SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

Vander Heiden, M. G., Cantley, L. C., & Thompson, C. B. (2009) · Science · doi:10.1126/science.1160809 · Cited by 16,197

Stem cells, cancer, and cancer stem cells

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Genome-scale CRISPR-Cas9 knockout screening in human cells

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ONCOMINE: A Cancer Microarray Database and Integrated Data-Mining Platform

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Aerobic glycolysis: Meeting the metabolic requirements of cell proliferation

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Genetic screens in human cells using the CRISPR-Cas9 system

Wang, T., Wei, J. J., Sabatini, D. M., & Lander, E. S. (2014) · Science · doi:10.1126/science.1246981 · Cited by 2,856

Exploiting tumour hypoxia in cancer treatment

Brown, J. M., & Wilson, W. R. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1367 · Cited by 2,828

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

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Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines

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HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption

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The role of SHMT2 in modulating lipid metabolism in hepatocytes via glycine-mediated mTOR activation

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Upregulation of SHMT2 Promotes Tumor Growth and Poor Prognosis of Breast Cancer through Activating VEGF and MAPK Signaling PathwayPreprint

Xie, S.-Y., Shi, D., Ouyang, Y. Q., Cheng, X.-Y., Chen, X., Jiang, T., Xia, W., Guo, L., & Lin, H. (2021) · Research Square · doi:10.21203/rs.3.rs-1016628/v1 · Cited by 22

MicroRNA‐628‐5p inhibits cell proliferation in glioma by targeting DDX59

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The role of dNTP metabolites in control of the embryonic cell cycle

Liu, B., & Großhans, J. (2019) · Cell Cycle · doi:10.1080/15384101.2019.1665948 · Cited by 21

Potential Correlation between Dietary Fiber-Suppressed Microbial Conversion of Choline to Trimethylamine and Formation of Methylglyoxal

Li, Q., Chen, H., Zhang, M., Wu, T., Liu, R., & Zhang, Z. (2019) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.9b04860 · Cited by 21

A Transcriptomic Regulatory Network among miRNAs, lncRNAs, circRNAs, and mRNAs Associated with L-leucine-induced Proliferation of Equine Satellite Cells

Xing, J., Qi, X., Liu, G., Li, X., Gao, X., Bou, G., Bai, D., Zhao, Y., Du, M., Dugarjaviin, M., et al. (2023) · Animals · doi:10.3390/ani13020208 · Cited by 20

Evaluating the clinical significance of SHMT2 and its co-expressed gene in human kidney cancer

Wang, H., Chong, T., Li, B.-Y., Chen, X.-S., & Zhen, W.-B. (2020) · Biological Research · doi:10.1186/s40659-020-00314-2 · Cited by 20

Robust tissue growth and angiogenesis in large-sized scaffold by reducing H 2 O 2 -mediated oxidative stress

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Inhibiting Glycine Decarboxylase Suppresses Pyruvate-to-Lactate Metabolism in Lung Cancer Cells

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Glioblastomas: Hijacking Metabolism to Build a Flexible Shield for Therapy Resistance

Bailleul, J., & Vlashi, E. (2023) · Antioxidants and Redox Signaling · doi:10.1089/ars.2022.0088 · Cited by 22

A five‑gene based risk score with high prognostic value in colorectal cancer

Pan, Y., Zhang, H., Zhang, M., Zhu, J., Yu, J., Wang, B., Qiu, J., & Zhang, J. (2017) · Oncology Letters · doi:10.3892/ol.2017.7097 · Cited by 19

Large scale analyses of genotype-phenotype relationships of glycine decarboxylase mutations and neurological disease severity

Farris, J. D., Calhoun, B., Alam†, M. S., Lee, S. W., & Haldar, K. (2020) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1007871 · Cited by 19

Methotrexate elicits pro-respiratory and anti-growth effects by promoting AMPK signaling

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Downregulation of SHMT2 promotes the prostate cancer proliferation and metastasis by inducing epithelial-mesenchymal transition

Chen, L., Liu, H., Ji, Y., Ma, Z., Shen, K., Shangguan, X., Qian, H., Zhao, Y., Pan, C.-W., & Xue, W. (2022) · Experimental Cell Research · doi:10.1016/j.yexcr.2022.113138 · Cited by 17

