The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells
Open accessAbstract
The role of cellular metabolism in regulating cell proliferation and differentiation remains poorly understood. For example, most mammalian cells cannot proliferate without exogenous glutamine supplementation even though glutamine is a non-essential amino acid. Here we show that mouse embryonic stem (ES) cells grown under conditions that maintain naive pluripotency are capable of proliferation in the absence of exogenous glutamine. Despite this, ES cells consume high levels of exogenous glutamine when the metabolite is available. In comparison to more differentiated cells, naive ES cells utilize both glucose and glutamine catabolism to maintain a high level of intracellular α-ketoglutarate (αKG). Consequently, naive ES cells exhibit an elevated αKG to succinate ratio that promotes histone/DNA demethylation and maintains pluripotency. Direct manipulation of the intracellular αKG/succinate ratio is sufficient to regulate multiple chromatin modifications, including H3K27me3 and ten-eleven translocation (Tet)-dependent DNA demethylation, which contribute to the regulation of pluripotency-associated gene expression. In vitro, supplementation with cell-permeable αKG directly supports ES-cell self-renewal while cell-permeable succinate promotes differentiation. This work reveals that intracellular αKG/succinate levels can contribute to the maintenance of cellular identity and have a mechanistic role in the transcriptional and epigenetic state of stem cells.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In addition to its role in cancer cells, α-KG supports the self-renewal of naive murine embryonic stem cells (mESCs) by promoting histone and DNA demethylation104.”
From Glutamine reliance in cell metabolism (2020) · cites this paper as [104]
In the citing paper
“However, the effect of αKG on cell fate is likely context specific as interventions that increase αKG levels in mouse ESCs favor self-renewal over differentiation (165, 166).”
From Regulation and function of the mammalian tricarboxylic acid cycle (2023) · cites this paper as [165]
In the citing paper
“Moreover, naïve mouse ESCs accumulate pools of αKG and acetyl-CoA, which may reinforce the pluripotent state by stimulating more open chromatin (165, 211, 212, 213, 214).”
From Regulation and function of the mammalian tricarboxylic acid cycle (2023) · cites this paper as [165]
In the citing paper
“The glutamine-independent phenotype exhibited by naïve mouse ESCs is coupled with a reduction in the contribution of glutamine-derived carbons to TCA cycle intermediates (165).”
From Regulation and function of the mammalian tricarboxylic acid cycle (2023) · cites this paper as [165]
In the citing paper
“While most cultured cell lines require glutamine supplementation to support cell survival and proliferation, naïve mouse ESCs can grow in the absence of exogenous glutamine.”
From Regulation and function of the mammalian tricarboxylic acid cycle (2023) · cites this paper as [165]
In the citing paper
“Interestingly, some cell types, such as embryonic stem cells and luminal breast cancer cells, are capable of proliferating in the absence of glutamine in the culture medium, indicating that in some cellular contexts, glutamine can be produced de novo (Carey et al., 2015; Kung et al., 2011).”
