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Vitexin Regulates Angiogenesis and Osteogenesis in Ovariectomy-Induced Osteoporosis of Rats via the VDR/PI3K/AKT/eNOS Signaling Pathway.

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A pleiotropic SIS-based hydrogel with immunomodulation via NLRP3 inflammasome inhibition for diabetic bone regeneration

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Tough physically crosslinked poly(vinyl alcohol)-based hydrogels loaded with collagen type I to promote bone regeneration in vitro and in vivo

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Innovative Biomaterials for Bone Tumor Treatment and Regeneration: Tackling Postoperative Challenges and Charting the Path Forward

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l-arginine promotes angio-osteogenesis to enhance oxidative stress-inhibited bone formation by ameliorating mitophagy

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Fabricating oxygen self-supplying 3D printed bioactive hydrogel scaffold for augmented vascularized bone regeneration

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Smart multifunctional Cu2O@RuO2 nanozyme for angiogenesis and osteogenesis in periodontitis

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Peripheral neuronal sensitization and neurovascular remodelling in osteoarthritis pain

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Sustained dual release of placental growth factor-2 and bone morphogenic protein-2 from heparin-based nanocomplexes for direct osteogenesis

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Micro-computed tomography characterization of tissue engineering scaffolds: effects of pixel size and rotation step

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Lentivirus‑mediated microRNA‑26a overexpression in bone mesenchymal stem cells facilitates bone regeneration in bone defects of calvaria in mice

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In vivo delivery of VEGF RNA and protein to increase osteogenesis and intraosseous angiogenesis

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Nuciferine prevents bone loss by disrupting multinucleated osteoclast formation and promoting type H vessel formation

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Utilizing biodegradable alloys as guided bone regeneration (GBR) membrane: Feasibility and challenges

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Harnessing electromagnetic fields to assist bone tissue engineering

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OASIS modulates hypoxia pathway activity to regulate bone angiogenesis

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An Extracellular Matrix-like Surface for Zn Alloy to Enhance Bone Regeneration

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Multifunctional Bionic Periosteum with Ion Sustained‐Release for Bone Regeneration

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The Biological Effects of Magnesium-Based Implants on the Skeleton and Their Clinical Implications in Orthopedic Trauma Surgery

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LIPUS promotes spinal fusion coupling proliferation of type H microvessels in bone

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Targeting the Metastatic Bone Microenvironment by MicroRNAs

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Bidirectional juxtacrine ephrinB2/Ephs signaling promotes angiogenesis of ECs and maintains self-renewal of MSCs

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From the Performance to the Essence: The Biological Mechanisms of How Tantalum Contributes to Osteogenesis

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Low-activity programming of the PDGFRβ/FAK pathway mediates H-type vessel dysplasia and high susceptibility to osteoporosis in female offspring rats after prenatal dexamethasone exposure

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Laminin alpha 4 promotes bone regeneration by facilitating cell adhesion and vascularization

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Development of a Gene-Activated Scaffold Incorporating Multifunctional Cell-Penetrating Peptides for pSDF-1α Delivery for Enhanced Angiogenesis in Tissue Engineering Applications

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Glucocorticoid-induced expansion of classical monocytes contributes to bone loss

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Neuron-to-vessel signaling is a required feature of aberrant stem cell commitment after soft tissue trauma

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Gli1 + -PDL Cells Contribute to Alveolar Bone Homeostasis and Regeneration

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Porous hydroxyapatite scaffold orchestrated with bioactive coatings for rapid bone repair

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Injectable Bone Cement Reinforced with Gold Nanodots Decorated rGO‐Hydroxyapatite Nanocomposites, Augment Bone Regeneration

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Blood prefabricated hydroxyapatite/tricalcium phosphate induces ectopic vascularized bone formation via modulating the osteoimmune environment

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Hematopoiesis, Inflammation and Aging—The Biological Background and Clinical Impact of Anemia and Increased C-Reactive Protein Levels on Elderly Individuals

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Oxygen-Generating Biomaterials for Translational Bone Regenerative Engineering

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Fabrication of a three-dimensional printed gelatin/sodium alginate/nano-attapulgite composite polymer scaffold loaded with leonurine hydrochloride and its effects on osteogenesis and vascularization

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Journey of Mineral Precursors in Bone Mineralization: Evolution and Inspiration for Biomimetic Design