Rewired Metabolism of Amino Acids and Its Roles in Glioma Pathology

Chen, S., Jiang, J., Shen, A., Miao, Y., Cao, Y., Zhang, Y., Cong, P., & Gao, P. (2022) · Metabolites · doi:10.3390/metabo12100918 · Cited by 17

Mitochondrial regulation in human pluripotent stem cells during reprogramming and β cell differentiation

Jasra, I. T., Cuesta‐Gomez, N., Verhoeff, K. K., Marfil‐Garza, B. A., Dadheech, N., & Shapiro, A. M. J. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1236472 · Cited by 17

Understanding serine and glycine metabolism in cancer: a path towards precision medicine to improve patient’s outcomes

Sánchez‐Castillo, A., & Kampen, K. R. (2024) · Discover Oncology · doi:10.1007/s12672-024-01544-6 · Cited by 18

Phenotypic selection with an intrabody library reveals an anti-apoptotic function of PKM2 requiring Mitofusin-1

Liu, T., Kuwana, T., Zhang, H., Heiden, M. G. V., Lerner, R. A., & Newmeyer, D. D. (2019) · PLoS Biology · doi:10.1371/journal.pbio.2004413 · Cited by 17

Identification of biomarkers associated with histological grade and prognosis of gastric cancer by co‑expression network analysis

Chen, W., Zhang, W., Wu, R., Cai, Y., Xue, X., & Cheng, J. (2019) · Oncology Letters · doi:10.3892/ol.2019.10869 · Cited by 17

A flap motif in human serine hydroxymethyltransferase is important for structural stabilization, ligand binding, and control of product release

Ubonprasert, S., Jaroensuk, J., Pornthanakasem, W., Kamonsutthipaijit, N., Wongpituk, P., Mee-udorn, P., Rungrotmongkol, T., Ketchart, O., Chitnumsub, P., Leartsakulpanich, U., et al. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.007454 · Cited by 17

PLEK2, RRM2, GCSH: A Novel WWOX-Dependent Biomarker Triad of Glioblastoma at the Crossroads of Cytoskeleton Reorganization and Metabolism Alterations

Kałuzińska‐Kołat, Ż., Kołat, D., Bednarek, A. K., & Płuciennik, E. (2021) · Cancers · doi:10.3390/cancers13122955 · Cited by 17

One-carbon metabolism in cancer cells: a critical review based on a core model of central metabolism

Mazat, J. (2021) · Biochemical Society Transactions · doi:10.1042/bst20190008 · Cited by 16

Evidence from a large-scale meta-analysis indicates eczema reduces the incidence of glioma

Wang, G., Xu, S., Cao, C., Dong, J., Chu, Y., He, G., & Xu, Z. (2016) · Oncotarget · doi:10.18632/oncotarget.11545 · Cited by 16

Metabolic regulation of species-specific developmental ratesPreprint

Díaz-Cuadros, M., Miettinen, T. P., Sheedy, D., Díaz‐García, C. M., Gapon, S., Hubaud, A., Yellen, G., Manalis, S. R., Oldham, W. M., & Pourquié, O. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.08.27.457974 · Cited by 16

Correlation between amino acid metabolism and self-renewal of cancer stem cells: Perspectives in cancer therapy

Zhang, Q., & Li, W. (2022) · World Journal of Stem Cells · doi:10.4252/wjsc.v14.i4.267 · Cited by 16

Anaplastic Thyroid Cancer Cells Upregulate Mitochondrial One-Carbon Metabolism To Meet Purine Demand, Eliciting A Critical Targetable Vulnerability

Sugarman, A. J., Huynh, L. D., Shabro, A., & Cristofano, A. D. (2023) · Cancer Letters · doi:10.1016/j.canlet.2023.216304 · Cited by 15

Superoxide dismutase 1 mediates adaptation to the tumor microenvironment of glioma cells via mammalian target of rapamycin complex 1

König, S., Straßheimer, F., Brandner, N. I., Schröder, J.-H., Urban, H., Harwart, L. F., Hehlgans, S., Steinbach, J. P., Ronellenfitsch, M. W., & Luger, A. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-02145-6 · Cited by 16