From The emerging hallmarks of cancer metabolism (2016) · cites this paper as Carey et al., 2015
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION
Bligh, E. G., & Dyer, W. J. (1959) · Canadian Journal of Biochemistry and Physiology · doi:10.1139/o59-099 · Cited by 54,751
Genome engineering using the CRISPR-Cas9 system
Ran, F. A., Hsu, P. D., Wright, J., Agarwala, V., Scott, D. A., & Zhang, F. (2013) · Nature Protocols · doi:10.1038/nprot.2013.143 · Cited by 11,133
A bivalent chromatin structure marks key developmental genes in embryonic stem cells
Bernstein, B. E., Mikkelsen, T. S., Xie, X., Kamal, M., Huebert, D. J., Cuff, J., Fry, B., Meissner, A., Wernig, M., Plath, K., et al. (2006) · Cell · doi:10.1016/j.cell.2006.02.041 · Cited by 5,361
Genome-wide maps of chromatin state in pluripotent and lineage-committed cells
Mikkelsen, T. S., Ku, M., Jaffe, D. B., Issac, B., Lieberman, E., Giannoukos, G., Alvarez, P., Brockman, W., Kim, T.-K., Koche, R. P., et al. (2007) · Nature · doi:10.1038/nature06008 · Cited by 4,129
The ground state of embryonic stem cell self-renewal
Ying, Q.-L., Wray, J., Nichols, J., Batlle-Morera, L., Doble, B., Woodgett, J., Cohen, P., & Smith, A. (2008) · Nature · doi:10.1038/nature06968 · Cited by 3,442
Aerobic glycolysis: Meeting the metabolic requirements of cell proliferation
Lunt, S. Y., & Vander Heiden, M. G. (2011) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-092910-154237 · Cited by 3,057
Polycomb complexes repress developmental regulators in murine embryonic stem cells
Boyer, L. A., Plath, K., Zeitlinger, J., Brambrink, T., Medeiros, L. A., Lee, T. I., Levine, S. S., Wernig, M., Tajonar, A., Ray, M. K., et al. (2006) · Nature · doi:10.1038/nature04733 · Cited by 2,568
Ying, Q.-L., Nichols, J., Chambers, I., & Smith, A. G. (2003) · Cell · doi:10.1016/s0092-8674(03)00847-x · Cited by 2,114
A unique regulatory phase of DNA methylation in the early mammalian embryo
Smith, Z. D., Chan, M. M., Mikkelsen, T. S., Gu, H., Gnirke, A., Regev, A., & Meissner, A. (2012) · Nature · doi:10.1038/nature10960 · Cited by 1,005
A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response
Kruidenier, L., Chung, C.-W., Cheng, Z., Liddle, J., Che, K., Joberty, G., Bantscheff, M., Bountra, C., Bridges, A., Diallo, H., et al. (2012) · Nature · doi:10.1038/nature11262 · Cited by 950
Flagged first, then by citations
Cited by
Sorted by citations
Items 301–400 of 1,000
Iverson, T. M., Singh, P. K., & Cecchini, G. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.104761 · Cited by 57
The immunometabolic ecosystem in cancer
Bantug, G. R., & Hess, C. (2023) · Nature Immunology · doi:10.1038/s41590-023-01675-y · Cited by 53
Pluripotency transcription factors and Tet1/2 maintain Brd4-independent stem cell identity
Finley, L. W. S., Vardhana, S. A., Carey, B. W., Alonso‐Curbelo, D., Koche, R. P., Chen, Y., Wen, D., King, B., Radler, M. R., Rafii, S., et al. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0086-3 · Cited by 51
Self-citationMenin regulates the serine biosynthetic pathway in Ewing sarcoma
Svoboda, L. K., Teh, S. S. K., Sud, S., Kerk, S. A., Zebolsky, A. L., Treichel, S., Thomas, D. G., Halbrook, C. J., Lee, H., Kremer, D. M., et al. (2018) · The Journal of Pathology · doi:10.1002/path.5085 · Cited by 52
Thioredoxin-1 improves the immunometabolic phenotype of antitumor T cells