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Subchondral osteoclasts and osteoarthritis: new insights and potential therapeutic avenues

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Research progress of the mechanisms and applications of ginsenosides in promoting bone formation

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Targeting adipocyte ESRRA promotes osteogenesis and vascular formation in adipocyte-rich bone marrow

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Injectable mineralized hydrogel microspheres for accelerated osteocyte network reconstruction and intelligent bone regeneration

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Combined treatment with Cinnamaldehyde and β-TCP had an additive effect on bone formation and angiogenesis in critical size calvarial defect in ovariectomized rats

Weng, S., Yan, D., Tang, J., Shen, Z., Wu, Z., Xie, Z.-J., Yang, J., Bai, B.-L., Chen, L., Boodhun, V., et al. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.10.085 · Cited by 34

An In Vitro Bone Tissue Regeneration Strategy Combining Chondrogenic and Vascular Priming Enhances the Mineralization Potential of Mesenchymal Stem Cells In Vitro While Also Allowing for Vessel Formation

Freeman, F. E., Haugh, M. G., & McNamara, L. M. (2015) · Tissue Engineering Part A · doi:10.1089/ten.tea.2014.0249 · Cited by 34

Mineralization pathways in the active murine epiphyseal growth plate

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Unraveling the mysteries of plasma cells

Schuh, W., Mielenz, D., & Jäck, H. (2020) · Advances in immunology · doi:10.1016/bs.ai.2020.01.002 · Cited by 38

ADAM17-regulated CX3CL1 expression produced by bone marrow endothelial cells promotes spinal metastasis from hepatocellular carcinoma

Sun, C. C., Hu, A., Wang, S., Tian, B., Jiang, L., Liang, Y., Wang, H., & Dong, J. (2020) · International Journal of Oncology · doi:10.3892/ijo.2020.5045 · Cited by 34

Osteocyte Vegf-a contributes to myeloma-associated angiogenesis and is regulated by Fgf23

Mulcrone, P. L., Edwards, S. K. E., Petrusca, D. N., Haneline, L. S., Delgado‐Calle, J., & Roodman, G. D. (2020) · Scientific Reports · doi:10.1038/s41598-020-74352-x · Cited by 34

Inhibition of SDF‐1/CXCR4 Axis to Alleviate Abnormal Bone Formation and Angiogenesis Could Improve the Subchondral Bone Microenvironment in Osteoarthritis

Qin, H., Zhao, X., Hu, Y., Wang, S., Ma, Y., He, S., Shen, K., Wan, H., Cui, Z., & Yu, B. (2021) · BioMed Research International · doi:10.1155/2021/8852574 · Cited by 34

Role of nitric oxide in orthodontic tooth movement (Review)

Yan, T., Xie, Y., He, H., Fan, W., & Huang, F. P. (2021) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2021.5001 · Cited by 34

Mechanically-regulated bone repair

Anani, T., & Castillo, A. B. (2021) · Bone · doi:10.1016/j.bone.2021.116223 · Cited by 48

CD301b+ macrophages mediate angiogenesis of calcium phosphate bioceramics by CaN/NFATc1/VEGF axis

Wang, J., Zhao, Q. P., Fu, L., Zheng, S., Wang, C., Han, L., Gong, Z., Wang, Z., Tang, H., & Zhang, Y. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2022.02.004 · Cited by 32

SWI/SNF Chromatin‐Remodeling Enzymes Brahma‐Related Gene 1 (BRG1) and Brahma (BRM) Are Dispensable in Multiple Models of Postnatal Angiogenesis But Are Required for Vascular Integrity in Infant Mice

Wiley, M. M., Muthukumar, V., Griffin, T. M., & Griffin, C. T. (2015) · Journal of the American Heart Association · doi:10.1161/jaha.115.001972 · Cited by 31

Macrophage miR-149-5p induction is a key driver and therapeutic target for BRONJ

Shen, X., Zhu, W., Zhang, P., Fu, Y., Cheng, J., Liu, L., Xu, R., & Jiang, H. (2022) · JCI Insight · doi:10.1172/jci.insight.159865 · Cited by 33

Effects of Metformin Delivery via Biomaterials on Bone and Dental Tissue Engineering

