULATURE

Adams, R. H., Bixel, M. G., Chen, Q., Koh, B. I., Liu, Y., & Sivaraj, K. K. (2022) · Experimental Hematology · doi:10.1016/j.exphem.2022.07.021