Chakraborty, P., Chatterjee, S., Kesarwani, P., Thyagarajan, K., Iamsawat, S., Dalheim, A. V., Nguyen, H. D., Selvam, S. P., Nasarre, P., Scurti, G. M., et al. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.006753 · Cited by 52
Shi, Y., Tian, M., Zhao, X., Tang, L., Wang, F., Wu, H., Liao, Q., Ren, H., Fu, W., Zheng, S., et al. (2024) · Nature Cardiovascular Research · doi:10.1038/s44161-024-00531-y · Cited by 50
He, F., Laranjeira, A. B. A., Kong, T., Lin, S., Ashworth, K. J., Liu, A., Lasky, N. M., Fisher, D. A. C., Cox, M. J., Fulbright, M. C., et al. (2023) · Journal of Clinical Investigation · doi:10.1172/jci172256 · Cited by 49
5-Hydroxymethylcytosine: the many faces of the sixth base of mammalian DNA
Kriukienė, E., Tomkuvienė, M., & Klimašauskas, S. (2024) · Chemical Society Reviews · doi:10.1039/d3cs00858d · Cited by 50
Emerging roles of mitochondrial functions and epigenetic changes in the modulation of stem cell fate
Zhang, C., Meng, Y., & Han, J. (2024) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-023-05070-6 · Cited by 51
Mitochondria in pluripotent stem cells: stemness regulators and disease targets
Folmes, C. D. L., Ma, H., Mitalipov, S. M., & Terzic, A. (2016) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2016.02.001 · Cited by 48
D’Aniello, C., Habibi, E., Cermola, F., Paris, D., Russo, F., Fiorenzano, A., Napoli, G. D., Melck, D. J., Cobellis, G., Angelini, C., et al. (2016) · Stem Cell Reports · doi:10.1016/j.stemcr.2016.11.011 · Cited by 48
Liu, Z., Zhang, Q., Zhang, H., Yi, Z., Ma, H., Wang, X., Wang, J., Liu, Y., Zheng, Y., Fang, W. J., et al. (2024) · Genome Medicine · doi:10.1186/s13073-024-01344-1 · Cited by 48
Metabolite regulation of epigenetics in cancer
Wang, P., Chen, L., Xiong, Y., & Ye, D. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114815 · Cited by 50
Metabolic adaptations direct cell fate during tissue regeneration
Perez, A. C., Millman, S. E., Janaki‐Raman, S., Ho, Y.-J., Hinterleitner, C., Barthet, V. J. A., Morris, J. P., Barriga, F. M., Reyes, J. S., Kyaw, A., et al. (2025) · Nature · doi:10.1038/s41586-025-09097-6 · Cited by 49
Self-citationConcise Review: Energy Metabolites: Key Mediators of the Epigenetic State of Pluripotency
Moussaieff, A., Kogan, N. M., & Aberdam, D. (2015) · Stem Cells · doi:10.1002/stem.2041 · Cited by 47
ISL1 and JMJD3 synergistically control cardiac differentiation of embryonic stem cells
Wang, Y., Li, Y., Guo, C., Lu, Q., Wang, W., Jia, Z., Chen, P., Ma, K., Reinberg, D., & Zhou, C. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw301 · Cited by 49
Shi, X., Tasdogan, A., Huang, F., Hu, Z., Morrison, S. J., & DeBerardinis, R. J. (2017) · Science Advances · doi:10.1126/sciadv.aao5268 · Cited by 47
Alpha-ketoglutarate affects murine embryo development through metabolic and epigenetic modulations
Zhang, Z., He, C., Zhang, L., Zhu, T., Lv, D., Li, G., Song, Y., Wang, J., Wu, H., Ji, P., et al. (2019) · Reproduction · doi:10.1530/rep-19-0018 · Cited by 47
Morganti, C., Bonora, M., Marchi, S., Ferroni, L., Gardin, C., Wieckowski, M. R., Giorgi, C., Pinton, P., & Zavan, B. (2020) · Cells · doi:10.3390/cells9041034 · Cited by 47
Metabolic Regulation of Epigenetic Modifications and Cell Differentiation in Cancer
Saggese, P., Sellitto, A., Martinez, C. A., Giurato, G., Nassa, G., Rizzo, F. M., Tarallo, R., & Scafoglio, C. (2020) · Cancers · doi:10.3390/cancers12123788 · Cited by 46