Human and Plasmodium serine hydroxymethyltransferases differ in rate-limiting steps and pH-dependent substrate inhibition behavior

Amornwatcharapong, W., Maenpuen, S., Chitnumsub, P., Leartsakulpanich, U., & Chaiyen, P. (2017) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2017.07.017 · Cited by 15

Bioinformatics analysis of gene expression profiles to diagnose crucial and novel genes in glioblastoma multiform

Vastrad, C. M., & Vastrad, B. M. (2018) · Pathology - Research and Practice · doi:10.1016/j.prp.2018.07.015 · Cited by 16

Hormonal regulation of glycine decarboxylase and its relationship to oxidative stress

Jog, R., Chen, G., Wang, J., & Leff, T. (2021) · Physiological Reports · doi:10.14814/phy2.14991 · Cited by 16

Metabolic Vulnerabilities in Multiple Myeloma

Lim, J. S. L., Chong, P. S. Y., & Chng, W. J. (2022) · Cancers · doi:10.3390/cancers14081905 · Cited by 15

Tumor suppressors microRNA-302d and microRNA-16 inhibit human glioblastoma multiforme by targeting NF-κB and FGF2

Wang, F., Yang, L., Sun, J., Zheng, J., Shi, L., Zhang, G., & Cui, N. (2017) · Molecular BioSystems · doi:10.1039/c7mb00139h · Cited by 15

MYC overrides HIF-1α to regulate proliferating primary cell metabolism in hypoxia

Copeland, C. A., Olenchock, B. A., Ziehr, D. R., McGarrity, S., Leahy, K., Young, J. D., Loscalzo, J., & Oldham, W. M. (2023) · eLife · doi:10.7554/elife.82597 · Cited by 12

Metabolic Characterization of Antifolate Responsiveness and Non-responsiveness in Malignant Pleural Mesothelioma Cells

Sato, Y., Matsuda, S., Maruyama, A., Nakayama, J., Miyashita, T., Udagawa, H., Umemura, S., Yanagihara, K., Ochiai, A., Tomita, M., et al. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01129 · Cited by 15

Integrated Bioinformatic Analysis Reveals TXNRD1 as a Novel Biomarker and Potential Therapeutic Target in Idiopathic Pulmonary Arterial Hypertension

Lin, W., Tang, Y., Zhang, M., Liang, B., Wang, M., Zha, L., & Yu, Z. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.894584 · Cited by 14

Metabolic remodeling of pyrimidine synthesis pathway and serine synthesis pathway in human glioblastoma

Nakamizo, A., Miyamatsu, Y., Hirose, H., Amano, T., Matsuo, S., Fujiwara, M., Shimamura, T., & Yoshimoto, K. (2022) · Scientific Reports · doi:10.1038/s41598-022-20613-w · Cited by 15

Targeting SHMTs and MTHFDs in cancer: attractive opportunity for anti-tumor strategy

Zhang, X., & Wang, Z. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1335785 · Cited by 13

Uncovering SIRT3 and SHMT2-dependent pathways as novel targets for apigenin in modulating colorectal cancer: In vitro and in vivo studies

Abdelmaksoud, N. M., Abulsoud, A. I., Abdelghany, T. M., Elshaer, S. S., Rizk, S. M., Senousy, M. A., & Maurice, N. W. (2024) · Experimental Cell Research · doi:10.1016/j.yexcr.2024.114150 · Cited by 14

Downregulating Serine Hydroxymethyltransferase 2 Deteriorates Hepatic Ischemia-Reperfusion Injury through ROS/JNK/P53 Signaling in Mice

Wu, H., He, B., Duan, S., & Yuan, F. (2019) · BioMed Research International · doi:10.1155/2019/2712185 · Cited by 13

Serine hydroxymethyltransferase 2 predicts unfavorable outcomes in multiple cancer: a systematic review and meta-analysis

Du, J., Huang, Y., Jing, S., Pei, Y., Qian, Y., & Zeng, Y. (2022) · Translational Cancer Research · doi:10.21037/tcr-21-2485 · Cited by 12