Zhu, M., Zhao, Z., Xu, H. H. K., Dai, Z., Yu, K., Xiao, L., Schneider, A., Weir, M. D., Oates, T. W., Bai, Y., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232415905 · Cited by 33

Harnessing cerium-based biomaterials for the treatment of bone diseases

Meng, X. L., Wang, W.-D., Li, S.-R., Sun, Z., & Zhang, L. (2024) · Acta Biomaterialia · doi:10.1016/j.actbio.2024.05.046 · Cited by 36

Endothelial heterogeneity in bone marrow: insights across development, adult life and leukemia

Boueya, I. L., Sandhow, L., Albuquerque, J. R. P., Znaidi, R., & Passaro, D. (2024) · Leukemia · doi:10.1038/s41375-024-02453-x · Cited by 33

Reduction of Longitudinal Vertebral Blood Perfusion and Its Likely Causes: A Quantitative Dynamic Contrast-enhanced MR Imaging Study of a Rat Osteoporosis Model

Zhu, J., Zhang, L., Wu, X., Xiong, Z., Qiu, Y., Hua, T., & Tang, G. (2016) · Radiology · doi:10.1148/radiol.2016152006 · Cited by 33

Preformed Vascular Networks Survive and Enhance Vascularization in Critical Sized Cranial Defects

Roux, B. M., Akar, B., Zhou, W., Stojkova, K., Barrera, B., Brankov, J. G., & Brey, E. M. (2018) · Tissue Engineering Part A · doi:10.1089/ten.tea.2017.0493 · Cited by 33

Role of microRNAs in osteogenesis of stem cells

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Artesunate, an Anti-Malaria Agent, Attenuates Experimental Osteoarthritis by Inhibiting Bone Resorption and CD31hiEmcnhi Vessel Formation in Subchondral Bone

Li, Y., Mu, W., Xu, B., Ren, J., Wahafu, T., Wuermanbieke, S., Ma, H., Gao, H., Liu, Y., Zhang, K., et al. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00685 · Cited by 33

Octacalcium phosphate collagen composite stimulates the expression and activity of osteogenic factors to promote bone regeneration

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The potassium channel Kcne3 is a VEGFA-inducible gene selectively expressed by vascular endothelial tip cells

Deckelbaum, R. A., Lobov, I. B., Cheung, E., Halász, G., Rajamani, S., Lerner, J. L., Tong, C., Li, Z., Boland, P. S., Dominguez, M. G., et al. (2019) · Angiogenesis · doi:10.1007/s10456-019-09696-8 · Cited by 34

Improved in vitro angiogenic behavior of human umbilical vein endothelial cells with oxidized polydopamine coating

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Generation of rhBMP-2-induced juvenile ossicles in aged mice

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The Role of Extracellular Vesicles (EVs) in the Epigenetic Regulation of Bone Metabolism and Osteoporosis

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Copper-Containing Alloy as Immunoregulatory Material in Bone Regeneration via Mitochondrial Oxidative Stress

Xu, D., Qian, J., Guan, X., Ren, L., Yang, K., Huang, X., Zhang, S., Chai, Y., Wu, X., Wu, H., et al. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.620629 · Cited by 33

Role of ex vivo Expanded Mesenchymal Stromal Cells in Determining Hematopoietic Stem Cell Transplantation Outcome

Crippa, S., Santi, L., Berti, M., Ponti, G. D., & Bernardo, M. E. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.663316 · Cited by 33

“Smart Exosomes”: A Smart Approach for Tendon Regeneration

FANG, W. H., Agrawal, D. K., & Thankam, F. G. (2021) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2021.0075 · Cited by 33

The RNA Methyltransferase METTL3 Promotes Endothelial Progenitor Cell Angiogenesis in Mandibular Distraction Osteogenesis via the PI3K/AKT Pathway

Jiang, W., Zhu, P., Huang, F., Zhao, Z., Zhang, T., An, X., Liao, F., Guo, L., Liu, Y., Zhou, N., et al. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.720925 · Cited by 33

Ginsenoside Compound K Enhances Fracture Healing via Promoting Osteogenesis and Angiogenesis

Ding, L., Gu, S., Zhou, B., Wang, M., Zhang, Y., Wu, S., Zou, H., Zhao, G., Gao, Z., & Xu, L. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.855393 · Cited by 33

Coupling of angiogenesis and odontogenesis orchestrates tooth mineralization in mice