Sebestyén, A. R., Dankó, T., Sztankovics, D., Moldvai, D., Raffay, R. E., Cervi, C., Krencz, I., Zsiros, V., Jeney, A., & Petővári, G. (2021) · Cancer and Metastasis Reviews · doi:10.1007/s10555-021-10006-2 · Cited by 48
T cell-based cancer immunotherapy: opportunities and challenges
Ma, K., Xu, Y., Cheng, H., Tang, K., Ma, J., & Huang, B. (2025) · 中国科学通报：英文版 · doi:10.1016/j.scib.2025.03.054 · Cited by 47
PHB Associates with the HIRA Complex to Control an Epigenetic-Metabolic Circuit in Human ESCs
Zhu, Z., Li, C., Zeng, Y., Ding, J., Qu, Z., Gu, J., Ge, L., Tang, F., Huang, X., Zhou, C., et al. (2016) · Cell stem cell · doi:10.1016/j.stem.2016.11.002 · Cited by 46
Mitochondrial Control and Guidance of Cellular Activities of T Cells
Chao, T. H., Wang, H., & Ho, P. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00473 · Cited by 47
Multiple Roles of MYC in Integrating Regulatory Networks of Pluripotent Stem Cells
Fagnocchi, L., & Zippo, A. (2017) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2017.00007 · Cited by 46
Ludikhuize, M. C., & Colman, M. J. R. (2020) · Antioxidants and Redox Signaling · doi:10.1089/ars.2020.8126 · Cited by 45
Glucose Deprivation Promotes Pseudohypoxia and Dedifferentiation in Lung Adenocarcinoma
Saggese, P., Pandey, A., Alcaraz, M., Fung, E., Hall, A., Yanagawa, J., Rodriguez, E. F., Grogan, T., Giurato, G., Nassa, G., et al. (2023) · Cancer Research · doi:10.1158/0008-5472.can-23-1148 · Cited by 44
Colorectal Cancer: Pathogenesis and Targeted Therapy
Li, J., Pan, J., Wang, L., Ji, G., & Dang, Y. (2025) · MedComm · doi:10.1002/mco2.70127 · Cited by 48
Urinary proteomics and metabolomics studies to monitor bladder health and urological diseases
Chen, Z., & Kim, J. (2016) · BMC Urology · doi:10.1186/s12894-016-0129-7 · Cited by 45
Role of HIF1 α Regulatory Factors in Stem Cells
Lee, H. J., Jung, Y. H., Choi, G. E., Kim, J. S., Chae, C. W., & Han, H. J. (2019) · International Journal of Stem Cells · doi:10.15283/ijsc18109 · Cited by 45
Mitochondrial DNA Dynamics in Reprogramming to Pluripotency
Sercel, A. J., Carlson, N. M., Patananan, A. N., & Teitell, M. A. (2021) · Trends in Cell Biology · doi:10.1016/j.tcb.2020.12.009 · Cited by 45
Beyond Genetics: The Role of Metabolism in Photoreceptor Survival, Development and Repair
Hanna, J., David, L. A., Touahri, Y., Fleming, T., Screaton, R. A., & Schuurmans, C. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.887764 · Cited by 45
The PLOD2/succinate axis regulates the epithelial–mesenchymal plasticity and cancer cell stemness
Tong, Y., Qi, Y., Xiong, G., Li, J., Scott, T. L., Chen, J., He, D., Li, L., Wang, C., Lane, A. N., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2214942120 · Cited by 43
ACLY and ACC1 Regulate Hypoxia-Induced Apoptosis by Modulating ETV4 via α-ketoglutarate
Keenan, M. M., Liu, B., Tang, X., Wu, J., Cyr, D. D., Stevens, R. D., Ilkayeva, O., Huang, Z., Tollini, L. A., Murphy, S. K., et al. (2015) · PLoS Genetics · doi:10.1371/journal.pgen.1005599 · Cited by 43
Singh, K., Krug, L., Basu, A., Meyer, P., Treiber, N., Beken, S. V., Wlaschek, M., Kochanek, S., Bloch, W., Geiger, H., et al. (2017) · Stem Cells · doi:10.1002/stem.2629 · Cited by 44
Metabolic Signaling to Epigenetic Alterations in Cancer
Kim, J., & Yeom, Y. I. (2017) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2017.185 · Cited by 45
Zhao, X. L., & Karpac, J. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.10.003 · Cited by 45