Targeting HOTAIRM1 ameliorates glioblastoma by disrupting mitochondrial oxidative phosphorylation and serine metabolism

Han, W., Wang, S., Qi, Y., Wu, F., Tian, N., Qiang, B., & Peng, X. (2022) · iScience · doi:10.1016/j.isci.2022.104823 · Cited by 13

Shift from stochastic to spatially-ordered expression of serine-glycine synthesis enzymes in 3D microtumors

Singh, M., Warita, K., Warita, T., Faeder, J. R., Lee, R., Sant, S., & Oltvai, Z. N. (2018) · Scientific Reports · doi:10.1038/s41598-018-27266-8 · Cited by 14

Structure and Kinetics of the S-(+)-1-Amino-2-propanol Dehydrogenase from the RMM Microcompartment of Mycobacterium smegmatis

Mallette, E., & Kimber, M. S. (2018) · Biochemistry · doi:10.1021/acs.biochem.8b00464 · Cited by 12

7T HR FID-MRSI Compared to Amino Acid PET: Glutamine and Glycine as Promising Biomarkers in Brain Tumors

Hangel, G. J., Lazen, P., Sharma, S., Hristoska, B., Cadrien, C., Furtner, J., Rausch, I., Lipka, A., Niess, E., Hingerl, L., et al. (2022) · Cancers · doi:10.3390/cancers14092163 · Cited by 12

Serine and glycine metabolism-related gene expression signature stratifies immune profiles of brain gliomas, and predicts prognosis and responses to immunotherapy

Chen, S., Zhang, S., Feng, W., Li, J., Yuan, Y., Li, W., Wang, Z., Yang, Y., & Liu, Y. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1072253 · Cited by 14

Metabolic Response of Triple-Negative Breast Cancer to Folate Restriction

Coleman, M. F., O’Flanagan, C. H., Pfeil, A. J., Chen, X., Pearce, J. B., Sumner, S., Krupenko, S. A., & Hursting, S. D. (2021) · Nutrients · doi:10.3390/nu13051637 · Cited by 12

Allosteric regulation of metabolism in cancer: endogenous mechanisms and considerations for drug design

Macpherson, J. A., & Anastasiou, D. (2017) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2017.03.022 · Cited by 12

Lactate Transport Inhibition Therapeutically Reprograms Fibroblast Metabolism in Experimental Pulmonary Fibrosis

Ziehr, D. R., Li, F., Parnell, K. M., Krah, N. M., Leahy, K. J., Guillermier, C., Gao, C., Prell, S. A., Vigder, N., Poli, S., et al. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.ads2673 · Cited by 16

Joint metabolomics and transcriptomics analysis systematically reveal the impact of MYCN in neuroblastoma

Du, B., Zhang, Y., Zhang, P., Zhang, M., Yu, Z., Li, L., Hou, L., Wang, Q., Zhang, X., & Zhang, W. (2024) · Scientific Reports · doi:10.1038/s41598-024-71211-x · Cited by 11

Sertraline/chloroquine combination therapy to target hypoxic and immunosuppressive serine/glycine synthesis-dependent glioblastomas

Sánchez‐Castillo, A., Savelkouls, K. G. M., Baldini, A., Hounjet, J., Sonveaux, P., Verstraete, P., Keersmaecker, K. D., Dewaele, B., Björkblom, B., Melin, B. S., et al. (2024) · Oncogenesis · doi:10.1038/s41389-024-00540-3 · Cited by 11

The role and research progress of serine metabolism in tumor cells

Lyu, H., Bao, S., Cai, L., Wang, M., Liu, Y., Sun, Y., & Hu, X. S. (2025) · Frontiers in Oncology · doi:10.3389/fonc.2025.1509662 · Cited by 13

DIA-MS Based Proteomics Combined with RNA-Seq Data to Unveil the Mitochondrial Dysfunction in Human Glioblastoma

Zeng, H., Hu, L., Chen, X., Han, Q., Li, H., Cheng, L., & Li, C.-X. (2023) · Molecules · doi:10.3390/molecules28041595 · Cited by 11

PRSS37 deficiency leads to impaired energy metabolism in testis and sperm revealed by DIA-based quantitative proteomic analysis

