Cited by 693Memory and Neural MechanismsNeural dynamics and brain functionNeuroscience and Neuropharmacology Research

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Hippocampal–prefrontal input supports spatial encoding in working memory

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Spellman, Timothy, Rigotti, Mattia, Ahmari, Susanne E., Fusi, Stefano, Gogos, Joseph A., Gordon, Joshua A.·2015·Nature

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Abstract

Spatial working memory, the caching of behaviourally relevant spatial cues on a timescale of seconds, is a fundamental constituent of cognition. Although the prefrontal cortex and hippocampus are known to contribute jointly to successful spatial working memory, the anatomical pathway and temporal window for the interaction of these structures critical to spatial working memory has not yet been established. Here we find that direct hippocampal-prefrontal afferents are critical for encoding, but not for maintenance or retrieval, of spatial cues in mice. These cues are represented by the activity of individual prefrontal units in a manner that is dependent on hippocampal input only during the cue-encoding phase of a spatial working memory task. Successful encoding of these cues appears to be mediated by gamma-frequency synchrony between the two structures. These findings indicate a critical role for the direct hippocampal-prefrontal afferent pathway in the continuous updating of task-related spatial information during spatial working memory.

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Are the Dorsal and Ventral Hippocampus Functionally Distinct Structures?
Fanselow, M. S., & Dong, H.-W. (2010) · Neuron · doi:10.1016/j.neuron.2009.11.031 · Cited by 3,358
Mnemonic coding of visual space in the monkey's dorsolateral prefrontal cortex
Funahashi, S., Bruce, C. J., & Goldman-Rakic, P. S. (1989) · Journal of Neurophysiology · doi:10.1152/jn.1989.61.2.331 · Cited by 2,685
Cellular basis of working memory
Goldman-Rakic, P. S. (1995) · Neuron · doi:10.1016/0896-6273(95)90304-6 · Cited by 2,663
A mesoscale connectome of the mouse brain
Oh, S. W., Harris, J. A., Ng, L., Winslow, B., Cain, N., Mihalas, S., Wang, Q., Lau, C., Kuan, L., Henry, A. M., et al. (2014) · Nature · doi:10.1038/nature13186 · Cited by 2,612
Models of Working Memory: Mechanisms of Active Maintenance and Executive Control
Miyake, A., & Shah, P. (1999) · Cited by 2,404
Principles of Neurodynamics: Perceptrons and the Theory of Brain Mechanisms
White, B. W., & Rosenblatt, F. (1963) · The American Journal of Psychology · doi:10.2307/1419730 · Cited by 1,818
PRINCIPLES OF NEURODYNAMICS. PERCEPTRONS AND THE THEORY OF BRAIN MECHANISMS
ROSENBLATT, F. (1961) · doi:10.21236/ad0256582 · Cited by 1,691
The importance of mixed selectivity in complex cognitive tasks
Rigotti, M., Barak, O., Warden, M. R., Wang, X.-J., Daw, N. D., Miller, E. K., & Fusi, S. (2013) · Nature · doi:10.1038/nature12160 · Cited by 1,639
Self-citation
Anatomical analysis of afferent projections to the medial prefrontal cortex in the rat
Hoover, W. B., & Vertes, R. P. (2007) · Brain Structure and Function · doi:10.1007/s00429-007-0150-4 · Cited by 1,365

Show all 51 references

Research works printed but not linked: 1

Baddeley, A. & Hitch, G. in Recent Advances in Learning and Motivation Vol. 8 (ed. Bower, G. A. ) 47–90 (Academic, 1974)

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Authors: Spellman, T., Rigotti, M., Ahmari, S. E., Fusi, S., Gogos, J. A., & Gordon, J. A.
Affiliations: Columbia University (US)
IBM Research - Thomas J. Watson Research Center (US)
University of Pittsburgh (US)
New York State Psychiatric Institute (US)
Corresponding author: Gordon, Joshua A.
ORCID: Spellman, Timothy
Rigotti, Mattia
Ahmari, Susanne E.
Fusi, Stefano
Gogos, Joseph A.
Gordon, Joshua A.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2015-06-08
Volume: 522
Issue: 7556
Pages: 309-314
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature14445
PMC: PMC4505751
OpenAlex: W1576349452
Cited by: 693
References: 51
Citations by year: 2026: 48 · 2025: 71 · 2024: 49 · 2023: 59 · 2022: 57 · 2021: 103 · 2020: 67 · 2019: 59 · 2018: 58 · 2017: 67 · 2016: 44 · 2015: 11
FWCI: 36.06
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Funders: National Institutes of Health (5r01mh096274-06)
National Institute of Mental Health (R01-MH096274, MH081968, K08MH087718, MH096274, R01MH081968)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: spatial working memory, hippocampus, prefrontal cortex, memory maintenance, memory retrieval, single-unit activity, mice
MeSH terms: Action Potentials, Afferent Pathways, Animals, Cues, Hippocampus, Male, Memory, Short-Term, Models, Neurological, Space Perception, Prefrontal Cortex, Mice, Optogenetics, Spatial Memory

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