Restall, I. J., Cseh, O., Richards, L. M., Pugh, T. J., Luchman, H. A., & Weiss, S. (2020) · Cancer Research · doi:10.1158/0008-5472.can-19-3923 · Cited by 42
Oxygen as a Master Regulator of Human Pluripotent Stem Cell Function and Metabolism
Nit, K., Tyszka‐Czochara, M., & Bobis‐Wozowicz, S. (2021) · Journal of Personalized Medicine · doi:10.3390/jpm11090905 · Cited by 43
Per- and polyfluoroalkyl substances target and alter human prostate stem-progenitor cells
Hu, W., Lu, R., Hu, D., Imir, O. B., Zuo, Q., Moline, D., Afradiasbagharani, P., Liu, L., Lowe, S., Birch, L. A., et al. (2021) · Biochemical Pharmacology · doi:10.1016/j.bcp.2021.114902 · Cited by 45
Induction and application of human naive pluripotency
Zhou, J., Hu, J., Wang, Y., & Gao, S. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112379 · Cited by 42
The malate shuttle detoxifies ammonia in exhausted T cells by producing 2-ketoglutarate
Weisshaar, N., Ma, S., Ming, Y., Madi, A., Mieg, A., Hering, M., Zettl, F., Möhr, K., ten Bosch, N., Stichling, D., et al. (2023) · Nature Immunology · doi:10.1038/s41590-023-01636-5 · Cited by 43
Fletcher, S. C., & Coleman, M. L. (2020) · Biochemical Society Transactions · doi:10.1042/bst20190333 · Cited by 44
Spontaneous hydrolysis and spurious metabolic properties of α-ketoglutarate esters
Parker, S. J., Encarnación-Rosado, J., Hollinshead, K. E. R., Hollinshead, D. M., Ash, L. J., Rossi, J. A. K., Lin, E. Y., Sohn, A. S. W., Philips, M. R., Jones, D. R., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-25228-9 · Cited by 43
Targeting fuel pocket of cancer cell metabolism: A focus on glutaminolysis
Sharma, S., Agnihotri, N., & Kumar, S. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2022.114943 · Cited by 42
Senescent cells: A therapeutic target for osteoporosis
Wang, T., Huang, S., & He, C. (2022) · Cell Proliferation · doi:10.1111/cpr.13323 · Cited by 47
The Promotion of Erythropoiesis via the Regulation of Reactive Oxygen Species by Lactic Acid
Luo, S., Zhang, D., Qin, Q., Lu, L., Luo, M., Guo, F., Shi, H., Jiang, L., Shao, B., Li, M., et al. (2017) · Scientific Reports · doi:10.1038/srep38105 · Cited by 41
The role of metabolic reprogramming in T cell fate and function.
Patsoukis, N., Bardhan, K., Weaver, J. D., Herbel, C., Seth, P., Li, L., & Boussiotis, V. A. (2016) · PubMed · Cited by 47
Mitochondrial regulation in spermatogenesis
Zhang, Z., Miao, J., & Wang, Y. (2022) · Reproduction · doi:10.1530/rep-21-0431 · Cited by 41
Farris, J. C., Pifer, P. M., Zheng, L., Gottlieb, E., Denvir, J., & Frisch, S. M. (2016) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-16-0050 · Cited by 43
Metabolism, Epigenetics, and Causal Inference in Heart Failure
Kimball, T. H., & Vondriska, T. M. (2019) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2019.11.009 · Cited by 40
The methyltransferase Suv39h1 links the SUMO pathway to HP1α marking at pericentric heterochromatin
Maison, C., Bailly, D., Quivy, J., & Almouzni, G. (2016) · Nature Communications · doi:10.1038/ncomms12224 · Cited by 46
Sharma, N. K., & Pal, J. K. (2020) · Current Molecular Medicine · doi:10.2174/1566524020666200521075252 · Cited by 40
Carrasco-Navarro, U., & Aguirre, J. (2021) · Journal of Fungi · doi:10.3390/jof7080624 · Cited by 39
Winkle, L. J. V. (2021) · Cells · doi:10.3390/cells10113154 · Cited by 39
The role of metabolic states in development and disease
