Cited by 2,155Bone Metabolism and DiseasesBone health and osteoporosis researchMesenchymal stem cell research

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Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone

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Kusumbe, Anjali P., Ramasamy, Saravana K., Adams, Ralf H.·2014·Nature

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Abstract

The mammalian skeletal system harbours a hierarchical system of mesenchymal stem cells, osteoprogenitors and osteoblasts sustaining lifelong bone formation. Osteogenesis is indispensable for the homeostatic renewal of bone as well as regenerative fracture healing, but these processes frequently decline in ageing organisms, leading to loss of bone mass and increased fracture incidence. Evidence indicates that the growth of blood vessels in bone and osteogenesis are coupled, but relatively little is known about the underlying cellular and molecular mechanisms. Here we identify a new capillary subtype in the murine skeletal system with distinct morphological, molecular and functional properties. These vessels are found in specific locations, mediate growth of the bone vasculature, generate distinct metabolic and molecular microenvironments, maintain perivascular osteoprogenitors and couple angiogenesis to osteogenesis. The abundance of these vessels and associated osteoprogenitors was strongly reduced in bone from aged animals, and pharmacological reversal of this decline allowed the restoration of bone mass.

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Self-citation
Targeting paraptosis in cancer: opportunities and challenges
Chen, F., Tang, H., Cai, X., Lin, J., Xiang, L., Kang, R., Liu, J., & Tang, D. (2024) · Cancer Gene Therapy · doi:10.1038/s41417-023-00722-y · Cited by 39

Authors: Kusumbe, A. P., Ramasamy, S. K., & Adams, R. H.
Affiliations: University of Münster (DE)
Corresponding author: Adams, Ralf H.
ORCID: Kusumbe, Anjali P.
Ramasamy, Saravana K.
Adams, Ralf H.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2014-03-12
Volume: 507
Issue: 7492
Pages: 323-328
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature13145
PMC: PMC4943525
OpenAlex: W2089254126
Cited by: 2,155
References: 53
Citations by year: 2026: 247 · 2025: 231 · 2024: 270 · 2023: 223 · 2022: 222 · 2021: 238 · 2020: 203 · 2019: 136 · 2018: 114 · 2017: 93 · 2016: 76 · 2015: 63 · 2014: 36
FWCI: 36.60
Type: journal article
Language: en
Update notices: erratum (2014-09-24)
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Max-Planck-Gesellschaft
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
Keywords: angiogenesis, bone formation, bone vascularity, endomucin, CD31, osteoprogenitors, HIF-1α, Notch signaling, bone aging, bone homeostasis, bone regeneration, fracture healing, bone loss
MeSH terms: Aging, Animals, Blood Vessels, Bone and Bones, Male, Mice, Inbred C57BL, Osteoblasts, Osteogenesis, Oxygen, Stem Cells, Neovascularization, Physiologic, Endothelial Cells, Mice, Hypoxia-Inducible Factor 1, alpha Subunit

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