Matsubara, T., Iga, T., Sugiura, Y., Kusumoto, D., Sanosaka, T., Tai-Nagara, I., Takeda, N., Fong, G., Ito, K., Ema, M., et al. (2022) · The Journal of Experimental Medicine · doi:10.1084/jem.20211789 · Cited by 33

Combined Effects of Polydopamine-Assisted Copper Immobilization on 3D-Printed Porous Ti6Al4V Scaffold for Angiogenic and Osteogenic Bone Regeneration

Wu, H.-Y., Lin, Y.-H., Lee, A. K.-X., Kuo, T.-Y., Tsai, C., & Shie, M. (2022) · Cells · doi:10.3390/cells11182824 · Cited by 33

AR / PCC herb pair inhibits osteoblast pyroptosis to alleviate diabetes‐related osteoporosis by activating Nrf2/Keap1 pathway

Fu, F., Luo, H., Du, Y., Chen, Y., Tian, K., Pan, J., Li, J., Wang, N., Bao, R., Jin, H., et al. (2023) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17928 · Cited by 32

Parathyroid hormone treatment partially reverses endplate remodeling and attenuates low back pain in animal models of spine degeneration

Ling, Z., Crane, J. L., Hu, H., Chen, Y., Wan, M., Ni, S., Demehri, S., Mohajer, B., Peng, X., Zou, X., et al. (2023) · Science Translational Medicine · doi:10.1126/scitranslmed.adg8982 · Cited by 34

Conformationally regulated “nanozyme-like” cerium oxide with multiple free radical scavenging activities for osteoimmunology modulation and vascularized osseointegration

Bao, S., Yu, D., Tang, Z., Wu, H., Zhang, H., Wang, N., Liu, Y., Huang, H. H., Liu, C., Li, X., et al. (2023) · Bioactive Materials · doi:10.1016/j.bioactmat.2023.12.006 · Cited by 34

YBX1 promotes type H vessel–dependent bone formation in an m5C-dependent manner

Li, Y., Guo, Q., Ye, M., Cai, G., Xiao, W.-F., Deng, S., & Xiao, Y. (2024) · JCI Insight · doi:10.1172/jci.insight.172345 · Cited by 32

Macrophages regulate angiogenesis-osteogenesis coupling induced by mechanical loading through the Piezo1 pathway

Liu, H., Zhou, H., Fan, Y., Li, J., Guo, Z., Xu, Q., Liu, Y., Gao, K., Lahcine, N. A., Zhang, J., et al. (2024) · Journal of Bone and Mineral Research · doi:10.1093/jbmr/zjae198 · Cited by 32

Lymphatic platelet thrombosis limits bone repair by precluding lymphatic transporting DAMPs

Zheng, Y., Cong, L., Zhao, L., Wang, P., Xing, L., Liu, J., Xu, H., Li, N., Zhao, Y., Yuan, L., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-56147-8 · Cited by 36

Intravital Multiphoton Imaging of the Bone and Bone Marrow Environment

Kim, J., & Bixel, M. G. (2019) · Cytometry Part A · doi:10.1002/cyto.a.23937 · Cited by 34

In Vivo Sequestration of Innate Small Molecules to Promote Bone Healing

Zeng, Y., Shih, Y.-R. V., Baht, G. S., & Varghese, S. (2019) · Advanced Materials · doi:10.1002/adma.201906022 · Cited by 32

Ectopic transient overexpression of OCT-4 facilitates BMP4-induced osteogenic transdifferentiation of human umbilical vein endothelial cells

Kim, S. H. L., Lee, S. S., Kim, I., Kwon, J., Kwon, S. C., Bae, T., Hur, J. K., Lee, H.-J., & Hwang, N. S.-Y. (2020) · Journal of Tissue Engineering · doi:10.1177/2041731420909208 · Cited by 32

Single-cell gene profiling and lineage tracing analyses revealed novel mechanisms of endothelial repair by progenitors

Deng, J., Ni, Z., Gu, W., Chen, Q., Nowak, W. N., Chen, T., Bhaloo, S. I., Zhang, Z., Hu, Y., Zhou, B., et al. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03480-4 · Cited by 32

Breast cancer bone metastases are attenuated in a Tgif1-deficient bone microenvironment