Sieber, M., & Spradling, A. C. (2017) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2017.03.002 · Cited by 40
Nutrients in the fate of pluripotent stem cells
Lu, V., Roy, I. J., & Teitell, M. A. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.09.013 · Cited by 40
Proteolytic rewiring of mitochondria by LONP1 directs cell identity switching of adipocytes
Fu, T., Sun, W., Xue, J., Zhou, Z., Wang, W., Guo, Q., Chen, X., Zhou, D., Xu, Z., Liu, L., et al. (2023) · Nature Cell Biology · doi:10.1038/s41556-023-01155-3 · Cited by 38
Okabe, K., Nawaz, A., Nishida, Y., Yaku, K., Usui, I., Tobe, K., & Nakagawa, T. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.586179 · Cited by 36
Chromatin and Epigenetic Rearrangements in Embryonic Stem Cell Fate Transitions
Sun, L., Fu, X., Ma, G., & Hutchins, A. P. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.637309 · Cited by 38
Derivation of feeder-free human extended pluripotent stem cells
Zheng, R., Geng, T., Wu, D., Zhang, T., He, H., Wang, L., Du, H., Zhang, D., Miao, Y., & Jiang, W. (2021) · Stem Cell Reports · doi:10.1016/j.stemcr.2021.06.001 · Cited by 38
Lin, Z., Liu, F., Shi, P., Song, A., Huang, Z., Zou, D., Chen, Q., Li, J., & Gao, X. (2018) · Stem Cell Research & Therapy · doi:10.1186/s13287-018-0792-6 · Cited by 38
Rethinking glutamine addiction
Krall, A. S., & Christofk, H. R. (2015) · Nature Cell Biology · doi:10.1038/ncb3278 · Cited by 37
Dietary interventions as regulators of stem cell behavior in homeostasis and diseasePreprint
Novak, J. S. S., Baksh, S. C., & Fuchs, E. V. (2021) · Genes & Development · doi:10.1101/gad.346973.120 · Cited by 38
Psat1-generated α-ketoglutarate and glutamine promote muscle stem cell activation and regenerationPreprint
Ciuffoli, V., Feng, X., Jiang, K., Acevedo-Luna, N., Ko, K. D., Wang, A. H. J., Riparini, G., Khateb, M., Glancy, B. C., Dell’Orso, S., et al. (2024) · Genes & Development · doi:10.1101/gad.351428.123 · Cited by 38
Non-canonical and developmental roles of the TCA cycle in plants
Zhang, T., Peng, J. T., Klair, A., & Dickinson, A. J. (2023) · Current Opinion in Plant Biology · doi:10.1016/j.pbi.2023.102382 · Cited by 36
Nucleotide depletion promotes cell fate transitions by inducing DNA replication stress
Do, B. T., Hsu, P. P., Vermeulen, S. Y., Wang, Z., Hirz, T., Abbott, K. L., Aziz, N., Replogle, J. M., Bjelosevic, S., Paolino, J. D., et al. (2024) · Developmental Cell · doi:10.1016/j.devcel.2024.05.010 · Cited by 36
N(6)-Methyladenine in eukaryotes
Alderman, M. H., & Xiao, A. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03146-w · Cited by 37
Tryptophan metabolism regulates proliferative capacity of human pluripotent stem cells
Someya, S., Tohyama, S., Kameda, K., Tanosaki, S., Morita, Y., Sasaki, K., Kang, M.-I., Kishino, Y., Okada, M., Tani, H., et al. (2021) · iScience · doi:10.1016/j.isci.2021.102090 · Cited by 36
Stem Cell Spheroids and Ex Vivo Niche Modeling: Rationalization and Scaling-Up
Chimenti, I., Massai, D., Morbiducci, U., Beltrami, A. P., Pesce, M., & Messina, E. (2017) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-017-9741-5 · Cited by 36
Chen, G., & Wang, J. (2019) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.01.005 · Cited by 35
Zhou, Q., Wang, Y., Lu, Z., Wang, B., Li, L., You, M., Wang, L., Cao, T., Zhao, Y., Li, Q., et al. (2023) · Obesity · doi:10.1002/oby.23707 · Cited by 35
Yang, R., Zhang, G., Meng, Z., Wang, L., Li, Y., Li, H., Yan, S., Wei, X., Wang, S., & Cui, H. (2024) · Neuro-Oncology · doi:10.1093/neuonc/noae222 · Cited by 35