Xiong, W., Ge, H., Shen, C., Li, C., Zhang, X., Tang, L., Shen, Y., Lu, S., Zhang, H., & Wang, Z. (2022) · Reproductive Sciences · doi:10.1007/s43032-022-00918-x · Cited by 11

Subtype-specific and co-occurring genetic alterations in B-cell non-Hodgkin lymphomaPreprint

Ma, M. C. J., Tadros, S., Bouska, A., Heavican, T., Yang, H., Deng, Q., Moore, D., Akhter, A., Hartert, K., Jain, N., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/674259 · Cited by 10

Glycine metabolomic changes induced by anticancer agents in A549 cells

Guo, K., Cao, Y., Li, Z., Zhou, X., Ding, R., Chen, K., Liu, Y., Qiu, Y., Wu, Z., & Fang, M. (2020) · Amino Acids · doi:10.1007/s00726-020-02853-0 · Cited by 13

The effect of neurosphere culture conditions on the cellular metabolism of glioma cells

Kahlert, U. D., Koch, K., Suwala, A. K., Hartmann, R., Cheng, M., Maciaczyk, D., Willbold, D., Eberhart, C. G., Glunde, K., & Maciaczyk, J. (2015) · Folia Neuropathologica · doi:10.5114/fn.2015.54422 · Cited by 9

GLDC promotes colorectal cancer metastasis through epithelial–mesenchymal transition mediated by Hippo signaling pathway

Yu, H., Hu, X., Zhang, Y., Wang, J., Ni, Z., Wang, Y., & Zhu, H. (2023) · Medical Oncology · doi:10.1007/s12032-023-02076-9 · Cited by 9

CYP3A5 unexpectedly regulates glucose metabolism through the AKT–TXNIP–GLUT1 axis in pancreatic cancer

Shao, M., Pan, Q., Tan, H., Wu, J., Lee, H. W., Huber, A. D., Wright, W. C., Cho, J., Yu, J., Peng, J., et al. (2023) · Genes & Diseases · doi:10.1016/j.gendis.2023.101079 · Cited by 8

TFE3 and HIF1α regulates the expression of SHMT2 isoforms via alternative promoter utilization in ovarian cancer cells

Wang, S.-Q., Liu, N., Zhang, Q., Li, B., Zhao, F.-Y., Li, C., Wang, H., & Liu, C. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-07445-y · Cited by 8

Cancer stem cells amino acid metabolism: Roles, mechanisms, and intervention strategies

Gong, Y., Wang, X., Chen, W., Tsai, H., & Liu, Y. (2025) · Cellular Signalling · doi:10.1016/j.cellsig.2025.111903 · Cited by 9

Digital twins for in vivo metabolic flux estimations in patients with brain cancer

Meghdadi, B., Al‐Holou, W. N., Scott, A. J., Mittal, A., Liang, N., Palavalasa, S., Achreja, A., O’Brien, A. M., Do, K., Wu, Z., et al. (2025) · Cell Metabolism · doi:10.1016/j.cmet.2025.10.022 · Cited by 8

Genomic analyses of glycine decarboxylase neurogenic mutations yield a large-scale prediction model for prenatal disease

Farris, J. D., Alam†, M. S., Rajashekara, A. M., & Haldar, K. (2021) · PLoS Genetics · doi:10.1371/journal.pgen.1009307 · Cited by 8

Oat Beta-Glucan as a Metabolic Regulator in Early Stage of Colorectal Cancer—A Model Study on Azoxymethane-Treated Rats

Wilczak, J., Prostek, A., Dziendzikowska, K., Gajewska, M., Kopiasz, Ł., Harasym, J., Oczkowski, M., & Gromadzka-Ostrowska, J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25094635 · Cited by 8

PRMT7 in cancer: Structure, effects, and therapeutic potentials

Yang, G., Liu, Y., Chen, R.-Y., Shi, J., Li, C.-Y., Wang, R., Lu, J., Yu, B., Zhang, L., Yu, B., et al. (2024) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2024.117103 · Cited by 8

A new view on functions of the lysine demalonylase activity of SIRT5

Nahálková, J. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.121572 · Cited by 8

Understanding The Regulatory Role of USP32 and SHMT2 in The Progression of Gastric Cancer.