Haider, M., Saito, H., Zarrer, J., Uzhunnumpuram, K., Nagarajan, S., Kari, V., Horn-Glander, M., Werner, S., Hesse, E., & Taipaleenmäki, H. (2020) · Breast Cancer Research · doi:10.1186/s13058-020-01269-8 · Cited by 32

Engineered Vascularized Flaps, Composed of Polymeric Soft Tissue and Live Bone, Repair Complex Tibial Defects

Redenski, I., Guo, S., Machour, M., Szklanny, A. A., Landau, S., Kaplan, B., Lock, R. I., Gabet, Y., Egozi, D., Vunjak‐Novakovic, G., et al. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202008687 · Cited by 32

A lithium-doped surface inspires immunomodulatory functions for enhanced osteointegration through PI3K/AKT signaling axis regulation

Peng, F., Qiu, L., Yao, M., Liu, L., Zheng, Y., Wu, S., Ruan, Q., Liu, X., Zhang, Y., Li, M., et al. (2021) · Biomaterials Science · doi:10.1039/d1bm01075a · Cited by 32

miR-188-3p targets skeletal endothelium coupling of angiogenesis and osteogenesis during ageing

He, W.-Z., Yang, M., Jiang, Y., He, C., Sun, Y.-C., Liu, L., Huang, M., Jiao, Y.-R., Chen, K.-X., Hou, J., et al. (2022) · Cell Death & Disease · doi:10.1038/s41419-022-04902-w · Cited by 30

Convergence of Scaffold-Guided Bone Reconstruction and Surgical Vascularization Strategies—A Quest for Regenerative Matching Axial Vascularization

Sparks, D. S., Savi, F. M., Saifzadeh, S., Schuetz, M., Wagels, M., & Hutmacher, D. W. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2019.00448 · Cited by 32

Balancing benefits and risks of glucocorticoids in rheumatic diseases and other inflammatory joint disorders: new insights from emerging data. An expert consensus paper from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO)

Cooper, C. C., Bardin, T., Brandi, M. L., Cacoub, P., Caminis, J. N., Civitelli, R., Cutolo, M., Dere, W. H., Devogelaer, J., Díez‐Pérez, A., et al. (2016) · Aging Clinical and Experimental Research · doi:10.1007/s40520-015-0522-1 · Cited by 32

Aging negatively impacts the ability of megakaryocytes to stimulate osteoblast proliferation and bone mass

Maupin, K. A., Himes, E. R., Plett, A., Chua, H. L., Singh, P., Ghosh, J., Mohamad, S., Abeysekera, I., Fisher, A., Sampson, C. H., et al. (2019) · Bone · doi:10.1016/j.bone.2019.07.010 · Cited by 31

Integrated OMICs unveil the bone-marrow microenvironment in human leukemia

Passaro, D., Albornoz, M. G., Diana, G., Chakravarty, P., Ariza‐McNaughton, L., Batsivari, A., Borràs-Eroles, C., Abarrategi, A., Waclawiczek, A., Ombrato, L., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109119 · Cited by 31

Endothelial Notch activity promotes angiogenesis and osteogenesis in bone

Ramasamy, S. K., Kusumbe, A. P., Wang, L., & Adams, R. H. (2014) · Nature · doi:10.1038/nature13146 · Cited by 1,071

Angiogenesis-osteogenesis coupling: a key element in bone physiology and regeneration

Boston, B., Ipe, D. S., Căpitănescu, B., Hamlet, S. M., Love, R. M., Nusem, I., Miroiu, R. I., Warnke, P. H., & Petcu, E. B. (2021) · Vascular Cell · doi:10.24238/13221-13-1-203 · Cited by 8

Unique bone marrow blood vessels couple angiogenesis and osteogenesis in bone homeostasis and diseases

Zhao, Y., & Xie, L. (2020) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14348 · Cited by 57

Endothelial diversity in bone vasculature coordinates osteogenesis and hematopoiesis

Iga, T. (2026) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-026-01702-6

1018 – HETEROGENEITY AND FUNCTIONAL SPECIALIZATION OF THE BONE MICROVASCULATURE

Adams, R. H., Bixel, M. G., Chen, Q., Koh, B. I., Liu, Y., & Sivaraj, K. K. (2022) · Experimental Hematology · doi:10.1016/j.exphem.2022.07.021