Modeling Mammalian Commitment to the Neural Lineage Using Embryos and Embryonic Stem Cells
Shparberg, R. A., Glover, H. J., & Morris, M. B. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00705 · Cited by 39
Morris, M. B., Özsoy, Ş., Zada, M., Zada, M., Zamfirescu, R. C., Todorova, M. G., & Day, M. L. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00140 · Cited by 35
Zhang, S., Zhao, J., Quan, Z., Li, H., & Qing, H. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.853911 · Cited by 35
Metabolic Controls on Epigenetic Reprogramming in Regulatory T Cells
Lü, J., Liang, Y., Meng, H., Zhang, A., Zhao, J., & Zhang, C. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.728783 · Cited by 34
One-Carbon Metabolism Links Nutrition Intake to Embryonic Development via Epigenetic Mechanisms
Wu, S., Zhang, J., Li, F., Du, W. T., Zhou, X., Wan, M., Fan, Y., Xu, X., Zhou, X., Zheng, L., et al. (2019) · Stem Cells International · doi:10.1155/2019/3894101 · Cited by 34
Erasing gametes to write blastocysts: metabolism as the new player in epigenetic reprogramming
Milazzotto, M. P., de Lima, C. B., da Fonseca, A. M., dos Santos, É. C., & Ispada, J. (2020) · Animal Reproduction · doi:10.1590/1984-3143-ar2020-0015 · Cited by 34
Metabolic therapy and bioenergetic analysis: The missing piece of the puzzle
Duraj, T., Carrión-Navarro, J., Seyfried, T. N., Garcia‐Romero, N., & Ayuso‐Sacido, Á. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2021.101389 · Cited by 36
Krantz, S., Kim, Y.-M., Srivastava, S., Leasure, J. W., Tóth, P. T., Marsboom, G., & Rehman, J. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.101410 · Cited by 34
Hematopoietic stem cell lineage specification
Pouzolles, M., Oburoglu, L., Taylor, N. N., & Zimmermann, V. S. (2016) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000260 · Cited by 37
PII Protein-Derived FRET Sensors for Quantification and Live-Cell Imaging of 2-Oxoglutarate
Lüddecke, J., Francois, L., Spät, P., Watzer, B., Chilczuk, T., Poschet, G., Hell, R., Radlwimmer, B., & Forchhammer, K. (2017) · Scientific Reports · doi:10.1038/s41598-017-01440-w · Cited by 35
Metabolic Signaling into Chromatin Modifications in the Regulation of Gene Expression
Gao, T. X., Díaz-Hirashi, Z., & Verdeguer, F. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19124108 · Cited by 34
Yang, C., Lee, D., Zhang, M. S., Tse, A. P., Wei, L., Bao, M. H., Wong, B. P., Chan, C. Y., Yuen, V. W., Chen, Y., et al. (2022) · Advanced Science · doi:10.1002/advs.202202104 · Cited by 33
Metabolic regulation of erythrocyte development and disorders
Lyu, J., Ni, M., Weiss, M. J., & Xu, J. (2024) · Experimental Hematology · doi:10.1016/j.exphem.2024.104153 · Cited by 36
Metabolism Is a Key Regulator of Induced Pluripotent Stem Cell Reprogramming
Spyrou, J., Gardner, D. K., & Harvey, A. J. (2019) · Stem Cells International · doi:10.1155/2019/7360121 · Cited by 33
Kang, H. S., Lee, J. H., Oh, K., Lee, E., Han, B., Park, K.-Y., Suh, J. M., Min, J., Chi, S., Lee, S. C., et al. (2020) · Metabolism · doi:10.1016/j.metabol.2020.154173 · Cited by 33
Metabolic Targeting of Cancer Stem Cells
Mukha, A., & Dubrovska, A. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.537930 · Cited by 33
Mitochondria and the permeability transition pore in cancer metabolic reprogramming
Guo, L. (2021) · Biochemical Pharmacology · doi:10.1016/j.bcp.2021.114537 · Cited by 34