Li, J., Bo, Y., Ding, B., & Wang, L. (2023) · PubMed Central · doi:10.22074/cellj.2022.557384.1046 · Cited by 7

Metabolic Patterns of High-Invasive and Low-Invasive Oral Squamous Cell Carcinoma Cells Using Quantitative Metabolomics and 13C-Glucose Tracing

Jiang, W.-R., Zhang, T., Zhang, H., Han, T.-L., Ji, P., & Ou, Z. (2023) · Biomolecules · doi:10.3390/biom13121806 · Cited by 7

The expression and clinical significance of serine hydroxymethyltransferase2 in gastric cancer

Shan, Y., Liu, D., Li, Y., Wu, C. L., & Ye, Y. (2024) · PeerJ · doi:10.7717/peerj.16594 · Cited by 7

Reprogramming of leukemic cell metabolism through the naphthoquinonic compound Quambalarine B

Vališ, K., Grobárová, V., Hernychová, L., Bugáňová, M., Kavan, D., Kalous, M., Černý, J., Stodůlková, E., Kuzma, M., Flieger, M., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.21663 · Cited by 7

In silico analysis of expression and DNA methylation profiles of NLRP13 inflammasome in tumor cells

Caldiran, F. Y., Berkel, Ç., Deveci, K., & Çaçan, E. (2022) · Human Gene · doi:10.1016/j.humgen.2022.201067 · Cited by 7

Reduction of Rapid Proliferating Tumour Cell Lines by Inhibition of the Specific Glycine Transporter GLYT1

Bierhals, C. G., Howard, A., & Hirst, B. H. (2021) · Biomedicines · doi:10.3390/biomedicines9121770 · Cited by 7

Hypomethylation of glycine dehydrogenase promoter in peripheral blood mononuclear cells is a new diagnostic marker of hepatitis B virus-associated hepatocellular carcinoma

Miao, L.-L., Wang, J., Liu, H.-H., Gao, S., Fan, Y.-C., & Wang, K. (2023) · Hepatobiliary & pancreatic diseases international · doi:10.1016/j.hbpd.2023.02.011 · Cited by 8

Deuterium MRI of serine metabolism in mouse models of glioblastoma

Hesse, F., Low, J. C. M., Cao, J., Bulat, F., Kreis, F., Wright, A. J., & Brindle, K. M. (2024) · Magnetic Resonance in Medicine · doi:10.1002/mrm.30198 · Cited by 6

Structural basis for selective inhibition of human serine hydroxymethyltransferase by secondary bile acid conjugate

Ota, T., Senoo, A., Shirakawa, M., Nonaka, H., Saito, Y., Itô, S., Ueno, G., Nagatoishi, S., Tsumoto, K., & Sando, S. (2021) · iScience · doi:10.1016/j.isci.2021.102036 · Cited by 6

Glycine Decarboxylase Suppresses the Renal Cell Carcinoma Growth and Regulates Its Gene Expressions and Functions

Chen, Y. D., Gao, K. X., Wang, Z., Deng, Q., Chen, Y. T., & Liang, H. (2022) · World Journal of Oncology · doi:10.14740/wjon1539 · Cited by 6

Profile Characterization of Biogenic Amines in Glioblastoma Patients Undergoing Standard-of-Care Treatment

Aboud, O., Liu, Y., Dahabiyeh, L. A., Abuaisheh, A., Li, F., Aboubechara, J. P., Riess, J. W., Bloch, O. G., Hodeify, R. F., Tagkopoulos, I., et al. (2023) · Biomedicines · doi:10.3390/biomedicines11082261 · Cited by 6

NFYB increases chemosensitivity in glioblastoma by promoting HDAC5-mediated transcriptional inhibition of SHMT2

Zhang, Y., Huang, H., Liu, P., & Xie, Y. (2023) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlad073 · Cited by 6

Spatially Resolved Bioenergetic and Genetic Reprogramming Through the Brain of Rats Bearing Implanted C6 Gliomas As Detected by Multinuclear High-Resolution Magic Angle Spinning and Genomic Analysis

