Cited by 693Memory and Neural MechanismsNeural dynamics and brain functionNeuroscience and Neuropharmacology Research

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Hippocampal–prefrontal input supports spatial encoding in working memory

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Spellman, Timothy, Rigotti, Mattia, Ahmari, Susanne E., Fusi, Stefano, Gogos, Joseph A., Gordon, Joshua A.·2015·Nature

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Abstract

Spatial working memory, the caching of behaviourally relevant spatial cues on a timescale of seconds, is a fundamental constituent of cognition. Although the prefrontal cortex and hippocampus are known to contribute jointly to successful spatial working memory, the anatomical pathway and temporal window for the interaction of these structures critical to spatial working memory has not yet been established. Here we find that direct hippocampal-prefrontal afferents are critical for encoding, but not for maintenance or retrieval, of spatial cues in mice. These cues are represented by the activity of individual prefrontal units in a manner that is dependent on hippocampal input only during the cue-encoding phase of a spatial working memory task. Successful encoding of these cues appears to be mediated by gamma-frequency synchrony between the two structures. These findings indicate a critical role for the direct hippocampal-prefrontal afferent pathway in the continuous updating of task-related spatial information during spatial working memory.

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Hippocampal and prefrontal contributions to memory-guided navigation depend on task epochPreprint
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Dopamine synchronizes hippocampal-prefrontal networks
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Authors: Spellman, T., Rigotti, M., Ahmari, S. E., Fusi, S., Gogos, J. A., & Gordon, J. A.
Affiliations: Columbia University (US)
IBM Research - Thomas J. Watson Research Center (US)
University of Pittsburgh (US)
New York State Psychiatric Institute (US)
Corresponding author: Gordon, Joshua A.
ORCID: Spellman, Timothy
Rigotti, Mattia
Ahmari, Susanne E.
Fusi, Stefano
Gogos, Joseph A.
Gordon, Joshua A.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2015-06-08
Volume: 522
Issue: 7556
Pages: 309-314
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature14445
PMC: PMC4505751
OpenAlex: W1576349452
Cited by: 693
References: 51
Citations by year: 2026: 48 · 2025: 71 · 2024: 49 · 2023: 59 · 2022: 57 · 2021: 103 · 2020: 67 · 2019: 59 · 2018: 58 · 2017: 67 · 2016: 44 · 2015: 11
FWCI: 36.06
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Funders: National Institutes of Health (5r01mh096274-06)
National Institute of Mental Health (R01-MH096274, MH081968, K08MH087718, MH096274, R01MH081968)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: spatial working memory, hippocampus, prefrontal cortex, memory maintenance, memory retrieval, single-unit activity, mice
MeSH terms: Action Potentials, Afferent Pathways, Animals, Cues, Hippocampus, Male, Memory, Short-Term, Models, Neurological, Space Perception, Prefrontal Cortex, Mice, Optogenetics, Spatial Memory

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Hippocampal–prefrontal input supports spatial encoding in working memory

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