Fatty acid oxidation is required for embryonic stem cell survival during metabolic stress
Yan, H., Malik, N., Kim, Y., He, Y., Li, M., Dubois, W., Liu, H., Peat, T. J., Nguyen, J. T., Tseng, Y., et al. (2021) · EMBO Reports · doi:10.15252/embr.202052122 · Cited by 33
Metabolic Control of Germline Formation and Differentiation in Mammals
Hayashi, Y., & Matsui, Y. (2022) · Sexual Development · doi:10.1159/000520662 · Cited by 35
Malhotra, A., Dey, A., Prasad, N., & Kenney, A. M. (2015) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-15-0278 · Cited by 33
Human induced pluripotent stem cells: A disruptive innovation
Vos, J. D., Bouckenheimer, J., Sansac, C., Lemaı̂tre, J.-M., & Assou, S. (2016) · Current Research in Translational Medicine · doi:10.1016/j.retram.2016.04.001 · Cited by 37
Metabotypes of breast cancer cell lines revealed by non-targeted metabolomics
Dubuis, S., Baenke, F., Scherbichler, N., Alexander, L. T., Schulze, A., & Zamboni, N. (2016) · Metabolic Engineering · doi:10.1016/j.ymben.2016.12.009 · Cited by 33
Plasticity in Glioma Stem Cell Phenotype and Its Therapeutic Implication
Iwadate, Y. (2017) · Neurologia medico-chirurgica · doi:10.2176/nmc.ra.2017-0089 · Cited by 33
Stem cell fate determination through protein O-GlcNAcylation
Sheikh, M. A., Emerald, B. S., & Ansari, S. A. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.rev120.014915 · Cited by 34
Tang, L., Xu, X., Xu, S., Liu, Z., He, Q., Li, W., Sun, J., Shuai, W., Mao, J., Zhao, J., et al. (2023) · Cell Reports Medicine · doi:10.1016/j.xcrm.2023.101026 · Cited by 32
Cardinal features of immune memory in innate lymphocytes
Santosa, E. K., & Sun, J. C.-Y. (2023) · Nature Immunology · doi:10.1038/s41590-023-01607-w · Cited by 32
Zhang, W., Bai, Y., Hao, L., Zhao, Y., Zhang, L., Ding, W., Qi, Y., & Xu, Q. (2024) · Journal of Bone and Mineral Research · doi:10.1093/jbmr/zjae121 · Cited by 32
Metadata
- Authors
- Carey, B. W., Finley, L. W. S., Cross, J. R., Allis, C. D., & Thompson, C. B.
- Affiliations
- Rockefeller University (US)
- Memorial Sloan Kettering Cancer Center (US)
- Corresponding author
- Allis, C. David
- Thompson, Craig B.
- Venue
- Nature
- Published
- 2014-12-10
- Volume
- 518
- Issue
- 7539
- Pages
- 413-416
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC4336218
- OpenAlex
- W2087814592
- Cited by
- 1,007
- References
- 31
- Citations by year
- 2026: 82 · 2025: 92 · 2024: 74 · 2023: 84 · 2022: 101 · 2021: 92 · 2020: 110 · 2019: 95 · 2018: 63 · 2017: 85 · 2016: 90 · 2015: 39
- FWCI
- 29.27
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- National Cancer Institute (R01CA105463, P30CA008748)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Keywords
- alpha-ketoglutarate, succinic acid, glutamine metabolism, glucose metabolism, naive pluripotency, mouse embryonic stem cells, histone demethylation, DNA demethylation, H3K27me3, TET enzymes, chromatin modification, stem cell self-renewal, cell differentiation, epigenetic regulation, cellular metabolism
- MeSH terms
- Animals, Cell Differentiation, Cell Line, Cell Membrane Permeability, Chromatin, Glucose, Histones, Ketoglutaric Acids, Methylation, Transcription, Genetic, Glutamic Acid, DNA Methylation, Succinic Acid, Pluripotent Stem Cells, Intracellular Space, Epigenesis, Genetic, Cell Proliferation, Mice, Embryonic Stem Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