Righi, V., García‐Martín, M. L., Mucci, A., Schenetti, L., Tugnoli, V., López‐Larrubia, P., & Cerdán, S. (2018) · Journal of Proteome Research · doi:10.1021/acs.jproteome.8b00130 · Cited by 7

SHMT2 is essential for mammalian preimplantation embryonic development through de novo biosynthesis of nucleotide metabolites

Shi, M., Huai, Y., Deng, T., Zhang, C., Song, J., Wang, J., Zhang, Y., Chen, Z., Zhao, H., Wu, K., et al. (2025) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2025.102499 · Cited by 5

RNA-mediated inhibition of mitochondrial SHMT2 impairs cancer cell proliferation

Liberati, F., Spizzichino, S., Russo, S. D., Borsatti, G. E., Riva, A., Magnifico, M., Bouzidi, A., Giardina, G., Arese, M., Rossi, C. S., et al. (2025) · Cell Death Discovery · doi:10.1038/s41420-025-02646-y · Cited by 4

Mitochondrial respiration supports cancer growth independent of OXPHOS

Chinopoulos, C. (2026) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2026.189593 · Cited by 5

Serine hydroxymethyl transferase is required for optic lobe neuroepithelia development in Drosophila

Silva, E. A. B., Venda, A. M. R., & Homem, C. C. F. (2023) · Development · doi:10.1242/dev.201152 · Cited by 5

PRMT7: a survive-or-die switch in cancer stem cells

Nicot, C. (2022) · Molecular Cancer · doi:10.1186/s12943-022-01602-z · Cited by 5

New Insights into the Link Between Melanoma and Obesity

Neagu, M. T., & Dobre, E.-G. (2024) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-63657-8_28 · Cited by 4

Identification and characterization of glycine decarboxylase as a direct target of snail in the epithelial–mesenchymal transition of cancer cells

Wang, J., Chen, G., Wu, J., & Li, J. (2018) · Tumor and Microenvironment · doi:10.4103/tme.tme_8_18 · Cited by 4

Are anti-glutamic acid decarboxylase 65-kDa isoform antibodies related to diabetes or brain tumor?

Maimaiti, B., Mijiti, S., Sun, H., Xie, Y., Jiang, T., Meng, Q., & Meng, H. (2022) · European journal of medical research · doi:10.1186/s40001-022-00674-3 · Cited by 4

Impairments in SHMT2 expression or cellular folate availability reduce oxidative phosphorylation and pyruvate kinase activity

Fiddler, J. L., Blum, J., Heyden, K. E., Castillo, L. F., Thalacker‐Mercer, A. E., & Field, M. S. (2023) · Genes & Nutrition · doi:10.1186/s12263-023-00724-3 · Cited by 4

Proteomic landscape of primary and metastatic brain tumors for heterogeneity discovery

Yang, S., Zhou, C., Zhang, L., Xiong, Y., Zheng, Y., Bian, L., & Liu, X. (2023) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.202300010 · Cited by 3

Targeting Tumor Metabolism to Overcome Radioresistance

Wahl, D. R., Petronek, M. S., Rashmi, R., Floberg, J. M., Allen, B. G., & Schwarz, J. K. (2020) · Cancer drug discovery and develogment/Cancer drug discovery and development · doi:10.1007/978-3-030-49701-9_10 · Cited by 4

Bourgeoning Cancer Targets

Kriplani, P. (2022) · Recent Patents on Anti-Cancer Drug Discovery · doi:10.2174/1574892817666220804142633 · Cited by 4

H3K27 Acetylation‐Activated GLDC Accelerated the Advancement of Oral Squamous Cell Carcinoma by Suppressing the p53 Signaling Pathway

Chen, X., Xu, Q., & Hai-bing, Y. (2024) · Environmental Toxicology · doi:10.1002/tox.24379 · Cited by 3

LncRNAs in hypoxic microenvironment; insight in their impact in cancer biology

Kuriakose, B. B., Hjazi, A., Saleh, R. O., Bishoyi, A. K., Jyothi, S. R., Almalki, S. G., Sridevi, G., Chaudhary, K., Zwamel, A. H., & Matchonov, O. (2025) · Functional & Integrative Genomics · doi:10.1007/s10142-025-01635-9 · Cited by 3

