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miR-34/449 miRNAs are required for motile ciliogenesis by repressing CP110

Song, Rui, Walentek, Peter, Sponer, Nicole, Klimke, Alexander, Lee, Joon Sub, Dixon, Gary, Harland, Richard, Wan, Ying +4 more·2014·Nature
DOI 10.1038/nature13413PMC PMC4119886
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  • miR-34/449 clusters repress the ciliogenesis inhibitor CP110.

    “Most notably, the miR-34/449 clusters that repress the ciliogenesis inhibitor CP110 are strong mechanistic candidates for AD-related ciliary vulnerability (Song et al., 2014).”

    From Cell-specific MicroRNA networks orchestrate the pathogenesis of Alzheimer’s disease (2026) · cites this paper as Song et al., 2014

  • Disruption of the miR-34/449-CP110 axis could contribute to impaired ventricular cilia and CSF flow, though this has not yet been directly demonstrated in AD tissue.

    “In combination with Aβ-induced ciliary slowing (Makibatake et al., 2023), this suggests that disruption of the miR-34/449-CP110 axis could contribute to impaired ventricular cilia and CSF flow, even though this has not yet been directly demonstrated in AD tissue (Song et al., 2014).”

    From Cell-specific MicroRNA networks orchestrate the pathogenesis of Alzheimer’s disease (2026) · cites this paper as Song et al., 2014

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Research works printed but not linked: 43

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Cited by

Sorted by citations

Authors
Song, R., Walentek, P., Sponer, N., Klimke, A., Lee, J. S., Dixon, G., Harland, R., Wan, Y., Lishko, P., Lize, M., Kessel, M., & He, L.
Venue
Nature
Publisher
Springer Science and Business Media LLC
Published
2014-06
Volume
510
Issue
7503
Pages
115-120
ISSN
  • 0028-0836
  • 1476-4687
DOI
10.1038/nature13413
PMC
PMC4119886
Cited by
222
References
7
Language
en
Licence
www.springer.com/tdm (tdm)

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