Magnetic Resonance Spectroscopy of 2‐Hydroxyglutarate and Glycine in Adult Subjects With Brainstem Gliomas

Tiwari, V., Ganji, S., An, Z., Pinho, M. C., Davis, L. T., McKnight, C. D., Berry, J. D., Mobley, B. C., Luo, L. Y., Mohler, A. C., et al. (2025) · NMR in Biomedicine · doi:10.1002/nbm.70153 · Cited by 5

Evaluation of LC/MS Methods for Hydrophilic Metabolites to Enable Integration of Human Blood Metabolome Data

Imado, Y., Takahashi, M., Soma, Y., Aburaya, S., Nakatani, K., Hanai, T., Bamba, T., & Izumi, Y. (2026) · Mass Spectrometry · doi:10.5702/massspectrometry.a0188 · Cited by 3

Metabolic remodeling and immune evasion in glioblastoma: a focus on serine and lipid networks

Jiang, D., Wang, C., Zhao, Y., & Li, Y. (2026) · Frontiers in Oncology · doi:10.3389/fonc.2026.1676560 · Cited by 3

Hydroxymethyltransferase 2 promotes the development of glioblastoma by mediating WTAP regulation of PTEN N6-methyladenosine modification

Wang, M., Sun, G., Fan, Y., Sima, G., Sun, X., Qiu, T., & Li, X. (2025) · Metabolic Brain Disease · doi:10.1007/s11011-025-01621-x · Cited by 3

Upregulated Expression of SHMT2 Predicts Poor Survival of Lung Adenocarcinoma

Guo, Q., Huang, G.-H., Chen, P., & Guo, C. (2025) · Genetics Research · doi:10.1155/genr/6104753 · Cited by 3

Fluxomics reveals cellular and molecular basis of increased renal ammoniagenesis

Mpabanzi, L., Wainwright, J., Boonen, B., van Eijk, H. M. H., Dhar, D. K., Karssemeijer, E., Dejong, C. H. C., Jalan, R., Schwartz, J., Damink, S. W. M. O., et al. (2022) · npj Systems Biology and Applications · doi:10.1038/s41540-022-00257-2 · Cited by 3

Biogenic Amines in Gliomas: A Comprehensive Literature Review

Abuaisheh, A., & Aboud, O. (2023) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2807141 · Cited by 4

Comparative metagenomic analysis reveals the adaptive evolutionary traits of siboglinid tubeworm symbionts

Liu, J., Zhou, Y., Feng, J., Cai, C., & Zhang, S. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1533506 · Cited by 2

Highlights from the Literature

Lawler, S. E., Hegi, M. E., Mansouri, S., & Aldape, K. D. (2015) · Neuro-Oncology · doi:10.1093/neuonc/nov134

SHMT2 Drives Ischemic Glioma Cell Survival and Sensitivity to Excess Glycine

(2015) · Cancer Discovery · doi:10.1158/2159-8290.cd-rw2015-075

TMIC-20. SERINE AND ONE-CARBON METABOLISM ADAPTING GLIOMA CELLS TO LOW GLUTAMINE MICROENVIRONMENT

Tanaka, K., Nagashima, H., Iwahashi, H., Hashiguchi, M., & Sasayama, T. (2022) · Neuro-Oncology · doi:10.1093/neuonc/noac209.1064

Serine-dependent redox homeostasis regulates glioblastoma cell survival

Engel, A. L., Lorenz, N. I., Klann, K., Münch, C., Depner, C., Steinbach, J. P., Ronellenfitsch, M. W., & Luger, A.-L. (2020) · British Journal of Cancer · doi:10.1038/s41416-020-0794-x · Cited by 85

Overexpression of mitochondrial serine hydroxyl-methyltransferase 2 is associated with poor prognosis and promotes cell proliferation and invasion in gliomas

Wu, M., Wanggou, S., Li, X., Liu, Q., & Xie, Y. (2017) · OncoTargets and Therapy · doi:10.2147/ott.s130409 · Cited by 33